Bone inflammation disease

This study looks at whether adding tirzepatide (a weight-loss drug) to standard ixekizumab treatment helps adults with active psoriatic arthritis who are overweight or obese. About 200 participants will receive both medications for up to 12 months. The goal is to see if this comb…

This early study is testing a new device called the ReNew Hip Implant in 15 people aged 14 to 64 with hip cartilage damage from conditions like osteoarthritis or hip impingement. The implant is surgically placed to repair the cartilage. Researchers are checking if it is safe and …

This trial tests whether a dietary supplement called protocatechuic acid (PCA) can improve health markers in people undergoing revision surgery for a knee prosthetic joint infection. Participants take PCA before and after surgery, and researchers measure changes in immune and met…

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

This study tests a non-invasive device that uses ultrasound to stimulate the spleen and reduce inflammation in people with moderate to severe rheumatoid arthritis. About 60 adults who haven't responded well to standard medications will use the device at home for 12 weeks, with so…

Researchers are testing whether deucravacitinib, a daily oral drug, can reduce joint swelling, tenderness, and skin symptoms in people with active psoriatic arthritis. The trial enrolls adults who have not taken biologic drugs for their arthritis or who previously received a TNF …

This study looks at the long-term safety and effectiveness of a drug called sonelokimab for people with psoriatic arthritis. About 1560 adults who finished an earlier study will receive the drug as a shot under the skin. Researchers will track side effects and how well the drug c…

This early-phase study tests a single injection of ICM-203, a gene therapy that delivers a gene to promote cartilage growth and reduce inflammation in the knee. About 18 adults with mild to moderate knee osteoarthritis will receive escalating doses to check safety and whether it …

This early-phase study tests a personalized cell therapy (rapcabtagene autoleucel) in 27 adults with difficult-to-treat rheumatoid arthritis or severe Sjogren's disease. The treatment uses a patient's own immune cells, modified to target and calm the overactive immune system. The…

This early-stage trial is testing a new drug called GS-0151 in 75 adults with rheumatoid arthritis. The main goal is to see if the drug is safe and how the body processes it. Participants will receive either GS-0151 or a placebo for 12 weeks.

This study tests a new total knee replacement system called LinkSymphoKnee, which uses an ultra-congruent bearing surface designed to provide stability and mimic natural knee movement. Researchers will enroll 600 adults aged 18 to 79 who need a knee replacement due to osteoarthri…

This early-stage study tests a new drug, CND261, in 47 adults with moderate to severe rheumatoid arthritis who haven't responded well to other treatments. The main goal is to check the drug's safety and how the body processes it. Researchers will also look for signs that it might…

This study follows 16 people who previously received ICM-203 (a gene therapy) or a placebo for knee osteoarthritis. Researchers will track delayed side effects and measure changes in knee pain and function over time. The goal is to understand the long-term safety and effectivenes…

This trial tests whether using a navigation system during hip replacement surgery leads to more accurate joint reconstruction than the traditional measured technique. Researchers will compare the surgeon's pre-operative 3-D plan with the actual post-operative result in 100 patien…

This study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…

This phase 3 trial tests whether an experimental drug called SHR0302 can reduce joint pain and swelling in people with active psoriatic arthritis, a condition that combines joint inflammation with psoriasis. About 418 adults with at least six months of symptoms and active joint d…

This study is testing a new type of knee replacement implant that does not use cement to hold it in place. The implant, called ATTUNE Cementless Rotating Platform, is designed for people with osteoarthritis. Researchers will follow 540 patients for two years to see if their abili…

This phase 3 trial tested guselkumab, a biologic drug given as a shot, in over 1,000 people with active psoriatic arthritis who had not responded well to other treatments. The goal was to see if it reduces symptoms like joint pain and swelling and slows joint damage seen on X-ray…

This phase 4 trial tests whether guselkumab (TREMFYA) can reduce spine-related symptoms in people with active psoriatic arthritis who have not used biologic drugs before. About 411 participants will receive either guselkumab or a placebo as a shot under the skin. The main goal is…

This study follows 200 adults who receive the Shoulder iD™ implant to treat severe rotator cuff tears or shoulder arthritis. Researchers measure how well the shoulder works and how often the implant needs to be fixed or replaced over 10 years. Participants attend regular check-up…

Researchers are testing whether a specific carbohydrate diet, which has anti-inflammatory effects in children with inflammatory bowel disease, can also reduce joint inflammation in children with juvenile idiopathic arthritis. The trial includes children up to age 16 with low to m…

This study tests an experimental drug called JNJ-77242113 (icotrokinra) against a placebo in 552 adults with active psoriatic arthritis who have not tried biologic treatments before. The main goal is to see if the drug reduces joint swelling and tenderness after 16 weeks. Partici…

This study follows 159 children aged 2 to 17 who have already completed a prior ustekinumab study for Crohn's disease, ulcerative colitis, or psoriatic arthritis. The goal is to collect long-term safety data by monitoring side effects, lab results, and injection-site reactions. P…

This study follows 500 people who received the INFINITY total ankle replacement to see how well the implant holds up over 10 years. Participants have ankle arthritis from rheumatoid arthritis, injury, or wear-and-tear. Researchers will measure implant survival and changes in pain…

This study tests whether an implantable vagus nerve stimulation device can safely reduce symptoms of rheumatoid arthritis in adults who have not gotten enough relief from at least two biologic or targeted synthetic DMARDs. Participants receive the device, which sends electrical p…

This trial compares two surgical approaches for a common type of ankle fracture. Half of the participants will have the posterior bone fragment fixed with a plate or screw, while the other half will not. The goal is to see if fixing this fragment makes the ankle joint stable enou…

This study follows 73 people who received a shoulder replacement using the Anatomical Shoulder Domelock System. The goal is to see how well the device works and how safe it is over 10 years. Participants have conditions like arthritis or avascular necrosis and have not improved w…

This study follows 200 adults with ankle arthritis who received the INFINITY ankle replacement. Researchers will check how long the implant lasts and monitor for any problems like loosening or cysts over 10 years. The goal is to see if this device works as well as other similar i…

This trial tests a new model where patients with infections receive intravenous antibiotics at home instead of staying in the hospital. Nurses from a municipal response team visit the patient, while hospital doctors oversee the treatment remotely using telemedicine and welfare te…

This study compares two treatments for end-stage hip osteoarthritis: total hip replacement surgery and progressive resistance training (strength exercises). About 109 adults aged 50 and older with severe hip arthritis will be randomly assigned to one of the two treatments. The ma…

This study tests whether a personalized diet, based on the latest Nordic Nutrition Recommendations, can reduce disease activity and cardiovascular risk in people newly diagnosed with rheumatoid arthritis. About 150 participants will be randomly assigned to either a diet following…

This Phase 3 trial tests a single injection of TG-C, a cell-based treatment, in 535 people with moderate knee osteoarthritis. The goal is to see if it reduces pain and improves knee function compared to a placebo injection. Participants are followed for two years to check safety …

This study compares three ways of delivering care for people with hip or knee osteoarthritis: a smartphone app with personalized exercises and education, a web-based exercise program, and standard group-based care. The goal is to see which approach best improves patients' ability…

This early-phase trial tests whether the weight-loss drug semaglutide can improve outcomes for obese patients waiting for total knee replacement. 54 participants will receive the drug for 48 weeks before and after surgery. The goal is to see if weight loss reduces pain and compli…

This trial aims to see if there is a difference in how well two cementless total knee replacement implants hold up over time. About 50 people with knee osteoarthritis will be randomly assigned to receive either the Triathlon Tritanium or the GMK Sphere implant. Using CT scans, re…

This study is testing the Persona Ti-Nidium knee implant in 240 people who need total knee replacement due to conditions like osteoarthritis or rheumatoid arthritis. The goal is to see if the implant is safe and improves knee function and pain. Participants will be followed over …

This study is testing a new knee implant called the Persona SoluTion PPS femur in 200 adults who need total knee replacement. The goal is to see if it safely improves knee function and reduces pain over two years. Participants will have their knee health measured before surgery a…

This trial tests whether adding screws to secure the cup part of a hip replacement makes a difference in how well the implant stays in place. Participants aged 65-80 with hip osteoarthritis will receive a hybrid hip replacement, and half will get screws while the other half won't…

This study is testing a new type of hip resurfacing device made entirely of ceramic, designed for people with hip osteoarthritis, necrosis, or dysplasia. The goal is to see if it is as safe and effective as existing metal-on-metal devices, but without releasing metal ions into th…

This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare di…

This study follows people with knee osteoarthritis who receive one of two total knee replacement designs: a cruciate-retaining (CR) or a posterior-stabilized (PS) implant. The goal is to compare how well each design relieves pain, restores function, and holds up over time. Resear…

This study tests whether the drug ixekizumab is safe and effective for children with certain types of juvenile arthritis (enthesitis-related arthritis and juvenile psoriatic arthritis). About 101 children aged 2 to 17 years will receive either ixekizumab or the standard drug adal…

This study tests a drug called sonelokimab in 960 adults with active psoriatic arthritis who have not used biologic treatments before. The goal is to see if it reduces joint pain and swelling better than a placebo. Participants receive injections over several months, and research…

This trial is testing two different cup designs for total hip replacement, both paired with the same stem, to see which one gives patients better hip function and less pain. About 120 people with hip arthritis or related conditions will be randomly assigned to receive either the …

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This trial compares two types of knee replacement implants: one that keeps the posterior cruciate ligament (CR) and one that does not (PS). Both are implanted using a computer-assisted personalized technique that aims to restore the knee's natural alignment. The study includes 14…

This trial compares two surgical procedures for people with painful thumb base osteoarthritis that hasn't improved with conservative care. One procedure removes the entire trapezium bone, while the other removes only a small portion to create a narrow gap. The study will track pa…

This trial tests whether injecting platelet-rich plasma (PRP) into the thumb joint can reduce pain and improve function in people with thumb base osteoarthritis. Participants are randomly assigned to receive either PRP or a saline placebo injection, and neither they nor the resea…

This trial is testing whether a single injection of micrografts made from a patient's own ear cartilage can improve symptoms and knee function in adults with moderate knee osteoarthritis. The micrografts are prepared from a small ear cartilage sample using a special device, witho…

This trial tests whether an investigational drug called SHR-1314 can reduce joint pain, swelling, and skin symptoms in adults with active psoriatic arthritis. Participants receive either SHR-1314 or a placebo injection over 24 weeks, with follow-up for safety. The study aims to s…

This trial tests whether a 12-week program of physical therapy or home exercises can reduce pain and improve shoulder function in adults with glenohumeral arthritis, compared with no treatment. Participants are randomly assigned to one of three groups: supervised physical therapy…

This trial is testing whether a single injection of stem cells taken from a patient's own belly fat can ease the pain and improve the function of knees damaged by osteoarthritis. Half of the participants will receive the stem cell treatment, while the other half will get a placeb…

This study is testing an oral medication called upadacitinib in children with polyarticular juvenile idiopathic arthritis (JIA), a condition causing joint inflammation. The goal is to understand how the drug moves through the body, its safety, and how well children tolerate it. P…

This study tests an investigational drug called emactuzumab for people with a rare joint tumor (TGCT) that can't be removed surgically. About 128 participants will receive either the drug or a placebo to see if it shrinks tumors and improves joint function. The goal is to offer a…

This trial compares two types of knee replacement implants in people aged 75 and older: a standard metal-backed component and a cheaper all-polyethylene (plastic) one. The goal is to see if the all-polyethylene implant performs as well in terms of pain relief, movement, and how l…

This study tests the drug bimekizumab in 89 adults with moderate to severe plaque psoriasis, some of whom also have psoriatic arthritis. Researchers will measure changes in gene activity in skin samples after 48 weeks of treatment. The goal is to understand how the drug affects t…

This study tests the drug anakinra in Chinese patients with two related inflammatory conditions: Systemic Juvenile Idiopathic Arthritis (SJIA) in children and Adult-Onset Still's Disease (AOSD) in adults. Participants receive a daily injection under the skin for 48 weeks. The goa…

This study follows 300 people who receive a hip replacement using either the Vivacit-E or Longevity liner, both made of a special plastic designed to last longer. The goal is to see how well these liners hold up over time, measuring how many are still in place without needing rep…

This study investigates whether adding two common drugs—valsartan (for high blood pressure) and celecoxib (for arthritis pain)—to standard metformin therapy can improve blood sugar control in people with type 2 diabetes. The trial enrolls adults with obesity, high blood pressure,…

This study tests whether a home exercise program using a blood pressure cuff to partially restrict blood flow can help people regain leg muscle strength and walking ability after a total knee replacement. Participants will do light exercises three times a week for ten weeks. The …

This trial tests whether injections of platelet-rich fibrin (iPRF), made from a patient's own blood, can reduce pain and improve jaw function in people with mild to moderate temporomandibular joint (TMJ) degeneration. Forty-two adults with TMJ arthritis or osteoarthritis will rec…

This study compares two types of shoulder replacement surgery—Total Shoulder Arthroplasty (TSA) and Reverse Total Shoulder Arthroplasty (RTSA)—in people aged 65 and older with advanced shoulder osteoarthritis. Participants are randomly assigned to one of the two procedures. The g…

This study follows 59 adults who received a specific shoulder replacement stem to see how well it works and holds up over 10 years. Researchers will track implant survival, side effects, and patient-reported pain and function. The goal is to confirm the device is safe and effecti…

This study tests whether a short, standardized 4-minute heart-healthy talk is as effective as a full 60-minute personalized session with a dietitian for lowering LDL cholesterol and improving diet. Participants are adults aged 30–80 with rheumatoid arthritis, psoriatic arthritis,…

This study tests whether taking a 7-day course of oral antibiotics after hip or knee replacement surgery can prevent joint infections in patients at higher risk due to conditions like obesity, diabetes, or autoimmune disease. About 4,600 participants will receive one of three ant…

This study was designed to test whether a combination of an educational booklet, team-based care from a rheumatologist, physical therapist, and psychologist, plus nurse-led phone calls and home symptom tracking, could help more Hispanic adults with rheumatoid arthritis achieve re…

This study compares two ways of managing rheumatoid arthritis in people taking adalimumab. One group gets standard care, while the other has their dose adjusted based on regular blood tests that measure drug levels and antibodies. The goal is to see if personalized dosing helps m…

This study follows 383 people who received a cementless hip replacement part called the Trident II Tritanium Acetabular Shell. Researchers want to see how many need a revision surgery within 5 years, compared to similar devices. The goal is to confirm the part works well and stay…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This study follows 94 people who received the FDA-approved H3 total ankle replacement for arthritis. Researchers will track serious device-related problems and how well the ankle works over 2 to 5 years. The goal is to confirm the device's safety and effectiveness in real-world u…

This study tests whether injections of platelet-rich plasma (PRP) or stem cells from belly fat can help people with knee osteoarthritis. 160 adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to get PRP, stem cells, both, or a placebo. Researchers wi…

This study was designed to test the safety and effectiveness of a new treatment called GC012F for people with difficult-to-treat rheumatoid arthritis. It planned to enroll adults aged 18 to 75 whose arthritis did not respond well to standard therapies. However, the study was with…

This study looks at how well a new knee replacement system, the JOURNEY™ II CR, works for people with knee osteoarthritis. About 170 adults aged 22 to 75 who need a total knee replacement will receive the implant. Researchers will measure knee movement, survival of the implant, a…

This phase 2 trial tests an injectable form of methotrexate called FBL-MTX for people with moderate-to-severe rheumatoid arthritis. The drug is designed to deliver methotrexate directly into the body using tiny fat bubbles, which may improve how well it works and reduce side effe…

This Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…

This early-phase trial tests a new cell therapy called BEN301 for several autoimmune diseases, including scleroderma and rheumatoid arthritis. The therapy uses specially engineered immune cells (CAR-Treg cells) to calm the overactive immune system. The study involves 24 adults an…

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This program provides ongoing access to certolizumab pegol (Cimzia) for adults with rheumatoid arthritis who took part in earlier open-label studies. Participants receive the standard maintenance dose of 200 mg every two weeks. The goal is to allow continued disease management or…

This study looks at how well upadacitinib (RINVOQ) works for people with axial spondyloarthritis, a type of inflammatory arthritis that causes chronic back pain. About 338 adults in Germany will take the drug as prescribed by their doctor and be followed for 52 weeks. Researchers…

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This phase 3 trial tests whether a new oral drug called TLL-018 works better than tofacitinib for active rheumatoid arthritis. The study includes 459 adults aged 18-65 who have not responded well to or cannot tolerate biologic treatments. Participants take either TLL-018 or tofac…

This study is testing a special implant (Tapestry) that helps repair a key shoulder tendon (subscapularis) during shoulder replacement surgery. About 100 adults with shoulder arthritis or injury will be followed for 2 years to see if the tendon heals better with the implant. The …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This study tests a non-invasive device that uses low-frequency electromagnetic fields to improve communication between immune cells. 120 adults with lupus, rheumatoid arthritis, or multiple sclerosis will receive either active or sham sessions three times a week for 12 weeks. The…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This study planned to test a hip implant called the Restoration Anatomic Acetabular Shell in people needing revision surgery after a previous hip replacement failed. The goal was to see how well the implant holds up over time. However, the study was withdrawn before enrolling any…

This study compares two versions of the Triathlon total knee prosthesis—one fixed with bone cement and one without—in 60 people with knee osteoarthritis. Researchers will use special X-ray techniques to see how well each implant stays in place over time, and also track patients' …

This study compares a single-stage surgery using implants coated with an antibiotic-loaded hydrogel to the standard two-stage surgery for treating chronic hip prosthesis infections. The single-stage approach aims to remove the infected implant and place a new one in the same oper…

This trial tests a new hip resurfacing system in 238 adults with hip osteoarthritis or mild dysplasia. The device is designed to cap the damaged joint rather than replace the entire hip. Researchers will compare pain, function, and safety to standard total hip replacement over tw…

This study tests an experimental injection called SHR-3045 in 30 adults with moderate to severe rheumatoid arthritis who did not get enough relief from other treatments. The goal is to see if it safely reduces joint pain and swelling. Participants are randomly assigned to receive…

This study is checking how well a new hip replacement part (the HYPE stem) works and lasts over 10 years. About 180 people with hip disease from arthritis or injury will get the implant. Doctors will use X-rays and surveys to see if the implant stays firmly in place and helps red…

This study planned to test a new hip replacement device (the HYPE stem) in people with hip arthritis or other hip damage. The goal was to see how well the device works and if it is safe. However, the study was withdrawn before any participants were enrolled, so no results are ava…

This study follows 194 people who received the Comprehensive Nano shoulder device to replace their shoulder joint due to arthritis, bone death, or deformity. Researchers will track how long the implant lasts and how well patients can use their shoulder over 10 years. The goal is …

This study follows 200 people who received a new type of ankle replacement designed to attach better to bone and wear out more slowly. Researchers will track pain, function, and how long the implant lasts over time. The goal is to see if this improved device helps people with sev…

This study follows 757 people who received the Persona Partial Knee system, a device used to replace only the damaged part of the knee. The goal is to see how long the implant lasts and how well patients function afterward. Participants have knee arthritis or related conditions a…

This study follows 118 people who already received a LEGION knee implant during total knee replacement surgery. Researchers will check how well the implants hold up over 10 years by measuring implant survival and patient quality of life using questionnaires. The goal is to confir…

This study tests whether injecting a concentrated sample of a patient's own bone marrow into the knee right after meniscus surgery can slow down or prevent arthritis. One hundred adults with a torn meniscus will receive either the bone marrow injection or a saltwater placebo, and…

This study tests a small device implanted on the vagus nerve in the neck to treat moderate to severe rheumatoid arthritis. About 243 adults who did not get enough relief from standard drugs will receive either active or inactive stimulation for 12 weeks, then all will receive act…

This program provides access to the VT-X7 system, which delivers antibiotics directly into the joint through a pump over 7 days, for people with a serious hip or knee infection after joint replacement. It is for patients who have already tried other treatments and have no other o…

This early-phase trial tests the safety of Allocetra-OTS, a cell therapy made from donor immune cells, injected into the knee joint of 18 people with end-stage osteoarthritis who are candidates for surgery. Researchers will monitor side effects and measure pain relief using a sta…

This study tests whether giving antibiotics directly into the bone during a standard cleaning surgery can better control joint infections and reduce the need for additional major surgeries. About 100 adults with infected knee or hip replacements will receive this targeted antibio…

This study is following 110 people who received a Tornier HRS shoulder replacement to see how well it improves pain and function. Participants have conditions like arthritis, fractures, or rotator cuff tears. The goal is to collect long-term safety and performance data for regula…

This study is observing about 881 people with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, or psoriasis who are taking Remsima (a biologic drug) either as a shot under the skin or through an IV. The goal is to track any serious side effects over time. Resear…

This study followed 413 people with hip arthritis who received a new type of hip replacement called the OXINIUM DH system. The goal was to see how well the implant worked and how safe it was over 10 years. Researchers checked pain, movement, and whether the implant stayed in plac…

This study is checking the long-term safety and performance of two hip implant devices (RingLoc Bipolar Acetabular Cup and Endo II Femoral Head) used in hip replacement surgery. Researchers will follow 116 patients who had their surgery at least eight years ago, tracking complica…

This Phase III trial tests whether combining baricitinib with an anti-TNF drug (adalimumab or etanercept) works better than baricitinib alone for people with rheumatoid arthritis who haven't responded to prior treatments. The study involves 160 adults aged 18-65 with active disea…

This study tests whether robot-assisted knee replacement surgery leads to better results than traditional manual surgery for people with knee osteoarthritis. About 95 participants will receive the robot-assisted procedure and use a special knee brace to track motion. Researchers …

This study follows 148 people with knee osteoarthritis who received the ANTHEM total knee replacement system. Researchers will check how well the implant holds up over 10 years by measuring survival rates and patient-reported knee function. The goal is to confirm the device is as…

This study is testing the CATALYSTEM hip system in 119 people who need a total hip replacement due to conditions like arthritis or hip damage. The goal is to see if the implant is safe and works well, focusing on how long it lasts without needing a second surgery. Participants wi…

This phase 3 study tests whether tildrakizumab, an injected drug, can reduce joint pain and swelling in people with active psoriatic arthritis who have not used anti-TNF treatments before. About 296 adults will receive either the drug or a placebo. The main goal is to see if at l…

This study follows 737 people who received a Persona knee implant to see how long it lasts and how well it works. Participants are adults aged 18-75 with severe knee pain from conditions like arthritis or bone damage. The goal is to track implant survival and knee function over t…

This study looks at how safe and effective the ANTHEM CR total knee system is for people with non-inflammatory degenerative joint disease who need a total knee replacement. About 153 participants will be followed for up to 10 years to check implant survival, bone health, and any …

This study compares two types of antibiotic-loaded bone cement used during hip fracture surgery to see which better prevents joint infections. About 7000 patients aged 60 and older with displaced femoral neck fractures will be included. Hospitals are randomly assigned to use eith…

This phase 3 study is testing the long-term safety and effectiveness of tildrakizumab, a biologic drug given as an injection, in people with psoriatic arthritis. Researchers are tracking side effects and how well the drug reduces joint pain, swelling, and other symptoms over time…

This phase I/II trial compares a single dose of CAR-T cell therapy (KYV101) to two doses of rituximab in 13 people with active, treatment-resistant rheumatoid arthritis. The main goals are to check safety and see if the CAR-T treatment can turn off certain immune markers linked t…

This study looks at two kinds of plastic used in total knee replacement surgery: one with vitamin E and one without. The goal is to see which one lasts longer, causes less wear, and helps patients move better. About 605 adults with knee arthritis or similar problems took part, an…

This pilot trial aimed to test the safety and feasibility of a single injection of a patient's own fat-derived cells (stromal vascular fraction) into the knee for post-traumatic osteoarthritis. It was designed for adults aged 18–45 with a history of knee injury. However, the stud…

This study looks at how well a specific knee replacement device, the Triathlon All-Polyethylene Tibia, works in people with knee arthritis. Researchers will follow 204 patients who already have the device to see how their knee function and pain change over time. The goal is to ch…

This study looks at the safety and performance of a cemented hip stem (TrendHip®) in 119 people who had hip replacement surgery. It tracks pain, function, and quality of life for up to 5 years after surgery. The goal is to confirm the device works well in everyday use.

This study compares two types of shoulder replacement surgery for people with glenohumeral osteoarthritis: hemiarthroplasty with a pyrocarbon implant and total shoulder arthroplasty. Researchers will track 74 participants for 10 years to see which surgery provides better pain rel…

This study tests whether stem cells taken from a person's own belly fat can help regenerate knee cartilage and reduce pain from osteoarthritis. Sixty adults with moderate to severe knee arthritis will receive either a stem cell injection or a standard hyaluronic acid shot. Resear…

This study follows 100 people who received a new type of knee replacement device called EVOLUTION® NitrX™. The goal is to see how safe and effective it is over time. Participants have conditions like arthritis or knee damage. The main measure is a patient-reported score of knee f…

This study follows 59 people who received a specific shoulder implant (Versa-Dial Reverse Ti Glenosphere) to see how safe and effective it is over up to 10 years. Participants have shoulder arthritis, fractures, or a failed previous replacement. Researchers track complications, r…

This study follows 102 people who received the aneXys hip replacement cup to see how safe and effective it is over 2 years. Researchers measure if the cup moves and track pain and function using standard scores. The goal is to confirm the device works well in everyday use.

This phase 3 trial in Lahore, Pakistan, will enroll 60 children aged 2–16 with newly diagnosed polyarticular juvenile idiopathic arthritis. Half will receive methotrexate alone, and half will receive methotrexate plus etanercept, a biologic drug. Researchers will measure how many…

This study looks at how well the ExploR Radial Head implant works over time for people who had elbow replacement surgery after an injury. Researchers will track about 93 patients to see how long the implant lasts and if any problems arise. The goal is to confirm the device is saf…

This pilot study looks at combining two knee surgeries into one: a partial knee replacement and an ACL repair. It aims to see if doing both at the same time is safe and effective for people with knee arthritis and a torn ACL. The study will collect data from 15 patients to measur…

This study looks at how well a specific knee replacement implant works over 10 years. Researchers are checking the safety and performance of the Legion knee implant in 126 people who already received it. The goal is to see how long the implant lasts and if it helps patients with …

This study tests a new antibiotic called omadacycline, taken once a day by mouth, against standard antibiotics for bone and joint infections. About 180 adults with these infections will be randomly assigned to receive either omadacycline or the usual care. The goal is to see if o…

This study aimed to see if a 3-week course of antibiotics works as well as a 6-week course for treating bone infections in the feet of people with diabetes. The trial planned to include adults with diabetes and a forefoot bone infection treated without surgery. However, the study…

This study tests a new oral drug called LNK01001 (Zemprocitinib) in 430 adults with moderate-to-severe rheumatoid arthritis who have not improved with other biologic treatments. Participants receive either the drug or a placebo for 24 weeks, followed by a long-term safety extensi…

This study compares two types of knee replacement surgery for people with arthritis limited to the kneecap area. One hundred patients will be randomly assigned to receive either a partial replacement (patellofemoral arthroplasty) or a full knee replacement. The goal is to see whi…

This study tests an oral drug called jaktinib in 265 adults with active ankylosing spondylitis, a type of arthritis that mainly affects the spine. Participants take either jaktinib or a placebo twice daily for 16 weeks. The main goal is to see if jaktinib can reduce pain and impr…

This study tests whether a pharmacist-led program can help people reduce their risk of heart disease. Over 1,000 adults with conditions like diabetes, high blood pressure, or obesity are taking part. Pharmacists use a step-by-step guide to assess risk and support lifestyle change…

This study compares two ways to recover after reverse total shoulder replacement: using a smartphone app (mymobility) for home exercises versus standard in-person physical therapy. Researchers will enroll 100 adults to see if the app works just as well. The main goal is to measur…

This study tests a new way to repair damaged knee cartilage using 3D printing, platelet-rich plasma, and a piece of the patient's own bone and tissue. It involves 60 adults with large cartilage injuries. The goal is to see if this approach improves knee function and helps cartila…

This study tests a new coating on a hip replacement implant that may help prevent infections and help the implant bond better with the bone. About 340 adults needing a hip replacement will receive either the coated or standard implant. The goal is to see if the coated implant wor…

This study tests whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve hand function in people with a severe form of hand osteoarthritis. About 163 adults with moderate to severe finger pain will receive either methotrexate or a placebo for 6…

This study compares two standard treatments for acute infection after hip or knee replacement: a single surgery to clean the joint versus two planned surgeries. About 490 participants will be randomly assigned to one approach. The goal is to see which method better prevents the n…

This study follows 700 people receiving a Persona total knee replacement to see how well the artificial joint works over time. Researchers will measure pain, function, and quality of life using patient questionnaires, and track how long the implant lasts (up to 10 years). The goa…

This study follows 163 people who received a LEGION knee replacement with a special VERILAST bearing surface to treat degenerative joint disease. Researchers track how long the implant lasts and how well patients function over time. The goal is to see if this newer device perform…

This study tests whether giving people free fruits and vegetables (a produce prescription) along with culturally tailored cooking classes can improve their nutrition and help manage chronic conditions like diabetes and high blood pressure. Thirty adults who already take medicatio…

This study looks at how stable a new type of knee replacement part (the tibial baseplate) is over time. It involves 31 people with knee osteoarthritis who are getting a total knee replacement. Researchers will use special X-rays to measure any movement of the implant between 6 mo…

This study follows 30 people with knee osteoarthritis who receive a cementless total knee replacement. Researchers use special X-ray techniques to measure how much the implant moves over two years. The goal is to see if the implant stays firmly in place, which could mean better o…

This study looks at how well a new knee replacement system works for people with severe knee pain from arthritis or previous failed surgeries. About 255 participants will receive the implant and be followed for up to 10 years. The goal is to see if the system improves knee alignm…

This study looks at 360 adults aged 18-75 who need a hip replacement due to arthritis or pain. It compares three different types of artificial hip parts to see which one causes less bone loss and gives better pain relief and movement over 5 years. Participants will have CT scans …

This study tracks 100 adults who need a hip replacement to see how well the Avenir cemented hip stem works and holds up over time. Participants have conditions like arthritis, hip fractures, or hip damage from past surgeries. The main goal is to measure how long the implant lasts…

This study is testing a shoulder replacement device called the Medacta Shoulder System in 100 people with shoulder arthritis or rotator cuff tears. The goal is to see how well the implant works after 2 years, focusing on shoulder function, safety, and patient satisfaction. Partic…

This study follows 777 adults aged 18-75 who received the Persona Total Knee System to treat severe knee pain and disability from conditions like osteoarthritis or rheumatoid arthritis. Researchers will track how long the implant lasts, how safe it is, and how well it improves pa…

This Phase 3 trial tests whether a single injection of ELIXCYTE, made from donor stem cells, can reduce knee pain better than a placebo (saline). About 165 adults aged 40-80 with moderate knee osteoarthritis who haven't gotten relief from standard treatments are participating. Th…

This study aimed to see if using a robotic system for partial knee replacement leads to better outcomes than traditional surgery. It planned to follow patients for 10 years to measure how much they 'forgot' about their new knee and how long the implant lasted. However, the study …

This study compares two types of hip implant liners—one with vitamin E and one without—to see which lasts longer and causes fewer problems like wear or bone damage. Researchers are following 400 adults aged 18 to 75 who need a hip replacement due to arthritis. The goal is to find…

This study tests a telehealth program called mCare PTOA for people who have had ACL knee surgery. The program includes five educational modules on joint health, self-care, weight management, physical activity, and work strategies. Researchers will compare knee function and readin…

This study follows over 1300 adults with moderate to severe rheumatoid arthritis who are starting filgotinib (Jyseleca) as part of their normal care. Researchers will track how long patients stay on the drug, their pain, fatigue, and daily function over two years. The goal is to …

This study compares two treatment strategies for rheumatoid arthritis (RA): aiming for low disease activity versus aiming for remission. 340 adults with RA who are starting or already on disease-modifying drugs will be randomly assigned to one of these targets. The goal is to see…

This study compares two types of wrist fusion surgery for people with advanced wrist arthritis (SNAC or SLAC). The simpler procedure, lunate-capitate fusion (LCF), is being tested against the standard four-corner fusion (4CF) to see if it provides similar grip strength and functi…

This Mayo Clinic study tests a new 3D MRI sequence called oZTEo, enhanced with deep learning, to detect bone erosions in the hands of people with inflammatory arthritis. The goal is to see if this advanced scan finds erosions better than standard MRI or X-rays. The study will enr…

This study looks at 174 adults with painful joint replacements who may have a chronic infection. Researchers are testing a combination of advanced lab tests, imaging, and tissue sampling to see which methods best detect the infection. The goal is to create a more reliable diagnos…

This study looks at whether a special type of PET scan (FDG-PET) can more accurately detect bone infections (osteomyelitis) in people with diabetic foot disease. Researchers will compare the scan results with MRI and follow patient outcomes to see how well it works. The goal is t…

This trial tests whether taking a daily probiotic alongside standard antibiotic treatment after surgery for an infected hip or knee joint can lower the chance of the infection coming back. The study involves 152 adults undergoing revision joint replacement for infection. Half wil…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This study tests the Shingrix vaccine in over 2,000 adults with autoimmune rheumatic diseases like rheumatoid arthritis and lupus, who are at higher risk for shingles. Researchers will compare vaccinated patients to unvaccinated ones to see if the vaccine is safe and triggers a s…

This study tests whether a supervised resistance exercise program can reduce the risk of osteoporosis and osteoarthritis in women aged 50-70 who have gone through menopause. Participants will do leg and core exercises twice a week for 30-40 minutes. Researchers will measure chang…

This study tests different types and doses of vitamin K in 55 adults aged 60 and older with knee osteoarthritis. Researchers want to see if vitamin K can improve knee health by measuring changes in blood markers. The goal is to find the best form and dose for future larger studie…

This study is testing a new surgical technique for total shoulder replacement that does not cut any muscles or tendons. Researchers want to see if this approach improves pain, strength, and motion in people with shoulder arthritis. About 50 patients will be followed after surgery…

This study tests a single injection called 4P004 for people with knee osteoarthritis and synovitis (inflammation). About 129 adults aged 40-80 will receive either the injection or a placebo. The goal is to see if it reduces daily knee pain and improves function over 12 weeks.

This study tests whether a disposable device called the Zero Degree Knee positioner helps people regain full knee extension faster after total knee replacement surgery. About 154 adults aged 40-80 with knee osteoarthritis will be randomly assigned to use the device at home or fol…

Researchers are comparing two ways to perform total knee replacement in patients with obesity and knee arthritis. One method uses custom-made guides based on each patient's knee scans, while the other uses standard surgical tools. The trial measures how well the knee aligns, how …

Researchers are testing FX201, an experimental gene therapy, in adults aged 30 to 80 with painful knee osteoarthritis. Participants receive a single injection of FX201 into the affected knee. The study first checks safety at increasing doses, then gives more people the same dose …

This study tests whether a 10-week telehealth program that combines gentle exercise with mindfulness can help people with knee osteoarthritis feel less pain and move better. Researchers will compare the mindful exercise group to an exercise-only group. All sessions happen remotel…

Researchers are observing people with knee osteoarthritis who receive an injection of Arthrosamid, a hydrogel, into the affected knee. The study follows about 200 adults over the long term to track side effects and changes in pain, stiffness, and physical function. Because it is …

This study looks at whether a 6-month thermal spa treatment program can meaningfully reduce pain and improve daily function in people with knee osteoarthritis. Researchers will compare results from 76 participants aged 50-80 who receive the spa therapy against an external group r…

This study compares robotic-assisted total knee replacement to the standard manual procedure in 86 adults aged 40-85 with severe knee arthritis. Participants will receive the same knee implant, but one group's surgery is guided by a robotic system. Researchers will measure pain, …

People with rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis often struggle to stay in work. This trial tests a 6-month vocational rehabilitation program called WORK-ON, which includes a coordinating occupational therapist, group sessions with peers, and ind…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

After hip replacement through a front incision, many people feel numbness, tingling, or burning in the thigh because a nearby nerve gets irritated. This trial tests whether a handheld massage gun, used at home twice a day for six weeks, can ease those symptoms faster than gentle …

This trial tests a six-month program where a coordinating rheumatology nurse helps people with inflammatory arthritis set goals and plan actions to manage their condition. Participants also get access to physiotherapy, occupational therapy, and social work support as needed. The …

Researchers are comparing two common surgical approaches during total hip replacement: removing the acetabular labrum (a ring of cartilage around the hip socket) or leaving it in place. The trial enrolls 200 adults with hip osteoarthritis who are scheduled for a primary unilatera…

This trial tests whether a wearable sensor that monitors home exercises helps people recover after total knee replacement. Researchers randomly assign 250 adults to either use the sensor or receive standard unsupervised home exercises. The study compares knee function, pain, and …

This study tests whether taking probiotic supplements for 6 months can reduce pain, improve knee function, and boost quality of life in women aged 45-70 with knee osteoarthritis. Researchers will compare the probiotic group to a placebo group to see if the gut bacteria help lower…

This study compares two ways to manage pain after total knee replacement: a continuous nerve catheter that delivers numbing medicine for days versus a single nerve block. Sixty-four adults scheduled for knee surgery will be randomly assigned to one of the two methods. Researchers…

This study tests whether an injected drug called pentosan polysulfate sodium can reduce knee pain and improve function in people with knee osteoarthritis. About 466 adults with moderate to severe knee arthritis who haven't found relief from other treatments will receive either th…

This study tests a goal-setting program for adults with knee problems like arthritis or injuries. Participants work with their surgeon to create specific, measurable goals and track progress. The aim is to see if this approach helps patients achieve their treatment goals and impr…

This study tests whether an extended-release steroid injection (Zilretta) given during knee meniscus surgery can reduce pain and inflammation in people with osteoarthritis. 150 adults aged 40 and older are enrolled. Researchers will measure knee pain scores and inflammatory marke…

This study tests whether the steroid hydrocortisone can improve knee movement after total knee replacement. About 132 patients, some with naturally stiff knees, will receive either the drug or a placebo right after surgery. Researchers will measure how well the knee bends and str…

This study tests whether a smartphone app called PIANISSIMO can encourage people with osteoarthritis to be more physically active. Participants set weekly step goals and receive daily notifications about physical activity and its benefits for joint health. The trial focuses on wh…

This study explores whether virtual reality (VR) can help reduce pain and anxiety in children aged 5-17 undergoing joint injections for juvenile idiopathic arthritis. Participants will use a VR headset during the procedure, and researchers will measure how practical it is for nur…

This study looks at whether adding cognitive behavioral therapy for insomnia (CBT-I) to standard knee osteoarthritis care (education and exercise) helps reduce pain and improve function. About 128 adults aged 45+ with both knee osteoarthritis and insomnia will be followed for 6 m…

This study tests whether a digital therapeutic called MORA Cure can reduce knee pain in adults over 50 with knee osteoarthritis and anterior knee pain. Participants use a mobile app for 8 weeks that provides personalized exercises and cognitive behavioral therapy content. The app…

This study tests whether a 10-week program called Positive Minds, Strong Joints is feasible for Black adults aged 50 and older with knee osteoarthritis. The program combines recommended exercise with mental health strategies to address pain, depression, and anxiety. Researchers w…

This phase II trial is testing whether an experimental lotion called ASKC200 can reduce pain in people with knee osteoarthritis. About 175 adults aged 40 to 80 with knee pain lasting at least six months will be randomly assigned to receive one of two strengths of ASKC200, a stand…

This early-stage study tests whether people with knee osteoarthritis can stick to a daily routine of self-injecting recombinant human growth hormone (rHGH) for six weeks. Researchers will track how well participants follow the regimen, along with changes in knee strength, range o…

This phase 3 trial tests whether an 800 mg modified-release ibuprofen tablet can reduce chronic knee pain from osteoarthritis better than a placebo. About 500 adults with knee osteoarthritis will take either the long-acting ibuprofen or a placebo daily for 12 weeks. Researchers w…

This trial tests whether suzetrigine (Journavx), a newly approved non-opioid pain medication, can effectively control pain after thumb basal joint replacement surgery. One hundred adults aged 40 to 80 will receive suzetrigine plus acetaminophen for five days after surgery, and th…

This study tests whether blocking certain arteries in the knee (geniculate artery embolization) can reduce pain and the need for opioid painkillers in people with knee osteoarthritis. Twelve participants will receive the procedure and be followed for a year with MRI scans and pai…

This study tests a single injection of Hydrogel OA 2% in 20 adults with knee osteoarthritis. The goal is to see if the gel is safe and tolerable over 13 weeks to 12 months. Participants must be 35–75 years old with a BMI between 20 and 35.

This phase 2 study tests whether bone marrow stem cells can safely reduce pain in people with low back pain from worn-out facet joints. Forty participants will receive injections into the painful joints and be monitored for side effects and pain levels. The goal is to see if this…

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the …

This study compares two robotic-assisted systems (Velys J&J and Cori S&N) for total knee replacement in 200 people with severe knee arthritis. Researchers will measure knee alignment, movement, and patient-reported outcomes like pain and function. The goal is to see if one robot …

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study tests whether a supervised exercise program before hip or knee replacement surgery can improve recovery, function, and quality of life. 44 adults with advanced osteoarthritis will do 3 weekly physiotherapy sessions plus daily home exercises for several weeks before the…

This pilot study explores whether a 7-day fast followed by 11 weeks of a plant-based diet can reduce skin and joint symptoms in people with psoriasis and psoriatic arthritis. Researchers will also look at changes in gut bacteria and overall quality of life. The study involves 30 …

This study looks at whether using a blood flow restriction cuff during physical therapy can help people with tennis elbow feel less pain and recover faster. The trial plans to enroll 250 adults aged 18 to 65 with confirmed tennis elbow. Participants will either receive standard p…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests whether a dietary supplement called Native CT-II® (a type of collagen from chicken sternum) can reduce pain and improve knee function in people with knee osteoarthritis. About 114 adults aged 40-65 with moderate-to-severe knee pain will take either the supplement…

This pilot study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. The treatment blocks abnormal blood vessels in the knee to reduce pain and swelling. Twenty participants will be randomly assigned to either receive the …

This study tested whether a personalized exercise program done 2-4 weeks before knee or hip replacement surgery could improve thinking and reduce delirium in adults aged 55 and older. Participants wore activity trackers and used a smartphone app. The study was suspended, so resul…

This small pilot study at Mayo Clinic is testing whether Electromagnetic Transduction Therapy (EMTT) can help people with osteoarthritis of the foot or ankle. Twenty participants will receive the treatment, and researchers will measure changes in pain and daily function. The goal…

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study looks at whether adding desensitization exercises to the usual hand rehab program can help rheumatoid arthritis patients who have central sensitization—a condition where the nervous system is extra sensitive to pain. About 81 adults with mild-to-moderate RA will be spl…

This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patient…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery. About 40 adults will receive the medicine either as a targeted block or as local infiltration. Participants will report their pain levels and any extra pain medicines they need. T…

This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40…

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study looks at 600 hip or knee replacement patients to compare three different wound closure products: Sylke adhesive dressing, Exofin skin glue, and Suture Strip Plus. The goal is to see which method causes the fewest allergic skin reactions and gives the best scar appearan…

This study compares two knee replacement systems, Persona and NexGen, in 332 people with knee osteoarthritis. Participants receive one of the two implants during surgery. Researchers track pain, function, and quality of life for up to two years to see if one system leads to bette…

This study looks at whether a treatment called pulsed radiofrequency (PRF) applied to a key shoulder nerve can help people with long-lasting shoulder pain that hasn't improved with standard treatments like painkillers or physical therapy. The study involves 60 adults with chronic…

This study tests whether doing guided exercises at home via video calls can reduce pain and improve movement in people with hip or knee osteoarthritis. 110 participants will either receive remote exercise sessions or standard education about their condition. The goal is to see if…

This study compares two types of blood flow restriction therapy (using a cuff to limit blood flow during exercise) against standard moderate strength training in 75 people with knee osteoarthritis. Participants will do supervised exercises twice a week for 8 weeks. The goal is to…

This study was designed to see if an artificial intelligence app could help people with knee osteoarthritis do their exercises correctly at home. It planned to compare the app group to a group using a paper exercise booklet. The study was withdrawn before any participants were en…

This study tests an online program designed to help people with inflammatory arthritis remain employed. The program includes eLearning modules, group video sessions, and consultations with an occupational therapist and vocational counselor. About 528 participants from three Canad…

This study looks at whether a 12-week group exercise program called Les Mills Thrive can change how muscles work and improve strength, balance, and symptoms in 42 older adults with knee osteoarthritis. Participants will attend weekly classes that include flexibility, strength, an…

This study tests whether a special traction pad placed between the patient and the surgery table can reduce numbness in the groin area after hip arthroscopy. About 120 patients having hip surgery at Northwestern Memorial Hospital will be asked about numbness and difficulty urinat…

This study tests whether a combination of a structured exercise program and a plant-based anti-inflammatory diet (the New Nordic Diet) can improve quality of life for people with mild to moderate knee osteoarthritis. Sixty participants will follow the training and diet plan, and …

This study tests a new medicine called Allocetra for people with knee osteoarthritis. It is injected directly into the knee joint to see if it safely reduces pain and improves function. About 160 adults aged 45-80 with moderate knee arthritis will receive either Allocetra or a pl…

This study tests whether adding ultrasound-guided nerve blocks before hip or knee replacement surgery can reduce pain and opioid use compared to standard pain management. 400 adults with osteoarthritis will be enrolled. The goal is to improve recovery and reduce side effects like…

This study tests a procedure called genicular artery embolization (GAE) for knee osteoarthritis pain. It involves injecting microscopic spheres into a knee artery to reduce blood flow and inflammation. About 100 people with moderate to severe knee pain will be randomly assigned t…

This study looks at whether a smaller dose of steroid injected into the knee with ultrasound guidance works as well as a larger dose given without ultrasound. The goal is to reduce side effects while still easing pain. About 140 people with knee osteoarthritis will receive one of…

This study tests three wearable devices designed to help children aged 7-16 with juvenile idiopathic arthritis (JIA) manage their condition. The tools include a heating wrap for pain, a gamified physio tool, and a classroom communication aid. Twenty-five children will use the dev…

This study tests whether a short course of oral methylprednisolone (a steroid) after knee replacement surgery can lower pain, reduce the need for strong painkillers, and lessen nausea. About 116 adults with knee osteoarthritis are taking part. The goal is to see if this simple me…

This study tests whether a nerve block combined with a thigh tourniquet can reduce pain in the back of the knee after total knee replacement. About 60 adults aged 40-85 will participate. The goal is to improve comfort and reduce the need for strong painkillers.

This study looks at whether adding HyalganBio injections to a physical exercise program helps people with shoulder osteoarthritis move better and feel less pain. About 72 adults aged 45 to 85 with chronic shoulder pain will be split into two groups: one gets three weekly injectio…

This study compares a standard physical therapy program with a targeted exercise program designed to improve knee alignment in adults aged 30-55 with mild to moderate knee osteoarthritis and bow-legged alignment. About 80 participants will do either standard exercises or specific…

This small study tests a procedure called radiofrequency ablation for people with chronic shoulder pain that hasn't improved with standard treatments like physical therapy or injections. The treatment uses heat to calm the nerves that send pain signals from the shoulder joint. Te…

This study was designed to test whether a new gel called Hydrogel OA 2% could safely relieve knee osteoarthritis pain better than a standard treatment. It planned to enroll adults with knee OA and give them one injection, then track side effects and symptom improvement for 26 wee…

This early study tests an injection called Allocetra for osteoarthritis at the base of the thumb. The trial includes 46 adults aged 40 and older whose pain hasn't improved with standard treatments. Researchers are checking if the injection is safe and whether it can reduce pain a…

This study compares two types of pain-relief pumps placed inside the knee joint after total knee replacement. 65 adults having outpatient knee surgery will be randomly assigned to receive either standard pain management or one of two pump brands. The goal is to see which approach…

This study tests whether a numbing and anti-inflammatory injection around the knee nerves can reduce pain and improve walking in people with knee arthritis. Thirty adults aged 50 and older with persistent knee pain will receive either the active injection or a placebo (salt water…

This study tests whether using a lower-pressure tourniquet during orthopedic surgeries can reduce pain and the need for opioid painkillers afterward. Standard tourniquets use high pressure, which can cause muscle weakness and pain. The experimental device sets pressure based on t…

This pilot study tests whether the anti-inflammatory drug naproxen can reduce pain in people with knee osteoarthritis. Twenty participants will take naproxen or a placebo in a crossover design, meaning each person tries both treatments at different times. The study measures daily…

This study tests a new procedure called genicular artery embolization using SakuraBead, a dissolvable bead that blocks small blood vessels in the knee to reduce pain. It involves 89 adults aged 40-79 with moderate to severe knee osteoarthritis that hasn't improved with standard t…

This study tests whether foot core exercises done at home via video calls can reduce pain and improve walking in people with rheumatoid arthritis. Eighteen adults will be split into two groups: one gets live video sessions, the other gets recorded exercises. The goal is to see if…

This study looks at whether whole-body vibration training can improve body composition, muscle strength, walking speed, and pain in 30 older adults with knee osteoarthritis and sarcopenic obesity. Participants will do vibration exercises, and researchers will measure changes in p…

This study looks at whether combining two types of exercises—Feldenkrais and active release—with standard physical therapy can help people with knee osteoarthritis feel less pain and move better. Forty adults aged 40 to 60 with mild to moderate knee OA will do these exercises thr…

This study was designed to test a device called RELAY that delivers both local anesthetic and electrical nerve stimulation through a single catheter after knee surgery. The goal was to provide up to 28 days of pain control, longer than current options. However, the study was with…

This study looks at whether a 6-day course of oral steroids after orthopedic surgery can help reduce pain, nausea, and improve movement. About 500 adults having common surgeries like joint replacement or fracture repair will be randomly assigned to receive either standard care or…

This study tests a single injection of Arthrosamid, a hydrogel made mostly of water, in 29 people with painful knee osteoarthritis. The goal is to see if it improves daily activity and reduces symptoms over 12 months. Participants wear an activity tracker to measure changes, and …

This study tests whether a standardized manual physiotherapy protocol can reduce pain and improve movement in people with tennis elbow. 160 participants will either receive the active treatment or follow a watchful waiting approach. Researchers will measure pain, grip strength, a…

This study compares robotic-assisted knee replacement to the traditional manual method in 100 people with severe knee arthritis. The goal is to see which approach leads to better knee alignment, movement, and patient satisfaction. Participants are randomly assigned to one of the …

This study tests whether adding blood flow restriction (a technique that gently limits blood flow to the legs) to walking on an anti-gravity treadmill can better reduce pain and improve function in people with knee osteoarthritis. About 70 adults aged 45-80 with knee arthritis wi…

This small, early study is testing a new device that uses low-frequency ultrasound waves in a bath to see if it can safely help heal knee osteoarthritis and reduce pain. Ten adults aged 40 and older with chronic knee pain will try the treatment every few days. The main goal is to…

This study planned to test an injection of doxycycline into the knee area to reduce chronic pain in people with osteoarthritis who cannot have surgery. The trial was withdrawn before enrolling any participants, so no data was collected. The goal was to see if the procedure could …

This study looks at whether adding a dietary supplement to an exercise program can reduce pain and improve movement in people with knee osteoarthritis. About 93 adults with mild to moderate knee arthritis will be split into three groups: supplement alone, supplement plus exercise…

This study looks at whether special nerve exercises can help reduce pain and sensitivity in people with tennis elbow (lateral epicondylitis). About 30 adults will be split into two groups: one gets standard care plus shockwave therapy, the other adds nerve mobilization exercises.…

This study tests whether adding a special laser treatment (CO2 infrared laser moxibustion) to standard exercise can reduce knee pain and improve movement in people with knee osteoarthritis. About 68 adults aged 55-65 with knee arthritis will receive either exercise alone or exerc…

This study looks at whether a special injection (hyaluronic acid plus amino acids) combined with home exercises can help people with chronic tennis elbow more than exercises alone. Researchers will review records of 60 patients aged 18 to 70 who had elbow pain for at least 6 week…

This study tests whether a single injection of a mix of platelet-rich plasma (from your own blood) and hyaluronic acid can safely reduce pain and improve function in people with moderate to severe knee osteoarthritis. About 280 adults with grade 3-4 knee arthritis will receive ei…

This study compares a mind-body approach called Basic Body Awareness Therapy (BBAT) to standard physiotherapy and home exercise for people with knee osteoarthritis. BBAT focuses on gentle, mindful movements to improve posture, balance, and pain management. Researchers will measur…

This study tests whether a procedure called genicular radiofrequency ablation can safely reduce persistent knee pain in people who still hurt more than a year after total knee replacement. The procedure uses heat to temporarily calm specific nerves around the knee. Half of the 44…

This study looks at whether adding a blood flow restriction cuff to targeted exercises helps adults aged 30-55 with mild to moderate knee osteoarthritis and bow legs feel less pain and move better. About 80 participants will be randomly assigned to do exercises either with or wit…

This study compares giving one dose of dexamethasone during knee replacement surgery versus two doses (one during surgery and one the next morning). The goal is to see which approach reduces pain, opioid use, and nausea while minimizing complications. About 339 adults undergoing …

This study tests whether applying cabbage leaves to the knee can reduce pain, improve physical function, and boost quality of life in people with knee osteoarthritis. Researchers will compare two different cabbage leaf preparations against standard care in 90 adults over four wee…

This study looks at two different methods to reduce pain in people who have had knee replacement surgery due to arthritis. One method uses radiofrequency (heat) to calm the nerve, and the other uses a chemical called phenol. The goal is to see which works better and is safer. Abo…

This study follows 40 adults aged 55+ with osteoarthritis who are getting low-dose radiation as part of their usual care. Researchers will track pain, function, and quality of life for up to a year to see if the treatment helps. The goal is to understand how well this approach wo…

This study tests whether giving patients a pain education booklet and video before knee or hip replacement surgery helps them feel less anxious and have less pain afterward. About 70 adults scheduled for elective joint replacement will be randomly assigned to receive the educatio…

This study tests whether using virtual reality (VR) during knee or hip surgery can help patients feel less anxious and need fewer sedating drugs. About 50 adults having surgery with a nerve block (awake but numb) will try VR and give feedback. The goal is to see if VR is a useful…

This study tests whether a special patch that delivers pulsed radiofrequency energy can reduce knee pain in people with osteoarthritis. Fifty adults aged 40-75 with chronic knee pain will receive either the real patch or a sham device. Researchers will measure pain and function o…

This study looks at two different non-surgical treatment plans for knee osteoarthritis in 300 military health system patients aged 18-60. The goal is to see which approach better improves physical function and reduces pain over one year. Participants will follow guidelines from t…

This study tests whether a home-based virtual reality system can help people with knee osteoarthritis do their physiotherapy exercises in a more engaging way. Fifty adults aged 45 and older with knee pain will be randomly assigned to either the VR program or standard physiotherap…

This study tests whether cutting a small nerve in the knee during a total knee replacement can reduce long-term pain. 178 adults having their first knee replacement will be randomly assigned to get either the standard surgery or the surgery plus the nerve cut. Researchers will tr…

This study compares a newer surgical approach that spares the rotator cuff to the traditional method for total shoulder replacement in 108 adults with arthritis. The goal is to see which approach leads to better shoulder function and recovery. Participants will be followed for at…

This early-stage study tests a new gel containing ketoprofen, applied to the skin, for people with knee osteoarthritis. The goal is to see if it reduces pain and improves knee function. Forty adults with knee osteoarthritis will be randomly assigned to receive the gel or a compar…

This study tests whether freezing specific nerves around the knee before total knee replacement surgery can reduce pain and the need for opioids afterward. One hundred adults scheduled for knee replacement will either receive the nerve-freezing treatment or a sham procedure. The …

This early-stage trial is testing whether injecting donated fat tissue into the small joints of the hand can reduce pain and improve movement in people with hand osteoarthritis. About 34 adults with joint pain and X-ray evidence of arthritis will receive the injection under local…

This study looks at whether a 12-week program of high-intensity interval exercise can improve heart function, reduce inflammation, and boost quality of life in people with rheumatoid arthritis. 87 adults with stable, low-to-moderate disease activity will take part. The program in…

This study tests whether turmeric (curcumin) can reduce pain and improve function in people with thumb-joint arthritis. One hundred adults will take turmeric capsules for four weeks and a placebo for another four weeks, then compare results. The goal is to see if this common spic…

This study looks at whether adding shock wave therapy to exercise helps people with tennis elbow (lateral epicondylitis) more than exercise alone. About 60 adults with tennis elbow will be assigned to either exercise only or exercise plus shock wave therapy. The main goal is to s…

This study tests if adding two extra nerve blocks to a standard one can improve pain control and recovery after hip replacement surgery. About 60 adults having hip surgery will be randomly assigned to receive either the standard block alone or the standard block plus the extra bl…

This study tests whether a training method that briefly restricts blood flow to the leg muscles can help reduce knee pain in people with hemophilia. Twelve participants will try both the real blood flow restriction and a sham version to compare effects. The goal is to see if this…

This study aimed to test the safety of a new drug called F8IL10, given as a joint injection every 4 weeks for 8 weeks, in people with rheumatoid arthritis who still have joint flares despite standard treatments. The goal was to find the safest dose. However, the study was withdra…

This study is testing a new computer-assisted navigation system for total knee replacement surgery in 126 adults with knee arthritis. The system helps surgeons place the artificial joint more accurately. Researchers will measure how well patients can use their knee 3 and 12 month…

This study tests whether injecting botulinum toxin into the thumb joint can reduce pain and improve function in people with thumb osteoarthritis (rhizarthrosis). Sixty adults with moderate to severe pain who have not responded to standard painkillers will receive either botulinum…

This study tested whether shortwave diathermy, a treatment that uses heat deep in the tissue, can help people with hand osteoarthritis. 36 adults aged 35-75 with hand osteoarthritis received either real or placebo treatment. Researchers measured pain, grip strength, and daily han…

This study tests a new knee brace designed to reduce joint pressure and a special low-intensity exercise method (blood flow restriction training) to strengthen leg muscles. Researchers will compare the new brace to a traditional one in 40 volunteers over 50 with knee osteoarthrit…

This study tests whether a special bioactive leg sleeve (Reparel) works better than standard TED compression stockings for reducing leg swelling, pain, and blood clot risk after hip replacement surgery. About 50 adults aged 18-89 having a first hip replacement will take part. The…

This study tests whether phone coaching and financial rewards can help people become more active after total knee replacement. 600 adults aged 40-85 will be split into three groups: usual care, activity tracker only, or activity tracker plus coaching and rewards. The goal is to s…

This study tests whether adding laser therapy to standard physiotherapy and exercise reduces knee osteoarthritis pain more than a sham (fake) laser plus exercise. Sixty-four adults with knee osteoarthritis will receive either real or sham laser treatments twice a week for six wee…

This early-stage trial tests whether injecting a person's own fat-derived stem cells into a painful arthritic hip is safe and might reduce pain. Researchers at Mayo Clinic are enrolling 24 adults aged 18-65 with hip osteoarthritis. The main goal is to check for side effects, whil…

This study tests a new injectable treatment called Neural Ice that uses cold energy to reduce chronic knee pain from osteoarthritis. About 263 adults aged 22 to 80 with moderate to severe pain will receive the injection and be monitored for 6 months. The goal is to see if it prov…

This study tests a new procedure called genicular artery embolization (GAE) against standard steroid injections for people with knee osteoarthritis. The goal is to see if blocking certain arteries with tiny beads can provide better pain relief than steroid shots. The trial involv…

This study tests whether turmeric extract capsules can lower inflammation and pain in people with knee osteoarthritis. 72 adults will take either turmeric or a placebo daily for 3 weeks. Researchers will measure pain and inflammatory markers in the blood.

This study was designed to see if a Botox injection into the knee joint could relieve arthritis pain better than a steroid injection. Researchers planned to use special MRI scans to measure inflammation. However, the trial was withdrawn before enrolling any participants, so no re…

This study tests whether a 6-month patient education program can improve quality of life for people with rheumatoid arthritis. The program covers topics like understanding the disease, monitoring symptoms, treatment options, nutrition, and stress management. Researchers will comp…

This study tests whether a gentle electrical brain stimulation device, used at home, can reduce chronic pain in people with rheumatoid arthritis whose inflammation is already well-controlled. Thirty-four participants will either receive real or sham stimulation over several sessi…

This study aimed to test a modified acupotomy technique for people with ankylosing spondylitis, a type of arthritis that causes back pain and stiffness. The approach used ultrasound to guide the procedure, with the goal of reducing disease activity. However, the study was withdra…

Researchers are sequencing the gut microbiomes of people with a wide range of conditions, from autism and Alzheimer's to Crohn's disease and multiple sclerosis, to see whether bacterial patterns differ by disease. The study also enrolls healthy participants for comparison. By mat…

This observational study follows adults with morbid obesity who undergo bariatric surgery to see if substantial weight loss changes the alignment of their hips, knees, and ankles. Researchers measure leg alignment using standing X-rays before surgery and at 3, 6, and 12 months af…

This study tests whether an AI chatbot can help people with hip or knee osteoarthritis feel less conflicted and anxious about their treatment choices. About 100 adults with osteoarthritis will chat with the AI before seeing their surgeon. Researchers will measure changes in decis…

This study aims to validate a new questionnaire that measures emotional wellbeing and patient perceptions after total knee replacement surgery for knee arthritis. Researchers will enroll 167 adults who had knee replacement within the last 3 months. The goal is to ensure the quest…

This study tests whether platelet-rich plasma (PRP) injections into the knee can change certain proteins in the blood of people with knee osteoarthritis. About 60 participants aged 18-70 will receive either PRP or a saltwater placebo, and researchers will compare protein levels t…

This study follows 76 people who received a pyrocarbon shoulder implant to see how well it works and holds up over 5 to 10 years. Researchers measure shoulder pain, function, and any complications. The goal is to confirm the implant is safe and effective for long-term use.

This study examines cartilage from people undergoing total knee replacement for osteoarthritis. Researchers will use a microscope to look at cell health, mitochondria, and autophagosomes, which are parts of cells involved in cleaning up damage. The goal is to better understand ho…

This study looks at records from over 500,000 Medicare beneficiaries with rheumatoid arthritis or ankylosing spondylitis who had major orthopedic procedures like joint replacements or spine surgery between 1999 and 2015. Researchers want to understand how often complications happ…

This study looks at how well a new hip replacement stem (Insignia) fits and stays in place over time. Researchers will review X-rays from 100 adults getting a first-time hip replacement to check for any signs of loosening. The goal is to see if the stem is safe and effective for …

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study looks at whether the number of pain sites or the type of pain (constant vs. intermittent) is linked to physical function in people with knee osteoarthritis. Researchers will measure function with a chair stand test and pain with questionnaires and pain drawings. The go…

This study is a large registry that follows nearly 16,000 people with psoriasis to monitor the long-term safety of several treatments, including biologic drugs like infliximab and ustekinumab. Participants receive their usual care while researchers track side effects, disease act…

This study follows over 1,500 people who received an Attune total knee replacement to see how long the implant lasts—up to 15 years. Participants had non-inflammatory degenerative joint disease (like osteoarthritis). The goal is to gather real-world data on the durability of four…

This study follows over 1,300 people with psoriatic arthritis who are starting either guselkumab (Tremfya) or an IL-17 inhibitor as part of their routine care. Researchers will track how long patients continue each treatment and monitor joint swelling and tenderness. The goal is …

This study will use a special blood test called mass spectrometry to look at immune cells in 500 people with various autoimmune diseases and healthy volunteers. The goal is to find patterns that could help doctors diagnose these conditions sooner. No treatments are being tested; …

This study looks at 219 people who had ACL reconstruction surgery about 10 years ago. Researchers will use MRI scans to check the health of the knee cartilage and compare it to the uninjured knee. The goal is to learn more about how osteoarthritis develops after a knee injury.

This study looks at how seeing or not seeing affects knee joint position sense in people with knee osteoarthritis. Researchers will measure how accurately 120 participants can position their knee with and without visual input. The goal is to better understand how the brain senses…

This study from the University of Pittsburgh is looking at how well people recover after total knee replacement surgery. It compares two types of surgery: one done with a robot's help and one done by hand. Researchers will follow 30 people who are already scheduled for knee repla…

This study follows 60 adults getting hip or knee replacement to track their sleep before and up to 6 months after surgery. Participants use a special device and app to measure sleep quality, pain, and recovery. The goal is to learn when sleep returns to normal so doctors can give…

This study follows children aged 6 to 17 with active juvenile enthesitis-related or psoriatic arthritis who are being treated with secukinumab. Researchers will track how long children stay on the drug, how much their symptoms improve, and whether they achieve remission. The goal…

This study looks at how physical, psychological, and movement-related factors work together in adults with chronic knee pain. By tracking these factors over time, researchers hope to understand why pain experiences differ between people. The goal is to develop practical tools tha…

This study evaluates a blood test that uses genetic and epigenetic information to help doctors predict which rheumatoid arthritis medication will work best for each patient. Researchers will collect blood samples from 1,410 adults with rheumatoid arthritis who have not responded …

This study aims to improve how doctors diagnose and treat chronic muscle and joint pain by using simple questionnaires and pain sensitivity tests. Researchers will study 250 adults with conditions like osteoarthritis, fibromyalgia, chronic low back pain, or inflammatory arthritis…

This study investigates how people with axial spondyloarthritis (axSpA) experience sudden worsening of symptoms, known as flares. Over 12 months, 40 participants use a digital diary to track symptoms, diet, lifestyle, and self-management strategies, and provide blood samples duri…

This study tests whether a simple isometric (static) hand exercise can change how people with rheumatoid arthritis feel pain. Researchers will measure pain tolerance, pressure thresholds, and muscle oxygen levels in 66 adults. The goal is to see if this type of exercise can help …

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study was designed to see if X-rays taken before knee replacement surgery could reliably show ligament damage in people with knee arthritis. It was an observational study, meaning no treatment was given. However, the study was withdrawn before enrolling any participants, so …

This study looks at whether a short, reassuring message given to adults before a clinic visit for common muscle or joint issues can affect their interest in extra care like tests, injections, or surgery. About 144 participants will either read the message or receive usual care, t…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study follows 200 people who received a smart knee implant (Persona IQ) that tracks movement after total knee replacement. The goal is to see if data from the implant and a phone app can help doctors understand recovery and spot problems early. Participants use a smartphone …

This study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…

This study looks at a protein called progranulin in the blood of people with ankylosing spondylitis (a type of arthritis that affects the spine) and compares it to healthy volunteers. Researchers want to see if progranulin levels are linked to disease activity and whether they ch…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study looks at 54 obese women getting knee replacements to see if a stemmed or non-stemmed tibial implant works better. The goal is to find out which type reduces the risk of the implant collapsing or loosening over time. Researchers will track these outcomes to guide future…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which …

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer question…

This study investigates how common spinal nerve pain is in people with ankylosing spondylitis (AS) and whether it affects their sleep. Researchers will use questionnaires to assess pain, sleep quality, quality of life, and fatigue in 292 AS patients. The goal is to better underst…

This study looks at nerve-related pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers will use a questionnaire to describe the pain and see how it relates to daily activities. About 130 adults with the condition will take par…

This study tests whether sending a short screening questionnaire directly to people with psoriasis can help detect psoriatic arthritis earlier. 18,000 participants will be randomly assigned to receive the questionnaire or not. Those with high scores will be advised to see a rheum…

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This early-stage study tests a handheld imaging device that uses magnetic particles to track stem cells after they are injected into the knee. Ten adults with mild-to-moderate knee osteoarthritis will receive a single injection of labeled stem cells, and the device will monitor t…

This study looks at bone erosions in the finger joints of 9 people with rheumatoid arthritis. Researchers use advanced imaging and tissue analysis to see tiny blood vessels and bone structure. The goal is to better understand how joint damage happens, which could lead to better m…

This study is observing 60 people who received a special hip replacement cup (Plasmafit Revision Structan) during routine surgery. Researchers are checking how well the cup works and how long it lasts by tracking hip function and any need for repeat surgery. No new treatment is b…

This early study tests a radioactive imaging agent called 89Zr-Cimzia in 10 people with rheumatoid arthritis. The goal is to see if it can highlight inflamed joints on a PET scan, comparing painful joints to pain-free ones. The study is currently suspended, and it is exploratory,…

This study aimed to compare knee movement in people who had one of two different total knee replacements. Researchers planned to measure how the knee bends and shifts during activities like stepping up and deep knee bends. The study was withdrawn before any participants were enro…

This study looks at whether stiffer tennis rackets are linked to tennis elbow in adult players. Researchers will survey about 200 tennis players about their racket stiffness, playing habits, and any elbow pain in the past year. They also want to see if sex or competitive level ch…

This study looks at how different eating habits—like being a vegetarian, eating fish, or drinking alcohol—might affect a person's chance of developing rheumatoid arthritis. Researchers are using data from half a million UK adults aged 40 to 70. They are not testing a new treatmen…

This study uses artificial intelligence to analyze X-rays and CT scans of the thumb joint affected by osteoarthritis. Researchers aim to develop automated tools to classify disease severity, detect implant loosening, and create 3D models for better surgical planning. The study in…

This study reviewed records of 166 knee replacement patients who received a nerve block for pain. Researchers compared pain scores 6-24 hours after the block wore off between two groups: one that received extra education about pain management before surgery and one that did not. …

This study compares robot-assisted spine surgery to the traditional method in 300 adults needing spinal fusion. The goal is to see if the robot helps place screws more accurately, reduces complications, and improves patient outcomes. Participants are randomly assigned to either r…

This study tests whether giving patients with hand problems like carpal tunnel syndrome or trigger finger a decision aid—a booklet with clear information about their condition and treatment options—helps them feel more satisfied and less conflicted about their choices. About 126 …

This study is tracking 120 people who received a HYPE SCS hip stem during total hip replacement. Researchers will monitor how long the implant lasts, how satisfied patients are, and any complications over 5 years. The goal is to confirm the device is safe and works as intended in…

This study follows 25 adults with rheumatoid arthritis for one year to see how their blood samples relate to changes in disease activity. The goal is to find early warning signs of a flare. Participants give blood at several visits while their joint swelling and inflammation are …

This study looks at whether adding an extra nerve block to the usual pain block can reduce inflammation after total knee replacement. Researchers will measure inflammation markers in the blood of 60 adults. The goal is to see if this approach leads to less pain medicine use and b…

This study planned to find out how often teenagers with juvenile idiopathic arthritis experience chronic pain, especially when their arthritis seems quiet or mild. Researchers wanted to measure pain intensity and how it affects daily life, school, sleep, and social activities. Th…

This study follows 248 adults receiving a CoreHip hip replacement to see how their hip function, pain, and leg length change over time. Participants are treated as part of routine care, and no extra tests or treatments are given. The goal is to collect real-world data on the impl…

This study was designed to track pregnancies in women with rare autoimmune and systemic diseases to understand complications and improve care. It planned to enroll women with conditions like lupus, rheumatoid arthritis, and scleroderma. However, the study was withdrawn before any…

This study is looking for genes that might make some people more likely to get an infection after hip or knee replacement surgery. Researchers will collect blood or saliva samples from 150 people in families with a history of such infections, plus unaffected relatives. The goal i…

This study looks at whether using a patient decision aid during doctor visits helps people with severe hip or knee osteoarthritis make better choices about surgery. Researchers will track how informed patients feel, their involvement in decisions, and their pain, function, and qu…

This study looks at three different knee replacement designs: one that keeps the ACL, one that substitutes for it, and one that sacrifices it. Researchers want to see which design gives the best function, pain relief, and satisfaction in 75 people with severe knee arthritis. Part…

This study follows 88 working-age adults (63 or younger) who had knee replacement surgery to see when and how many return to work. Researchers track pain, knee function, and work ability using questionnaires over 1.5 years. The goal is to identify factors that help or hinder retu…

This study aimed to see if a 4-week running form retraining program could reduce knee pain and improve function in runners with mild to moderate knee osteoarthritis. It planned to measure changes in symptoms and knee joint loads. However, the study was withdrawn before any partic…

This study aimed to understand the link between non-alcoholic fatty liver disease (NAFLD) and psoriatic disease (psoriasis and psoriatic arthritis) in overweight adults. Researchers planned to use the drug guselkumab (Tremfya) to see if it improved both conditions. However, the t…

This study looks at a new way of paying for healthcare called bundled payments, where providers get a single payment for an entire episode of care. Researchers will analyze Medicare data from 440 provider organizations to see if this approach improves quality and reduces costs fo…

This study compares having both knees replaced at the same time versus one after the other in people with knee osteoarthritis. About 224 participants will be randomly assigned to one approach. Researchers will track recovery, joint function, and quality of life to help guide pati…

This study involves 100 people with knee osteoarthritis to compare different ways of measuring knee function, including patient questionnaires and physical tests like walking and standing. The goal is to understand how subjective reports and objective performance relate to each o…

This study follows 125 adults aged 18-75 who are getting a hip replacement with a new type of implant (the Trident II shell). The main goal is to see how long the implant lasts without needing another surgery. Researchers will also track patients' pain and function using a standa…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…

This study is a large registry that will follow 5,000 people with psoriatic arthritis or spondyloarthritis across North America. Researchers will collect information on how different approved treatments work and their side effects over time. The goal is to better understand these…

This study is building a large collection of blood samples from 3,000 people with rheumatoid arthritis. Researchers will use these samples to look for biomarkers that could help predict disease activity or treatment side effects. Participants must already be in a registry and sta…

This study looks at how hot bone gets during total knee replacement surgery when using a burr (robotic) versus a saw (conventional). Twenty patients will have their bone temperature measured with an infrared thermometer during the procedure. The goal is simply to compare the heat…

This study collects fluid from the joints of 149 adults having knee, hip, or shoulder surgery. Researchers will analyze the fluid for molecules and genetic clues that could help detect osteoarthritis earlier or predict how the disease will progress. The goal is to build a biobank…

This study asks over 2,300 people with various joint conditions (like arthritis, fractures, and hip problems) to fill out surveys about their treatment preferences. Researchers want to learn how factors like pain, recovery time, cost, and surgery versus non-surgery affect patient…

This study will use advanced heart scans (coronary CT angiography) on 4,000 people with rheumatoid arthritis aged 50-75. The goal is to better understand why people with this condition have higher risks of heart attacks, strokes, and lung problems. Researchers will track particip…

This study surveys 384 physiotherapists in Pakistan to find out which rehabilitation approaches they use after total knee replacement. The goal is to identify common practices, variations, and challenges. Results may help standardize care and improve recovery for future patients.

This study looks at whether using a 3D patient-specific alignment during knee replacement surgery leads to better walking, less pain, and stronger muscles. Researchers will measure movement, pain, and strength in 45 adults who had surgery two years ago. The goal is to understand …

This study compares robot-assisted knee replacement to the standard manual technique in 50 patients with partial knee arthritis. The goal is to see which method better prevents early implant loosening, measured with special X-rays. Participants will be followed for two years afte…

This study aimed to see if custom carbon fiber braces could reduce forces on the ankle joint after a fracture, potentially lowering the risk of arthritis. It planned to enroll adults with healed ankle fractures and test different brace designs. However, the study was withdrawn be…

This study follows 124 golfers who have hip, knee, or shoulder replacement surgery. Researchers track how many return to golf, how long it takes, and how their game and joint function change over a year. The goal is to give patients and doctors clear, realistic expectations about…

This study compares two types of hip replacement implants to see if one raises metal levels in the blood more than the other. Fifty-two adults getting a hip replacement will be randomly assigned to receive either a standard implant or a newer 'dual mobility' design. Researchers w…

This observational study plans to enroll 120,000 people with various chronic diseases like pancreatitis, diabetes, and arthritis. Researchers will collect blood samples and health data to study how genetics and lifestyle affect disease progression. The goal is to find common dise…

This study looked at 104 people having knee replacement surgery to see if removing the surgical drain before or after starting gentle knee movement exercises (called continuous passive motion) reduces fluid buildup. The goal is to find the best timing to help healing and reduce s…

This study is building a large national registry of 30,000 people having hip or knee replacement surgery. Researchers will collect information on pain, physical function, and any complications before and after surgery. The goal is to learn what works best in real-world practice a…

This study looks at how the Insignia hip stem moves inside the body after a hip replacement. About 25 people with hip arthritis will get special X-rays and CT scans over two years to check for any shifting. The goal is to see if the stem stays stable and to compare two different …

This study looks at why people with bone cancer (skeletal sarcoma) get more infections after joint replacement surgery than those with arthritis. Researchers will collect tissue and blood samples from 40 patients to compare immune and bacterial factors. The goal is to understand …

This study tests whether a smartphone app can help people with psoriatic arthritis manage their condition with fewer in-person doctor visits. About 278 adults who already use certain arthritis medications will use the app to report symptoms. Researchers will compare visit frequen…

This study is following 230 adults who received a G7 hip replacement system to see how long the implant lasts and how well it works. Participants have hip problems like arthritis or bone death. The study does not test a new treatment but simply watches and records outcomes over t…

This study looks at a type of bacteria called Staphylococcus pettenkoferi, often found in diabetic foot ulcers. Researchers will analyze the DNA of 230 bacterial samples to see if certain strains are more harmful. The goal is to understand if this bacteria plays a role in making …

This study looks at 150 people with knee osteoarthritis to see how often night pain and nerve pain (neuropathic pain) occur together. Researchers will use questionnaires and physical exams to measure pain and sleep quality. The goal is to better understand these pain types and th…

This study looks at whether the shingles vaccine (HZ/su) is safe for pregnant women aged 18-49 with weakened immune systems. Researchers will track about 2,800 women to see if the vaccine raises the risk of birth defects or other problems in their babies. The goal is to provide r…

This study compares two treatments for a torn hip labrum in people aged 40 and older: arthroscopic surgery to repair the tear versus physical therapy alone. Researchers want to find out which approach leads to better hip function and less pain. The goal is to help doctors and pat…

This study looks at whether helping people with inflammatory arthritis address social needs—like food, housing, or transportation—can reduce missed doctor visits. About 100 adults with conditions like rheumatoid arthritis or lupus who have missed appointments in the past year wil…

This study aimed to see if analyzing joint tissue (synovial biopsies) could help doctors pick the best biologic drug for people with rheumatoid arthritis who had not responded to standard treatments. It planned to assign patients to either an anti-TNF or a JAK inhibitor based on …

This study follows 747 young, active people (ages 14-40) who had hip surgery for femoroacetabular impingement (FAI). Researchers want to find out which patient traits, disease features, and surgical factors lead to the best outcomes. Participants fill out surveys about pain, func…

This study follows 1,598 adults with rheumatoid arthritis (RA) over time to identify biological markers that can predict how well a patient will respond to a drug or whether they might have side effects. Researchers also aim to understand how the disease progresses and affects da…

This study aimed to understand how body weight influences the way etanercept works in obese adults and children with arthritis. Researchers planned to use blood samples and computer models to find the best dose for heavier patients. However, the study was withdrawn before enrolli…

This study was designed to see if a new monitoring algorithm could detect early signs of ovarian damage in women and girls who had cancer treatment. Researchers planned to compare a group using the new algorithm with a group that received standard care. However, the study was wit…

This study follows 600 people with moderate to severe rheumatoid arthritis who are prescribed Tyenne, a biosimilar of tocilizumab. Researchers will track how long patients stay on the treatment over 12 months. The goal is to see how well the drug works in everyday medical practic…