New ankle implant tracked for 10 years in 500 arthritis patients

NCT ID NCT03063593

Ongoing Disease control Sponsor: Stryker Trauma and Extremities Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study follows 500 people who received the INFINITY total ankle replacement to see how well the implant holds up over 10 years. Participants have ankle arthritis from rheumatoid arthritis, injury, or wear-and-tear. Researchers will measure implant survival and changes in pain, function, and quality of life using questionnaires.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: INFINITY Total Ankle System (artificial ankle joint implant)
What this could lead to: If successful, this study could confirm that the INFINITY ankle replacement is a reliable long-term option for people with severe ankle arthritis, potentially improving pain and mobility for many years.
What could go wrong: This is an observational study, not a controlled trial, so it cannot prove the implant is better than other treatments. Results depend on patient follow-up, and some implants may fail over time, requiring revision surgery.

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Conditions

The condition(s) this trial relates to.

osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ARTHRITIS, RHEUMATOID DEGENERATIVE ARTHRITIS POST-TRAUMATIC OSTEOARTHRITIS

Contacts and locations

Locations

North Bristol NHS Trust Southmead Hospital

Bristol, BS105NB, United Kingdom
North Tyneside General Hospital

Newcastle upon Tyne, NE29 8NH, United Kingdom
Nottingham University Hospitals NHS Trust

Nottingham, NG5 1PB, United Kingdom
RJAH Orthopaedic Hospital

Oswestry, Shropshire, SY10 7AG, United Kingdom
Royal Bournemouth Hosptial

Bournemouth, Dorset, BH7 7DW, United Kingdom
Royal Devon and Exeter NHS Foundation Trust

Exeter, EX2 5DW, United Kingdom
Royal Infirmary of Edinburgh

Edinburgh, EH16 4SA, United Kingdom
Royal National Orthopaedic Hospital

Middlesex, HA7 4LP, United Kingdom
Sheffield Teaching Hospital

Sheffield, South Yorksire, S5 7AU, United Kingdom
Torbay Hospital

Torquay, Devon, TQ2 7AA, United Kingdom
University Hairmyres Hospital

Bothwell, Scotland, G71 8BB, United Kingdom
Wrightington Hospital

Wigan, WN6 9EP, United Kingdom

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