Bone inflammation disease

This study tests whether a wearable bioimpedance wristband (like a fitness tracker) helps people with severe obesity and knee osteoarthritis improve their body composition—gaining muscle and losing fat—before joint replacement surgery. All participants receive coaching on body co…

This study followed 65 adults with ankle arthritis (from wear-and-tear, injury, or conditions like rheumatoid arthritis) who received the Cadence Total Ankle System implant. Researchers tracked how long the implant lasted without needing removal or revision, checking at 2, 5, and…

This study tested a special bone graft material (MatriBONE mixed with the patient's own bone marrow) for spinal fusion surgery in people with painful degenerative back problems. The goal was to see how well the bones fused together after 12 months. However, the trial was stopped …

This study tested an experimental drug called LY3541860 in 35 adults with moderate-to-severe rheumatoid arthritis who had not improved enough on other treatments. The goal was to see if the drug could reduce joint swelling and pain. However, the trial was terminated early, so the…

This study tests whether an additional dose of a COVID-19 vaccine can improve immune protection in adults and children with autoimmune diseases like rheumatoid arthritis, lupus, multiple sclerosis, and others who are taking immunosuppressive medications. Participants who had a we…

This study looked at a shoulder implant used to treat pain and joint problems from conditions like arthritis, fractures, and rotator cuff tears. It involved 67 adults who received the implant and tracked how long it lasted and any side effects over 10 years. The goal was to confi…

This phase 2 study tested an experimental oral drug called BGB-45035 in 49 adults with moderate to severe rheumatoid arthritis who had not responded well to standard treatments. Participants received either the drug or a placebo to see if it could reduce joint pain and swelling. …

This study tested an experimental drug called GS-0272 in adults with rheumatoid arthritis to see if it is safe and how the body processes it. The trial was stopped early, so results are limited. About 55 people were planned to take part, receiving either the drug or a placebo.

This study tested a treatment called Chondron, made from a patient's own cartilage cells, for repairing ankle cartilage defects. The trial aimed to see if the treatment could improve cartilage quality and ankle function over 18 months. However, the study was terminated early and …

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it could slow cartilage loss and reduce pain in people with knee osteoarthritis. The trial planned to follow 576 participants for up to 5 years, but it was terminated early. The mai…

This study tested a combination pill called IHL-675A, which contains cannabidiol (CBD) and hydroxychloroquine, in people with rheumatoid arthritis. The goal was to see if it safely reduces pain and improves daily function. The trial planned to enroll 128 volunteers but was termin…

This study tested a drug called lorecivivint, given as a knee injection, to see if it could safely slow knee osteoarthritis and improve pain and function over two years. It enrolled 276 people who had already completed an earlier study. The trial was terminated early, so the full…

This study compared two surgical options—hip arthroscopy (a minimally invasive procedure) and total hip replacement—for adults aged 40 to 60 with early hip osteoarthritis. The goal was to see which surgery provides better pain relief and function. However, the trial was stopped e…

This study looked at the TITAN Reverse Shoulder System, a device used to replace the shoulder joint in people with severe arthritis and a torn rotator cuff. The goal was to see if it relieves pain and improves movement. About 151 people were planned to take part, but the study wa…

This small, early-phase study tested a single injection of lorecivivint into the knee joint of 13 people with moderate-to-severe knee osteoarthritis. The goal was to see if the drug could slow cartilage loss, measured by MRI scans. The trial was terminated early, so the results a…

This early-stage trial tested whether adding an experimental drug called VIB4920 to standard TNF-inhibitor therapy could improve disease control in people with rheumatoid arthritis. Only 2 participants were enrolled before the study was terminated, so no meaningful conclusions ca…

This study tested methotrexate, a common arthritis drug, for treating joint pain and swelling caused by cancer treatments that boost the immune system. The goal was to help patients stop taking steroids like prednisone, which have many side effects. The trial was stopped early af…

This study tested peresolimab, an experimental drug, in 491 adults with moderately-to-severely active rheumatoid arthritis who had not responded well to other treatments. The goal was to see if peresolimab could reduce joint pain and swelling better than a placebo. However, the s…

This early study tested whether a single infusion of zoledronic acid, a drug used for osteoporosis, could improve bone health and slow joint damage after an ACL tear. Only 4 people were enrolled before the trial was terminated, so the results are very limited. The study aimed to …

This study looked at whether a smart injection device (Smartclic) helps rheumatoid arthritis patients take their etanercept medication as prescribed. Researchers tracked 60 patients in Colombia for 40 weeks, measuring how often they used the device and how their symptoms changed.…

This study tested whether injecting a person's own fat-derived stem cells into arthritic joints could safely reduce pain and improve movement. Only 14 people with osteoarthritis of the knee, hip, ankle, shoulder, or wrist took part before the study was stopped early. The results …

This study looked at how well a custom knee replacement system worked for people with knee osteoarthritis. Researchers tracked complications in 52 adults who had the surgery. The study was stopped early, so results are limited.

This study aimed to see if bariatric surgery or medical weight loss (diet and exercise) helps severely obese patients lose enough weight to safely undergo hip or knee replacement. Only 3 people took part before the study was stopped early. The goal was to get patients to a BMI of…

This study looked at how well the P.F.C. Sigma knee replacement implant works in people with severe knee arthritis. Researchers planned to follow 723 patients for at least 5 years after surgery, tracking pain, function, and any complications. However, the study was terminated ear…

This study tested whether using a smartphone app and a hand grip device could help people with rheumatoid arthritis manage their condition with fewer in-person doctor visits. About 94 adults with active rheumatoid arthritis were randomly assigned to use the app or continue standa…

This study aimed to develop a biomarker test using blood or joint fluid to detect tissue damage (necrosis) caused by metal-on-metal hip implants. Researchers planned to enroll 174 patients, including those needing revision surgery and a control group. The goal was to see if the t…

This early-phase study tested a new radioactive imaging drug called 11C-MC1 to see if it can help detect inflammation in people with rheumatoid arthritis or idiopathic inflammatory myopathy, as well as in healthy volunteers. Participants received PET/CT scans after an injection o…

This study tested whether special treadmill training before knee replacement surgery could help prevent falls afterward. Participants practiced recovering from trips or pushes on a treadmill. The trial was stopped early and only enrolled 5 people, so it is not clear if the traini…

This study compared two pain medications—Ultracet (tramadol/acetaminophen) and Voltaren (diclofenac)—in people with ankylosing spondylitis who were already taking disease-modifying anti-rheumatic drugs (DMARDs). The goal was to see which one worked better for pain relief over 8 w…

This study looked at whether adding an iPACK nerve block to standard pain treatments (adductor canal block and local injections) helps people feel less pain and recover faster after total knee replacement. Only 10 people were enrolled before the study was stopped early. The goal …

This study tested whether gloves with tiny semiconductors embedded in the fabric could reduce pain and improve hand function in people with hand osteoarthritis. Sixteen participants wore either the active gloves or identical-looking placebo gloves. The trial was terminated early,…

This study looked at whether a drug called ZYNRELEF can control pain and reduce the need for strong opioid painkillers after knee replacement surgery. It included 29 adults aged 35-70 with knee osteoarthritis. The study was terminated early, so results are limited.

This study looked at whether a special arm sleeve with embedded semiconductors, combined with injections of platelet-rich plasma and stem cells, could reduce pain and improve elbow function in people with tennis elbow. Only 5 adults aged 18-65 took part before the study was stopp…

This study compared two surgical treatments for thumb arthritis at the base of the thumb. The standard surgery removes a small bone and fills the space with a tendon graft. The newer method uses a special tape to hold the thumb bone in place. The study was stopped early and inclu…

This early-stage study tested the safety of an experimental drug called Allocetra, injected directly into the joint, for people with psoriatic arthritis. Only 5 participants were enrolled. The main goal was to check for side effects, with some initial data on pain relief. The stu…

This study looked at three treatments for thumb base arthritis: a platelet-rich plasma (PRP) injection, a corticosteroid (Kenalog) injection, or a placebo (saline) injection. The goal was to see which best improved hand function and pain. The trial enrolled 74 people with early-s…

This study looked at whether adding a nerve block (adductor canal block) to a standard pain injection around the knee provides extra pain relief for people having total knee replacement. About 93 adults with osteoarthritis participated. The goal was to find the best way to manage…

This study tested an investigational drug called QUC398 in 101 people with painful knee osteoarthritis. Participants received either QUC398 injections or a placebo. The goal was to see if the drug could reduce knee pain and improve cartilage health. The trial was terminated early…

This study tested an injection called lorecivivint for people with knee osteoarthritis. The goal was to see if it safely reduces pain and improves knee function over three years. The study was stopped early and included 72 adults aged 40 to 80.

This study tested whether a digital home exercise program (SimpleTherapy) could work as well as standard in-person physical therapy for people with chronic knee osteoarthritis pain. The plan was to have 32 adults with knee pain do exercises at home three times a week for six week…

This early-stage study aimed to see if a concentrated dose of a person's own bone marrow cells, given during shoulder surgery, is safe for treating painful shoulder arthritis. Only 2 people aged 50 or older took part before the study was stopped. The main goal was to check for si…

This study tested a new way to inject the drug ZILRETTA into the hip joint for people with hip osteoarthritis. The goal was to see if using different needle sizes could improve the success rate of the injection. Only one person took part before the study was stopped early.

This study tested whether low level laser therapy (LLLT) could reduce pain and improve hand function in people with hand osteoarthritis. About 83 military members and their families received either real or sham laser treatment weekly for six weeks. The trial was terminated early,…

This study compared three different injections—platelet-rich plasma, botulinum toxin, and steroids—for treating tennis elbow pain. It aimed to see which worked best for pain relief. Only 13 people took part before the study was stopped early.

This study tested whether a small device that sends mild electrical pulses to the vagus nerve (through the ear) can reduce pain and inflammation in children with juvenile idiopathic arthritis. The trial planned to enroll children ages 5 to 18, but was terminated early after only …

This study aimed to see if taking NSAIDs (like naproxen) on a regular schedule could reduce arthritis symptoms and prevent long-term joint problems in people with Lyme disease. Only 3 participants were enrolled before the study was stopped, so no clear conclusions can be drawn. T…

This study compares a new minimally invasive procedure called genicular artery embolization (GAE) to standard steroid injections for reducing knee pain from osteoarthritis. It was designed for adults over 40 whose knee pain hasn't improved with other treatments. The goal is to se…

This study tested an experimental drug called GSK3858279 in 314 adults with moderate to severe knee osteoarthritis pain. The goal was to find the best dose that reduces pain safely. However, the trial was stopped early, so we have less information than planned.

This study tested a temporary peripheral nerve stimulation system (SPRINT PNS) placed near the knee for up to 60 days to relieve chronic pain from osteoarthritis. Only 12 people were enrolled, and the trial was terminated early. Researchers measured pain intensity, quality of lif…

This study tested two injected drugs, canakinumab and LNA043, for people with painful knee osteoarthritis. It aimed to see if they could reduce pain and improve cartilage. The trial was stopped early and included only 23 participants, so results are limited.

This study tested a program where people with rheumatoid arthritis (RA) were paired with a trained peer supporter for up to 6 months. The goal was to see if sharing experiences and support could improve daily function, medication adherence, and symptoms like pain and fatigue. The…

This study tested whether teaching people recovering from ACL reconstruction to run with a forefoot strike and a faster step rate could reduce knee pain and improve function. Ten active-duty soldiers and cadets participated. The approach is non-invasive and focuses on retraining …

This study tested a custom knee orthosis (brace) in people with medial knee osteoarthritis. Participants wore the brace for 8 weeks and completed a questionnaire about pain, stiffness, and function. The study was terminated early and only enrolled 2 people, so no firm conclusions…

This study aimed to see how total hip replacement changes the way the pelvic bone moves during daily activities like sitting and standing. Researchers used an ultrasound device to measure pelvic tilt in 15 people with hip arthritis before and after surgery. The study was terminat…

This study looked at whether a newer, low-dose X-ray system (EOSedge) produces images good enough for planning hip replacement or revision surgery, compared to standard digital X-rays. About 97 adults who needed hip surgery X-rays took part. The goal was to see if using just one …

This study looked at how two common pain relievers—celecoxib (a Coxib) and naproxen (an NSAID)—affect blood clotting in people with rheumatoid arthritis who also have heart disease or are at high risk for it. All participants took low-dose aspirin daily. The goal was to see if on…

This study looked at whether people with nickel allergy do better with special nickel-free knee implants. Researchers compared standard implants to nickel-free ones in 9 patients with self-reported nickel sensitivity. The goal was to see if nickel allergy affects pain, function, …

This study looked for new markers in blood and joint fluid to help doctors tell the difference between septic arthritis (a joint infection) and juvenile idiopathic arthritis (an inflammatory condition) in children. Researchers planned to analyze samples from 100 children under 15…

This study aimed to compare the gut bacteria of children newly diagnosed with juvenile idiopathic arthritis, type 1 diabetes, or inflammatory bowel disease with those of their healthy siblings. Researchers wanted to see if differences in gut microbes and diet could explain why so…

This study looked at how immunosuppressive medications used for rheumatoid arthritis and spondyloarthritis affect the body's ability to fight COVID-19. Researchers measured viral load and immune responses in 150 patients and their infected family members. The goal was to understa…

This study aimed to see if using a patient's healthy knee as a guide for aligning a new knee joint during replacement surgery leads to better results than the standard method. Researchers planned to compare two groups of people with arthritis in one knee, using CT scans to plan t…

This study looked at two different ways surgeons place the top part of a reverse shoulder replacement: sitting on top of the bone (onlay) or set into the bone (inlay). The goal was to see if one method leads to better arm movement after surgery. The study enrolled 19 people with …

This study looked at a specific hip implant shell (the Pinnacle Acetabular Shell) used in total hip replacement. Researchers wanted to see how much the implant moved (migrated) over two years using a special X-ray technique called RSA. They also tracked how patients felt and func…

This study aimed to understand how age influences serious health issues like infections, cancer, heart disease, and bone fractures in people with rheumatoid arthritis. Researchers compared patients over 65 with younger adults (18-50) who had the same disease. The study was stoppe…

This study looked at whether custom-made knee implants (ConforMIS iTotal) help people move better than standard off-the-shelf implants after knee replacement surgery. About 215 adults with osteoarthritis took part. Researchers measured walking, daily activities, and sports perfor…

This study looked at how JAK-STAT inhibitors, a type of drug used for rheumatoid arthritis, affect certain immune cells called regulatory B cells. Researchers analyzed blood samples from 27 patients to see if these drugs could boost anti-inflammatory functions. The study was term…

This pilot study analyzed special immune cells called regulatory T cells (Tregs) in the joint fluid of 19 people with rheumatoid arthritis during a flare-up. Researchers compared these cells to Tregs in the blood to understand how they behave in inflamed joints. No treatment was …

This study collected bone, cartilage, skin, and fat tissue from 50 patients undergoing surgery at Children's National Medical Center. The goal was to grow cells from these tissues in the lab and analyze them to better understand bone and connective tissue diseases. The study was …

This study looked at whether a condition called intermetatarsal bursitis (inflammation between foot bones) causes pain in people with rheumatoid arthritis. Researchers used MRI and ultrasound to examine the feet of 3 participants and tested steroid injections. The study was termi…

This study looked at whether people with both rheumatoid arthritis and type 2 diabetes have a harder time controlling their diabetes than those with osteoarthritis and diabetes. Researchers planned to follow 176 adults to see how quickly they needed new diabetes treatments. Howev…

This study looked at whether a single IV dose of oxytocin, a natural hormone, could reduce pain from heat on the skin. It included 7 people — some healthy and some with severe knee arthritis. Researchers measured pain scores during a 5-minute heat test. The study was terminated e…

This study looked at different X-ray views and MRI scans to see which best shows cartilage damage in arthritic knees. Researchers planned to include 225 people with knee osteoarthritis, but only 8 were enrolled before the study was stopped. The goal was to improve how doctors dec…