Ankle implant tracked for Long-Term success in arthritis patients

NCT ID NCT03247023

Terminated Disease control Sponsor: Smith & Nephew, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study followed 65 adults with ankle arthritis (from wear-and-tear, injury, or conditions like rheumatoid arthritis) who received the Cadence Total Ankle System implant. Researchers tracked how long the implant lasted without needing removal or revision, checking at 2, 5, and 10 years. The goal was to see if the device is safe and durable for long-term use.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Integra Cadence Total Ankle System (ankle replacement implant)
What this could lead to: If successful, this could confirm that the Cadence ankle implant is a safe and durable option for people with severe ankle arthritis, potentially improving mobility and reducing pain for years.
What could go wrong: This trial was terminated early and only enrolled 65 people, so results may be limited. As with any joint replacement, risks include implant loosening, infection, or need for revision surgery.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

osteoarthritis rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEGENERATIVE ARTHRITIS RHEUMATOID ARTHRITIS TRAUMATIC ARTHRITIS

Contacts and locations

Locations

CHRU Tours

Tours, 37044, France
Clinica Nostra Senhora del Remei

Barcelona, 08024, Spain
Foot and Ankle Institute

Woluwe-St-Lambert, B-1200, Belgium
North Cumbria University Hospitals

Carlisle, CA2 7HY, United Kingdom
St. Michael's Hospital

Toronto, M5C 1R6, Canada
Universitair Ziekenhuis Gent

Ghent, 9000, Belgium

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