Knee osteoarthritis drug trial halted early – what we know

NCT ID NCT04864392

Terminated Disease control Sponsor: Novartis Pharmaceuticals Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested an experimental drug called LNA043, given as injections into the knee, to see if it could slow cartilage loss and reduce pain in people with knee osteoarthritis. The trial planned to follow 576 participants for up to 5 years, but it was terminated early. The main goal was to measure changes in cartilage thickness using MRI.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

LNA043 (an experimental drug injected into the knee joint)

What this could lead to

If successful, this could point toward a treatment that slows cartilage loss and eases pain in knee osteoarthritis.

What could go wrong

The trial was terminated early, so results are limited. It is still experimental and may not prove effective or safe in larger studies.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease osteoarthritis osteoarthritis, knee

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OSTEOARTHRITIS

Contacts and locations

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Locations

AMR Knoxville

Knoxville, Tennessee, 37920, United States
Annapolis Rheumatology LLC

Fairfax, Virginia, 22033, United States
Artemis Institute Clinical Research

Riverside, California, 92503, United States
Arthemis Clinical Research

San Diego, California, 92103, United States
Center For Pharmaceutical Research

Kansas City, Missouri, 64114, United States
Charlottesville Medical Research

Charlottesville, Virginia, 22911, United States
Chicago Clinical Research Inst

Chicago, Illinois, 60607, United States
Clinical Research of West Florida Inc

Tampa, Florida, 33603, United States
Clinical Trials Research

Lincoln, California, 95648, United States
Conquest Research

Winter Park, Florida, 32789, United States
Drug Trials America

Hartsdale, New York, 10530, United States
Elite Clinical Studies

Phoenix, Arizona, 85018, United States
Long Beach Clinical Trials

Long Beach, California, 90806, United States
Metroplex Clinical Research

Dallas, Texas, 75231, United States
Northern California Research

Sacramento, California, 95821, United States
Novartis Investigative Site

Caba, C1428AZF, Argentina
Novartis Investigative Site

Córdoba, X5000EOC, Argentina
Novartis Investigative Site

San Miguel de Tucumán, 4000, Argentina
Novartis Investigative Site

Broadmeadow, New South Wales, 2292, Australia
Novartis Investigative Site

Maroochydore, Queensland, 4558, Australia
Novartis Investigative Site

Woodville South, South Australia, 5011, Australia
Novartis Investigative Site

Hobart, Tasmania, 7000, Australia
Novartis Investigative Site

Malvern East, Victoria, 3145, Australia
Novartis Investigative Site

Christchurch, 8011, Australia
Novartis Investigative Site

St Leonards, 2065, Australia
Novartis Investigative Site

Waikanae Beach, 5036, Australia
Novartis Investigative Site

Québec, Quebec, G1V 3M7, Canada
Novartis Investigative Site

Trois-Rivières, Quebec, G9A 3Y2, Canada
Novartis Investigative Site

Beijing, Beijing Municipality, 100044, China
Novartis Investigative Site

Bengbu, 233004, China
Novartis Investigative Site

Brno, Czech Republic, 66250, Czechia
Novartis Investigative Site

Pardubice, Czech Republic, 530 02, Czechia
Novartis Investigative Site

Brno-Zidonice, CZE, 61500, Czechia
Novartis Investigative Site

Brno, 638 00, Czechia
Novartis Investigative Site

Uherské Hradiště, 686 01, Czechia
Novartis Investigative Site

Aarhus N, 8200, Denmark
Novartis Investigative Site

Gandrup, 9362, Denmark
Novartis Investigative Site

Vejle, 7100, Denmark
Novartis Investigative Site

Tallinn, 10128, Estonia
Novartis Investigative Site

Tartu, 50708, Estonia
Novartis Investigative Site

Vadodara, Gujarat, 390022, India
Novartis Investigative Site

Belagavi, Karnataka, 590010, India
Novartis Investigative Site

Lucknow, Uttar Pradesh, 226003, India
Novartis Investigative Site

Pune, 411019, India
Novartis Investigative Site

Shinagawa, Tokyo, 140 0014, Japan
Novartis Investigative Site

Shinjuku Ku, Tokyo, 160-0008, Japan
Novartis Investigative Site

Suginami, Tokyo, 166-0002, Japan
Novartis Investigative Site

Chuoh-ku, 104-0031, Japan
Novartis Investigative Site

Osaka, 543-0027, Japan
Novartis Investigative Site

Guadalajara, Jalisco, 44650, Mexico
Novartis Investigative Site

Culiacán, Sinaloa, 80000, Mexico
Novartis Investigative Site

Ciudad de, CP 06700, Mexico
Novartis Investigative Site

Kielce, 25-017, Poland
Novartis Investigative Site

Krakow, 31-501, Poland
Novartis Investigative Site

Poznan, 60-446, Poland
Novartis Investigative Site

Warsaw, 02-677, Poland
Novartis Investigative Site

Santiago, A Coruna, 15705, Spain
Novartis Investigative Site

Sabadell, Barcelona, 08208, Spain
Novartis Investigative Site

Barcelona, Catalonia, 08003, Spain
Novartis Investigative Site

A Coruña, 15006, Spain
Novartis Investigative Site

Madrid, 28046, Spain
Novartis Investigative Site

Seville, 41010, Spain
Novartis Investigative Site

Changhua, 50006, Taiwan
Novartis Investigative Site

Tainan, 704302, Taiwan
Novartis Investigative Site

Glasgow, Scotland, G51 4TF, United Kingdom
Novartis Investigative Site

Barnet, EN5 3DJ, United Kingdom
Novartis Investigative Site

Norwich, NR4 7UY, United Kingdom
Pioneer Research Solutions

Sugar Land, Texas, 77479, United States
Sensible Healthcare

Ocoee, Florida, 34761, United States
Sharps Hospital Grossmont

La Mesa, California, 91942, United States
Stamford Therapeutics Consortium LLC

Stamford, Connecticut, 06905, United States
Tandem clinical research

Marrero, Louisiana, 70072, United States
The Center for Rheumatology and Bone Research

Wheaton, Maryland, 20902, United States
Tucson Orthopedic Institute PC

Tucson, Arizona, 85712, United States
Virginia Ispine Physicians PC

Richmond, Virginia, 23238, United States