CBD-Hydroxychloroquine combo tested for arthritis pain – but trial ends early
NCT ID NCT05942911
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested a combination pill called IHL-675A, which contains cannabidiol (CBD) and hydroxychloroquine, in people with rheumatoid arthritis. The goal was to see if it safely reduces pain and improves daily function. The trial planned to enroll 128 volunteers but was terminated early with only 20 participants. Participants took the combo, CBD alone, hydroxychloroquine alone, or a placebo twice daily for 24 weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
IHL-675A (a combination of cannabidiol and hydroxychloroquine)
What this could lead to
If it works, this could point toward a new treatment option for rheumatoid arthritis that combines CBD with a standard drug to improve pain and daily function.
What could go wrong
The trial was terminated early with only 20 participants, so results are very limited. It is a small Phase II study, so even if safe, it may not prove effective or lead to a new therapy.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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AusTrials Wellers Hill
Wellers Hill, Queensland, 4121, Australia
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AusTrials Westside (Taringa)
Taringa, Queensland, 4068, Australia
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Captain Sterling Medical Centre
Nedlands, Western Australia, 6009, Australia
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Coast Joint Care
Maroochydore, Queensland, 4558, Australia
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Emeritus Research
Sydney, New South Wales, 2019, Australia
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Emeritus Research Melbourne
Camberwell, Victoria, 3124, Australia
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Genesis Research Services
Broadmeadow, New South Wales, 2292, Australia
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Novatrials
Kotara, New South Wales, 2289, Australia
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Paratus Clinical (Woden Dermatology)
Phillip, Australian Capital Territory, 2606, Australia
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Royal Prince Alfred Hospital
Camperdown, New South Wales, 2050, Australia