CBD-Hydroxychloroquine combo tested for arthritis pain – but trial ends early

NCT ID NCT05942911

Terminated Disease control Sponsor: Incannex Healthcare Ltd Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tested a combination pill called IHL-675A, which contains cannabidiol (CBD) and hydroxychloroquine, in people with rheumatoid arthritis. The goal was to see if it safely reduces pain and improves daily function. The trial planned to enroll 128 volunteers but was terminated early with only 20 participants. Participants took the combo, CBD alone, hydroxychloroquine alone, or a placebo twice daily for 24 weeks.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: IHL-675A (a combination of cannabidiol and hydroxychloroquine)
What this could lead to: If it works, this could point toward a new treatment option for rheumatoid arthritis that combines CBD with a standard drug to improve pain and daily function.
What could go wrong: The trial was terminated early with only 20 participants, so results are very limited. It is a small Phase II study, so even if safe, it may not prove effective or lead to a new therapy.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Arthralgia arthritic joint disease Fatigue Pain rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

AusTrials Wellers Hill

Wellers Hill, Queensland, 4121, Australia
AusTrials Westside (Taringa)

Taringa, Queensland, 4068, Australia
Captain Sterling Medical Centre

Nedlands, Western Australia, 6009, Australia
Coast Joint Care

Maroochydore, Queensland, 4558, Australia
Emeritus Research

Sydney, New South Wales, 2019, Australia
Emeritus Research Melbourne

Camberwell, Victoria, 3124, Australia
Genesis Research Services

Broadmeadow, New South Wales, 2292, Australia
Novatrials

Kotara, New South Wales, 2289, Australia
Paratus Clinical (Woden Dermatology)

Phillip, Australian Capital Territory, 2606, Australia
Royal Prince Alfred Hospital

Camperdown, New South Wales, 2050, Australia

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