New pill for rheumatoid arthritis shows promise in early trial

NCT ID NCT07100938

Terminated Disease control Sponsor: BeiGene Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 study tested an experimental oral drug called BGB-45035 in 49 adults with moderate to severe rheumatoid arthritis who had not responded well to standard treatments. Participants received either the drug or a placebo to see if it could reduce joint pain and swelling. The trial was terminated early, so the full results are not available.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: BGB-45035 (an oral drug)
What this could lead to: If successful, this could point toward a new oral treatment option for people with rheumatoid arthritis who haven't responded well to standard therapies.
What could go wrong: This trial was terminated early with only 49 participants, so results are limited. The drug may not prove effective or safe in larger studies.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

hereditary sensory and autonomic neuropathy rheumatoid arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

RHEUMATOID ARTHRITIS

Contacts and locations

Locations

Affiliated Hospital of Liaoning University of Traditional Chinese Medicine

Shenyang, Liaoning, 110000, China
Affiliated Hospital of Nantong University

Nantong, Jiangsu, 201203, China
Affiliated Hospital of North Sichuan Medical College

Nanchong, Sichuan, 637000, China
Anhui Provincial Hospital

Hefei, Anhui, 230000, China
Beijing Friendship Hospital, Capital Medical University

Beijing, Beijing Municipality, 100050, China
Chenzhou No1 Peoples Hospital

Chenzhou, Hunan, 423000, China
Huashan Hospital Fudan University

Shanghai, Shanghai Municipality, 200040, China
Nanfang Hospital, Southern Medical University

Guangzhou, Guangdong, 510515, China
Nanjing Drum Tower Hospital,the Affiliated Hospital of Nanjing University Medical School

Nanjing, Jiangsu, 210008, China
Nanyang Central Hospital

Nanyang, Henan, 473000, China
Northern Jiangsu Peoples Hospital

Yangzhou, Jiangsu, 225001, China
Peking University First Hospital

Beijing, Beijing Municipality, 100034, China
Pingxiang Peoples Hospital

Pingxiang, Jiangxi, 337055, China
Sichuan Academy of Medical Sciences and Sichuan Provincial Peoples Hospital

Chengdu, Sichuan, 610071, China
Sun Yat Sen Memorial Hospital, Sun Yat Sen University (North)

Guangzhou, Guangdong, 510000, China
The Affiliated Hospital of Inner Mongolia Medical University

Hohhot, Inner Mongolia, 010050, China
The First Affiliated Hospital of Bengbu Medical University

Bengbu, Anhui, 233004, China
The First Affiliated Hospital of Guangxi Medical University

Nanning, Guangxi, 530021, China
The First Affiliated Hospital of Henan University of Science and Technology

Luoyang, Henan, 471003, China
The First Affiliated Hospital of Nanchang University Branch Donghu

Nanchang, Jiangxi, 330006, China
The First Affiliated Hospital of Xian Jiaotong University

Xi'an, Shaanxi, 710061, China
The First Affiliated Hospital, Sun Yat Sen University

Guangzhou, Guangdong, 510080, China
The First Hospital of Jilin University

Changchun, Jilin, 130021, China
The First Peoples Hospital of Changzhou

Changzhou, Jiangsu, 213000, China
The Second Affiliated Hospital of Chongqing Medical University

Chongqing, Chongqing Municipality, 400010, China
The Second Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
The Second Affiliated Hospital of Zhejiang University School of Medicine

Hangzhou, Zhejiang, 310009, China
The Second Xiangya Hospital of Central South University

Changsha, Hunan, 410011, China
Zhengzhou Central Hospital

Zhengzhou, Henan, 450007, China

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