Knee implant study halted early: what we know
NCT ID NCT00734110
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study looked at how well the P.F.C. Sigma knee replacement implant works in people with severe knee arthritis. Researchers planned to follow 723 patients for at least 5 years after surgery, tracking pain, function, and any complications. However, the study was terminated early, so the full long-term data is not available.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
P.F.C. Sigma Total Knee System (a knee replacement implant)
What this could lead to
If successful, this could confirm that the P.F.C. Sigma knee implant provides lasting pain relief and improved function for people with severe knee arthritis.
What could go wrong
The study was terminated early, so results may be incomplete. As a device study, individual outcomes vary and risks include implant failure, infection, or need for revision surgery.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Princess Alexandra Hospital NHS Trust
Harlow, Essex, CM20 1QX, United Kingdom