Can a fluid from amniotic cells ease ankle arthritis pain?
NCT ID NCT05092646
First seen Aug 07, 2026 · Last updated Aug 07, 2026
Summary
This study tests whether a single injection of Axolotl Ambient, a fluid rich in growth factors derived from human amniotic cells, can reduce pain and improve function in people with ankle osteoarthritis. Participants will be randomly assigned to receive either the investigational injection or a saline placebo, and neither they nor the researchers will know which they received. The trial focuses on measuring changes in pain and function scores over time, as well as safety.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Axolotl Ambient (CA20), a fluid derived from human amnion cells, injected into the ankle joint
- What this could lead to
- If it works, this could offer a new, non-surgical way to reduce ankle osteoarthritis pain and improve mobility.
- What could go wrong
- This is a small early-stage pilot study, so results may not hold up in larger trials. The injection could cause side effects or fail to outperform a placebo.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Injury Care Research
Boise, Idaho, 83713, United States
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OrthoCarolina Foot and Ankle Institute
Charlotte, North Carolina, 28207, United States
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Orthopedic Specialists of Louisiana
Shreveport, Louisiana, 71101, United States
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