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Real-World study tests upadacitinib for back pain in axial spondyloarthritis

NCT ID NCT05094128

Ongoing Disease control Sponsor: AbbVie Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study looks at how well upadacitinib (RINVOQ) works for people with axial spondyloarthritis, a type of inflammatory arthritis that causes chronic back pain. About 338 adults in Germany will take the drug as prescribed by their doctor and be followed for 52 weeks. Researchers will measure disease activity and pain control using standard questionnaires and blood tests.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

upadacitinib (RINVOQ)

What this could lead to

If successful, this study could show that upadacitinib effectively controls disease activity and reduces pain in people with axial spondyloarthritis in everyday clinical settings.

What could go wrong

This is an observational real-world study, not a controlled trial, so results may be less definitive. Upadacitinib is already approved, so this is about confirming effectiveness rather than a breakthrough.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ankylosing spondylitis spondyloarthropathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AXIAL SPONDYLARTHRITIS (R-AXSPA)

Contacts and locations

Locations

  • ACURA Rheumazentrum Baden-Bade /ID# 249751

    Baden-Baden, Baden-Wurttemberg, 76530, Germany

  • Aurich and Sieburg, Magdeburg /ID# 240518

    Magdeburg, Saxony-Anhalt, 39104, Germany

  • Barmherzige Bruder MVZ Klinikum Straubing GmbH /ID# 240523

    Straubing, 94315, Germany

  • Baumann & Lang, Plauen, DE /ID# 244369

    Plauen, 08523, Germany

  • Beyer, Kaiserslautern, DE /ID# 240444

    Kaiserslautern, Rhineland-Palatinate, 67659, Germany

  • Dr. Bolze, Ludwigshafen, DE /ID# 251012

    Ludwigshafen, 67069, Germany

  • Dr. Walberer /ID# 249752

    Burglengenfeld, 93133, Germany

  • Dres. Karger/Baerlecken /ID# 240442

    Cologne, 50996, Germany

  • Dres. Weinhardt/Knobel/Doepfer /ID# 248195

    Hamburg, 22523, Germany

  • Eisterhues, Braunschweig, DE /ID# 239438

    Braunschweig, 38100, Germany

  • Fachpraxis fuer Rheumatologie und Osteologie /ID# 243358

    Bruchhausen-Vilsen, Lower Saxony, 27305, Germany

  • Fricke-Wagner, Zwickau, DE /ID# 240452

    Zwickau, 08060, Germany

  • Hamann and Teich and Boche,Leipzig /ID# 240445

    Leipzig, Saxony, 04109, Germany

  • Harmuth, Marktredwitz, DE /ID# 240455

    Marktredwitz, 95615, Germany

  • Heilig, Heidelberg, DE /ID# 240492

    Heidelberg, Baden-Wurttemberg, 69120, Germany

  • Kerckhoff Klinik /ID# 252219

    Bad Nauheim, 61231, Germany

  • Krankenhaus Porz am Rhein /ID# 243765

    Cologne, North Rhine-Westphalia, 51149, Germany

  • Krankenhaus St. Josef /ID# 249747

    Wuppertal, 42105, Germany

  • Krankenhaus Waldfriede /ID# 268389

    Berlin, 14163, Germany

  • Krankenhaus der Barmherzigen Brüder Trier /ID# 240524

    Trier, Rhineland-Palatinate, 54292, Germany

  • Kreiskrankenhaus Demmin /ID# 240451

    Demmin, 17109, Germany

  • Kremers, Juelich, DE /ID# 243357

    Jülich, 52428, Germany

  • Kupka and Kupka, Altenburg, DE /ID# 240479

    Altenburg, Thuringia, 04600, Germany

  • MVZ Ambulantes Rheumazentrum Erfurt /ID# 244448

    Erfurt, Thuringia, 99096, Germany

  • MVZ Herzogin Elisabeth Hospital /ID# 267983

    Braunschweig, 38114, Germany

  • MVZ für Rheumatologie Dr. M. Welcker /ID# 240521

    Planegg, 82152, Germany

  • MVZ-Medizinisches Versorgungszentrum Daun GmbH /ID# 254839

    Daun, 54550, Germany

  • Marycz, Amberg, DE /ID# 240483

    Amberg, 92224, Germany

  • Medizinische Hochschule Hannover /ID# 262814

    Hanover, Lower Saxony, 30625, Germany

  • Medizinischen Versorgungszentrums Agilomed /ID# 240481

    Chemnitz, Saxony, 09130, Germany

  • Melzer, Seesen, DE /ID# 240484

    Seesen, 38723, Germany

  • Michael Mueller, Freiberg, DE /ID# 240489

    Freiberg, 09599, Germany

  • Praxis Barmen /ID# 240449

    Wuppertal, 42285, Germany

  • Praxis Barmen /ID# 277515

    Wuppertal, 42285, Germany

  • Praxis Bernd Mueller /ID# 240488

    Homburg, Saarland, 66424, Germany

  • Praxis Dilltal /ID# 240520

    Ehringshausen, 35630, Germany

  • Praxis Dr. Annekatrin Rossbach /ID# 240495

    Mansfeld / Großörner, 06343, Germany

  • Praxis Dr. Haas /ID# 242982

    Tübingen, Baden-Wurttemberg, 72072, Germany

  • Praxis Dr. Liebhaber /ID# 240480

    Halle, Saxony-Anhalt, 06128, Germany

  • Praxis Dr. Rinaldi /ID# 242984

    Ulm, Baden-Wurttemberg, 89073, Germany

  • Praxis Dr. Sabine Reckert /ID# 245142

    Potsdam, Brandenburg, 14469, Germany

  • Praxis Dr. Silke Zinke /ID# 240526

    Berlin, 13055, Germany

  • Praxis Dr. med Thilo Klopsch /ID# 240461

    Neubrandenburg, 17033, Germany

  • Praxis Dr. med. Angela Seifert /ID# 245107

    Berlin, 12555, Germany

  • Praxis Dres. Sensse/Sensse /ID# 240517

    Gifhorn, 38518, Germany

  • Praxis F. Schattenberg /ID# 257646

    Waren, 17192, Germany

  • Praxis Hein & Gess /ID# 240456

    Nienburg, 31582, Germany

  • Praxis K. Pagel /ID# 240490

    Hoppegarten, Brandenburg, 15366, Germany

  • Praxis S. Bresgulewski /ID# 240662

    Bad Bertrich, 56864, Germany

  • Praxis internistische Rheumatologie /ID# 240515

    Leipzig, Saxony, 04129, Germany

  • Praxis. F. Bigdeli-Wilshusen /ID# 272904

    Hanover, Lower Saxony, 30173, Germany

  • Private Practice - Dr. Daniel Bestler /ID# 251860

    Erfurt, 99096, Germany

  • Private Practice - Dr. Hauke E. Heintz /ID# 254037

    Hamburg, 22391, Germany

  • Private Practice - Dr. Sebastian Schuh /ID# 240498

    Coburg, 96450, Germany

  • Prof-med-stud.de /ID# 240458

    Munich, 80935, Germany

  • RHIO Forschungsinstitut /ID# 240525

    Meerbusch, 40668, Germany

  • Rheumahaus Studien GbR, Potsdam, DE /ID# 245231

    Potsdam, Brandenburg, 14467, Germany

  • Rheumapraxis Berlin /ID# 242987

    Berlin, 12435, Germany

  • Rheumapraxis Dr. Prothmann /ID# 240671

    Püttlingen, Saarland, 66346, Germany

  • Rheumapraxis Weimar /ID# 268387

    Weimar, Thuringia, 99427, Germany

  • Rheumapraxis am Webereck /ID# 240454

    Augsburg, 86157, Germany

  • Rheumathologie Ulm /ID# 240494

    Ulm, 89073, Germany

  • Rheumatologie Kassel /ID# 275998

    Kassel, Lower Saxony, 34125, Germany

  • Rheumatologische Facharztpraxis - Naumburg (Saale) /ID# 240477

    Naumburg, Saxony-Anhalt, 06618, Germany

  • Rheumatologische Praxis Dr. Jochen Walter /ID# 250263

    Rendsburg, Schleswig-Holstein, 24768, Germany

  • Rheumatologische Schwerpunktpraxis /ID# 245392

    Stuttgart, Baden-Wurttemberg, 70372, Germany

  • Rheumatologisches Medizinisches Versorgungszentrum Dresden /ID# 240516

    Dresden, Saxony, 01109, Germany

  • Rheumazentrum Ratingen /ID# 240465

    Ratingen, 40882, Germany

  • Rheumazentrum Ruhrgebiet /ID# 240460

    Herne, North Rhine-Westphalia, 44649, Germany

  • Stille, Hanover, DE /ID# 252222

    Hanover, Lower Saxony, 30161, Germany

  • Wernicke, Hohen Neuendorf, DE /ID# 250626

    Hohen Neuendorf, 16540, Germany

  • Zentrum fuer Rheumatologie und Schmerzmedizin /ID# 244370

    Hanover, 30159, Germany