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Can a diet calm inflamed joints in children with arthritis?

NCT ID NCT04205500

Disease control Sponsor: Uppsala University Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

Researchers are testing whether a specific carbohydrate diet, which has anti-inflammatory effects in children with inflammatory bowel disease, can also reduce joint inflammation in children with juvenile idiopathic arthritis. The trial includes children up to age 16 with low to medium disease activity. Participants follow the diet, and researchers measure changes in inflamed joints, physical function, pain, and morning stiffness, along with gut bacteria and short-chain fatty acids in stool samples.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
specific carbohydrate diet
What this could lead to
If the diet works, it could offer a dietary way to ease joint inflammation and improve daily function in children with juvenile idiopathic arthritis.
What could go wrong
This is a small early trial, and the diet may not reduce joint inflammation. Following the diet can be challenging for children and families.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Sep 2017

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Up to 16 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Participants should fulfill criteria for JIA according to the ILAR criteria * Participants should not be older than 16 years at onset of disease * Participants should have a low-medium disease activity with an E-SR of 30 at the most and/or no more than two active joints at inclusion. * DMARD and bDMARD should not have been changed within the last 12 weeks before inclusion. * Any gastro- intestinal complaints should be investigated before inclusion. * Fecal calprotectin should be normal. * The child as well as the parents need to be motivated for the child to try a dietary intervention for at least four weeks, preferably longer. Exclusion criteria: * Children with the systemic category of JIA. * Children with an unstable inflammatory situation with \> 2 inflamed joints and/or an E-SR of more than 30.

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Conditions

The condition(s) this trial relates to.

arthritic joint disease juvenile idiopathic arthritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Juvenile idiopathic arthritis

Contacts and locations

Locations

  • Uppsala university

    Uppsala, Uppsala County, 75185, Sweden

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