Uterine disorder

This study tests whether a temporary uterus transplant from a living donor can allow women with uterine factor infertility—who lack a functioning uterus—to become pregnant and deliver a healthy baby. Recipients receive immunosuppressive drugs to prevent rejection, and the uterus …

This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative …

This study tests a bivalent HPV vaccine in healthy infants (9 months), toddlers (15 months), children (2-5 years), and unmarried young women (15-20 years) in Ghana. Researchers want to see if the vaccine is safe and triggers a strong immune response, especially when given alongsi…

This study tests a new drug called BMS-986340, alone or with other cancer treatments, in people with advanced solid tumors like lung, colon, or breast cancer. The goal is to find safe doses and check for side effects. About 1,100 adults with tumors that have worsened after standa…

This early-phase trial is testing a new drug, FOG-001, in about 595 people with advanced or metastatic solid tumors, including colorectal, prostate, and liver cancers. The drug is given alone or with other cancer treatments to see if it is safe and shrinks tumors. The study is cu…

This early-stage trial is testing an experimental drug called SIM0505 in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any early signs that the drug shrinks tumors. About 414 participants will re…

This study is testing whether adding the immunotherapy drug dostarlimab to standard chemotherapy and radiation can help women with a rare and aggressive type of cervical cancer called small cell neuroendocrine carcinoma. About 45 women with early to advanced stages of the disease…

This study compares a new drug called Rina-S to standard chemotherapy (paclitaxel or doxorubicin) in people with endometrial cancer that has returned or worsened after platinum-based chemo and immunotherapy. About 660 participants will be randomly assigned to receive either Rina-…

This phase II trial is testing whether combining two immunotherapy drugs, nivolumab and ipilimumab, works better than nivolumab alone for women with recurrent endometrial cancer that has a specific DNA repair defect (dMMR). About 81 participants will receive either the combinatio…

This study tests a new drug called CR-001 in adults with advanced solid tumors that have spread. The goal is to find the safest dose and see if it can shrink tumors. About 290 people will take part in this early-phase trial.

This phase III trial tests whether giving an extra round of chemotherapy and immunotherapy (pembrolizumab) before the usual chemoradiation can help people with high-risk, locally advanced cervical cancer live longer without the cancer growing. About 336 participants will be rando…

This phase 2 trial tests whether adding an experimental immune-boosting drug (CDX-1140) to two standard immunotherapies (pembrolizumab and bevacizumab) can shrink tumors in people whose ovarian cancer has returned. About 80 adults with recurrent ovarian, fallopian tube, or perito…

This phase 3 trial compares a new drug called Rina-S to standard chemotherapy in 82 people with platinum-resistant ovarian cancer. Participants are randomly assigned to receive either Rina-S or one of four approved chemotherapies. The goal is to see if Rina-S can delay cancer gro…

This phase 3 trial tests whether adding targeted drugs (trastuzumab and pertuzumab) to standard chemotherapy can better shrink tumors in people with HER2-positive endometrial cancer. The study plans to enroll 360 participants with various stages of the disease. However, the trial…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This early-phase study tests a new drug called GS-0201, given alone or with another cancer drug (sacituzumab govitecan), in adults with advanced solid tumors that have not responded to other treatments. The main goals are to check safety, find the best dose, and see how the body …

This study tests a combination of two drugs, sacituzumab govitecan and cisplatin, in people with ovarian or endometrial cancer that has come back but still responds to platinum-based treatments. The goal is to find the safest dose and see how well the drugs shrink tumors. About 5…

This phase 2 trial is testing a drug called datopotamab deruxtecan (Dato-DXd), alone or with other cancer medicines, in people with advanced or metastatic solid tumours. The study includes seven cancer types and aims to see if the drug shrinks tumours and how safe it is. Around 4…

This study tests an experimental drug called SMP-3124LP, which is a liposomal (fat-encapsulated) version of a cancer-fighting compound. It is for adults with advanced solid tumors that have not responded to standard treatments. The trial has two parts: first, finding the safest d…

This early-phase trial is testing a new drug called PHST001, which helps the immune system attack cancer cells by blocking a protein called CD24. The study will first test PHST001 alone, then in combination with standard chemotherapy, in adults with advanced solid tumors (includi…

This trial is investigating whether adding radiation therapy to a standard combination of chemotherapy and two targeted drugs can improve outcomes for people with stage IVB cervical cancer. The study combines external beam radiation and internal brachytherapy with cisplatin, pacl…

This study tests a new drug called AZD8205, alone or with another drug (rilvegostomig), in people with advanced solid tumors like breast, ovarian, and lung cancers. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 460 adults whose c…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This phase 3 trial compares a once-weekly growth hormone injection (lonapegsomatropin) to a daily one (somatropin) in 186 prepubertal children with growth failure due to Turner syndrome, SHOX deficiency, being small for gestational age, or idiopathic short stature. The goal is to…

This trial is testing whether an experimental drug called TUB-040, when added to standard chemotherapy and a targeted therapy, is safe and tolerable for women with a specific type of advanced ovarian cancer. The study involves about 72 participants whose cancer has returned but s…

This phase II study is testing whether women with certain types of early-stage endometrial cancer can safely receive less aggressive treatment after surgery. The approach is guided by the tumor's molecular profile—either POLE-mutated or p53 wildtype/NSMP. Around 393 participants …

This early-phase trial tests MGC026, a biologic drug given by IV, in 250 adults with advanced solid tumors that have not responded to standard treatments. The study has two parts: first, finding a safe dose, then expanding to see if the drug shrinks tumors. Participants receive u…

This early-stage trial tests two experimental mRNA therapies (mRNA-4106 and mRNA-4200) in 42 people with advanced solid tumors like melanoma, lung, or liver cancer. Some participants receive the mRNA therapy alone, others get it combined with the immunotherapy drug pembrolizumab.…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage trial is testing an investigational drug called ARR-002 in adults with advanced or metastatic ovarian or endometrial cancer, including cases that have stopped responding to platinum-based chemotherapy. The main goals are to assess the drug's safety, tolerability,…

This trial is investigating whether combining an immunotherapy drug (a PD-1 inhibitor like sintilimab or pembrolizumab) with progesterone therapy can help young women with early-stage, mismatch repair-deficient (MMRd) endometrial cancer achieve complete remission while preserving…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This Phase III trial tests whether adding the drug bevacizumab to a standard chemotherapy plus immunotherapy regimen can help people with a specific type of advanced or recurrent endometrial cancer (pMMR, TP53 mutated). About 255 participants will be randomly assigned to one of t…

This trial asks whether robot-assisted hysterectomy is as effective as traditional open surgery for treating early-stage cervical cancer. About 800 women with stage IB (excluding IB3) or IIA1 cervical cancer will be randomly assigned to one of the two surgical approaches. The mai…

This early-phase study tests an experimental drug called DM002 in about 160 people with advanced solid tumors (ovarian, prostate, endometrial, colorectal, or other solid cancers). The study has two parts: first, finding a safe dose by giving small groups gradually higher doses; s…

This phase 3 trial tests whether taking the drug olaparib for one year works as well as taking it for two years to keep ovarian cancer from coming back. The study includes 880 people with advanced ovarian cancer (stage III or IV) who have a BRCA mutation or similar DNA repair pro…

This trial tests the safety of tolvaptan, a drug that helps the body remove extra water, in 20 children aged 28 days to 18 years with autosomal recessive polycystic kidney disease (ARPKD). The goal is to see if the drug can slow kidney function decline and reduce the need for dia…

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has sprea…

This early-phase study tests a new drug called STRO-004 in adults with advanced solid tumors that have not responded to standard treatments. The study has three parts: finding a safe dose of STRO-004 alone, testing that dose in more patients, and combining STRO-004 with another d…

This large Phase 3 study tests a new medicine called Sofetabart Mipitecan for people with ovarian, fallopian tube, or peritoneal cancer. It includes two groups: those whose cancer stopped responding to platinum chemotherapy within six months (platinum-resistant), and those whose …

This early-stage trial is testing an experimental drug called EVOLVE104 in people with advanced bladder cancer or several types of squamous cell carcinoma (lung, esophagus, skin, and others). The study aims to find a safe dose and see if the drug can shrink tumors. It is for pati…

This early-phase study tests a new drug called HWK-016 in people with advanced ovarian or endometrial cancers that have not responded to other treatments. The drug is designed to deliver a toxic payload directly to cancer cells that carry a specific marker (MUC16). The main goals…

This early-phase study tests a new drug called BGB-43395 in people with advanced HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. Researchers want to find the safest and most effective dose, either alone or combined wi…

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests a drug called ifinatamab deruxtecan (I-DXd) in people with 13 types of advanced solid tumors that have come back or spread. The trial aims to see how well the drug shrinks tumors and what side effects it causes. About 520 participants will receive the drug intrav…

This study tests a new drug called BI 3820768 in adults with advanced germ cell tumors, endometrial cancer, or ovarian cancer who have run out of treatment options. The drug aims to help the immune system fight cancer. Researchers will give increasing doses to find a safe amount …

This early-stage study tests a new drug called HWK-007 in people with advanced solid tumors, including certain ovarian, endometrial, and lung cancers. The drug is designed to target a protein (PTK7) found on cancer cells and deliver a chemotherapy-like payload directly to them. T…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This early-stage trial tests a new drug called LY4052031, which is designed to deliver a cancer-killing agent directly to tumor cells that have a protein called Nectin-4. The study includes 420 adults with advanced or metastatic solid tumors such as bladder, breast, lung, and oth…

This trial is testing a shorter course of radiation therapy for women who have had surgery for cervical cancer. Instead of the usual many weeks of daily treatments, participants receive a slightly higher dose each day over about three and a half weeks. The goal is to see if this …

This large Phase 3 trial will test a new drug called Rina-S, alone or with bevacizumab, against standard platinum-based chemotherapy for women with ovarian cancer that has returned after initial treatment. About 688 participants will be randomly assigned to receive either the new…

This Phase 1 trial tests IDOV-Immune, a genetically engineered virus designed to infect and destroy cancer cells while boosting the immune system. It is for adults with advanced solid tumors (like colorectal, pancreatic, or lung cancer) that have not responded to standard treatme…

This study tests a new drug, Rina-S, in people with advanced solid tumors that have spread or can't be removed by surgery. The goal is to see if Rina-S is safe and how well it works against cancers like ovarian, lung, and breast cancer. About 884 participants will receive the dru…

This Phase 3 trial tests whether adding the experimental drug Rina-S to standard care (bevacizumab or monitoring) can help keep platinum-sensitive ovarian cancer from returning after chemotherapy. About 528 participants will receive either Rina-S alone, Rina-S plus bevacizumab, b…

This early-phase study tests a new drug (PLN-101095) alone or with pembrolizumab in adults whose advanced solid tumors have stopped responding to standard immunotherapy. About 124 participants will receive the treatment to check safety and early signs of tumor shrinkage. The goal…

This early-stage trial is testing whether combining two cancer drugs (lenvatinib and pembrolizumab) with a shorter course of pelvic radiation is safe for people with recurrent or unresectable endometrial cancer. The study aims to find the best dose of lenvatinib when used in this…

This study tests two experimental drugs, elironrasib and daraxonrasib, given alone or together, in people with advanced solid tumors that have a specific KRAS G12C mutation. The goal is to see if the drugs are safe and can shrink or control the cancer. About 534 adults with lung,…

This early-stage trial tests an experimental drug called CTX-10726 in about 70 people with advanced gastroesophageal, liver, endometrial, or kidney cancers that have stopped responding to standard treatments. The main goal is to check safety and find the right dose. Participants …

This trial compares two surgical approaches for early-stage cervical cancer: robotic-assisted surgery using the da Vinci system versus traditional open surgery. Researchers are asking whether the minimally invasive robotic method can match or improve upon open surgery in terms of…

This phase 2 trial tests whether the drug letrozole can extend the time before uterine leiomyosarcoma returns after initial treatment. About 40 women with early-stage disease will be randomly assigned to take letrozole daily or to be observed without treatment. The main goal is t…

This study tests an experimental drug called IDP-001 in people with advanced or metastatic solid tumors, including certain lung, head and neck, and other cancers. The trial has two phases: first to check safety and find the right dose, then to see if the drug can shrink tumors. A…

This phase II trial is testing whether a short course of radiation combined with the immunotherapy drug adebrelimab and a single platinum chemotherapy drug can eliminate all signs of cancer before surgery in women with locally advanced cervical cancer. Participants receive the co…

This study tests whether a silicone cervical pessary can reduce vaginal bleeding and help women with placenta previa carry their pregnancy longer. About 190 pregnant women with this condition will either receive the pessary or standard care. The goal is to see if this simple devi…

This trial investigates whether salsalate, an anti-inflammatory drug, can reduce the elevated risk of cardiovascular disease seen in women with endometriosis. Researchers will measure blood vessel function and markers of inflammation in 24 women with endometriosis compared to hea…

This pilot trial tests whether using placental tissue analysis from a prior complicated pregnancy can guide treatment with the blood thinner enoxaparin to reduce the risk of recurrent adverse outcomes. The study enrolls women who had a previous pregnancy affected by early deliver…

This early-phase trial is testing an experimental biologic drug, DBC-664, in adults with advanced solid tumors such as ovarian, lung, and stomach cancers that have spread or come back. The study has two parts: first, finding a safe dose, and then expanding to see how well the dru…

This early-phase trial is testing an experimental oral drug called RGT-490 in about 63 adults with advanced solid tumors (including certain breast, ovarian, and endometrial cancers) that have a PIK3CA gene mutation and have stopped responding to standard treatments. The main goal…

This study compares two methods to control bleeding during laparoscopic myomectomy (surgery to remove fibroids from the uterus). One method uses a temporary tourniquet to block blood flow, and the other injects a medicine called epinephrine into the uterus to narrow blood vessels…

This study tests whether a program of exercise and nutrition counseling helps women with ovarian or endometrial cancer stick with their chemotherapy plan. About 200 women who are about to start chemotherapy will be randomly assigned to either receive weekly coaching sessions on p…

This early-phase trial tests a new drug called STC-15, either alone or combined with an immunotherapy drug (toripalimab), in people with advanced solid tumors or certain sarcomas. The study aims to check safety and whether the drugs shrink tumors. About 107 participants will be e…

This phase II trial tests the drug abemaciclib in people whose ovarian or endometrial cancer has returned and whose tumors have a specific genetic change (CDK4/6 pathway activation). Abemaciclib is a pill that blocks certain enzymes that cancer cells need to grow. The study will …

This trial tests whether a 3-day low-residue diet can replace a rectal enema for bowel preparation before laparoscopic endometrial cancer surgery. One hundred women scheduled for surgery will be randomly assigned to either the diet or an enema. The study measures how well the sur…

This study tests an experimental drug called Tulmimetostat (DZR123) in people with advanced solid tumors or lymphomas that have not improved with standard treatments. The drug is taken as a daily pill, either alone or combined with another drug (enzalutamide) for certain prostate…

This trial tests SPEDOX-6, a version of the chemotherapy drug doxorubicin wrapped in a protein shell, in people with advanced solid tumors such as soft-tissue sarcoma, triple-negative breast cancer, non-small cell lung cancer, cervical cancer, ovarian cancer, and certain pancreat…

This study investigates a new treatment approach for locally advanced cervical cancer that combines carbon ion radiotherapy with immunotherapy (anti-PD-1) and chemotherapy. The goal is to see if this triple therapy improves how long patients live without their cancer progressing.…

This study tests two drugs, pembrolizumab and lenvatinib, in people with a type of uterine cancer that has come back after initial treatment. The cancer must be mismatch repair proficient, meaning it has a specific genetic feature. The goal is to see if this drug combination can …

This study tests whether giving two injections of a long-acting hormone (GnRH-a) before standard hormone therapy can improve pregnancy rates in women with deep infiltrating endometriosis undergoing their first frozen embryo transfer. The hormone pretreatment aims to suppress endo…

This study tests a radiation treatment called Cesium-131 brachytherapy for women whose cervical or endometrial cancer has returned in the vagina after prior pelvic radiation. Tiny radioactive seeds are placed directly into the tumor to kill cancer cells while sparing healthy orga…

This study is for women with a certain type of endometrial cancer (called MMR-D/MSI-H) who have already had surgery. It tests whether adding radiation and an immunotherapy drug called dostarlimab can help keep the cancer from coming back. About 62 participants will receive the co…

This study tests whether a uterus from a deceased donor can be transplanted into women who cannot get pregnant due to a missing or non-working uterus. Participants must first create and freeze at least six embryos through IVF. After transplant and recovery, embryos are implanted.…

This study aims to help 10 women with absolute uterine infertility (no uterus or one that doesn't work) have a baby through a uterus transplant from a donor. Participants will first undergo IVF to create embryos, then receive the transplant, followed by embryo transfer and pregna…

This study compares two hormone drugs (megestrol acetate and micronized progesterone) in 140 women with endometrial cancer or precancer. Participants take one of the drugs for a short time before their scheduled surgery. Researchers will measure how well each drug slows cancer ce…

This early-stage trial tests a daily oral drug called CGT6297 in 90 adults with advanced solid tumors that have a specific mutation in the PIK3CA gene. The study has two parts: first, finding a safe dose, and then looking for signs that the drug shrinks tumors. It focuses on peop…

This study tests whether a two-month hormone pretreatment (GnRH agonist plus letrozole) before standard frozen embryo transfer can improve live birth rates in women with adenomyosis. About 222 participants will be randomly assigned to either the new regimen or standard care. The …

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study compares three surgical techniques for managing placenta accreta, a condition where the placenta grows too deeply into the uterine wall. The goal is to find which method causes the least blood loss during delivery. The trial will enroll 42 pregnant women with this cond…

This study follows 261 people with persistent, recurrent, or metastatic cervical cancer who are taking pembrolizumab (Keytruda) with or without bevacizumab (Avastin). Some participants may choose to stop pembrolizumab early if their tumor shrinks or disappears, while others conti…

This early-phase trial is testing an experimental oral drug called KST-6051 in adults with advanced or metastatic solid tumors that have a KRAS mutation, including certain lung, pancreatic, and colorectal cancers. The main goal is to check the drug's safety and how the body proce…

This trial investigates whether collecting and storing a patient's own blood stem cells before chemoradiotherapy, then re-infusing them after treatment, can help rebuild healthy blood cells faster. The study includes 40 women with cervical cancer who are scheduled for chemoradiot…

This phase 2 trial tests a drug called mirvetuximab soravtansine in 50 women with a specific type of endometrial cancer that has come back or won't go away. The drug targets a protein called folate receptor alpha, which is often found on these cancer cells. Researchers want to se…

This study tests a new treatment for people with advanced or recurrent cervical cancer linked to high-risk HPV. The treatment uses specially engineered immune cells (CC-EIEs) designed to target and attack the cancer. Participants receive several infusions of these cells, and rese…

This study tests a personalized vaccine made from a patient's own tumor proteins, given alone or with the immunotherapy drug pembrolizumab. The goal is to see if the combination is safe and helps the immune system attack advanced solid tumors. About 132 people with various advanc…

This early-phase study tests whether a short course of radiation (1 week instead of the usual 5) combined with standard chemotherapy (carboplatin and paclitaxel) is practical for people with stage III endometrial cancer. The trial will enroll 28 participants and aims to see if mo…

This early-stage trial tests an experimental drug called mocertatug rezetecan in 675 adults with advanced solid tumors that have not responded to standard treatments. The drug is designed to deliver a toxin directly to cancer cells. The main goals are to check safety, find the ri…

This trial investigates whether specially engineered immune cells (CAR-T cells) can safely treat advanced or recurrent cervical cancer. The cells are designed to recognize and attack cancer cells that carry certain markers like GD2 or Mesothelin. The study involves 20 adults with…

This phase 2 trial tests whether combining hormone therapy (letrozole) with a targeted drug (abemaciclib), and possibly adding metformin or gedatolisib, can control estrogen-receptor-positive endometrial cancer that has returned or spread. The study enrolls adults with this cance…

This early-stage trial explores whether injecting the immunotherapy drug nivolumab directly into lymph nodes before standard surgery is feasible and safe for people with cervical cancer. The study involves 12 participants and aims to see if this targeted approach can shrink tumor…

This early-phase study is testing an experimental drug called IDE034 in 150 adults with advanced solid tumors (such as lung, ovarian, or colorectal cancer) that have not responded to standard treatments. The main goals are to check the drug's safety, find the right dose, and see …

This study tests whether a shorter, 3-week course of radiation works as well as the standard 5-week course for women with locally advanced cervical cancer. About 396 women will be randomly assigned to one of the two schedules, both combined with chemotherapy. If the shorter sched…

This study tests a combination of two drugs, becotatug vedotin and zimberelimab, in 30 people with recurrent or metastatic cervical, vulvar, or vaginal cancer. The goal is to see if the treatment can shrink tumors and control the disease. Participants must have already tried at l…

This study tests whether giving DHA (a type of omega-3 fat) early to very preterm infants who are small at birth can improve head growth without causing too much fat gain. The trial will include 152 infants and measure head size and body fat at 36 weeks adjusted age. If successfu…

This early-phase trial tests a new type of immune cell therapy called CIML NK cells in 18 people with recurrent ovarian cancer that no longer responds to standard chemotherapy. The cells are taken from the patient, trained in a lab to better attack cancer, and then infused into t…

This study compares a shorter course of brachytherapy (3 sessions) to the standard 4-session regimen for locally advanced cervical cancer. About 41 participants will receive either 3 or 4 high-dose radiation treatments based on what is feasible for them. The goal is to see if the…

This study tests an experimental drug called YH32364 in adults with advanced solid tumors that have high levels of EGFR and have not responded to previous treatments. The trial has two parts: first, finding a safe dose in about 30 people, then testing that dose in 50 people with …

This early-stage trial is testing a new type of immune cell therapy for people with advanced cancers that have a specific protein called KK-LC-1. The cancers being studied include stomach, breast, cervical, and lung cancer. Participants will receive chemotherapy followed by a sin…

This study tests whether a single infusion of a patient's own genetically engineered immune cells (E7 TCR-T cells) can shrink or eliminate HPV-related cancers before the patient receives standard treatment like chemo-radiation or surgery. The trial enrolls 15 adults with advanced…

This early-stage trial is testing a new drug called XmAb541 in people with advanced ovarian, endometrial, or germ cell tumors that have not responded to standard treatments. The main goal is to see if the drug is safe and to find the best dose. About 282 participants will receive…

This phase 3 trial tests whether taking Relugolix combination therapy (Rel-CT) right after endometriosis surgery leads to better quality of life and less chance of the disease coming back. About 110 women having laparoscopic or robotic surgery for endometriosis will be randomly a…

This phase 2 trial is testing a combination of two immunotherapy drugs (iparomlimab and tuvonralimab) plus standard chemotherapy before surgery in 103 women with locally advanced cervical cancer. The goal is to see if this approach can shrink tumors enough to allow less extensive…

This study tests a new immunotherapy for people with advanced HPV-related cancers, such as cervical, throat, anal, and penile cancers. Participants receive specially engineered immune cells designed to attack cancer cells carrying the HPV16 virus. The goal is to see if this treat…

This study tests a new drug called INV-8989 in people with advanced solid tumors that have a specific genetic change called KRAS G12D. The trial has two phases: the first finds the safest dose, and the second checks how well the drug shrinks tumors. About 178 adults with cancers …

This study is for overweight or obese women aged 18–45 with atypical endometrial hyperplasia, a precancerous condition of the uterine lining. Participants will receive either a levonorgestrel-releasing IUD (Mirena) or megestrol acetate pills, combined with a weight management pro…

This phase 2 trial tests whether a combination of a gonadotropin-releasing hormone agonist (triptorelin) and letrozole can achieve better complete response rates than standard hormone therapy (megestrol acetate or medroxyprogesterone acetate) in women with early-stage endometrial…

This study tests a combination of an immune-boosting drug (TQB2450) and a high-dose hormone (progestin) to treat young women (ages 18-45) with a specific type of early-stage endometrial cancer (MMRd). The goal is to eliminate the cancer while preserving the uterus so patients can…

This early-phase trial tests a new drug called AVA6103 in 174 people with advanced solid tumors (like pancreatic, stomach, or lung cancer) that have not responded to standard treatments. The drug is designed to activate only inside tumors, potentially killing cancer cells while r…

This study compares a new barbed suture (SYMMCORA) with a standard one (V-Loc) for closing the vaginal cuff after laparoscopic hysterectomy. The goal is to see if the new suture reduces stitching time without increasing complications. About 132 women having elective laparoscopic …

This phase 2 trial is testing two immunotherapy drugs, durvalumab and tremelimumab, alone or together, in 60 people with colorectal or endometrial cancer. The goal is to see if these drugs can shrink tumors or slow cancer growth. The study focuses on patients with different genet…

This study tests an experimental drug called INV-6452 in adults with advanced breast cancer (HR+/HER2-) or other solid tumors that have stopped responding to standard treatments. The goal is to find the safest dose and see if the drug can shrink tumors. About 201 participants wil…

This study is testing Bearing nsPVA particles, used during a procedure called uterine artery embolization, to treat uterine fibroids in 100 women. The goal is to see if these particles safely block blood flow to fibroids, reducing symptoms like pain and heavy bleeding. Participan…

This study looks at whether a surgery called transcervical resection of the septum (TCRS) can improve pregnancy outcomes for infertile women with a uterine septum who are planning IVF. The trial will compare live birth rates between women who get the surgery and those who don't. …

This study tests a new drug called BC3195 combined with pembrolizumab (an immunotherapy) in people with advanced solid tumors that have spread. The goal is to find a safe dose and see if the combination can shrink tumors. About 111 adults with certain cancers will take part.

This study tests a combination of immunotherapy drugs (PD-1/PD-L1 inhibitors) with chemotherapy, with or without bevacizumab, in 120 adults with metastatic, persistent, or recurrent cervical cancer. The goal is to see if this approach helps patients live longer and controls the d…

This study looks at 100 women with infertility to see how common chronic endometritis (a long-term inflammation of the womb lining) is and whether antibiotic treatment can improve their chances of getting pregnant and having a healthy baby. Participants will have a camera test an…

This study tests a new antibody called HMBD-001 combined with two existing cancer drugs (cetuximab and docetaxel) in people with advanced squamous cell cancers of the lung, head and neck, esophagus, cervix, or skin. The goal is to see if the combination is safe and can shrink tum…

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This phase 2 trial is testing elacestrant, a pill that breaks down estrogen receptors, in 30 people with advanced uterine sarcomas that are fueled by estrogen. The goal is to see if the drug can shrink tumors or slow their growth. Participants must have tumors that strongly expre…

This study tests a single injection of Radspherin®, a radioactive treatment given directly into the abdomen, for people with advanced ovarian, fallopian tube, or primary peritoneal cancer that has spread to the lining of the belly. About 114 participants will receive either stand…

This early-stage trial tests two vaccines designed to help the immune system fight HPV16, a virus linked to cervical cancer. The study includes 30 women with persistent HPV16 infection and mild cervical cell changes (ASC-US or LSIL). Participants receive a DNA vaccine followed by…

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers…

This Phase 3 trial tests whether adding the immunotherapy drug cadonilimab to standard chemotherapy and radiation can improve outcomes for people with locally advanced cervical cancer. About 378 participants will be randomly assigned to receive either the new combination or stand…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This study tests new treatments for endometrial cancer based on the genetic makeup of each person's tumor. About 1,615 participants will be assigned to one of four trials depending on their cancer's molecular profile. The goal is to see if these tailored therapies can prevent the…

This study tests an experimental drug called SKB518, given alone or with chemotherapy, in 280 people with advanced ovarian, cervical, or endometrial cancers. The goal is to see if the drug can shrink tumors or slow cancer growth. Researchers will also monitor side effects.

This pilot study tests a conservative management strategy for placenta accreta, a serious pregnancy complication where the placenta grows too deeply into the uterine wall. Instead of the standard treatment—a hysterectomy (removing the uterus) after a C-section—doctors will leave …

This early-phase trial tests a new drug, UCB4594, in people with advanced solid tumors that haven't responded to standard treatments. The drug is a monoclonal antibody that targets a protein called HLA-G on cancer cells, potentially helping the immune system attack them. The stud…

This early-stage study is testing an experimental drug called MK-6204 in about 90 adults with advanced solid tumors (such as colorectal, lung, or stomach cancer) that have not responded to standard therapies. The main goals are to check the drug's safety and find the right dose. …

This phase II trial is testing whether the immunotherapy drug dostarlimab, alone or combined with bevacizumab, can control recurrent gynecological clear cell carcinoma better than standard chemotherapy. About 198 women with this rare cancer type will be randomly assigned to one o…

This study tests a new drug called MDX2001 in people with advanced solid tumors that have spread. The main goals are to check the drug's safety and see if it can shrink tumors. About 285 adults with various cancers like lung, breast, or colon cancer will take part. This is an ear…

This phase 2 trial is testing two drugs, abemaciclib and letrozole, in 100 people with rare estrogen receptor-positive ovarian cancers (low grade serous carcinoma or granulosa cell tumors). The goal is to see if the combination can shrink tumors and control the disease. Participa…

This study tests a drug called tegavivint in children, teens, and young adults whose solid tumors have come back or stopped responding to treatment. The goal is to find the safest dose and see if it can shrink tumors by blocking a key growth signal inside cancer cells. About 147 …

Stanford University is testing the da Vinci Xi robot for various surgeries in children aged 6-21. The study will enroll 250 participants to check if the robot is safe and works well. The goal is to see if robotic surgery can be a good option for kids needing procedures like gallb…

This early-stage study tests a two-part system to find and treat metastatic cancer. First, a radioactive tracer is used to spot tumors on a PET scan. Then, a similar radioactive drug is given to deliver radiation directly to the cancer cells. The goal is to see if this approach i…

This study tests whether a donated uterus can help 10 women who were born without a uterus or had it removed to carry a pregnancy. Participants will receive a uterus from a living or deceased donor, then try in vitro fertilization (IVF) to become pregnant. The goal is a live birt…

This study is for people with endometrial cancer that has come back or spread to a few other spots. It tests a new drug called cadonilimab given together with standard chemotherapy and radiation. The goal is to see if this combination can shrink tumors and help people live longer…

This study compares vaginal repair surgery alone versus surgery followed by leuprorelin, a drug that temporarily stops menstruation. The goal is to see if delaying periods helps the scar defect heal better. The trial includes 94 women with cesarean scar defects and adenomyosis wh…

This study tests the drug nivolumab in people with advanced rare cancers that have a specific marker (PD-L1). The goal is to see if the drug can shrink or control the tumors when other treatments have stopped working. Up to 28 adults will receive treatment for up to 12 months, an…

This study tests a new treatment called GT101, which uses immune cells taken from a patient's own tumor to fight recurrent or metastatic cervical cancer. About 83 adults will receive either GT101 or a standard chemotherapy drug. The goal is to see if the cell therapy can delay ca…

This study tests a new drug called XNW28012 in people with advanced solid tumors (pancreatic, ovarian, cervical, or colorectal cancers) that have stopped responding to standard treatments. The trial has two parts: first, finding a safe dose, then expanding to see if the drug shri…

This study tests a combination of two drugs, cabozantinib and dostarlimab, in 37 women with recurrent gynecologic carcinosarcoma, a rare and aggressive cancer. The goal is to see if the combo can keep the cancer from growing for at least 6 months. Participants must have had at le…

This study is for women with advanced ovarian cancer who have had complete surgery and chemotherapy. It compares two maintenance treatments: niraparib alone versus niraparib plus bevacizumab. The goal is to see which approach better delays cancer progression. About 390 participan…

This study compares two surgical techniques to reduce blood loss during open fibroid removal. Forty women with symptomatic uterine fibroids will be randomly assigned to either bilateral uterine artery ligation or a pericervical mechanical tourniquet. The goal is to see which meth…

This early-stage trial is testing an experimental drug called MOv18 IgE in people with advanced ovarian, endometrial, or triple-negative breast cancers that have a specific protein (folate receptor alpha) on their cells. The study has two parts: first, finding the safest dose, an…

This early-phase study tests a new drug called azenosertib (ZN-c3) combined with standard chemotherapy or bevacizumab in people with ovarian, peritoneal, or fallopian tube cancer that has stopped responding to platinum-based treatment. About 172 participants will receive differen…

This Phase 3 trial is testing a new drug called SHR-A2102 against standard chemotherapy in 398 people with recurrent or metastatic cervical cancer that has not responded to platinum-based chemo and PD-(L)1 inhibitors. The main goal is to see if SHR-A2102 helps people live longer.…

This early-stage trial is testing a new treatment called VET3-TGI, a virus designed to infect and destroy cancer cells. It is being given alone or with the immunotherapy drug atezolizumab to 60 people with advanced solid tumors that have not responded to standard treatments. The …

This study tests a new treatment for ovarian cancer that has returned after initial therapy. It combines a personalized vaccine made from a patient's own white blood cells (FRαDC) with an immunotherapy drug (pembrolizumab) to help the immune system attack cancer cells. The trial …

This study tests whether injecting a lab-made collagen into the uterus, along with daily hormone pills, can help shrink early-stage endometrial cancer or precancerous growths. The goal is to preserve fertility in women aged 45 or younger. Thirty participants will either receive t…

This study compares a newer, less invasive laparoscopic hysterectomy (with special tumor-free techniques) to the standard open abdominal surgery for stage IB2 cervical cancer. About 524 women will be randomly assigned to one of the two surgeries. The main goal is to see if the la…

This study tests a new drug called WJB001 combined with various chemotherapy drugs in people with advanced solid tumors that have not responded to standard treatments. The trial has three stages to find the safest dose, check how the body processes the drug, and see if it shrinks…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study tests two drugs, envafolimab (an immunotherapy) and lenvatinib (a targeted therapy), alone or together, in 108 people with advanced endometrial cancer that has worsened after standard chemotherapy. The main goal is to see if the drugs shrink tumors. Researchers will al…

This study tests whether adding an experimental drug (APL-2) to standard immunotherapy (pembrolizumab) and/or a targeted therapy (bevacizumab) can better control recurrent ovarian, fallopian tube, or peritoneal cancer that causes fluid buildup in the belly or chest. About 60 adul…

This study is testing whether adding medroxyprogesterone acetate to standard doxycycline treatment can better cure chronic endometritis and improve pregnancy outcomes in women with recurrent reproductive failure. One thousand women aged 20-45 will be randomly assigned to receive …

This study compares three surgical treatments for endometriomas (ovarian cysts from endometriosis) in 332 women aged 18-43 who want to become pregnant. Participants are randomly assigned to cystectomy, plasma vaporization, or sclerotherapy. The main goal is to see which approach …

This study tests a new drug called CMS-D002 for women with uterine fibroids who have heavy menstrual bleeding. About 120 women aged 18-50 will take either the drug or a placebo daily for 12 weeks. The goal is to see if the drug can reduce bleeding to normal levels and shrink fibr…

This early-phase trial is testing the drug talazoparib together with radiation therapy in 24 women whose gynecologic cancer (ovarian, endometrial, cervical, or related cancers) has come back after previous treatment. Talazoparib blocks enzymes that cancer cells need to grow, and …

This phase II trial is testing whether the immunotherapy drug pembrolizumab (Keytruda) can treat high-grade cervical precancer (CIN 2/3 or carcinoma in situ). The study will enroll 25 women and measure how many have a complete response at 6 months. The goal is to see if this drug…

This study tests whether a single, extremely high dose of radiation, guided by advanced MRI technology, can control liver tumors that have spread from other cancers better than the usual high dose. About 114 adults with up to 3 liver metastases will be randomly assigned to receiv…

This study tests a drug called azenosertib in 25 women with a rare and aggressive type of uterine cancer that has come back or not gone away. The goal is to see how the drug affects cancer cells and whether it can shrink tumors or slow the disease. Participants take the drug and …

This phase 2 trial is testing whether adding a precise radiation boost to standard treatment can shrink large cervical tumors more effectively. Seventeen participants with bulky squamous cell carcinoma will receive external radiation plus a targeted boost, followed by internal br…

This phase 2 trial is testing a shorter course of radiation therapy (hypofractionated IMRT) given alongside chemotherapy (cisplatin) for cervical cancer. The goal is to see if this approach can reduce the overall treatment time from the usual 7-8 weeks while still controlling the…

This study looks at whether giving the 9vHPV (Gardasil-9) vaccine to women who already have HPV16 or 18 can reduce the virus's ability to infect others. Researchers will measure viral activity in cervical, anal, and oral samples before and after vaccination. The goal is to see if…

This early-phase study tests a new treatment that combines specially grown immune cells (cCTL) with immunotherapy for people with advanced gynecologic cancers like ovarian, cervical, or endometrial cancer. The goal is to see if the combination is safe and can shrink tumors. About…

This study tests a new drug called CNSI-Fe(II), which is injected directly into tumors. It uses iron to trigger a type of cell death called ferroptosis, aiming to control advanced solid tumors like lung, pancreas, and colorectal cancers. The trial involves 54 adults whose current…

This study tests whether a daily dose of pravastatin, a common heart medication, can safely prolong pregnancy in women diagnosed with severe early-onset preeclampsia or fetal growth restriction. The trial will include 154 pregnant women between 24 and 30 weeks of gestation, rando…

This early-phase trial is testing a new drug called 177Lu-RAD204, which is a radioactive antibody designed to seek out and destroy cancer cells that have a protein called PD-L1 on their surface. The study will involve 30 adults with advanced solid tumors (like lung, breast, or sk…

This study tests whether using a tourniquet (a tight band) around the lower uterus during surgery for placenta accreta can improve newborn Apgar scores. Placenta accreta is a condition where the placenta doesn't detach after birth, causing severe bleeding. The trial will involve …

This study looks at whether women with a rare, slow-growing uterine cancer (low-grade endometrial stromal sarcoma) can safely stop taking their hormone-blocking pills (aromatase inhibitors) after long-term use. Half the participants will stop the pills and half will continue, and…

This study tests whether a daily supplement containing vitamin D, EGCG (from green tea), D-chiro-inositol, and vitamin B6 can shrink uterine fibroids in women who are eligible for surgery. Sixty women will take either the supplement or a placebo for three months. The main goal is…

This early-stage trial is testing a new drug called TORL-1-23 in about 90 people with advanced solid tumors, including ovarian, endometrial, and lung cancers. The drug is an antibody drug conjugate designed to target and kill cancer cells. The main goals are to check safety, find…

This study tests whether two drugs, abemaciclib and letrozole, can help keep advanced or recurrent endometrial cancer from getting worse. About 32 people with a specific type of estrogen-sensitive cancer will take these pills daily after initial treatment. The goal is to see if t…

This study tests a less invasive weight-loss procedure called endoscopic suture gastroplasty (ESG) in 74 obese women who have had curative treatment for endometrial cancer. The goal is to see if ESG is safe and effective for helping these women lose weight, since obesity raises t…

This study tests two drugs, ergometrine and carbetocin, injected into the uterus during fibroid removal surgery to see which reduces blood loss more. Forty women with symptomatic fibroids will be randomly assigned to receive one of the drugs. The goal is to find a better way to c…

This early-stage trial tests an experimental oral drug called CSCJC3456 in 102 people with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any signs that the drug can shrink tumors. Participants take the table…

This early-phase study tests a new radioactive drug, [177Lu]Lu-AKIR001, in 15 adults with advanced solid tumors (like thyroid, head and neck, cervical, vulvar, or lung cancer) that have stopped responding to standard treatments. The main goal is to check the drug's safety and sid…

This study tests a new drug called TCC1727 combined with other medicines (benmelstobart, olaparib, or topotecan) in people with advanced solid tumors, including lung, stomach, endometrial cancer, and melanoma. The goal is to find the safest dose and see if the combination helps s…

This study tests whether treating asymptomatic bacteriuria (a bladder infection with no symptoms) in pregnant women can reduce the number of preterm births, stillbirths, and underweight babies. Over 1,100 pregnant women in seven low- and middle-income countries will receive eithe…

This study tests a modified virus (KD01) that targets and kills cancer cells, given alone or with an immunotherapy drug (AK104). It includes 97 women with cervical or endometrial cancer, some of whom have not responded to standard treatments. The goal is to see if the virus is sa…

This study is working on a new, non-invasive test to help rule out uterine cancer in women aged 45 and older who have abnormal bleeding. Researchers will collect samples from 4,500 women to see how well the test detects cancer and identifies benign cases. If successful, it could …

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This study in Mozambique is testing two new technologies to improve cervical cancer screening and diagnosis. Researchers will compare a rapid HPV test and a special imaging device against standard methods in about 678 women. The goal is to find faster, more accurate ways to detec…

This study is collecting vaginal fluid samples from 4,200 people to develop a new test for endometrial cancer. Participants include those with abnormal uterine bleeding or a recent endometrial cancer diagnosis. The goal is to find biomarkers that could lead to a simple, non-invas…

This study tests a low-cost HPV test that can be done in one visit, so women get results and treatment on the same day. It aims to reduce the number of women lost to follow-up in cervical cancer screening programs. The study will enroll 1,000 women in remote areas of El Salvador.

Endometriosis is a painful condition where tissue similar to the uterine lining grows outside the uterus, often causing pain and infertility. Currently, diagnosis requires invasive surgery. This study investigates whether measuring two proteins, SNCG and BCL6, in blood or menstru…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This trial tests whether applying vaginal estrogen before a colposcopy helps doctors see the cervix more clearly in women aged 50 and older. As women age, the area where precancerous changes occur can become harder to view, which may lead to missed diagnoses or repeat procedures.…

This study looks at whether giving women at-home kits to test for HPV (a virus that can cause cervical cancer) makes it easier for them to get screened. About 100 women who are overdue for screening will receive a kit and be asked to return a sample by mail. Researchers will comp…

This study evaluates whether an HPV DNA test can more accurately detect pre-cancerous cervical changes than standard Pap smears in 1,500 women in South Africa, including those with and without HIV. Participants undergo HPV testing, followed by colposcopy and biopsy if needed. The…

This study investigates whether urine samples can be used to screen for cervical cancer in women living with HIV. Researchers will compare the accuracy of urine HPV testing with self-collected and provider-collected samples to detect cervical precancer (CIN2 or worse). The goal i…

This study tests whether a smartphone-based AI ultrasound, operated by health workers with minimal training, can accurately estimate gestational age, detect placenta position, and identify fetal presentation in pregnant women in rural Democratic Republic of the Congo. The goal is…

This trial investigates whether advanced MRI scans can better detect placenta adhesion abnormalities (PAA) in pregnant women between 30 and 38 weeks. PAA occurs when the placenta grows too deeply into the uterine wall, raising risks of severe bleeding and emergency hysterectomy d…

This study explores whether an artificial intelligence (AI) program can accurately identify endometrial cancer or precancerous changes by analyzing standard transvaginal ultrasound images. Researchers will compare the AI's predictions with results from endometrial biopsies in 300…

This study is testing a new artificial intelligence (AI) system that reads ultrasound videos to help doctors diagnose placenta accreta spectrum (PAS), a condition where the placenta grows too deeply into the womb. About 561 pregnant women aged 18-45 with certain risk factors will…

This study tests a new blood test called EndoCheck that uses artificial intelligence to detect endometriosis in women with chronic pelvic pain. Researchers aim to see if the test is accurate enough to replace or reduce the need for exploratory surgery. About 1,200 women aged 14 t…

This study is testing a new, affordable AI system to screen for cervical cancer in low- and middle-income countries. The AI analyzes urine samples and cervical images to detect high-risk HPV and precancerous changes. About 3,200 unscreened women aged 25-49 in Zimbabwe will take p…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing whether a special full-body PET/CT scan can spot endometriosis without needing surgery. Up to 30 women with suspected endometriosis will get two scans using different tracers that highlight bleeding and scarring. The scan results will be compared with findin…

This study follows 20,000 women who take a new saliva test (Endotest) to diagnose endometriosis. Researchers want to see how the test result—positive or negative—affects their quality of life, emotions, and care decisions. Participants fill out questionnaires and share medical da…

This study looks at whether DNA markers in urine, vaginal, and cervical samples can better identify endometrial cancer risk in women with postmenopausal bleeding. About 600 participants will provide samples and undergo standard ultrasound. The goal is to see if these non-invasive…

This study is testing a new imaging agent called 18F-T2, which is designed to highlight tumors that produce a protein called CAIX. About 200 adults with various cancers (like kidney, lung, or breast cancer) will receive an injection of 18F-T2 and then undergo a PET/CT scan. The g…

This study is testing a new, non-invasive lab test that uses menstrual blood to diagnose endometriosis. Currently, diagnosis requires surgery, which can take years to get. The study will enroll 200 women aged 14-49 to see how accurate the test is compared to standard methods.

This study is testing a new blood test that looks at RNA (genetic material) to quickly tell if a person with belly pain has an infection inside the abdomen, like appendicitis or diverticulitis. About 1,000 adults and children over age 7 with abdominal pain will give a blood sampl…

This study is testing whether a simple urine sample can be used instead of a cervical swab to screen for HPV, the virus that causes most cervical cancers. The researchers will collect first-void urine from 350 women aged 30–65 using a special device and compare the results to the…

This study aims to find markers in menstrual blood that can diagnose endometriosis, a painful condition affecting many women. Researchers will compare menstrual blood from 250 women with and without endometriosis, and also look at changes after surgery. If successful, this could …

This study aims to find a gentler way to detect uterine cancer early in people with abnormal bleeding. Instead of relying only on a biopsy, researchers will use a health questionnaire and a self-collected vaginal swab to look for cancer-related genetic changes and microbiome patt…

This study is testing whether a self-administered Pap smear is as accurate as the traditional one done by a healthcare provider. Researchers will recruit 250 women in rural Alabama who need routine cervical cancer screening. Each woman will do a self-collected sample right before…

This study is testing whether a special PET scan called 18F-FES PET/CT can find endometriosis lesions more accurately than standard MRI. The scan measures estrogen receptors in the lesions, which may help doctors understand pain levels and guide treatment. About 20 women with end…

This study is testing whether giving women a simple self-sampling kit to use at home can increase the number of women who get screened for cervical cancer. The trial will enroll 15,000 women in Czech Republic, especially those who haven't had a Pap smear in over 3 years. Particip…

This study is looking at whether a protein called L-PGDS can be used to diagnose adenomyosis, a condition where uterine tissue grows into the muscle wall, causing pain and heavy bleeding. Researchers will measure L-PGDS levels in vaginal swabs, blood, and urine from 60 women with…

This study compares the standard Pap smear with a new blood test that looks for three proteins to detect early cervical changes and cancer. About 558 women aged 18-85 will participate. The goal is to see if the blood test is as good or better at finding problems early.

This study tests a new device called the Calla introducer for cervical cancer screening. Researchers want to see if women prefer it over the standard speculum used during Pap smears. About 305 healthy women aged 21-65 will participate. The goal is to improve comfort and screening…

This study is testing whether special light-based devices can detect cervical cancer by identifying unique optical signatures of abnormal tissue. Researchers will use three different devices—a bench-top spectrometer, a portable spectrometer, and a pocket-sized colposcope—on 350 w…

This study tests whether a specific ultrasound measurement can reliably detect superficial endometriosis on the uterosacral ligaments. Researchers will compare ultrasound findings with laparoscopic surgery results in 64 women undergoing gynecological surgery. If a clear cutoff th…

This study is testing a new, non-invasive way to detect endometrial cancer using DNA methylation testing on urine and vaginal samples collected by patients themselves. Researchers will compare samples from 120 women—half with endometrial cancer and half healthy—to see if the test…

This study aims to create an educational tool that helps women and their doctors make informed choices about using a levonorgestrel-releasing intrauterine system (LNG-IUS) to prevent endometrial cancer. Researchers will survey 270 women, both with and without a history of the dis…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests whether taking green tea extract (EGCG) and vitamin D3 daily can prevent uterine fibroids from growing back after surgical removal. About 240 women who have had fibroid surgery will receive either the supplements or a placebo. The goal is to see if this simple co…

This study tests whether at-home HPV self-sampling (using urine or a vaginal swab) can help more people get screened for cervical cancer compared to the traditional in-clinic Pap smear. About 735 Latinx individuals aged 30-65 who haven't had a Pap test in at least three years wil…

This study aims to make cervical cancer prevention easier for women who often miss out on routine care, such as those experiencing homelessness, substance use, or incarceration. Researchers will offer the HPV vaccine (Gardasil-9) and a self-swab test during regular sexual health …

This study tests a patient navigation program to help women in Senegal overcome barriers to cervical cancer screening and follow-up care. Researchers will work with community health workers to guide women through the process, addressing stigma and misinformation. The goal is to i…

This study tests whether a general practitioner's encouragement can increase the number of women who get screened for cervical cancer. Over 11,000 women aged 25-65 in France who are behind on screening will be involved. The goal is to see if a simple conversation with their famil…

This study checks how well the HPV vaccine prevents cervical HPV infection in women in Sikkim, India, about 7 years after the vaccine was introduced. Researchers will collect cervical samples from 5,500 married women aged 18-22 and compare infection rates to those before vaccinat…

This study offers free genetic testing to 5,000 women, trans men, and non-binary people with female reproductive organs, regardless of family history. The goal is to find hidden gene changes that raise the risk of breast, ovarian, bowel, and womb cancers. Participants use a smart…

This study looks at whether a structured ultrasound program (OxGRIP) can help detect babies that are not growing well in the womb, which is a major risk factor for stillbirth. The program adds a routine scan at 36 weeks and extra scans for at-risk women. Researchers will compare …

This study looks at possible eye-related side effects in people with cervical cancer that has returned or spread, who are being treated with the drug TIVDAK. About 100 participants will receive TIVDAK every 3 weeks and undergo regular eye exams before, during, and after treatment…

This Phase 3 trial tests HMI-115, a monoclonal antibody, in 540 women with moderate to severe endometriosis pain. Participants receive either the drug or a placebo for 24 weeks, with a 28-week extension. The goal is to see if HMI-115 reduces menstrual and pelvic pain better than …

This study compares two standard radiation methods—proton therapy and photon therapy—for women with newly diagnosed cervical or endometrial cancer. The goal is to see which approach causes fewer stomach and bowel side effects. About 116 participants will be randomly assigned to o…

This trial tests a blended e-health program designed to help women with breast or gynecologic cancer cope with fear of their cancer returning or worsening. The program combines remote group sessions with online modules that teach skills to manage unhelpful thoughts and promote he…

This phase 2 trial tests whether guarana, a natural supplement from the Amazon, can reduce fatigue in 86 people with neuroendocrine tumors or gynecologic cancers. Participants take either guarana or a placebo daily for up to 42 days, and researchers measure changes in fatigue usi…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This study tests whether a therapy called Meaning-Centered Psychotherapy for Latinos (MCP-L) can help reduce anxiety and depression in 300 Latino patients with advanced cancer. Participants receive either MCP-L or standard cognitive behavioral therapy over about 3 months. The goa…

This study tests whether a personalized activity coaching program can help women feel less tired during pelvic radiation therapy for endometrial cancer. Sixteen participants will be randomly assigned to receive coaching or usual care. The main goal is to see if the program is pra…

This trial tests whether a three-day low-residue diet and deeper muscle relaxation, alone or together, can improve the surgical view during vNOTES hysterectomy (a scarless procedure through the vagina). The study involves 160 women having hysterectomy for non-cancer conditions. R…

Endometriosis often causes long-lasting pelvic pain that can disrupt daily life. This trial tests whether specialized pelvic floor physical therapy, combined with a structured exercise program, can lower pain more than a placebo version of the therapy. Women aged 18 to 45 with co…

This trial investigates whether a minimally invasive procedure called endovascular embolization can relieve chronic pelvic pain in women with pelvic congestion syndrome. The study will enroll 30 women who have had pelvic pain for more than six months and have imaging evidence of …

This trial tests whether a custom-formulated, high-CBD hemp product can reduce pain in women with endometriosis, adenomyosis, or chronic pelvic inflammatory disease. Over 7 days, participants receive either the CBD product or a placebo. Researchers will measure how the body proce…

This phase 2 trial tests a custom high-CBD sublingual product against a placebo in 30 women with endometriosis. Over 12 weeks, researchers will measure changes in pain and quality of life. The goal is to see if cannabinoids can help manage symptoms where few proven options exist.

This trial tests whether preparing the cervix with medication before office hysteroscopy helps postmenopausal women have a more successful and less painful procedure. Participants are randomly assigned to receive either oral misoprostol, vaginal estrogen for 7 or 14 days, or no p…

This study tests a new way to deliver radiation therapy for endometrial cancer using daily MRI scans to guide the beam. The goal is to give a higher dose of radiation to the tumor while sparing nearby organs like the bowel and bladder. Thirty participants will receive 15 sessions…

This study tests whether a specialized kit helps women with endometriosis manage pain during sex. The kit includes a guidebook, a tracking app, a TENS device, lubricants, and supplements. One hundred women aged 18 to 45 with confirmed endometriosis and sexual pain will either use…

This study tests a 12-week digital program called Samphire Guided Care for people with menstrual or pelvic health conditions like PMS, endometriosis, or menopause. The program combines a wearable device that gently stimulates the brain, coaching, and symptom tracking to see if it…

This study is testing a precise type of radiation (proton beam) given to the pelvis after surgery for cervical, uterine, or endometrial cancer. The goal is to see if it causes fewer bowel side effects than standard radiation. About 25 adults who need pelvic radiation after surger…

This study tests whether infusing platelet-rich plasma (PRP) into the uterus can thicken the uterine lining and improve pregnancy success in women with infertility who have had failed IVF cycles due to a thin lining. About 62 women will receive either PRP or a placebo during a fr…

This study tests whether using cold wraps plus compression (cryocompression) on hands and feet during chemotherapy can reduce nerve damage (peripheral neuropathy) in people with gynecologic cancer. About 190 participants will be randomly assigned to receive either cryocompression…

This study tests a personalized physical activity program for women over 60 with gynecologic cancers who are receiving chemotherapy or other systemic treatments. The program includes a wearable activity tracker and a smartphone app, plus optional features like an exercise partner…

This study tests a newer, more precise type of radiation called SBRT for women with stage IIIC cervical cancer. The goal is to see if it can safely deliver high doses to cancer in the pelvic lymph nodes while causing fewer side effects than standard radiation. About 150 women wil…

This study tests whether injecting the local anesthetic bupivacaine into the small surgical cuts and the vaginal cuff at the end of a laparoscopic hysterectomy can lower postoperative pain. 120 women having the surgery for non-cancer reasons will be randomly assigned to receive t…

This study tests if whole-body cryotherapy (standing in a -120°C chamber for 3 minutes) can safely reduce pain and improve quality of life in people with endometriosis. Thirty participants with chronic pelvic pain will attend 5 sessions over 4 weeks. Researchers will measure pain…

This study tests whether a high-protein nutrition plan combined with resistance exercises, started weeks before surgery and continued for 24 weeks after, can help older adults with cancer preserve their physical function. The trial enrolls Veterans aged 55 and older with certain …

This study tests whether pulsed electromagnetic field (PEMF) therapy can reduce pain and improve quality of life in women with endometriosis. Sixty women aged 18–45 will receive either real PEMF or a sham device three times a week for 8 weeks. Researchers will measure pain, pelvi…

This study tests whether a physiotherapy program that combines gentle exercise with pain education can reduce pain and improve daily life for women with endometriosis. About 62 women will take part, with half receiving the combined program and half receiving pain education alone.…

This study tests whether special pelvic floor exercises, guided by a biofeedback device, can improve sexual function in women who had radiation for cervical cancer. Sixty survivors with sexual problems will be randomly assigned to either biofeedback-assisted training or standard …

This study is testing whether a shorter course of pelvic radiation after surgery works as well as the standard longer schedule for people with cervical or endometrial cancer. The shorter schedule means fewer hospital visits and less time in treatment. About 120 participants will …

This study tests a new surgical technique called intra-operative dual laparoscopy and neo-rectoscopy (IDLnR) for treating bowel endometriosis. Researchers will compare it to standard laparoscopic surgery in 192 women aged 18-55. The goal is to see if the new method leads to bette…

This study tests whether listening to an educational podcast can improve quality of life, reduce stigma, and increase satisfaction for people with chronic pelvic pain or endometriosis. One hundred participants will either receive standard care or standard care plus access to the …

This study is testing whether a low-FODMAP diet can reduce pain and improve quality of life in women with endometriosis who also have gut symptoms like bloating and nausea. Researchers will compare the diet to standard care in 150 women aged 18-45. The goal is to see if changing …

This study tests whether Reiki therapy can reduce anxiety and pain in people receiving brachytherapy for gynecologic cancers. 70 participants will either receive Reiki or standard care during their treatment. Researchers will measure changes in anxiety, pain, and mood using quest…

This study tests whether a 5-minute educational video about uterine fibroids and their treatments can help patients feel less conflicted when deciding on a treatment plan. About 154 women with fibroids will be randomly assigned to watch the video before their appointment or recei…

This Phase 3 trial tests whether the experimental drug KLH-2109 can reduce heavy menstrual bleeding in people with uterine fibroids. About 254 participants will take either KLH-2109 or a standard treatment for 24 weeks, tracking their bleeding and visiting the clinic for safety c…

This study tests whether using a virtual reality headset during brachytherapy (a type of internal radiation for cervical cancer) can reduce pain, anxiety, and the need for medication. Twenty women will try VR during one treatment session and compare it to a session without VR. Th…

This study tests whether a whole food plant-based diet can reduce pain in women with endometriosis. 120 women aged 18-45 with moderate to severe pelvic pain will be randomly assigned to either follow the special diet or stay on their usual diet for 12 weeks. The goal is to see if…

This study is testing whether a 21-day spa program—including mineral water baths, exercise, and diet—can improve kidney function and reduce symptoms in 150 adults aged 40-70 with chronic kidney or urinary tract diseases. Participants receive standard spa care at a resort in the C…

This early-stage trial tests a new, easier-to-absorb version of megestrol acetate (a drug that stimulates appetite) in 5 women with advanced cervical cancer who are undergoing chemoradiation. The goal is to see if it helps them maintain weight and improve nutrition during treatme…

This phase 2 trial tests whether a vaginal DHEA suppository can safely improve vaginal health in 25 women who had radiation for gynecologic, anal, or rectal cancer. Radiation often causes dryness, burning, and pain, similar to menopause. DHEA is a hormone replacement that may hel…

This study looks at two standard radiation treatments for early-stage endometrial cancer to see which one causes less sexual dysfunction. About 258 women who have had surgery for early-stage endometrial cancer will receive either 3 or 6 sessions of vaginal brachytherapy. The main…

This study tests whether pelvic floor physical therapy can reduce bowel and bladder control problems that often happen after radiation for cervical cancer. Twenty-eight women who are getting pelvic radiation will start physical therapy four weeks after finishing radiation. The th…

This study tests whether spraying a low-dose lidocaine solution under the diaphragm during single-incision laparoscopic surgery can reduce shoulder pain afterward. About 100 women having surgery for benign gynecological conditions like ovarian cysts or uterine fibroids will take …

This study looks at whether combining pain neuroscience education with therapeutic exercise can reduce pain, improve quality of life, and lower pain-related distress in women with endometriosis. About 32 adult women diagnosed with endometriosis will take part. Researchers will tr…

This study tests whether a small electrical device (TENS) can reduce pelvic pain in women with endometriosis or adenomyosis. 92 women on stable hormone therapy will use the device for 45 minutes daily over 4 weeks, rating their pain on a scale. The goal is to see if the device lo…

This study compares High-Intensity Focused Ultrasound (HIFU), a non-invasive procedure using sound waves to destroy fibroids, to myomectomy, a surgical removal. About 112 women aged 18-50 with symptomatic fibroids will be randomly assigned to one treatment. Researchers will track…

This study looks at whether alternate day fasting (eating very little every other day) before chemotherapy can help reduce side effects and improve quality of life for women with ovarian, endometrial, or uterine cancer. About 30 women who have had surgery and are about to start c…

This study looks at how much pelvic pain is reduced in women with Pelvic Congestion Syndrome after a procedure called gonadal vein embolization. About 30 women will take part, and researchers will use a simple survey to measure pain before and after treatment. They also want to f…

This study tests whether a program of exercise, nutrition advice, and mental support before surgery helps gynecological cancer patients recover faster and feel better. About 64 women with ovarian or endometrial cancer will be randomly assigned to either standard care or the preha…

This study tests whether adding a gentle electrical acupoint stimulation (TEAS) to a standard three-drug anti-nausea regimen can further reduce vomiting after laparoscopic surgery. Researchers will compare active TEAS to a sham (fake) version in 780 women at high risk for postope…

This study tests a new way of giving radiation for cervical cancer. Instead of using the same plan for weeks, an AI adjusts the radiation daily based on the tumor's position, and weekly MRI scans help guide it. The goal is to reduce side effects like bladder and bowel problems. A…

This study tests whether a food supplement called Doliral can improve quality of life and reduce pelvic pain in women with endometriosis. About 60 women with confirmed endometriosis and ongoing pelvic pain will take either Doliral or a placebo for 12 weeks. Researchers will track…

This study explores whether acupuncture can reduce nerve pain and numbness caused by chemotherapy in people with gynecologic, urologic, or rectal cancers. About 75 participants will be randomly assigned to receive real acupuncture, sham acupuncture, or usual care for 6 weeks. The…

This study compares a fast, 1-week radiation treatment to a standard 6-8 week schedule for reducing pain in people with advanced cervical cancer that cannot be cured. The goal is to see if the shorter schedule provides similar or better pain relief. The trial is recruiting 230 pa…

This study tests whether a 16-week, virtually supervised exercise program can help patients with ovarian or endometrial cancer maintain leg function and reduce chemotherapy-induced nerve damage. Thirty patients who have had surgery and are starting first-line chemo will be assign…

This pilot study tests whether internet-based Acceptance and Commitment Therapy (ACT) can help people with endometriosis cope with chronic pain. Ten participants will receive online sessions focused on mindfulness, acceptance, and value-based behavior change, with phone support f…

This study tests whether a daily pill called relugolix can safely reduce heavy menstrual bleeding in women with uterine fibroids. About 120 premenopausal women will receive either relugolix or a placebo for several weeks. The main goal is to see if the drug lowers blood loss to n…

This study is for people with cervical or pancreatic cancer who are scheduled to receive chemoradiotherapy. Researchers will collect tumor samples, blood, and imaging data before, during, and after treatment to see how the tumor environment changes over time. The goal is to learn…

This study looks at whether measuring the heart's pumping and relaxing ability in fetuses with growth restriction can signal how well they are doing. Researchers will use a special ultrasound technique to assess heart function in pregnant women after 28 weeks. The goal is to see …

This study is testing a mobile app called mSaada that helps community health workers educate women, track screening, and send reminders for cervical cancer screening. The trial involves 6,000 women and health workers across 12 health facilities in western Kenya. The goal is to se…

This study looks at the best times to send messages that encourage physical activity to older cancer survivors (65+) who have chronic pain. About 50 participants will wear an activity tracker and rate their pain four times a day using a smartphone app. The goal is to see if certa…

This study looks at tumor samples from 2,100 Chinese patients with lung, gynecologic, bile duct, or bladder cancers. Researchers will compare different HER2 testing methods to see how well they agree with each other. The goal is to improve the accuracy of HER2 testing, which help…

This study will compare patient satisfaction between telehealth (video or phone) and in-person follow-up visits after minimally invasive gynecologic surgery. About 100 women will be randomly assigned to one of the two follow-up methods. The goal is to see if virtual visits are as…

This large screening trial enrolls up to 2,900 people with advanced solid tumors that have spread or not responded to standard treatment. Researchers use genetic tests on tumor samples to find specific mutations, then assign patients to treatment trials testing drug combinations …

This study is collecting medical records and lab results from 70 people diagnosed with a rare type of cervical cancer called clear cell carcinoma. Researchers want to understand the cancer's features and molecular profile better. No new treatments or drugs are being tested—this i…

This study looks at the genetic makeup of advanced endometrial cancer in 500 women in Russia. Researchers will test tumor samples for specific gene changes to see how common they are and what treatments patients receive. The goal is to gather information, not to test a new treatm…

This study is observing about 1,715 people with early-stage endometrial cancer to see how often the cancer comes back and how often lymphedema (swelling) happens after standard treatment. Participants will have regular check-ups for 36 months. The goal is to gather real-world dat…

This study tests whether real-time AI feedback helps healthcare professionals measure fetal size more accurately during ultrasound. 75 participants (novices, intermediates, and experts) will be randomly assigned to use AI assistance or standard methods. The main goal is to see if…

This study follows women aged 18 to 45 with endometriosis, along with healthy matched controls, for 24 months to see how the condition affects pain, cyst recurrence, and pregnancy outcomes. Participants receive their usual care, and researchers collect clinical data at regular in…

This study looks at how people with endometrial cancer find medical information and how satisfied they are with it. Researchers will also ask patients if they'd be interested in using an AI-powered educational tool. The goal is to understand current needs and see if AI could help…

This study looks at whether vitamin D levels in the blood and cervical fluid before treatment can predict how well chemoradiotherapy works for locally advanced cervical cancer. Researchers will measure vitamin D in 100 women undergoing standard treatment and track their response …

This study collects tissue samples, medical data, and family histories from over 1,100 people being screened for colorectal or endometrial cancer. Researchers hope to discover new genes and mechanisms that increase cancer risk, especially in hereditary cancer syndromes. The goal …

This study aims to understand the challenges women with endometriosis face when trying to access pelvic health physiotherapy in Quebec. Researchers will interview patients, survey physiotherapists, and hold group discussions with patients and healthcare providers. The goal is to …

This study looks at the immune system of 120 women aged 18-40 with chronic pelvic pain that hasn't improved with hormone treatment. Researchers will measure specific immune markers in the blood to see if there is a unique pattern linked to the pain. The goal is to better understa…

This study looks at how tiny particles released by the placenta, called extracellular vesicles, affect pregnancy complications like pre-eclampsia and gestational diabetes. Researchers will collect samples from 360 pregnant and non-pregnant women to understand these particles bett…

This observational study investigates whether prenatal ultrasound can predict placental abnormalities found after delivery. Researchers will compare imaging features from 320 pregnancies with and without placental pathology. The goal is to improve detection of placental issues th…

This study will test tumor samples from 350 adults with gynecological cancers (endometrial, ovarian, cervical, vulvar, and vaginal) to see how often they have high levels of the HER2 protein. Researchers will use two standard lab tests to measure HER2. The goal is to learn how co…

This study in Botswana tests different outreach strategies to help women with cervical cancer start treatment within 90 days. Researchers will compare clinic calls, direct patient contact, and text message reminders. The goal is to find the best way to close the gap between diagn…

This study tracks the long-term safety and effectiveness of the growth hormone treatment Growtropin-II in children with short stature. It includes up to 5,000 children with growth hormone deficiency, idiopathic short stature, Turner syndrome, or those born small for gestational a…

This study investigates how pelvic floor muscle strength, endurance, and relaxation ability are linked to chronic pelvic pain in women with endometriosis. Researchers will compare 50 women with endometriosis to 50 healthy women, measuring muscle function with a vaginal pressure d…

This study looks at how deeply argon beam coagulation (a tool that uses ionized gas to seal tissue) penetrates the ovary during laparoscopic surgery for ovarian endometriomas. Researchers will apply the technique to the cyst surface before removing it, then examine the tissue und…

This study looks at how surgery for severe deep endometriosis impacts a woman's egg supply, measured by a hormone called AMH. Researchers will follow 100 women aged 18 to 39 for 12 months after surgery. The goal is to see if the procedure lowers AMH levels, which could help guide…

This study looks at whether digital tools like chatbots, games, and videos can help parents in Nigeria decide to vaccinate their daughters against HPV, a virus that can cause cervical cancer. About 3,340 parents of unvaccinated girls aged 9-14 will be randomly assigned to try one…

This study looks at whether it is safe for women with endometrial cancer to fast overnight before their surgery. Many women with this cancer have high blood sugar and inflammation, which may help the cancer grow. The study will check if fasting is doable and liked by patients, an…

This study investigates why endometriosis and migraine often occur together. Researchers will measure pain sensitivity and sex hormone levels in four groups: people with endometriosis, people with migraine, people with both conditions, and healthy controls. Participants complete …

This study investigates why endometriosis causes pelvic pain by measuring how the body processes heat, cold, and pressure. Researchers will also analyze hormone levels, immune markers, and genetic factors from blood, urine, saliva, and tissue samples. Participants are females age…

This study looks at tissue samples from 40 women with endometriosis to see how certain molecules behave in diseased tissue compared to healthy tissue. The goal is to better understand what causes endometriosis. No treatments are being tested—this is a fact-finding study using sto…

This study asks Black women aged 45 and older how they feel about using a vaginal fluid sample to test for DNA markers of endometrial cancer. The goal is to understand if women would accept this as a screening method. No treatment is given—just a 30-minute virtual interview to ga…

This study investigates why some advanced or recurrent endometrial cancers respond to immunotherapy while others do not. Researchers will collect tumor samples from 510 patients before they start immunotherapy and use lab-grown tumor models to study molecular and genetic features…

This study compares how laparoscopic removal of ovarian cysts affects ovarian reserve—a key measure of fertility potential—in women with endometriotic cysts versus non-endometriotic cysts. Researchers will measure levels of anti-Müllerian hormone (AMH) before and three months aft…

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study is for young adults (ages 21-45) who had certain cancers as teens or young adults. Researchers are adapting a program that helps survivors manage their health after cancer treatment. The goal is to see if this program improves survivors' confidence and ability to handl…

This study follows thousands of very low birth-weight and premature infants to track their development over time. Researchers collect data on pregnancy, birth, and early childhood outcomes to identify factors that influence brain and body development. No treatments are tested—thi…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study is looking at 135 women with and without endometriosis to understand how hormones, environmental chemicals, and vaginal bacteria differ between the groups. Researchers hope to find patterns that could lead to faster diagnosis and better treatments. Participants give bl…

This observational registry is gathering data from 500 adults whose gynecologic cancer has returned after prior radiation therapy. Doctors are using reirradiation or other ablative strategies as part of standard care, and the registry will track how well these treatments control …

This study is looking at 180 women with advanced cervical cancer who were treated with radiation and chemotherapy. Researchers want to see if high levels of certain proteins (called IAPs) in the original tumor biopsy can predict whether the cancer will come back within two years.…

This study is observing 300 women with female sexual organs who are receiving radiotherapy for certain cancers. Researchers want to understand why some patients have more sexual side effects than others. They will track sexual quality of life and look at radiation doses to find p…

This study compares two manual therapy techniques—seated extension glides and supine downslip glides—to see which better improves neck rotation range of motion. Researchers will enroll 128 healthy adults aged 18-45 with no history of neck pain. The goal is to help physical therap…

This study tests whether giving gynecologic cancer patients a list of questions to ask their doctor improves their confidence, reduces distress, and builds trust. About 70 adults with newly diagnosed or suspected gynecologic cancer will either receive the question list or usual c…

This study is looking for certain cells in the blood of people with 9 types of advanced cancers that have spread. Researchers will take one blood sample from each of 450 participants before they start a new treatment. They will use two different lab methods to see if they can fin…

This study looks at why some babies grow poorly early in pregnancy for no known reason. Researchers will measure a key hormone (progesterone) in the mother's blood and examine a protective protein in the placenta after birth. By comparing 58 pregnancies, they hope to uncover clue…

This study looks at two surgical methods for early-stage endometrial cancer: laparoscopy (keyhole surgery) and laparotomy (open surgery). It aims to see which one helps patients recover faster, especially in places with limited medical resources. About 48 women will take part, an…

This study follows 200 babies diagnosed with poor growth in the womb (IUGR) using advanced ultrasound and MRI scans. Researchers want to understand how the baby's brain, heart, and placenta change over time. The goal is to link these changes to the child's development after birth…

This study aims to better understand pre-eclampsia and intrauterine growth restriction (IUGR), serious pregnancy complications affecting about 9% of pregnancies. Researchers will collect placenta, blood, and urine samples from 500 pregnant women—both with and without these condit…

This study tests an online training program designed to help primary health care workers in Brazil give better advice on physical activity and reducing sedentary time. Over 3,300 health professionals will take the self-paced course and have their counseling skills measured before…

This study is testing a special PET scan (FES PET/CT) to see how active estrogen receptors are in uterine cancer that has spread or returned. About 30 women with this type of cancer will get the scan before starting a new treatment. The results won't change their treatment plan b…

This study compares two surgical techniques for removing a uterine septum—a wall of tissue inside the uterus that can cause pregnancy complications. One method uses scissors without electricity, while the other uses a heated wire. Researchers will track surgery time, costs, and r…

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This observational study is looking at 350 women with early-stage endometrial cancer to see if doctors can better predict who really needs lymph node removal during surgery. Participants receive standard care and are followed for three years. The goal is to find out if some patie…

This study is testing two new ultrasound techniques to see if they can tell the difference between healthy pregnancies and those affected by fetal growth restriction (FGR), where the baby is smaller than expected. Researchers will scan 60 pregnant women every three weeks using a …

This study tests a new tool called TRTRM that predicts which older cancer patients are at high risk for severe side effects from treatment. Researchers will use the tool to adjust drug doses and monitoring for patients aged 65 and older with solid tumors. The goal is to see if th…

This study looks at whether joining a support group can improve emotional well-being and reduce feelings of isolation for people with a rare cervical cancer called NECC. About 40 adults with NECC will take part. Researchers will use surveys to measure changes in how participants …

This study collects tumor and blood samples from 3,300 people at high genetic risk for breast, ovarian, and related cancers. Researchers want to learn how these cancers develop and how well treatments work. Participants include those with BRCA1/2 or other gene mutations, or a str…

This study looks at how pesticides and the bacteria in your gut and genital tract might be linked to endometriosis and infertility. Researchers will compare 160 women with and without endometriosis to find patterns in their DNA and bacteria. The goal is to better understand the d…

This study looks at 1,000 women undergoing IVF to understand how tiny organisms in the womb (the microbiome) may cause chronic endometritis, a condition that can harm fertility. Researchers will collect samples from the vagina and womb to compare the microbes in women with and wi…

This study listens to 150 people with endometriosis across Europe to understand how they manage their condition every day. Researchers want to learn what makes people feel empowered or abandoned by their support systems. Participants will share their stories through diaries, inte…

This study aims to validate a gene test that identifies oxygen-starved (hypoxic) tumours in bladder and prostate cancer patients. About 30 participants will provide tumour samples and blood, and some will have MRI scans. The goal is to see if this test can help doctors choose mor…

This study is testing whether HPV DNA found in blood and urine can be used as a simple, non-invasive way to detect cervical cancer and monitor how well treatment is working. Researchers will collect samples from 30 women newly diagnosed with cervical cancer before and after their…

This study aims to understand how stem cells from menstrual blood and the immune system behave differently in women with endometriosis compared to healthy women. Researchers will collect menstrual blood, tissue samples, and questionnaires from 40 women aged 18-45. No treatments a…

This study compares two types of uterine incisions (high vs low) during a first cesarean section to see which leads to fewer scar defects. 168 pregnant women having their first C-section will be randomly assigned to one of four groups, combining incision type with a stitching tec…

This trial is testing whether using a uterine manipulator during minimally invasive hysterectomy for endometrial cancer affects the chance of cancer coming back. About 1,030 women with early-stage endometrial cancer will be randomly assigned to have surgery with or without the de…

This study looks at how a pregnant person's metabolism—specifically insulin resistance and fat burning—may be linked to placenta health and pregnancy complications like preeclampsia and gestational diabetes. Researchers will follow 50 pregnant women at high or moderate risk for p…

This study aims to gather and analyze detailed medical information from 10,000 people diagnosed with endometrial cancer in Italy. Researchers will look at how the cancer's molecular and immune features affect how long patients stay free of the disease and how long they live overa…

This study surveys about 264 Italian hospitals that treat endometrial cancer to find out how often they use POLE testing. POLE testing helps doctors know which patients have a very low risk of cancer returning and may not need extra treatment. The goal is to understand current pr…

This study follows 200 women with gynecologic cancer and their partners to see how sexual function changes over time. Researchers use questionnaires at diagnosis, 6 months, and 12 months after treatment. The goal is to understand when sexual counseling might be most helpful, with…

This study looks at 300 people with Lynch syndrome, a genetic condition that raises the risk of colorectal cancer. Researchers want to understand why some patients still develop cancer even with regular check-ups. They will analyze blood, gut bacteria, and hair samples to find cl…

This study looks at whether an interactive video program, combined with help from a community health worker, can increase cervical cancer screening among African American women who are overdue for a test. About 288 women will take part, completing two phone surveys and having the…

This study is testing a unified first trimester screening approach to predict serious pregnancy complications like preeclampsia, fetal growth restriction, and birth defects. Researchers will enroll 2,000 pregnant women in the Czech Republic to see if combining standard tests can …

This study uses a special contrast dye (SonoVue) during ultrasound to look at blood flow in the placenta of pregnant women with fetal growth restriction. The goal is to better understand how the placenta works when the baby is not growing well. Thirty women who have already decid…

This study looks at whether using ultrasound during surgery can help doctors more accurately find and treat deep endometriosis in the bowel. About 200 women with suspected bowel endometriosis will have an ultrasound probe placed in the vagina or rectum during their operation. The…

This study tests whether artificial intelligence can help more women in Occitanie, France, complete cervical cancer screening. About 3,000 women aged 30-65 who haven't been screened recently will be invited to use a self-sampling kit. The goal is to see if AI-assisted decision-ma…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study follows 200 women aged 20-50 with adenomyosis, a condition causing pelvic pain and heavy bleeding. Researchers will observe which treatments doctors prescribe and how well they work over 12 months. The goal is to understand current medical practices and help develop be…

This study is a large registry that collects information on very low birth weight infants (weighing 401-1000 grams or born before 29 weeks) at multiple hospitals. Researchers track the babies' health, treatments, and outcomes to find patterns and improve future care. No experimen…

This study follows 200 adult women who visit the gynecological emergency department for endometriosis or related symptoms. Researchers want to see if emergency care leads to proper follow-up, like specialist visits or imaging. The goal is to understand how well the emergency syst…

This study is for pregnant women whose babies are not growing well due to a problem with the placenta. Researchers will use artificial intelligence and special ultrasound scans to better predict which babies are at risk for complications. The goal is to improve care and outcomes …

This study is a patient registry for women diagnosed with Preterm Premature Rupture of Membranes (PPROM) before 37 weeks of pregnancy. Researchers will collect data from 3,000 participants to identify possible causes, evaluate care trends, and review short- and long-term outcomes…

This study looks at the best way to manage women who have a molar pregnancy (a rare abnormal pregnancy) and also have a lung nodule found on a CT scan. Researchers want to see if starting chemotherapy right away is better than waiting to see if the nodule goes away on its own. Ab…

This study looks at how the uterus absorbs fluid during early pregnancy, which may affect fertility. Researchers will compare tissue samples from women with and without endometriosis or infertility. The goal is to understand the role of certain proteins in this process. No treatm…

This study aims to find the best time to measure cervical length during a standard pregnancy ultrasound (anatomy scan) to improve accuracy. Researchers will compare measurements taken at the start versus the end of the scan in 550 pregnant individuals. They will also test if a sp…

This study looks at whether a special PET scan and a blood test for HPV can detect any remaining cervical cancer cells after standard chemoradiation. About 64 people with cervical cancer will be followed after their usual treatment. The goal is to see if these tests can predict i…

This study looks at whether a blood test can detect HPV DNA in people with HPV-related anal or cervical cancer who are receiving radiation therapy. Researchers will collect blood samples before, during, and after treatment to see if the virus's genetic material shows up and if it…

This study compares three different surgical methods for removing abnormal cervical tissue (conization) to see which one causes the least heat-related damage. The goal is to improve the accuracy of lab analysis after surgery. 150 women needing this procedure will take part, and p…

This study looks at women who had radiation therapy for cervical or endometrial cancer to see how often they experience long-term side effects in the bowel or bladder. Researchers will review medical records of 300 patients treated at Tata Memorial Hospital. The goal is to unders…

This study looks at whether MRI scans can help doctors predict which women with endometriosis will benefit from the drug dienogest. Researchers will follow 48 women aged 19-45 who are starting dienogest for the first time. By comparing MRI images before treatment with changes in …

This study looks at whether using a uterine manipulator during hysterectomy changes sexual function three months after surgery. Sixty women having a hysterectomy for non-cancer reasons will be randomly assigned to have the surgery with or without the tool. The main goal is to com…

This study follows 650 women with endometriosis who want to have children after diagnosis. Researchers compare pregnancy rates and the need for fertility treatments between those who had surgery and those who took medication. The goal is to understand which approach leads to bett…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…

This study is testing whether a web and mobile phone program can help Hispanic women who have had breast, uterine, or ovarian cancer, along with their adult daughters, eat better and be more active. The program includes 8 online modules. The main goal is to see if the program is …

This study will analyze data from 1,800 past cervix cancer patients to develop machine learning tools. The goal is to automate tumor detection and treatment planning, and to identify which patients might benefit from more intensive or advanced radiation techniques. No new treatme…

This study at Mayo Clinic is testing new AI-based image processing techniques (AIR Recon DL and Sonic DL) to see if they can make MRI scans faster and clearer for detecting pelvic abnormalities like endometrial and prostate cancer. Researchers will compare the new methods to stan…

This study looks back at medical records of 350 people with cervical cancer that has come back or spread to a few spots. The goal is to see how well treatments like radiation or surgery work, alone or with chemotherapy. Researchers want to find out which patients benefit most fro…

This study looks at why pregnant women living at high altitudes have higher rates of preeclampsia and poor fetal growth. Researchers will collect tissue samples from women having scheduled C-sections in Denver (low altitude) and Summit County (high altitude) to compare how their …

This study looks at 1,000 women to see how ultrasound features of adenomyosis (a condition where the uterine lining grows into the muscle wall) match up with their symptoms like pain and heavy bleeding. Participants get one routine ultrasound and fill out a symptom questionnaire.…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV and tumor DNA) can help doctors monitor treatment and spot early signs of cancer returning in people with HPV-related cervical and oropharyngeal cancers. Researchers will follow 480 participants …

This study looks at whether changes in a blood marker called CRP can help predict how well immunotherapy works in women with advanced gynecologic cancers (cervical, endometrial, ovarian, or vulvar). Researchers will track CRP levels in 120 women receiving immunotherapy plus chemo…

This study looks at better ways to provide cervical cancer screening and treatment to women living with HIV in Nigeria. About 2,400 women will take part. Researchers will compare two sets of strategies to see which works best for getting women screened and treated. The goal is to…

This study tests whether 3D-printed custom applicators can deliver radiation more precisely than standard cylinder applicators for gynecologic cancers like endometrial, vaginal, and vulvar cancer. Ten participants will receive brachytherapy with a personalized 3D-printed mold. Th…

This study aims to see if a newer type of scan, called PET/MRI, is better than the standard PET/CT scan at finding cancer spread in lymph nodes for people with cervical cancer. About 50 adults with stage IB2 to IVA cervical cancer will be enrolled. Researchers will compare the ac…

This study looks at how the dose and storage conditions of a dye called indocyanine green (ICG) affect its ability to find sentinel lymph nodes during surgery for cervical, endometrial, and vulvar cancers. Researchers will enroll 30 patients to see which approach works best and s…

This study aims to create a complex lab-grown model of endometrial tissue using biopsies from women with and without endometriosis. Researchers will test how different hormone treatments affect the tissue, with the goal of predicting individual responses. The study involves 90 wo…

This study is a large German registry that will follow nearly 2,000 people with advanced ovarian or endometrial cancer. Researchers will collect information on the treatments patients actually receive, how their disease responds, and their quality of life. The goal is to understa…