Extra radiation boost shows promise for bulky cervical cancer
NCT ID NCT07435376
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether adding a precise radiation boost to standard treatment can shrink large cervical tumors more effectively. Seventeen participants with bulky squamous cell carcinoma will receive external radiation plus a targeted boost, followed by internal brachytherapy. The main goal is to see if the boost reduces tumor volume enough before brachytherapy, while also monitoring side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- radiation therapy (intra-lesional boost IMRT and high-dose-rate brachytherapy)
- What this could lead to
- If successful, this approach could improve tumor shrinkage before brachytherapy, potentially leading to better local control and outcomes for patients with bulky cervical cancer.
- What could go wrong
- This is a small, early-phase trial with only 17 participants, so results may not apply broadly. The extra radiation could increase side effects, and it's unclear if it will improve long-term survival.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Seoul National University Bundang Hospital
RECRUITINGSeongnam-si, Gyeonggi-do, 13620, South Korea
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Other studies related to the condition(s) this trial covers.
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