New trial tests drug combo to keep ovarian cancer at bay

NCT ID NCT05183984

Recruiting now Disease control Sponsor: ARCAGY/ GINECO GROUP Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is for women with advanced ovarian cancer who have had complete surgery and chemotherapy. It compares two maintenance treatments: niraparib alone versus niraparib plus bevacizumab. The goal is to see which approach better delays cancer progression. About 390 participants will be followed for up to 24 months.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: niraparib and bevacizumab
What this could lead to: If successful, this could show that adding bevacizumab to niraparib maintenance helps keep ovarian cancer from returning longer than niraparib alone.
What could go wrong: This is a phase 2 trial, so results are still early. The combination may not improve outcomes and could increase side effects like high blood pressure or fatigue.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

fallopian tube cancer ovarian cancer ovarian carcinoma ovarian endometrioid adenocarcinoma ovarian serous adenocarcinoma primary peritoneal carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

OVARIAN CANCER

Contacts and locations

Locations

Asan Medical Center
NOT_YET_RECRUITING

Seoul, Songpa-gu, 05505, South Korea
CH Valence
NOT_YET_RECRUITING

Valence, 26000, France
CHR Orléans
NOT_YET_RECRUITING

Orléans, 45100, France
CHRU Besançon - Hôpital Jean Minjoz
NOT_YET_RECRUITING

Besançon, 25000, France
CHU Grenoble-Alpes - Site Nord (La Tronche)
NOT_YET_RECRUITING

La Tronche, 38700, France
CHU Montpellier - Hôpital Saint Eloi
NOT_YET_RECRUITING

Montpellier, 34295, France
CHU Tours - Hôpital Bretonneau
NOT_YET_RECRUITING

Tours, 37044, France
CHU de Dijon - Bourgogne
NOT_YET_RECRUITING

Dijon, 21000, France
CHU de Limoges - Hôpital Dupuytren
NOT_YET_RECRUITING

Limoges, 87042, France
CHU de Poitiers - Hôpital de la Milétrie
NOT_YET_RECRUITING

Poitiers, 86021, France
CHU de Saint-Etienne - Pôle de Cancérologie
NOT_YET_RECRUITING

Saint-Priest-en-Jarez, 42055, France
CHU de Santiago de Compostela
RECRUITING

Santiago de Compostela, 15706, Spain
CHU de Strasbourg Hôpital de Hautepierre
NOT_YET_RECRUITING

Strasbourg, France
Cancer Institute Hospital Of JFCR
RECRUITING

Tokyo, Ariake, Koto, 135-8550, Japan
Centre Azuréen de Cancérologie
NOT_YET_RECRUITING

Mougins, 06250, France
Centre CARIO - HPCA
NOT_YET_RECRUITING

Plérin, 22190, France
Centre Eugène Marquis
NOT_YET_RECRUITING

Rennes, 35042, France
Centre François Baclesse
RECRUITING

Caen, 14076, France
Centre Georges François Leclerc
NOT_YET_RECRUITING

Dijon, 21079, France
Centre Henri Becquerel
NOT_YET_RECRUITING

Rouen, 76038, France
Centre Hospitalier de Cholet
NOT_YET_RECRUITING

Cholet, 49300, France
Centre Jean Perrin
NOT_YET_RECRUITING

Clermont-Ferrand, 63011, France
Centre Léon Bérard
NOT_YET_RECRUITING

Lyon, 69373, France
Centre ONCOGARD - Institut de cancérologie du Gard
NOT_YET_RECRUITING

Nîmes, 30029, France
Centre Oscar Lambret
NOT_YET_RECRUITING

Lille, 59020, France
Clinica Universidad de Navarra.
NOT_YET_RECRUITING

Pamplona, 31008, Spain
Clinique Tivoli-Ducos
NOT_YET_RECRUITING

Bordeaux, 33000, France
Clinique Victor Hugo
NOT_YET_RECRUITING

Le Mans, 72000, France
Clínica Universidad de Navarra
RECRUITING

Madrid, 28027, Spain
Complejo Hospitalario de Navarra
RECRUITING

Pamplona, 31008, Spain
Coruña University Hospital (CHUAC)
RECRUITING

A Coruña, 15006, Spain
Ehime University Hospital
NOT_YET_RECRUITING

Ehime, Toonshi, 791-0295, Japan
Firenze-Careggi
NOT_YET_RECRUITING

Florence, 50134, Italy
Fondazione IRCCS Istituto Nazionale dei Tumori
RECRUITING

Milan, 20133, Italy
Fundación Investigación Clínico de Valencia.
RECRUITING

Valencia, 46010, Spain
Groupe Hospitalier Diaconesses - Croix Saint-Simon
NOT_YET_RECRUITING

Paris, 75020, France
Groupe Hospitalier Mutualiste de Grenoble - Institut Daniel Hollard
NOT_YET_RECRUITING

Grenoble, 38028, France
Groupe Hospitalier Pitié Salpêtrière
NOT_YET_RECRUITING

Paris, 75013, France
Gustave Roussy
NOT_YET_RECRUITING

Villejuif, 94805, France
HCL - Centre Hospitalier Lyon Sud (Hospices Civils de Lyon)
RECRUITING

Pierre-Bénite, 69495, France
HCL - Groupe Hospitalier Est
NOT_YET_RECRUITING

Bron, France
HCL - Hôpital de la Croix Rousse
NOT_YET_RECRUITING

Lyon, France
Hospital Clínico Universitario Virgen de la Arrixaca
RECRUITING

El Palmar, Murcia, 30120, Spain
Hospital San Pedro de Alcantara
RECRUITING

Cáceres, 10003, Spain
Hospital Universitari Dexeus
RECRUITING

Barcelona, 08028, Spain
Hospital Universitari MutuaTerrassa
RECRUITING

Terrassa, 08221, Spain
Hospital Universitario Central de Asturias
RECRUITING

Oviedo, 33011, Spain
Hospital Universitario La Paz
NOT_YET_RECRUITING

Madrid, 28046, Spain
Hospital Universitario Puerta de Hierro
NOT_YET_RECRUITING

Madrid, 28222, Spain
Hospital Universitario de Jerez
NOT_YET_RECRUITING

Jerez de la Frontera, 11407, Spain
Hospital Virgen de la Victoria
RECRUITING

Málaga, 29010, Spain
Hospital del Mar
RECRUITING

Barcelona, 08003, Spain
Hôpital Européen Georges Pompidou
NOT_YET_RECRUITING

Paris, 75015, France
Hôpital Morvan CHRU de Brest
NOT_YET_RECRUITING

Brest, 29200, France
Hôpital Nord Marseille
NOT_YET_RECRUITING

Marseille, 13915, France
Hôpital Privé Jean Mermoz
NOT_YET_RECRUITING

Lyon, 69373, France
Hôpital Privé du Confluent
NOT_YET_RECRUITING

Nantes, 44277, France
Hôpital Saint-Joseph
NOT_YET_RECRUITING

Paris, 75014, France
Hôpital Tenon
NOT_YET_RECRUITING

Paris, 75020, France
Hôpital cochin
NOT_YET_RECRUITING

Paris, 75014, France
ICANS - Institut de cancérologie Strasbourg Europe
NOT_YET_RECRUITING

Strasbourg, 67033, France
ICO - Centre René Gauducheau
NOT_YET_RECRUITING

Saint-Herblain, 44800, France
ICO Paul Papin
NOT_YET_RECRUITING

Angers, 49055, France
Institut Bergonié
NOT_YET_RECRUITING

Bordeaux, 33076, France
Institut Claudius Regaud
RECRUITING

Toulouse, 31059, France
Institut Jean Godinot
NOT_YET_RECRUITING

Reims, 51100, France
Institut Mutualiste Montsouris
NOT_YET_RECRUITING

Paris, 75014, France
Institut Paoli Calmettes
NOT_YET_RECRUITING

Marseille, 13009, France
Institut régional du cancer de Montpellier
NOT_YET_RECRUITING

Montpellier, 34090, France
Istituto Europeo di Oncologia (IEO)
RECRUITING

Milan, 20141, Italy
Jichi Medical UH
NOT_YET_RECRUITING

Shimotsuke, Tochigi, 〒329-0498 3311-1, Japan
Kurume University Hospital Clinical Research Center
RECRUITING

Kurume, Fukuoka, 〒830-0011 6, Japan
National Cancer Center
RECRUITING

Seoul, Gyeonggi-do, 10408, South Korea
National Cancer Center Hospital East
NOT_YET_RECRUITING

Kashiwanoha, Chiba, 277-8577, Japan
National Cancer Centre Singapore
NOT_YET_RECRUITING

Singapore, 168583, Singapore
National University Hospital
RECRUITING

Seoul, Jongno-gu, 03080, South Korea
National University Hospital (NUH)
NOT_YET_RECRUITING

Singapore, 119074, Singapore
Niigata Cancer Center Hospital
RECRUITING

Niigata, Niigata, 951-8566, Japan
ORACLE - Centre d'Oncologie de Gentilly
NOT_YET_RECRUITING

Nancy, 54000, France
Okayama University Hospital
NOT_YET_RECRUITING

Kita-ku, Okayama-ken, 700-8558, Japan
Ospedale San Gerardo Monza
RECRUITING

Monza, 20900, Italy
Presidio Ospedaliero di Sondrio
NOT_YET_RECRUITING

Sondrio, 23100, Italy
Sainte Catherine Institut du cancer Avignon-Provence
NOT_YET_RECRUITING

Avignon, 84918, France
Saitama Medical University International Medical Center
RECRUITING

Saitama, 350-1298, Japan
Samsung Medical Center
RECRUITING

Seoul, Gangnam-gu, 06351, South Korea
Severance Hospital
RECRUITING

Seoul, Seodaemun-gu, 03722, South Korea
University of Tsukuba Hospital
RECRUITING

Tsukuba, Ibaraki-Pref, 305-8576, Japan
Yamagata University Hospital
NOT_YET_RECRUITING

Yamagata, Yamagata, 990-9585, Japan

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