New drug SIM0505 enters first human tests for advanced cancers
NCT ID NCT06792552
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-stage trial is testing an experimental drug called SIM0505 in adults with advanced solid tumors that have not responded to standard treatments. The study aims to find a safe dose and check for any early signs that the drug shrinks tumors. About 414 participants will receive the drug by injection every three weeks.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SIM0505 (an experimental drug given by injection)
What this could lead to
If successful, this could point toward a new treatment option for people with advanced solid tumors who have not responded to standard therapies.
What could go wrong
This is a very early Phase 1 trial, so the drug may not be safe or effective. Side effects are unknown, and the main goal is to find a safe dose, not to prove it works.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Hospital of Jining Medical University
RECRUITINGJining, Shandong, 272000, China
Contact Phone: •••-•••-••••
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Cancer Hospital of Shandong First Medical University
RECRUITINGJinan, Shandong, 250117, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Emory Winship Cancer Institute
RECRUITINGAtlanta, Georgia, 30322, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Hackensack University Medical Center
RECRUITINGHackensack, New Jersey, 07601, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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HunanCancer Hospital
RECRUITINGChangsha, Hunan, 430100, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Icahn School of Medicine at Mount Sinai
RECRUITINGNew York, New York, 10128, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Liaoning Cancer Hospital & Institute
NOT_YET_RECRUITINGShenyang, China, 110092, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Roswell Park Cancer Institute
RECRUITINGBuffalo, New York, 14263, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sarah Cannon Research Institute (SCRI) - Lake Nona
RECRUITINGOrlando, Florida, 32827, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sarah Cannon Research Institute (SCRI) - Nashville
RECRUITINGNashville, Tennessee, 37203, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-sen University Cancer Center
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Fourth Hospital of Hebei Medical University (Heibei Tumor Hospital)
NOT_YET_RECRUITINGShijiazhuang, China, 050010, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The first medical center of PLA general hospital
RECRUITINGBeijing, Beijing Municipality, 100000, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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UT Health San Antonio - Mays Cancer Center
RECRUITINGSan Antonio, Texas, 78229, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University Medical Center of New Orleans LSU-LCMC Health Cancer Center
NOT_YET_RECRUITINGNew Orleans, Louisiana, 70112, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact