New hope for advanced endometrial cancer: immunotherapy combo under study
NCT ID NCT05112991
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests two drugs, envafolimab (an immunotherapy) and lenvatinib (a targeted therapy), alone or together, in 108 people with advanced endometrial cancer that has worsened after standard chemotherapy. The main goal is to see if the drugs shrink tumors. Researchers will also track how long any response lasts and overall survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
envafolimab (an immunotherapy drug) and lenvatinib (a targeted therapy drug)
What this could lead to
If successful, this could provide a new treatment option for people with advanced endometrial cancer who have not responded to standard chemotherapy.
What could go wrong
This is an early Phase II trial with only 108 participants, so results may not apply to everyone. The drugs can cause side effects like fatigue, high blood pressure, or immune-related reactions.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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:Hubei Cancer Hospital
RECRUITINGWuhan, Hubei, 430079, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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:Linyi Cancer Hospital
RECRUITINGLinyi, Shandong, 276002, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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:Nanjing Maternity and Child Health Care Hospital
RECRUITINGNanjing, Jiangsu, 210004, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Beijing Cancer Hospital
RECRUITINGBeijing, Beijing Municipality, 100142, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Cancer Hospital of The University of Chinese Academy of Sciences
RECRUITINGHangzhou, Zhejiang, 310005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Chongqing University Three Gorges Hospital
RECRUITINGChongqing, Chongqing Municipality, 40030, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fudan University Shanghai Cancer Center
RECRUITINGShanghai, Shanghai Municipality, 200032, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Fujian Cancer Hospital
RECRUITINGFuzhou, Fujian, 350014, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Ganzhou Cancer Hospital
RECRUITINGGanzhou, Jiangxi, 341005, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Henan Cancer Hospital
RECRUITINGZhengzhou, Henan, 450003, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Liaoning Cancer Hospital
RECRUITINGShenyang, Liaoning, 110801, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Qilu Hospital of Shandong University
RECRUITINGJinan, Shandong, 250063, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Shandong Cancer Hospital
RECRUITINGJinan, Shandong, 250117, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Sun Yat-Sen Memorial Hospital
RECRUITINGGuangzhou, Guangdong, 510120, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tai'an Center Hospital
RECRUITINGTai’an, Shandong, 271099, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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The Second Xiangya Hospital of Central South University
RECRUITINGChangsha, Hunan, 200001, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Tianjin Medical University Cancer Institute&Hospital
RECRUITINGTianjing, Tianjing, 300181, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Wuhan Union Hospital of China
RECRUITINGWuhan, Hubei, 430022, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Yueyang Center Hospital
RECRUITINGYueyang, Hunan, 414604, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact