Could a simple supplement shrink fibroids and prevent surgery?

NCT ID NCT05448365

Recruiting now Disease control Sponsor: Lo.Li.Pharma s.r.l Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a daily supplement containing vitamin D, EGCG (from green tea), D-chiro-inositol, and vitamin B6 can shrink uterine fibroids in women who are eligible for surgery. Sixty women will take either the supplement or a placebo for three months. The main goal is to see if the fibroids get smaller and if fewer women end up needing surgery.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: combination of vitamin D, epigallocatechin gallate (EGCG), D-chiro-inositol, and vitamin B6
What this could lead to: If it works, this could offer a natural supplement option to shrink fibroids and help some women avoid surgery.
What could go wrong: This is a small early-phase trial with only 60 participants and no phase designation, so results may not be conclusive. The supplement may not shrink fibroids enough to make a real difference.

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Conditions

The condition(s) this trial relates to.

leiomyoma uterine corpus leiomyoma vitamin D deficiency

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

D-CHIRO-INOSITOL EPIGALLOCATECHIN GALLATE INOSITOL UTERINE FIBROIDS VITAMIN B6 VITAMIN D

Contacts and locations

Locations

Ospedale Dario camberlingo
RECRUITING

Francavilla Fontana, Apulia, 72021, Italy
Ospedale Veris Delli Ponti
NOT_YET_RECRUITING

Scorrano, Apulia, 73020, Italy

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