Hope for women with recurrent pregnancy failure: new drug combo trial

NCT ID NCT07488949

Recruiting now Disease control Sponsor: Fang Wang Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study is testing whether adding medroxyprogesterone acetate to standard doxycycline treatment can better cure chronic endometritis and improve pregnancy outcomes in women with recurrent reproductive failure. One thousand women aged 20-45 will be randomly assigned to receive either the combination or doxycycline alone for 14 days. The researchers will track cure rates, pregnancy rates, and live birth rates to see which approach works best.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: doxycycline and medroxyprogesterone acetate
What this could lead to: If successful, this could provide a more effective treatment for chronic endometritis, potentially improving pregnancy and live birth rates in women with recurrent reproductive failure.
What could go wrong: This is a single-center trial with no phase designation, and the addition of medroxyprogesterone may not significantly improve outcomes over doxycycline alone. Side effects from the medications are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

chronic endometritis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHRONIC ENDOMETRITIS

Contacts and locations

Locations

Lanzhou University Second Hospital
RECRUITING

Lanzhou, Gansu, 730030, China

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