Could a common supplement boost antibiotic success for a hidden cause of infertility?
NCT ID NCT07180563
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This study tests whether adding berberine (a natural compound) to the standard antibiotic doxycycline works better than doxycycline alone for chronic endometritis, an inflammation of the uterine lining that can cause infertility. About 206 women with the condition will take either the combination or the antibiotic alone for 14 days. The main goal is to see if the infection clears more often with the combination, and to track polyp recurrence.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- berberine and doxycycline
- What this could lead to
- If it works, this could offer a more effective treatment for chronic endometritis, potentially improving fertility outcomes and reducing uterine polyp recurrence.
- What could go wrong
- This is an early Phase 1/2 trial with only 206 participants, so results may not apply to everyone. Side effects like nausea, rash, or drug fever are possible, and the combination may not be more effective than doxycycline alone.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
The Fourth Affiliated Hospital of Zhejiang University School of Medicine
RECRUITINGYiwu, Zhejiang, 322000, China
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- A simple look inside the uterus may reveal hidden inflammation — no lab needed
- Hormone pretreatment may boost IVF success in stubborn uterine infection
- Uterine infection linked to infertility: antibiotics may boost pregnancy chances
- Hope for women with recurrent pregnancy failure: new drug combo trial
- Herbal-Antibiotic combo aims to beat stubborn womb infection