New Triple-Drug attack on cervical cancer enters final testing

NCT ID NCT07216703

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 07, 2026 · Updated 9 times

Summary

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has spread and who have a specific protein (PD-L1) will receive either the new combo or standard chemo. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: sacituzumab tirumotecan (sac-TMT) combined with pembrolizumab (Keytruda) and bevacizumab (Avastin)
What this could lead to: If successful, this combination could become a new first-line maintenance treatment for metastatic cervical cancer, potentially helping patients live longer or delay cancer progression.
What could go wrong: This is a large phase 3 trial, but the combination involves multiple drugs, which may increase side effects. It is not yet proven to be better than current standard care.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 cervical cancer cervical carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

ASST Spedali Civili ( Site 2001)
RECRUITING

Brescia, 25123, Italy
ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1403)
RECRUITING

Chaïdári, Attica, 124 62, Greece
AULSS 2 MARCA TREVIGIANA ( Site 2011)
RECRUITING

Treviso, 95123, Italy
Aichi Cancer Center ( Site 2114)
RECRUITING

Nagoya, Aichi-ken, 464-8681, Japan
Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 1401)
RECRUITING

Athens, Attica, 115 28, Greece
Antwerp University Hospital ( Site 0407)
RECRUITING

Edegem, Antwerpen, 2650, Belgium
Aretaieio Hospital Oncology Unit ( Site 1402)
RECRUITING

Athens, Attica, 115 28, Greece
Asan Medical Center ( Site 2904)
RECRUITING

Seoul, 05505, South Korea
Azienda Ospedaliera Ordine Mauriziano di Torino ( Site 2006)
RECRUITING

Torino, 10128, Italy
Bradfordhill ( Site 0702)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile
CANCER TREAMTENT CLINIC AND CLINICAL TRIALS SA DE CV ( Site 2204)
RECRUITING

Guadalajara, Jalisco, 44260, Mexico
CHRU de Brest-Institut de cancérologie et d'Hématologie ( Site 1202)
RECRUITING

Brest, Brittany Region, 29609, France
CHU Strasbourg-Hautepierre ( Site 1207)
RECRUITING

Strasbourg, Alsace, 67098, France
CIDO SpA-Oncology ( Site 0708)
RECRUITING

Temuco, Araucania, 4810148, Chile
CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0604)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada
CRO-IRCCS ( Site 2014)
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy
Cancer Institute Hospital of JFCR ( Site 2119)
RECRUITING

Koto, Tokyo, 135-8550, Japan
Carmel Hospital ( Site 1901)
RECRUITING

Haifa, 3436212, Israel
Centre François Baclesse ( Site 1201)
RECRUITING

Caen, Calvados, 14076, France
Centre Hospitalier de l'Université de Montréal ( Site 0616)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0611)
RECRUITING

Québec, Quebec, G1J 1Z4, Canada
Centro Cancerológico del Caribe (CECAC) ( Site 0906)
RECRUITING

Barranquilla, Atlántico, 080002, Colombia
Centro de Investigacion Clinica de Oaxaca ( Site 2207)
RECRUITING

Oaxaca City, 68020, Mexico
Centro de Oncología e Investigación de Buenos Aires ( Site 0107)
RECRUITING

Berazategui, Buenos Aires, B1884BBF, Argentina
Chang Gung Memorial Hospital ( Site 3302)
RECRUITING

Taoyuan, 333, Taiwan
Chulalongkorn University ( Site 3403)
RECRUITING

Bangkok, Bangkok, 10330, Thailand
Clinica Somer ( Site 0903)
RECRUITING

Rionegro, Antioquia, 054040, Colombia
Cliniques Universitaires Saint-Luc ( Site 0402)
RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1200, Belgium
Cork University Hospital ( Site 1802)
RECRUITING

Cork, T12 E8YV, Ireland
Curo Oncology. ( Site 2811)
RECRUITING

Pretoria, Gauteng, 0084, South Africa
Debreceni Egyetem Klinikai Kozpont ( Site 1601)
RECRUITING

Debrecen, 4032, Hungary
FALP ( Site 0701)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile
Faculty of Medicine Siriraj Hospital ( Site 3401)
RECRUITING

Bangkok, Bangkok, 10700, Thailand
Fakultni nemocnice Kralovske Vinohrady ( Site 1002)
RECRUITING

Prague, Praha 10, 100 34, Czechia
Fakultni nemocnice Ostrava ( Site 1005)
RECRUITING

Ostrava, Moravian-Silesian Region, 708 52, Czechia
Fakultní Nemocnice Brno ( Site 1003)
RECRUITING

Brno, Brno-mesto, 602 00, Czechia
Florida Cancer Specialists - East ( Site 7000)
RECRUITING

West Palm Beach, Florida, 33401, United States
Florida Cancer Specialists - South ( Site 7001)
RECRUITING

Fort Myers, Florida, 33901, United States
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 2008)
RECRUITING

Milan, Milano, 20133, Italy
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2012)
RECRUITING

Roma, 00168, Italy
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0512)
RECRUITING

São José do Rio Preto, São Paulo, 15091-000, Brazil
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0111)
RECRUITING

La Rioja, F5300COE, Argentina
Fundación Respirar ( Site 0101)
RECRUITING

Belgrano, Buenos Aires F.D., C1118AAT, Argentina
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0511)
RECRUITING

Barretos, São Paulo, 14784-400, Brazil
Grand Hopital de Charleroi ( Site 0404)
RECRUITING

Charleroi, Hainaut, 6060, Belgium
Grupo Médico ASSET ( Site 2203)
RECRUITING

Mexico City, Mexico City, 03100, Mexico
Gunma Prefectural Cancer Center ( Site 2109)
RECRUITING

Ōta, Gunma, 373-8550, Japan
Higiea Oncologia ( Site 2205)
RECRUITING

Mexico City, Mexico City, 11819, Mexico
Hillel Yaffe Medical Center ( Site 1903)
RECRUITING

Hadera, 0038100, Israel
Hopelands Cancer Centre ( Site 2816)
RECRUITING

Hilton, KwaZulu-Natal, 3245, South Africa
Hopital Europeen Georges Pompidou ( Site 1210)
RECRUITING

Paris, 75015, France
Hosp Clinico Universitario de Valencia ( Site 3001)
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain
Hospital Araújo Jorge ( Site 0518)
RECRUITING

Goiânia, Goiás, 74605070, Brazil
Hospital Provincial del Centenario ( Site 0106)
RECRUITING

Rosario, Santa Fe Province, S2002KDS, Argentina
Hospital Ramon y Cajal ( Site 3005)
RECRUITING

Madrid, 28034, Spain
Hospital São Lucas da PUCRS ( Site 0516)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil
Hospital Universitari Vall d Hebron ( Site 3003)
RECRUITING

Barcelona, 08035, Spain
Hospital Universitario 12 de Octubre ( Site 3007)
RECRUITING

Madrid, 28041, Spain
Hospital Universitario La Paz ( Site 3004)
RECRUITING

Madrid, 28046, Spain
Hospital Universitario Reina Sofia ( Site 3006)
RECRUITING

Córdoba, 14004, Spain
Hyogo Cancer Center ( Site 2118)
RECRUITING

Akashi, Hyōgo, 673-8558, Japan
IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0517)
RECRUITING

São Paulo, São Paulo, 04014-002, Brazil
IC La Serena Research ( Site 0710)
RECRUITING

La Serena, Coquimbo Region, 1720430, Chile
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 2009)
RECRUITING

Meldola, Forli-Cesena, 47014, Italy
Institut Bergonié - Centre Régional de Lutte Contre Le Cancer de Bordeaux et Sud Ouest ( Site 1204)
RECRUITING

Bordeaux, Gironde, 33076, France
Institut Català d'Oncologia (ICO) - Girona ( Site 3002)
RECRUITING

Girona, Gerona, 17007, Spain
Instituto Misionero del Cancer ( Site 0112)
RECRUITING

Posadas, Misiones Province, N3300KAZ, Argentina
Instituto Nacional De Cancerologia ( Site 0909)
RECRUITING

Bogotá, Bogota D.C., 111511, Colombia
Instituto Nacional de Câncer - INCA ( Site 0515)
RECRUITING

Rio de Janeiro, 20220-410, Brazil
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0105)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina
Instituto de Oncologia de Rosario ( Site 0104)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0514)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil
Istituto Europeo di Oncologia ( Site 2003)
RECRUITING

Milan, 20141, Italy
Iwate Medical University Hospital ( Site 2116)
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan
KLES Prabhakar Kore Hospital & Medical Research Centre [M] ( Site 1705)
RECRUITING

Belagavi, Karnataka, 590010, India
Kanagawa Cancer Center ( Site 2121)
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan
Karolinska Universitetssjukhuset-Solna ( Site 3102)
RECRUITING

Stockholm, Stockholm County, 171 64, Sweden
Keio University Hospital ( Site 2103)
RECRUITING

Shinjyuku, Tokyo, 160-8582, Japan
Kurume University Hospital ( Site 2112)
RECRUITING

Kurume, Fukuoka, 830-0011, Japan
LBM ONCOPOLE CLAUDIUS REGAUD ( Site 1203)
RECRUITING

Toulouse, Haute-Garonne, 31059, France
Laboratorio de Patología Clínica del Hospital Universitario "Dr. José Eleuterio González" ( Site 2202)
RECRUITING

Monterrey, Nuevo León, 64460, Mexico
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6009)
RECRUITING

New York, New York, 10016, United States
Liga Norte Riograndense Contra o Câncer ( Site 0513)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil
Linköping University Hospital ( Site 3101)
RECRUITING

Linköping, Östergötland County, 581 85, Sweden
London Health Sciences Centre ( Site 0613)
RECRUITING

London, Ontario, N6A 5W9, Canada
Mackay Memorial Hospital ( Site 3303)
RECRUITING

Taipei, 10449, Taiwan
Maharaj Nakorn Chiang Mai Hospital ( Site 3402)
RECRUITING

Chiang Mai, 50200, Thailand
Mahatma Gandhi Cancer Hospital and Research Institute ( Site 1714)
RECRUITING

Visakhapatnam, Andhra Pradesh, 530017, India
Mater Misercordiae University Hospital ( Site 1804)
RECRUITING

Dublin, D07 R2WY, Ireland
Mazowiecki Szpital Wojewódzki w Siedlcach ( Site 2601)
RECRUITING

Siedlce, Warmian-Masurian Voivodeship, 08-110, Poland
McGill University Health Centre ( Site 0602)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada
Medizinische Universitaet Innsbruck ( Site 0301)
RECRUITING

Innsbruck, Tyrol, 6020, Austria
Medizinische Universitaet Wien ( Site 0302)
RECRUITING

Vienna, State of Vienna, 1090, Austria
Medizinische Universitat Graz ( Site 0303)
RECRUITING

Graz, Styria, 8036, Austria
Minnesota Oncology Hematology, PA ( Site 8003)
RECRUITING

Edina, Minnesota, 55435, United States
Mount Sinai Braman Comprehensive Cancer Center ( Site 5043)
RECRUITING

Miami Beach, Florida, 33140, United States
Mount Sinai Comprehensive Cancer Center ( Site 6000)
RECRUITING

Miami Beach, Florida, 33140, United States
Nancy N. & J.C. Lewis Cancer and Research Pavillion - Research Department ( Site 6005)
RECRUITING

Savannah, Georgia, 31405, United States
Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 2604)
RECRUITING

Gliwice, Silesian Voivodeship, 44-102, Poland
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2605)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland
National Cancer Center ( Site 2905)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea
National Cheng Kung University Hospital ( Site 3308)
RECRUITING

Tainan, 704, Taiwan
National Hospital Organization Hokkaido Cancer Center ( Site 2108)
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan
National Hospital Organization Kyushu Cancer Center ( Site 2102)
RECRUITING

Fukuoka, 811-1395, Japan
National Taiwan University Hospital ( Site 3301)
RECRUITING

Taiwan, Taipei, 10002, Taiwan
Nemocnice AGEL Novy Jicin a.s. ( Site 1004)
RECRUITING

Nový Jičín, Moravian-Silesian Region, 741 01, Czechia
Niigata Cancer Center Hospital ( Site 2110)
RECRUITING

Niigata, 951-8566, Japan
Nova Scotia Cancer Centre ( Site 0617)
RECRUITING

Halifax, Nova Scotia, B3H 1V7, Canada
ONCOCENTRO APYS-ACEREY ( Site 0703)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile
Okayama University Hospital ( Site 2101)
RECRUITING

Okayama, 700-8558, Japan
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6001)
RECRUITING

Tulsa, Oklahoma, 74146, United States
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007)
RECRUITING

Eugene, Oregon, 97401, United States
Oncomédica S.A.S ( Site 0905)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia
Oncólogos del Occidente S.A.S. ( Site 0908)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia
Országos Onkológiai Intézet ( Site 1603)
RECRUITING

Budapest, 1122, Hungary
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2111)
RECRUITING

Osaka, 541-8567, Japan
Ospedale Cannizzaro ( Site 2010)
RECRUITING

Catania, 95126, Italy
Ospedale Humanitas San Pio X ( Site 2013)
RECRUITING

Milan, Lombardy, 20159, Italy
Pontificia Universidad Catolica de Chile-CICUC ( Site 0706)
RECRUITING

Santiago, Region M. de Santiago, 8330073, Chile
Princess Margaret Cancer Centre ( Site 0601)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada
Pôle Santé Léonard de Vinci ( Site 1209)
RECRUITING

Chambray-lès-Tours, Centre-Val de Loire, 37170, France
Rabin Medical Center ( Site 1904)
RECRUITING

Petah Tikva, 4941492, Israel
Ramathibodi Hospital ( Site 3404)
RECRUITING

Bangkok, Bangkok, 10400, Thailand
Rambam Health Care Campus ( Site 1907)
RECRUITING

Haifa, 3109601, Israel
Saitama Medical University International Medical Center ( Site 2106)
RECRUITING

Hidaka, Saitama, 350-1298, Japan
Samsung Medical Center ( Site 2903)
RECRUITING

Seoul, 06351, South Korea
Scientia Investigacion Clinica S.C. ( Site 2201)
RECRUITING

Chihuahua City, 31207, Mexico
Seoul National University Hospital ( Site 2901)
RECRUITING

Jongno-gu, Seoul, 03080, South Korea
Severance Hospital Yonsei University Health System ( Site 2902)
RECRUITING

Seodaemun-Gu, Seoul, 03722, South Korea
Shaare Zedek Medical Center ( Site 1905)
RECRUITING

Jerusalem, 9103102, Israel
Shizuoka Cancer Center ( Site 2104)
RECRUITING

Sunto-gun,, Shizuoka, 411-8777, Japan
Skanes Universitetssjukhus Lund ( Site 3103)
RECRUITING

Lund, Skåne County, 22242, Sweden
Sourasky Medical Center ( Site 1902)
RECRUITING

Tel Aviv, 6423906, Israel
St Jame's Hospital ( Site 1801)
RECRUITING

Dublin, D08 NHY1, Ireland
Sunnybrook Research Institute ( Site 0605)
RECRUITING

Toronto, Ontario, M4N 3M5, Canada
Swietokrzyskie Centrum Onkologii. ( Site 2602)
RECRUITING

Kielce, Świętokrzyskie Voivodeship, 25-734, Poland
TRIALS 365 ( Site 6008)
RECRUITING

Shreveport, Louisiana, 71103, United States
Taichung Veterans General Hospital ( Site 3304)
RECRUITING

Taichung, 40705, Taiwan
Texas Oncology - DFW ( Site 8005)
RECRUITING

Fort Worth, Texas, 76104, United States
Texas Oncology - Northeast Texas ( Site 8002)
RECRUITING

Tyler, Texas, 75702, United States
Texas Oncology-The Woodlands ( Site 8000)
RECRUITING

The Woodlands, Texas, 77380, United States
The Christie Hospital NHS Foundation Trust ( Site 3602)
RECRUITING

Withington, Manchester, M20 4BX, United Kingdom
The Jikei University Hospital ( Site 2107)
RECRUITING

Minato, Tokyo, 105-8471, Japan
UZ Gent ( Site 0406)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium
UZ Leuven ( Site 0401)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium
Uniklinikum Salzburg Landeskrankenhaus ( Site 0304)
RECRUITING

Salzburg, 5020, Austria
Univ. Pretoria and Steve Biko Academic Hospitals ( Site 2804)
RECRUITING

Pretoria, Gauteng, 0002, South Africa
Universitaetsklinikum Jena ( Site 1303)
RECRUITING

Jena, Thuringia, 07747, Germany
University of Tennessee Medical Center ( Site 6012)
RECRUITING

Knoxville, Tennessee, 37920, United States
University of Virginia Cancer Center ( Site 5044)
RECRUITING

Charlottesville, Virginia, 22908, United States
University of Virginia Cancer Center ( Site 6014)
RECRUITING

Charlottesville, Virginia, 22908, United States
University of the Ryukyus Hospital ( Site 2117)
RECRUITING

Ginowan, Okinawa, 901-2725, Japan
Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1001)
RECRUITING

Prague, 128 08, Czechia
Western General Hospital ( Site 3604)
RECRUITING

Edinburgh, Edinburgh, City of, EH4 2XU, United Kingdom
Winship Cancer Institute of Emory University ( Site 5005)
RECRUITING

Atlanta, Georgia, 30308, United States
Wits Clinical Research ( Site 2803)
RECRUITING

Johannesburg, Gauteng, 2193, South Africa
Wits Clinical Research ( Site 2813)
RECRUITING

Soweto, Gauteng, 2113, South Africa
Women & Infants Hospital ( Site 6003)
RECRUITING

Providence, Rhode Island, 02905, United States
Women's Cancer Center of Nevada ( Site 6011)
RECRUITING

Las Vegas, Nevada, 89106, United States

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