New Triple-Drug attack on cervical cancer enters final testing

NCT ID NCT07216703

Recruiting now Disease control Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has spread and who have a specific protein (PD-L1) will receive either the new combo or standard chemo. The study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

sacituzumab tirumotecan (sac-TMT) combined with pembrolizumab (Keytruda) and bevacizumab (Avastin)

What this could lead to

If successful, this combination could become a new first-line maintenance treatment for metastatic cervical cancer, potentially helping patients live longer or delay cancer progression.

What could go wrong

This is a large phase 3 trial, but the combination involves multiple drugs, which may increase side effects. It is not yet proven to be better than current standard care.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 cervical cancer cervical carcinoma Uterine Cervical Neoplasms

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CERVICAL CANCER

Contacts and locations

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Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1403)
RECRUITING

Chaïdári, Attica, 124 62, Greece

Contact Phone: •••-•••-••••
Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 1401)
RECRUITING

Athens, Attica, 115 28, Greece

Contact Phone: •••-•••-••••
Antwerp University Hospital ( Site 0407)
RECRUITING

Edegem, Antwerpen, 2650, Belgium

Contact Phone: •••-•••-••••
Aretaieio Hospital Oncology Unit ( Site 1402)
RECRUITING

Athens, Attica, 115 28, Greece

Contact Phone: •••-•••-••••
Asan Medical Center ( Site 2904)
RECRUITING

Seoul, 05505, South Korea

Contact Phone: •••-•••-••••
Azienda Ospedaliera Ordine Mauriziano di Torino ( Site 2006)
RECRUITING

Torino, 10128, Italy

Contact Phone: •••-•••-••••
Bradfordhill ( Site 0702)
RECRUITING

Santiago, Region M. de Santiago, 8420383, Chile

Contact Phone: •••-•••-••••
CANCER TREAMTENT CLINIC AND CLINICAL TRIALS SA DE CV ( Site 2204)
RECRUITING

Guadalajara, Jalisco, 44260, Mexico

Contact Phone: •••-•••-••••
CHU Strasbourg-Hautepierre ( Site 1207)
RECRUITING

Strasbourg, Alsace, 67098, France

Contact Phone: •••-•••-••••
CIDO SpA-Oncology ( Site 0708)
RECRUITING

Temuco, Araucania, 4810148, Chile

Contact Phone: •••-•••-••••
CIUSSS de l Estrie Centre Hospitalier Universitaire de Sherbrooke ( Site 0604)
RECRUITING

Sherbrooke, Quebec, J1H 5N4, Canada

Contact Phone: •••-•••-••••
CRO-IRCCS ( Site 2014)
RECRUITING

Aviano, Friuli Venezia Giulia, 33081, Italy

Contact Phone: •••-•••-••••
Cancer Institute Hospital of JFCR ( Site 2119)
RECRUITING

Koto, Tokyo, 135-8550, Japan

Contact Phone: •••-•••-••••
Carmel Hospital ( Site 1901)
RECRUITING

Haifa, 3436212, Israel

Contact Phone: •••-•••-••••
Centre Hospitalier de l'Université de Montréal ( Site 0616)
RECRUITING

Montreal, Quebec, H2X 0C1, Canada

Contact Phone: •••-•••-••••
Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0611)
RECRUITING

Québec, Quebec, G1J 1Z4, Canada

Contact Phone: •••-•••-••••
Centro Cancerológico del Caribe (CECAC) ( Site 0906)
RECRUITING

Barranquilla, Atlántico, 080002, Colombia

Contact Phone: •••-•••-••••
Centro de Investigacion Clinica de Oaxaca ( Site 2207)
RECRUITING

Oaxaca City, 68020, Mexico

Contact Phone: •••-•••-••••
Centro de Oncología e Investigación de Buenos Aires ( Site 0107)
RECRUITING

Berazategui, Buenos Aires, B1884BBF, Argentina

Contact Phone: •••-•••-••••
Chang Gung Memorial Hospital ( Site 3302)
RECRUITING

Taoyuan, 333, Taiwan

Contact Phone: •••-•••-••••
Chulalongkorn University ( Site 3403)
RECRUITING

Bangkok, Bangkok, 10330, Thailand

Contact Phone: •••-•••-••••
Clinica Somer ( Site 0903)
RECRUITING

Rionegro, Antioquia, 054040, Colombia

Contact Phone: •••-•••-••••
Cliniques Universitaires Saint-Luc ( Site 0402)
RECRUITING

Brussels, Bruxelles-Capitale, Region de, 1200, Belgium

Contact Phone: •••-•••-••••
Debreceni Egyetem Klinikai Kozpont ( Site 1601)
RECRUITING

Debrecen, 4032, Hungary

Contact Phone: •••-•••-••••
FALP ( Site 0701)
RECRUITING

Santiago, Region M. de Santiago, 7500921, Chile

Contact Phone: •••-•••-••••
Faculty of Medicine Siriraj Hospital ( Site 3401)
RECRUITING

Bangkok, Bangkok, 10700, Thailand

Contact Phone: •••-•••-••••
Fakultni nemocnice Kralovske Vinohrady ( Site 1002)
RECRUITING

Prague, Praha 10, 100 34, Czechia

Contact Phone: •••-•••-••••
Fakultni nemocnice Ostrava ( Site 1005)
RECRUITING

Ostrava, Moravian-Silesian Region, 708 52, Czechia

Contact Phone: •••-•••-••••
Fakultní Nemocnice Brno ( Site 1003)
RECRUITING

Brno, Brno-mesto, 602 00, Czechia

Contact Phone: •••-•••-••••
Florida Cancer Specialists - East ( Site 7000)
RECRUITING

West Palm Beach, Florida, 33401, United States

Contact Phone: •••-•••-••••
Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 2008)
RECRUITING

Milan, Milano, 20133, Italy

Contact Phone: •••-•••-••••
Fondazione Policlinico Universitario Agostino Gemelli IRCCS -Ginecologia Oncologica ( Site 2012)
RECRUITING

Roma, 00168, Italy

Contact Phone: •••-•••-••••
Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto ( Site 0512)
RECRUITING

São José do Rio Preto, São Paulo, 15091-000, Brazil

Contact Phone: •••-•••-••••
Fundación CORI para la Investigación y Prevención del Cáncer ( Site 0111)
RECRUITING

La Rioja, F5300COE, Argentina

Contact Phone: •••-•••-••••
Fundación Respirar ( Site 0101)
RECRUITING

Belgrano, Buenos Aires F.D., C1118AAT, Argentina

Contact Phone: •••-•••-••••
Fundação Pio XII - Hospital de Câncer de Barretos ( Site 0511)
RECRUITING

Barretos, São Paulo, 14784-400, Brazil

Contact Phone: •••-•••-••••
Grand Hopital de Charleroi ( Site 0404)
RECRUITING

Charleroi, Hainaut, 6060, Belgium

Contact Phone: •••-•••-••••
Grupo Médico ASSET ( Site 2203)
RECRUITING

Mexico City, Mexico City, 03100, Mexico

Contact Phone: •••-•••-••••
Gunma Prefectural Cancer Center ( Site 2109)
RECRUITING

Ōta, Gunma, 373-8550, Japan

Contact Phone: •••-•••-••••
Higiea Oncologia ( Site 2205)
RECRUITING

Mexico City, Mexico City, 11819, Mexico

Contact Phone: •••-•••-••••
Hillel Yaffe Medical Center ( Site 1903)
RECRUITING

Hadera, 0038100, Israel

Contact Phone: •••-•••-••••
Hopelands Cancer Centre ( Site 2816)
RECRUITING

Hilton, KwaZulu-Natal, 3245, South Africa

Contact Phone: •••-•••-••••
Hopital Europeen Georges Pompidou ( Site 1210)
RECRUITING

Paris, 75015, France

Contact Phone: •••-•••-••••
Hosp Clinico Universitario de Valencia ( Site 3001)
RECRUITING

Valencia, Valenciana, Comunitat, 46010, Spain

Contact Phone: •••-•••-••••
Hospital Araújo Jorge ( Site 0518)
RECRUITING

Goiânia, Goiás, 74605070, Brazil

Contact Phone: •••-•••-••••
Hospital Provincial del Centenario ( Site 0106)
RECRUITING

Rosario, Santa Fe Province, S2002KDS, Argentina

Contact Phone: •••-•••-••••
Hospital Ramon y Cajal ( Site 3005)
RECRUITING

Madrid, 28034, Spain

Contact Phone: •••-•••-••••
Hospital São Lucas da PUCRS ( Site 0516)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90610-000, Brazil

Contact Phone: •••-•••-••••
Hospital Universitari Vall d Hebron ( Site 3003)
RECRUITING

Barcelona, 08035, Spain

Contact Phone: •••-•••-••••
Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 2202)
RECRUITING

Monterrey, Nuevo León, 64460, Mexico

Contact Phone: •••-•••-••••
Hospital Universitario 12 de Octubre ( Site 3007)
RECRUITING

Madrid, 28041, Spain

Contact Phone: •••-•••-••••
Hospital Universitario La Paz ( Site 3004)
RECRUITING

Madrid, 28046, Spain

Contact Phone: •••-•••-••••
Hospital Universitario Reina Sofia ( Site 3006)
RECRUITING

Córdoba, 14004, Spain

Contact Phone: •••-•••-••••
Hyogo Cancer Center ( Site 2118)
RECRUITING

Akashi, Hyōgo, 673-8558, Japan

Contact Phone: •••-•••-••••
IBCC - Instituto Brasileiro de Controle do Câncer ( Site 0517)
RECRUITING

São Paulo, São Paulo, 04014-002, Brazil

Contact Phone: •••-•••-••••
IC La Serena Research ( Site 0710)
RECRUITING

La Serena, Coquimbo Region, 1720430, Chile

Contact Phone: •••-•••-••••
IRCCS - Istituto Romagnolo per lo Studio dei Tumori (IRST) "Dino Amadori" ( Site 2009)
RECRUITING

Meldola, Forli-Cesena, 47014, Italy

Contact Phone: •••-•••-••••
Institut Català d'Oncologia (ICO) - Girona ( Site 3002)
RECRUITING

Girona, Gerona, 17007, Spain

Contact Phone: •••-•••-••••
Instituto Misionero del Cancer ( Site 0112)
RECRUITING

Posadas, Misiones Province, N3300KAZ, Argentina

Contact Phone: •••-•••-••••
Instituto Nacional De Cancerologia ( Site 0909)
RECRUITING

Bogotá, Bogota D.C., 111511, Colombia

Contact Phone: •••-•••-••••
Instituto Nacional de Câncer - INCA ( Site 0515)
RECRUITING

Rio de Janeiro, 20220-410, Brazil

Contact Phone: •••-•••-••••
Instituto de Investigaciones Clinicas Mar del Plata ( Site 0105)
RECRUITING

Mar del Plata, Buenos Aires, B7600FZO, Argentina

Contact Phone: •••-•••-••••
Instituto de Oncologia de Rosario ( Site 0104)
RECRUITING

Rosario, Santa Fe Province, S2000KZE, Argentina

Contact Phone: •••-•••-••••
Irmandade da Santa Casa de Misericordia de Porto Alegre ( Site 0514)
RECRUITING

Porto Alegre, Rio Grande do Sul, 90020-090, Brazil

Contact Phone: •••-•••-••••
Istituto Europeo di Oncologia ( Site 2003)
RECRUITING

Milan, 20141, Italy

Contact Phone: •••-•••-••••
Iwate Medical University Hospital ( Site 2116)
RECRUITING

Shiwa-gun, Iwate, 028-3695, Japan

Contact Phone: •••-•••-••••
Kanagawa Cancer Center ( Site 2121)
RECRUITING

Yokohama, Kanagawa, 241-8515, Japan

Contact Phone: •••-•••-••••
Karolinska Universitetssjukhuset-Solna ( Site 3102)
RECRUITING

Stockholm, Stockholm County, 171 64, Sweden

Contact Phone: •••-•••-••••
Kurume University Hospital ( Site 2112)
RECRUITING

Kurume, Fukuoka, 830-0011, Japan

Contact Phone: •••-•••-••••
Laura and Isaac Perlmutter Cancer Center at NYU Langone ( Site 6009)
RECRUITING

New York, New York, 10016, United States

Contact Phone: •••-•••-••••
Liga Norte Riograndense Contra o Câncer ( Site 0513)
RECRUITING

Natal, Rio Grande do Norte, 59062-000, Brazil

Contact Phone: •••-•••-••••
Linköping University Hospital ( Site 3101)
RECRUITING

Linköping, Östergötland County, 581 85, Sweden

Contact Phone: •••-•••-••••
Mackay Memorial Hospital ( Site 3303)
RECRUITING

Taipei, 10449, Taiwan

Contact Phone: •••-•••-••••
Maharaj Nakorn Chiang Mai Hospital ( Site 3402)
RECRUITING

Chiang Mai, 50200, Thailand

Contact Phone: •••-•••-••••
Mater Misercordiae University Hospital ( Site 1804)
RECRUITING

Dublin, D07 R2WY, Ireland

Contact Phone: •••-•••-••••
Mazowiecki Szpital Wojewódzki w Siedlcach ( Site 2601)
RECRUITING

Siedlce, Warmian-Masurian Voivodeship, 08-110, Poland

Contact Phone: •••-•••-••••
McGill University Health Centre ( Site 0602)
RECRUITING

Montreal, Quebec, H4A 3J1, Canada

Contact Phone: •••-•••-••••
Medizinische Universitaet Innsbruck ( Site 0301)
RECRUITING

Innsbruck, Tyrol, 6020, Austria

Contact Phone: •••-•••-••••
Medizinische Universitaet Wien ( Site 0302)
RECRUITING

Vienna, State of Vienna, 1090, Austria

Contact Phone: •••-•••-••••
Medizinische Universitat Graz ( Site 0303)
RECRUITING

Graz, Styria, 8036, Austria

Contact Phone: •••-•••-••••
Minnesota Oncology Hematology, PA ( Site 8003)
RECRUITING

Edina, Minnesota, 55435, United States

Contact Phone: •••-•••-••••
Mount Sinai Comprehensive Cancer Center ( Site 6000)
RECRUITING

Miami Beach, Florida, 33140, United States

Contact Phone: •••-•••-••••
Nancy N. & J.C. Lewis Cancer and Research Pavillion - Research Department ( Site 6005)
RECRUITING

Savannah, Georgia, 31405, United States

Contact Phone: •••-•••-••••
Narodowy Instytut Onkologii - Oddzial w Gliwicach-III Klinika Radioterapii i Chemioterapii ( Site 2604)
RECRUITING

Gliwice, Silesian Voivodeship, 44-102, Poland

Contact Phone: •••-•••-••••
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - Panstwowy Instytut Badawczy w Warszawie ( Site 2605)
RECRUITING

Warsaw, Masovian Voivodeship, 02-781, Poland

Contact Phone: •••-•••-••••
National Cancer Center ( Site 2905)
RECRUITING

Goyang-si, Kyonggi-do, 10408, South Korea

Contact Phone: •••-•••-••••
National Cheng Kung University Hospital ( Site 3308)
RECRUITING

Tainan, 704, Taiwan

Contact Phone: •••-•••-••••
National Hospital Organization Hokkaido Cancer Center ( Site 2108)
RECRUITING

Sapporo, Hokkaido, 003-0804, Japan

Contact Phone: •••-•••-••••
National Hospital Organization Kyushu Cancer Center ( Site 2102)
RECRUITING

Fukuoka, 811-1395, Japan

Contact Phone: •••-•••-••••
National Taiwan University Hospital ( Site 3301)
RECRUITING

Taiwan, Taipei, 10002, Taiwan

Contact Phone: •••-•••-••••
Nemocnice AGEL Novy Jicin a.s. ( Site 1004)
RECRUITING

Nový Jičín, Moravian-Silesian Region, 741 01, Czechia

Contact Phone: •••-•••-••••
Niigata Cancer Center Hospital ( Site 2110)
RECRUITING

Niigata, 951-8566, Japan

Contact Phone: •••-•••-••••
ONCOCENTRO APYS-ACEREY ( Site 0703)
RECRUITING

Viña del Mar, Valparaiso, 2520598, Chile

Contact Phone: •••-•••-••••
Okayama University Hospital ( Site 2101)
RECRUITING

Okayama, 700-8558, Japan

Contact Phone: •••-•••-••••
Oklahoma Cancer Specialists and Research Institute, LLC ( Site 6001)
RECRUITING

Tulsa, Oklahoma, 74146, United States

Contact Phone: •••-•••-••••
Oncology Associates of Oregon, P.C.(Willamette Valley Cancer Institute) (WVCI) ( Site 8007)
RECRUITING

Eugene, Oregon, 97401, United States

Contact Phone: •••-•••-••••
Oncomédica S.A.S ( Site 0905)
RECRUITING

Montería, Departamento de Córdoba, 230002, Colombia

Contact Phone: •••-•••-••••
Oncólogos del Occidente S.A.S. ( Site 0908)
RECRUITING

Pereira, Risaralda Department, 660001, Colombia

Contact Phone: •••-•••-••••
Országos Onkológiai Intézet ( Site 1603)
RECRUITING

Budapest, 1122, Hungary

Contact Phone: •••-•••-••••
Osaka Prefectural Hospital Organization Osaka International Cancer Institute ( Site 2111)
RECRUITING

Osaka, 541-8567, Japan

Contact Phone: •••-•••-••••
Ospedale Cannizzaro ( Site 2010)
RECRUITING

Catania, 95126, Italy

Contact Phone: •••-•••-••••
Ospedale Humanitas San Pio X ( Site 2013)
RECRUITING

Milan, Lombardy, 20159, Italy

Contact Phone: •••-•••-••••
Pontificia Universidad Catolica de Chile-CICUC ( Site 0706)
RECRUITING

Santiago, Region M. de Santiago, 8330073, Chile

Contact Phone: •••-•••-••••
Princess Margaret Cancer Centre ( Site 0601)
RECRUITING

Toronto, Ontario, M5G 2M9, Canada

Contact Phone: •••-•••-••••
Rabin Medical Center ( Site 1904)
RECRUITING

Petah Tikva, 4941492, Israel

Contact Phone: •••-•••-••••
Ramathibodi Hospital ( Site 3404)
RECRUITING

Bangkok, Bangkok, 10400, Thailand

Contact Phone: •••-•••-••••
Rambam Health Care Campus ( Site 1907)
RECRUITING

Haifa, 3109601, Israel

Contact Phone: •••-•••-••••
Saitama Medical University International Medical Center ( Site 2106)
RECRUITING

Hidaka, Saitama, 350-1298, Japan

Contact Phone: •••-•••-••••
Samsung Medical Center ( Site 2903)
RECRUITING

Seoul, 06351, South Korea

Contact Phone: •••-•••-••••
Scientia Investigacion Clinica S.C. ( Site 2201)
RECRUITING

Chihuahua City, 31207, Mexico

Contact Phone: •••-•••-••••
Seoul National University Hospital ( Site 2901)
RECRUITING

Jongno-gu, Seoul, 03080, South Korea

Contact Phone: •••-•••-••••
Severance Hospital Yonsei University Health System ( Site 2902)
RECRUITING

Seodaemun-Gu, Seoul, 03722, South Korea

Contact Phone: •••-•••-••••
Shaare Zedek Medical Center ( Site 1905)
RECRUITING

Jerusalem, 9103102, Israel

Contact Phone: •••-•••-••••
Shizuoka Cancer Center ( Site 2104)
RECRUITING

Sunto-gun,, Shizuoka, 411-8777, Japan

Contact Phone: •••-•••-••••
Skanes Universitetssjukhus Lund ( Site 3103)
RECRUITING

Lund, Skåne County, 22242, Sweden

Contact Phone: •••-•••-••••
Sourasky Medical Center ( Site 1902)
RECRUITING

Tel Aviv, 6423906, Israel

Contact Phone: •••-•••-••••
Sunnybrook Research Institute ( Site 0605)
RECRUITING

Toronto, Ontario, M4N 3M5, Canada

Contact Phone: •••-•••-••••
Swietokrzyskie Centrum Onkologii. ( Site 2602)
RECRUITING

Kielce, Świętokrzyskie Voivodeship, 25-734, Poland

Contact Phone: •••-•••-••••
TRIALS 365 ( Site 6008)
RECRUITING

Shreveport, Louisiana, 71103, United States

Contact Phone: •••-•••-••••
Taichung Veterans General Hospital ( Site 3304)
RECRUITING

Taichung, 40705, Taiwan

Contact Phone: •••-•••-••••
Texas Oncology - DFW ( Site 8005)
RECRUITING

Fort Worth, Texas, 76104, United States

Contact Phone: •••-•••-••••
Texas Oncology - Northeast Texas ( Site 8002)
RECRUITING

Tyler, Texas, 75702, United States

Contact Phone: •••-•••-••••
Texas Oncology-The Woodlands ( Site 8000)
RECRUITING

The Woodlands, Texas, 77380, United States

Contact Phone: •••-•••-••••
The Christie Hospital NHS Foundation Trust ( Site 3602)
RECRUITING

Withington, Manchester, M20 4BX, United Kingdom

Contact Phone: •••-•••-••••
The Jikei University Hospital ( Site 2107)
RECRUITING

Minato, Tokyo, 105-8471, Japan

Contact Phone: •••-•••-••••
UZ Gent ( Site 0406)
RECRUITING

Ghent, Oost-Vlaanderen, 9000, Belgium

Contact Phone: •••-•••-••••
UZ Leuven ( Site 0401)
RECRUITING

Leuven, Vlaams-Brabant, 3000, Belgium

Contact Phone: •••-•••-••••
Uniklinikum Salzburg Landeskrankenhaus ( Site 0304)
RECRUITING

Salzburg, 5020, Austria

Contact Phone: •••-•••-••••
University of Tennessee Medical Center ( Site 6012)
RECRUITING

Knoxville, Tennessee, 37920, United States

Contact Phone: •••-•••-••••
University of Virginia Cancer Center ( Site 6014)
RECRUITING

Charlottesville, Virginia, 22908, United States

Contact Phone: •••-•••-••••
University of the Ryukyus Hospital ( Site 2117)
RECRUITING

Ginowan, Okinawa, 901-2725, Japan

Contact Phone: •••-•••-••••
Vseobecna fakultni nemocnice v Praze-Gynekologicko-porodnicka klinika 1.LF a VFN ( Site 1001)
RECRUITING

Prague, 128 08, Czechia

Contact Phone: •••-•••-••••
Winship Cancer Institute of Emory University ( Site 5005)
RECRUITING

Atlanta, Georgia, 30308, United States

Contact Phone: •••-•••-••••
Women & Infants Hospital ( Site 6003)
RECRUITING

Providence, Rhode Island, 02905, United States

Contact Phone: •••-•••-••••
Women's Cancer Center of Nevada ( Site 6011)
RECRUITING

Las Vegas, Nevada, 89106, United States

Contact Phone: •••-•••-••••