Can a common breast cancer drug slow uterine sarcoma?
NCT ID NCT05649956
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial tests whether the drug letrozole can extend the time before uterine leiomyosarcoma returns after initial treatment. About 40 women with early-stage disease will be randomly assigned to take letrozole daily or to be observed without treatment. The main goal is to see if letrozole improves progression-free survival.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- letrozole
- What this could lead to
- If it works, this could offer a way to delay cancer recurrence after initial treatment for uterine leiomyosarcoma.
- What could go wrong
- This is a small early-phase trial with only 40 participants, so results may not apply broadly. Letrozole may not improve outcomes and could have side effects.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Locations
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Asplundh Cancer Pavilion
RECRUITINGWillow Grove, Pennsylvania, 19090, United States
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Atlantic Health System
RECRUITINGMorristown, New Jersey, 07960, United States
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Broward Health Medical Center
RECRUITINGFort Lauderdale, Florida, 33316, United States
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East Carolina University Health Medical Center
RECRUITINGGreenville, North Carolina, 27834, United States
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Endeavor Health - Kellogg Cancer Center
RECRUITINGEvanston, Illinois, 60201, United States
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Highlands Ranch Hospital
RECRUITINGHighlands Ranch, Colorado, 80129, United States
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Indiana University Melvin and Bren Simon Comprehensive Cancer Center
RECRUITINGIndianapolis, Indiana, 46202, United States
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LSU Health Sciences Center
RECRUITINGNew Orleans, Louisiana, 70112, United States
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Mount Sinai Comprehensive Cancer Center
RECRUITINGMiami Beach, Florida, 33140, United States
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OhioHealth Arthur G.H. Bing, MD Cancer Center
RECRUITINGColumbus, Ohio, 43214, United States
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OhioHealth Grant Medical Center
RECRUITINGColumbus, Ohio, 43215, United States
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OhioHealth Marion General Hospital
RECRUITINGMarion, Ohio, 43302, United States
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OhioHealth Research Institute
RECRUITINGColumbus, Ohio, 43214, United States
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OhioHealth Riverside Methodist Hospital
RECRUITINGColumbus, Ohio, 43214, United States
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Overlook Medical Center
RECRUITINGSummit, New Jersey, 07901, United States
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University of Colorado Cancer Center - Anschutz Cancer Pavilion
RECRUITINGAurora, Colorado, 80045, United States
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University of Massachusetts Memorial Medical Center
RECRUITINGWorcester, Massachusetts, 01605, United States
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University of Minnesota
RECRUITINGMinneapolis, Minnesota, 55455, United States
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University of New Mexico Comprehensive Cancer Center
RECRUITINGAlbuquerque, New Mexico, 87131, United States
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University of Oklahoma Health Stephenson Cancer Center
RECRUITINGOklahoma City, Oklahoma, 73104, United States
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WK Physician Network-Gynecologic Oncology Associates
RECRUITINGShreveport, Louisiana, 71103, United States
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Winship Cancer Institute, Emory Hospital
RECRUITINGAtlanta, Georgia, 30322, United States
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Woman and Infants Hospital of Rhode Island
RECRUITINGProvidence, Rhode Island, 02905, United States
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Women's Cancer Center of Nevada
RECRUITINGLas Vegas, Nevada, 89106, United States
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Women's Cancer Center of Nevada
RECRUITINGLas Vegas, Nevada, 89511, United States
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