Obesity disorder

This early-stage study tests the safety and tolerability of a new injectable drug called LAE103 in healthy overweight or obese adults, and in healthy postmenopausal women. Researchers will also test LAE103 combined with another drug, LAE102. The goal is to find out if the drug is…

This study is testing different amounts of behavioral coaching for 900 children aged 5-17 with obesity. Kids and their caregivers are randomly assigned to receive between 13 and 26 hours of lifestyle coaching over six months, including nutrition advice, web-based learning, and co…

This study tests whether patients can safely go home within 6 hours of bariatric surgery instead of staying overnight. 200 adults with obesity will be randomly assigned to same-day discharge or overnight stay. The main goal is to see how many need emergency care within a week.

This study tests whether mobile health technology, like smartphone apps and activity trackers, can help overweight or obese African American women increase their physical activity. Participants will wear a wrist device to track steps and sleep, use a study app, and may receive co…

This study tests whether a weekly injection of semaglutide (a drug used for weight loss and diabetes) can help adults with overweight or obesity avoid gaining weight after they stop smoking. About 197 participants will also use nicotine patches to help them quit. The goal is to s…

This study tests whether a weekly injection of semaglutide (a GLP-1 drug used for obesity) can improve the brain's reproductive hormone signals in obese adolescent girls with polycystic ovary syndrome (PCOS). Twenty girls aged 12–18 will receive the drug plus lifestyle advice for…

This clinical trial is testing an experimental drug called ABBV-295 to see if it can help adults with obesity or overweight lose weight. The study will compare different doses of the drug against a placebo (a dummy injection) to measure its effect on body weight over 32 weeks. Pa…

This trial tests whether adding resistance training (like weight lifting) to the weight-loss drug tirzepatide helps preserve thigh muscle in adults with obesity. Participants will receive tirzepatide and either a structured exercise program or usual care. The main goal is to see …

This trial tests whether elénzia CONTROL®, a dietary supplement, can support weight management in adults who have either never used GLP-1 weight-loss medications or recently stopped them. Participants take two capsules daily for 16 weeks, and researchers compare weight changes ag…

Researchers are testing a 12-week online program that teaches adults with type 2 diabetes and excess weight to follow a low-fat vegan diet. Participants meet weekly with a physician and a registered dietitian for education and support. The team measures body composition, blood su…

This study tests an experimental drug called ALN-2232, given alone or together with the approved weight-loss drug tirzepatide, in 156 adults with obesity. The goal is to see if the combination is safe and leads to more weight loss than either drug alone. Participants will receive…

This study tests an experimental oral drug called ecnoglutide in 84 Chinese adults who are overweight or obese. The main goal is to check safety and how the body processes the drug, while also measuring weight changes. Participants take either the drug or a placebo daily for seve…

Researchers are testing a new once-weekly injection called NNC0487-0111 in about 400 Japanese adults with overweight or obesity. Half the participants receive the drug and half receive a placebo, assigned by chance. The main goal is to measure how much body weight changes over th…

This trial is testing an experimental once-daily pill called ASC30 in adults who are overweight or have obesity and also have type 2 diabetes. The study aims to see if ASC30 can help with long-term weight loss and improve blood sugar control compared to a placebo. Participants wi…

This Phase 3 trial is testing an experimental once-daily oral medication called ASC30 in adults with obesity or overweight who also have weight-related health conditions like high blood pressure or sleep apnea. The study aims to see if ASC30 can lead to significant weight loss ov…

This study is testing a new approach for people with obesity and type 2 diabetes. It combines two procedures done through the mouth: one uses mild electric pulses to regenerate the lining of the upper intestine, and the other reduces stomach size by stitching it like a sleeve. Th…

This phase 3 trial tests whether maridebart cafraglutide (MariTide) can reduce heart failure events like hospitalizations and urgent visits in people with obesity and a specific type of heart failure (preserved or mildly reduced ejection fraction). About 5,056 participants will r…

This study is testing a new single-port robot to help perform weight loss surgery in 50 overweight or obese adults. The goal is to see if the robot makes the surgery safer and more effective, while also reducing surgeon fatigue. Participants must have a BMI of 27.5 or higher and …

This study tests whether a wearable device and AI app can help obese adults lose more weight than standard diet and exercise alone. About 120 participants will follow a 6-month program with coaching and tracking. The goal is to see if technology boosts weight loss and improves he…

This pilot study tests a temporary, flexible tube called a duodenal-jejunal bypass sleeve. It is placed in the upper intestine using an endoscope and left for 3 months to help with weight loss and improve metabolic syndrome. The study involves 20 adults with obesity or excess wei…

This study tests whether a low dose of the weight-loss drug mazdutide, an intensive lifestyle program, or both can help people with obesity maintain weight loss for a year after initially losing weight with a higher drug dose. About 420 adults with a BMI between 28 and 45 will ta…

This study looks at how exercise and eating more fruits and vegetables affect the heart and metabolic health of 120 teens aged 13–17 with obesity. Participants will be split into four groups: standard care, exercise only, diet only, or both exercise and diet. Over 12 weeks, resea…

Researchers are testing a new oral drug called ACCG-2671 to see if it is safe and how the body processes it. The trial includes healthy volunteers and people with obesity, some of whom are already taking a GLP-1 drug for weight loss. Participants will receive either ACCG-2671 or …

This Phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 1600 people who are obese or overweight and also have type 2 diabetes. The drug works by mimicking natural hormones that help control appetite and blood sugar. Participants will receive eit…

This study tests whether giving free summer day camp vouchers to low-income children with overweight or obesity can help them manage their weight. Eighty children aged 5-11 who are on Medicaid will be randomly assigned to either receive a voucher for an 8-week summer day camp or …

This study tests whether a dietary supplement made from omega-3 fatty acids (called SPM) can reduce blood vessel damage caused by inflammation in people with obesity and high blood pressure. Researchers will give 60 participants either the supplement or a placebo for 12 weeks and…

This phase 3 trial is testing a new weekly injection called enicepatide for weight loss in 2000 adults with obesity or overweight who do not have type 2 diabetes. Participants will receive either the drug or a placebo for 72 weeks. The main goal is to see how much weight they los…

This early-stage trial tests an investigational oral medicine called IBI3042, which is being developed as a potential treatment for overweight and obesity. The study has two parts: Part A gives a single dose to healthy adults, while Part B gives repeated doses over 13 weeks to ad…

This study tests whether the drug lumateperone can improve mood and reduce inflammation in adults with bipolar depression who also have obesity. Over about six weeks, participants take lumateperone daily and undergo mood assessments and an MRI to estimate brain age. The goal is t…

This study tests whether tirzepatide, a drug used for weight loss and diabetes, can slow tumor growth in people with obesity-driven endometrial cancer. About 20 participants will take the drug before their scheduled hysterectomy. Researchers will compare cancer cell activity in t…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who do not use a CPAP machine. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Par…

This phase 3 study tests aleniglipron, an oral medication taken once daily, for helping adults with obesity or overweight and type 2 diabetes manage their weight over the long term. Participants receive either aleniglipron or a placebo for 76 weeks. The main goal is to see how mu…

This study tests whether adding a digital behavioral tool called Evira to standard obesity medication (liraglutide or semaglutide) helps teens with obesity lose more weight than medication alone. Forty adolescents aged 12-17 will be randomly assigned to either the combination or …

This phase 3 trial is testing a once-weekly injection called enicepatide in 300 Chinese adults who are obese or overweight, with or without type 2 diabetes. The drug works by mimicking two gut hormones to reduce appetite and improve blood sugar control. Participants will receive …

This study tracks 200 adults with obesity in the EU who choose to get the Orbera365 intragastric balloon. The balloon is placed in the stomach and filled with saline to help people feel full and eat less. Researchers will monitor serious side effects and how much weight participa…

This study looks at whether people who take GLP-1 receptor agonists (like Ozempic or Wegovy) should continue them after having bariatric surgery. Researchers will compare weight loss, blood sugar control, gut health, and hunger in 150 adults who either keep taking the drug or sto…

Researchers test a device called the ENDOPLY System that folds the stomach through an endoscope, without surgery. The study enrolls 10 adults with class I or II obesity who have tried multiple diets. Doctors measure how long the procedure takes, how many folds they place, and whe…

Researchers are testing a combination of a gonadotropin-releasing hormone agonist injection and the drug letrozole in obese women with early-stage endometrial cancer that has not responded to progestin. The goal is to see if this hormone-blocking approach can shrink tumors and al…

This phase 3 trial is testing whether an experimental drug called AZD6234, given as a weekly injection, can help adults with obesity or overweight lose more weight when added to their current incretin-based therapy. The study includes about 500 participants who either have type 2…

This trial investigates an experimental drug called GUB-UCN2 for people with obesity and type 2 diabetes. The study includes healthy volunteers and those with the conditions, testing the drug alone or alongside standard care. The main goal is to check safety and how the drug beha…

This phase 2 trial tests whether tirzepatide, a drug used for diabetes and weight loss, can reduce binge-eating episodes and help with weight loss in adults with obesity and binge-eating disorder. About 105 participants will receive tirzepatide, a placebo, or the existing drug li…

This study tests a once-weekly injection called NNC0487-0111 in 300 adults with overweight or obesity and moderate-to-severe obstructive sleep apnea who use a breathing device. The goal is to see if the drug helps with weight loss and reduces breathing pauses during sleep. Partic…

This study looks at whether eating cottonseed oil just three times a week can help lower cholesterol and reduce heart disease risk. Researchers will give 75 overweight or at-risk adults meal replacement shakes with different amounts of cottonseed oil for 56 days. They will measur…

This early-stage trial tests a new drug called AZD1043 in 104 healthy adults who are overweight or obese. The goal is to check the drug's safety and how the body processes it. Participants receive either the drug or a placebo by injection. The study includes people of Japanese an…

This Phase 3 trial is investigating whether lower doses of oral semaglutide can help adults with overweight or obesity lose weight. Participants will take either the medication or a placebo daily, and researchers will measure the percentage change in body weight. The goal is to f…

This study tests whether the drug tirzepatide, given once weekly, helps adults with obesity (but without diabetes) lose weight and avoid developing type 2 diabetes. About 3,000 participants will receive either tirzepatide or standard care for up to 5 years. The goal is to see if …

This trial asks whether two different ways of giving survodutide—a pre-filled syringe and a vial—deliver the same amount of drug into the body. It involves healthy adults or those who are overweight or obese, aged 18 to 55. Each participant receives a single dose of both forms at…

This phase 3 trial is testing a new daily pill called elecoglipron for weight loss in 4500 adults who are obese or overweight, with or without type 2 diabetes. Participants will take the pill or a placebo for 72 weeks, alongside diet and exercise. The main goal is to see how much…

This phase 3 trial tests a weekly injection called eloralintide in 800 adults with moderate-to-severe obstructive sleep apnea who are also overweight or have obesity. The study looks at whether the drug can improve sleep apnea symptoms and help with weight loss. Participants are …

This Phase 2 trial is testing several experimental drugs—including tirzepatide and others—for long-term weight management in adults with obesity or overweight. About 1,481 participants will receive one of the drugs or a placebo. The goal is to see if these treatments are safe and…

This study tests a new weekly injection called eloralintide in 900 adults with obesity or overweight who are already taking a weekly incretin drug (like Ozempic or Wegovy) but still have excess weight. Participants will receive either eloralintide or a placebo for about 80 weeks …

This study tests two experimental drugs, macupatide and eloralintide, alone or together, to help adults with obesity or overweight and type 2 diabetes lose weight. About 200 participants will receive the drugs or a placebo for 48 weeks. The main goal is to see how much weight the…

This study tests a new once-weekly medicine called eloralintide to help people with obesity or overweight and type 2 diabetes lose weight. About 1035 adults will receive either the drug or a placebo for around 75 weeks. Researchers will measure changes in body weight, fat, waist …

This pilot study asks whether adding daily protein shakes, with or without a blend of culinary spices, can help adults on GLP-1 medications keep their muscle mass and strength while losing weight. Researchers will enroll 75 adults who recently started a GLP-1 drug and are losing …

This early-stage trial tests an investigational drug called MWN105, given as a weekly injection for 8 weeks, in Chinese adults who are overweight or obese but do not have diabetes. The study aims to see if the drug is safe and tolerable, and how it moves through the body. Partici…

This trial tests whether a daily synbiotic supplement, which combines prebiotics and beneficial bacteria, can improve gut health and mental well-being in people with obesity. Researchers will give 120 adults with a BMI between 30 and 40 either the supplement or a placebo for 12 w…

This study tests a digital program for overweight teens aged 12-18 that uses AI coaching, games, and real-time feedback to encourage healthy eating and exercise. Two hundred participants will either use the digital program or receive standard health education for three months. Th…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This early-stage trial is investigating whether an experimental drug called NNC0721-8060 is safe and how it works in adults with overweight or obesity. Participants will receive either the new drug, a placebo, or an existing weight-management medication (semaglutide) via injectio…

This clinical trial is testing an investigational medicine called cagrilintide to see how well it helps people with overweight or obesity lose weight. Participants will receive either cagrilintide or a placebo (an inactive substance) by injection, and their weight change will be …

This pilot study tests whether tirzepatide, a drug already used for type 2 diabetes and obesity, can improve markers of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in people with obesity. Eight participants will take tirzepatide for 12 months and undergo bloo…

This phase 3 trial tests whether adding tirzepatide (a weight-loss drug) to mirikizumab (an anti-inflammatory drug) helps people with moderate-to-severe ulcerative colitis who are also overweight or obese. The goal is to see if the combination can reduce both gut symptoms and bod…

This study is testing whether adding the weight-loss drug tirzepatide to the standard psoriasis medication ixekizumab helps people with moderate-to-severe plaque psoriasis who are also overweight or obese. About 200 adults will receive tirzepatide injections for up to 12 months. …

This study tests whether adding the weight-loss drug tirzepatide to the Crohn's drug mirikizumab helps people with moderate-to-severe Crohn's disease who are also overweight or have obesity. About 290 adults will receive either mirikizumab alone or mirikizumab plus tirzepatide. T…

This study tests a once-weekly injection called NNC0487-0111 in 630 adults who are overweight or obese and have type 2 diabetes. Participants receive either the active drug or a placebo for about a year. The main goal is to see how much weight they lose, with additional checks on…

This study tests whether a weekly injection of tirzepatide, combined with healthy eating and exercise, helps adolescents with obesity and related conditions like high blood pressure or prediabetes lose weight and improve their health. About 300 teens who completed a prior study c…

This Phase 3 trial tests a new drug called KAI-9531, given as a weekly injection, in 1700 adults who are overweight or obese and have type 2 diabetes. The study compares KAI-9531 to a placebo to see if it leads to greater weight loss and better blood sugar control over 76 weeks. …

This study tests a new weekly injection called KAI-9531 to help people with obesity or overweight lose weight. It is for adults who do not have diabetes but have weight-related health problems like high blood pressure or sleep apnea. About 1800 participants will receive either th…

This early-stage trial tests a new drug called ALN-6222 in 88 adults with obesity (BMI 30-40). Participants receive a single injection of either the drug or a placebo. The main goal is to check safety and how the body processes the drug, not weight loss. It is the first time this…

This phase 3 study is testing whether a new drug called maridebart cafraglutide (MariTide) can reduce the risk of heart attacks, strokes, and death in people with heart disease who are overweight or obese. About 12,800 participants will receive either the drug or a placebo, added…

This study looks at whether a 12-week structured diet and exercise plan can help adults aged 50 and older with obesity and insulin resistance lose fat and improve muscle function. Participants will receive all meals and exercise three times a week under supervision. The goal is t…

This study compares two lifestyle programs for people with type 2 diabetes or prediabetes: one using a ketogenic diet and the other a low-fat diet. Over 12 months, researchers will track changes in weight, blood sugar, blood pressure, and heart health. The goal is to see which di…

This phase 3 trial tests whether the drug maridebart cafraglutide (MariTide) can help people with obesity or overweight lose weight and keep it off over the long term. Participants who completed an earlier trial will receive either the drug or a placebo. The study measures weight…

This study tests a 'Food as Medicine' program for 250 children aged 8-15 who are at risk for chronic diseases like obesity. Families get help from a community health worker who sets nutrition goals and connects them to healthy food resources. The goal is to see if this improves d…

This study tests a drug called maridebart cafraglutide (MariTide) in people who are overweight or obese and also have type 2 diabetes. The goal is to see if the drug can help with long-term weight loss and blood sugar control, and to check its safety over time. Participants recei…

This trial tests whether a 12-week Nordic walking program, which uses poles to engage more muscles and burn more calories than regular walking, improves cardiovascular fitness in overweight or obese adults with type 2 diabetes and recent heart problems. Participants are randomly …

This trial investigates whether an investigational drug called NNC0487-0111, given as a once-weekly injection, can change how much energy the body uses in adults with overweight or obesity. It compares the drug against a low-calorie diet and a placebo, focusing on metabolic rates…

This study aims to help overweight or obese taxi and ride-share drivers lose weight through a combination of counseling, text messages, phone support, and self-monitoring tools. Researchers will enroll about 1,785 drivers in New York City to find out which parts of the program wo…

This study tests whether restarting semaglutide (Wegovy) just two weeks after sleeve gastrectomy helps teens with severe obesity lose more weight than surgery alone. About 150 teens aged 12–18 who were already on semaglutide before surgery will be randomly assigned to restart the…

This study tests whether empagliflozin, a drug used for diabetes, can reduce chronic inflammation in people with obesity and metabolic syndrome. Researchers will measure immune cells and blood vessel function in 74 adults. The goal is to find a new way to lower heart disease risk…

This early-stage trial tests an experimental oral drug, NNC6022-0004, in healthy adults and people with obesity. The study checks how safe the drug is, how the body processes it, and whether food affects its absorption. Participants receive either the drug or a placebo capsule by…

This trial tests whether high-intensity interval training (HIIT) on a stationary bike, done under low-oxygen conditions that mimic an altitude of 3,000 meters, reduces belly fat more than the same exercise in normal air. Researchers will enroll 32 adults aged 50-75 with overweigh…

This phase 2 trial tests whether adding an experimental drug called AT673 to the standard diabetes medication semaglutide leads to greater weight loss and better blood sugar control in adults with type 2 diabetes who are overweight or obese. Participants receive either a low or h…

This study tests a new weekly injection called KAI-9531 to help people with obesity lose weight. It involves 1,200 adults who do not have diabetes and compares KAI-9531 to semaglutide (a known weight-loss drug) and a placebo. The main goal is to see how much weight participants l…

This study tests whether a virtual weight management program that includes a support person (like a family member or friend) helps Veterans with obesity lose weight. 320 Veterans and their partners will participate in 8 virtual sessions over 14 weeks. The main goal is to see if t…

This trial compares two surgical techniques used during one-anastomosis gastric bypass for severe obesity. One method sets the length of the bypassed intestine based on the patient's measured total small bowel length, while the other uses standard lengths based on body mass index…

This early-stage study tests an experimental drug called LY4174794 in 108 healthy volunteers who are overweight or have obesity. The main goal is to check the drug's safety and how the body processes it, not to measure weight loss. Participants will receive either the drug or a p…

This trial tests whether obese patients with endometrial cancer or a precancerous condition can safely undergo a hysterectomy and weight loss surgery at the same time. Researchers want to see if a fast-track referral process can get patients to surgery within 8 to 12 weeks of dia…

This trial tests whether semaglutide, a drug used for diabetes and weight loss, can help restore ovulation in girls and women aged 12 to 35 with polycystic ovary syndrome (PCOS) and obesity. Participants receive semaglutide for 10 months, with doses increased over time. Researche…

This study tests two drugs, cagrilintide and semaglutide (alone or together as CagriSema), to help children and adolescents with overweight or obesity lose weight. About 460 participants will receive either the drugs or a placebo for up to 5 years. The main goal is to see how muc…

This study tests whether mirabegron (a bladder medication) and tadalafil (used for erectile dysfunction) can improve blood sugar control in people with prediabetes and obesity. About 96 adults will take one or both drugs or a placebo for 14 weeks. The goal is to see if these drug…

This Phase 3 study tests whether a new drug called CagriSema helps people with severe obesity (with or without type 2 diabetes) lose more weight than the existing drug semaglutide. About 2,500 participants will receive either CagriSema or semaglutide for 83 weeks. The main goal i…

This phase 3 trial is testing whether an experimental once-daily tablet called elecoglipron can help Asian adults with obesity or overweight lose weight, when combined with diet and exercise. The study includes people with or without type 2 diabetes. Participants will receive eit…

This clinical trial is testing an experimental drug called AZD6234, given as a weekly injection, to see if it can help adults with obesity or overweight lose weight. The study will compare the drug against a placebo (a dummy injection) to measure the change in body weight over 68…

This study compares two approaches for adults with severe obesity: an intensive non-surgical program (meal replacements, behavior support, and weight-loss medication) versus bariatric surgery. Researchers will track 500 participants to see which method better improves health and …

This study tests whether a structured, multidisciplinary obesity care program—which may include the weight-loss drug semaglutide—helps adults with obesity lose more weight than usual care. Adults aged 18-65 with a BMI of 30 or higher will be followed for 18 months to see if they …

This pilot study tests whether a 12-week diet that includes at least one daily serving of lean beef, as part of a healthy meal plan, can improve blood sugar control in adolescent girls with PCOS. Participants will receive nutrition counseling and free beef, and researchers will m…

This study tests a new once-weekly injection called eloralintide to help adults with obesity or overweight lose weight. About 1980 people who do not have type 2 diabetes will take part for up to 75 weeks, with some continuing for 2 more years. The goal is to see if the drug safel…

This European trial tests a 24-week lifestyle program for 400 night-shift workers. The program, delivered via a mobile app and workshops, focuses on sleep, stress, diet, and exercise. The goal is to see if it helps workers sleep longer and improve their health.

This trial tests whether a personalized diet and exercise plan during the first month of chemotherapy can make leukemia cells more sensitive to treatment in older children, adolescents, and young adults with B-cell acute lymphoblastic leukemia (B-ALL). The study also aims to redu…

This study tests a new medicine called NNC0487-0111 in about 5,600 people who have both heart failure and obesity. Participants receive either the drug or a placebo as a weekly injection. The goal is to see if the drug reduces the risk of heart failure worsening, hospitalization,…

This trial tests a fully digital program that combines a virtual coach for depression with a video-based weight loss plan. It aims to help racial and ethnic adults aged 50 and older who have both obesity and depression. Participants are randomly assigned to start the program imme…

This study investigates whether a 16-week course of a probiotic supplement can increase feelings of fullness (satiety) and alter the composition of gut bacteria in healthy adults aged 20–70 with a BMI of 25 or higher. Participants take either the probiotic or a placebo daily and …

This trial tests whether taking inulin, a type of dietary fiber, for two weeks can improve cardiovascular health, muscle function, and the balance of gut and vaginal bacteria in perimenopausal women who are overweight or have obesity. Participants will take either inulin or a pla…

This trial tests whether a mobile app called NutriSteppe can improve blood sugar control and weight loss in adults with type 2 diabetes or obesity who are already taking GLP-1 medications like semaglutide. Over 12 weeks, half the participants will use the app for personalized mea…

This trial tests a smartphone app that sends brief mindfulness and self-compassion exercises immediately after a person regains weight or skips a weigh-in. The goal is to help people stay motivated and continue healthy behaviors instead of giving up. About 120 adults with overwei…

This study tests a weight loss program for 522 low-income adults with obesity in Louisiana. Participants receive health coaching, digital self-monitoring tools, and group support to find community wellness resources. The goal is to see if this approach leads to greater weight los…

This study tests a new tablet called DA-302168S to help people lose weight. It is for adults aged 18-75 who are overweight or obese. The study will compare the drug to a placebo to see if it is safe and effective. About 840 people will take part in China.

This trial tests whether a low-calorie diet combined with intensive lifestyle coaching can help adults with type 2 diabetes achieve remission—meaning blood sugar levels return to normal without medication. Participants are randomly assigned to either the intervention or standard …

This study tests whether a behavioral program that reduces evening light exposure and encourages finishing meals at least four hours before bedtime can improve how the body handles sugar. Overweight adults aged 18-45 who habitually sleep less than 6.5 hours per night will be rand…

This study looks at whether inspiratory muscle training—exercises that strengthen breathing muscles—can improve asthma in children aged 6 to 17 with moderate to severe asthma. It compares two training intensities against a sham (inactive) device over 8 weeks. The trial also exami…

This trial compares two approaches for treating advanced metabolic dysfunction-associated steatohepatitis (MASH), a serious liver condition linked to obesity. About 120 adults with MASH and liver fibrosis will be randomly assigned to either metabolic surgery (gastric bypass or sl…

This study compares two weight-loss strategies: GLP-1 medications (like semaglutide or tirzepatide) versus a structured diet and exercise program. Adults with a BMI of 27.5 or higher are followed for three months to see which approach better improves heart and metabolic markers, …

This study investigates whether combining bariatric surgery with a GLP-1 receptor agonist (semaglutide) leads to greater and more sustained weight loss than surgery alone in people with obesity. Researchers will follow 400 participants across multiple centers in China for up to t…

This trial tests whether a diet adapted to Puerto Rican culture can lower the risk of heart disease, type 2 diabetes, and obesity. Researchers will compare culturally tailored nutrition advice—emphasizing traditional healthy foods and limiting unhealthy ones—with standard healthy…

This study tests whether a structured exercise and nutrition program can slow the loss of muscle mass, strength, and function in adults aged 65 and older with type 2 diabetes and obesity who are taking semaglutide. Participants receive either standard health advice or a 26-week p…

This study tests whether semaglutide, a drug used for weight loss, can reduce markers of heart disease risk in adolescents aged 12 to 15 with severe obesity (class 2 or 3). Participants receive semaglutide and undergo heart scans, body composition tests, and blood work over about…

This study tests whether adding sleep coaching to a standard weight-loss program helps teens with overweight or obesity lose more weight and improve their eating habits. Fifty adolescents aged 14–18 who have sleep issues (like trouble falling asleep or short sleep) will join a 16…

This study tests whether different types of patient education—group classes, a website, or free dental hygiene samples—can improve drinking habits and oral care in people who have had bariatric surgery. Many patients face tooth decay and enamel erosion after surgery due to change…

This study tests a digital tool called PREVENT that helps doctors in rural clinics give personalized advice on physical activity and healthy eating to patients with obesity. The tool creates tailored behavior-change recommendations and shows a map of local resources like parks or…

This study compares two types of keto diets—one high in saturated fat and one high in unsaturated fat (like canola oil)—against a standard low-fat diet in 175 adults who are overweight or have prediabetes or type 2 diabetes. Researchers will measure changes in cholesterol, blood …

This study looks at whether combining a structured exercise and nutrition program with weight-loss medication helps adults with obesity keep more muscle and stay physically strong, compared to taking the medication alone. About 120 adults aged 18-70 will take part over one year. …

This study investigates whether sleeping in a low-oxygen environment (similar to an altitude of about 8,500 feet) for 8 hours each night can enhance weight loss in adults with obesity who are also following a reduced-calorie diet. Over 8 weeks, participants use a special tent at …

This study investigates whether adding cardiovascular or resistance exercise to standard obesity medication helps adults with overweight or obesity retain lean muscle mass while losing weight. Participants are prescribed an FDA-approved obesity medication by their doctor and are …

This study compares three diets for weight loss in adults with type 1 diabetes who are overweight or obese. Participants will follow either a moderate carbohydrate restriction, an early time-restricted eating plan, or a standard calorie-restricted diet. The goal is to see which a…

This study investigates whether drinking a fiber-rich kodo millet porridge every day for 12 weeks can improve gut bacteria diversity and metabolic health in overweight or obese adults. Participants will consume a standardized porridge beverage while keeping their usual diet and a…

This trial compares two ways of monitoring blood sugar in adults recently diagnosed with type 2 diabetes (within the last 3 months). Half of the 80 participants use a real-time continuous glucose monitor (CGM) that provides constant feedback, while the other half use standard fin…

This study uses MRI scans to measure how weight loss treatments affect fat in the liver, pancreas, and other organs of adolescents aged 12 to 18 with severe obesity. Researchers compare two approaches: GLP-1 receptor agonist drugs combined with lifestyle changes versus lifestyle …

This study tests whether a 12-week program of home-delivered DASH-diet groceries and cooking classes can help adults with high blood pressure and obesity lower their blood pressure and lose weight. 150 participants will be randomly assigned to either the food program or usual car…

This study tests a new drug called NNC0487-0111, given as a once-weekly injection, to see if it helps people with obesity lose weight safely. About 1,150 adults who have tried to lose weight before will receive either the drug or a placebo. The main goal is to measure how much bo…

This study tests a culturally tailored sleep program called Sleep BETTER for African American pregnant women who are overweight or obese. The program combines sleep hygiene tips and cognitive-behavioral techniques to help improve glucose metabolism and reduce pregnancy complicati…

This study tests whether Taiwan green propolis, a natural bee product, can improve blood lipids and body fat in adults with metabolic dysfunction-associated steatotic liver disease (MASLD), a common fatty liver condition linked to obesity and high cholesterol. About 60 participan…

This study explores whether a short-term low-energy diet (using meal replacements) can help adolescents aged 12–17 with obesity and type 2 diabetes lose weight and potentially achieve diabetes remission. Participants follow the diet for 12 weeks, then gradually reintroduce food o…

This study tests whether wearing a continuous glucose monitor (CGM) for 3 months helps adults with prediabetes better control their blood sugar and stick to lifestyle changes compared to standard finger-prick testing. About 80 participants will be randomly assigned to use a CGM o…

This study tests whether limiting food intake to an 8-hour window each day (without counting calories) can reduce liver fat in people with obesity and a type of fatty liver disease called MASLD. Seventy-two participants will either follow this eating pattern plus standard advice,…

This study looks at whether inducing labor at 39 weeks of pregnancy is better than waiting for labor to start naturally in women with a BMI of 30 or higher. The goal is to see if early induction lowers the chance of needing a C-section. About 1,900 women in Denmark will take part…

This study compares two blood sugar targets for overweight or obese women with gestational diabetes. One group aims for stricter goals (fasting under 90 mg/dL, after meals under 120 mg/dL), while the other follows standard targets (fasting under 95 mg/dL, after meals under 140 mg…

This study compares weight loss using semaglutide (a drug) versus a calorie-restricted diet in 100 people with obesity and heart failure with reduced ejection fraction. The goal is to see which approach better improves peak oxygen uptake, a measure of exercise capacity, after 52 …

This study looks at whether strength training (like weightlifting) can help adults taking GLP-1 obesity drugs keep their muscle and improve mental health. Forty inactive adults with obesity will either do supervised resistance exercise twice a week for 3 months or just take the m…

This study is testing a mobile app called Adhera Caring Digital Program for Obesity (ACDP-O) in 280 families. The app provides personalized education, mental health monitoring, and wearable device integration to support weight management and well-being in adolescents and young ad…

This study looks at whether eating most of your daily calories in the morning or the evening leads to better long-term weight loss. About 174 adults with obesity will follow a reduced-calorie diet and exercise plan for 12 months. Researchers will track weight, sleep, and appetite…

This study tests whether adding appetite-suppressant drugs (topiramate or phentermine) to lifestyle counseling can help people who have regained weight after bariatric surgery. About 120 adults who had sleeve gastrectomy or gastric bypass at least 18 months ago and regained at le…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests whether a structured cardiac rehabilitation program with exercise and lifestyle coaching, started after a standard catheter ablation procedure, can help obese patients with atrial fibrillation stay free from the heart rhythm disorder longer. Researchers will foll…

This study tests whether taking a probiotic for 3 months can improve how the body processes fats after a meal in adults aged 50-70 who are overweight or moderately obese but otherwise healthy. 66 participants will receive either the probiotic or a placebo. The main goal is to see…

This study tests a new magnetic device that creates a shortcut in the gut to help with weight loss and blood sugar control, comparing it to the popular drug semaglutide (Ozempic/Wegovy). Twenty adults with obesity and type 2 diabetes will be randomly assigned to either the one-ti…

This study looks at how well the drug tirzepatide works in everyday life for people with obesity (without diabetes) or type 2 diabetes (with or without obesity). About 160 adults in Paraguay will take the drug as part of their regular care and be followed for 52 weeks. Researcher…

This study is testing whether e-cigarettes or nicotine replacement therapy (patches and lozenges) can help obese smokers quit or reduce smoking. Sixty participants will use one of the two products for 8 weeks, and researchers will track how many cigarettes they smoke, their carbo…

This study tests a 16-week behavioral program called T1DAL, designed specifically for teens with type 1 diabetes who have overweight or obesity. About 50 teens will be randomly assigned to either the program or usual care. The program includes virtual group sessions and one-on-on…

This study directly compares two popular weight-loss medications, tirzepatide and semaglutide, in 120 adults with obesity and metabolic syndrome. Participants will be randomly assigned to one drug and monitored for 12 months using advanced body scans, blood tests, and AI analysis…

This study tests whether a supervised, equipment-free high-intensity interval training (HIIT) program can improve heart and muscle fitness, body composition, and blood markers in adults aged 18-55 who are overweight or obese. Participants will do body-weight exercises in small gr…

This study looks at what happens to your body when you take anti-obesity medications like semaglutide or tirzepatide, and whether adding aerobic or resistance exercise helps preserve muscle and bone while losing fat. About 40 adults will be assigned to either standard care (medic…

This study tests a personalized diet and exercise program guided by a smartphone app in 140 obese adults with coronary heart disease. Participants receive custom meal plans and daily weight tracking to help them lose weight safely. The goal is to see if this approach improves wei…

This Phase 1 study looks at how CagriSema, semaglutide, and cagrilintide affect muscle health in 100 adults aged 50-70 with obesity and slightly high blood sugar. Participants will receive one of the drugs or a placebo for up to 15 months. The main goal is to measure how well mus…

This study tests whether a supplement called Xanthigen helps overweight adults lose weight. About 180 people with a BMI between 27 and 30 will take either a low dose, high dose, or placebo for 16 weeks. Researchers will measure weight, BMI, and waist size to see if the supplement…

This study compares time-restricted eating (eating only within a 12-hour window each day) to standard calorie-restricted diets in 128 children aged 8-17 with obesity. Over 48 weeks, researchers will measure weight loss and how well children stick to the diet. The goal is to find …

This study tests a telehealth program to help cancer survivors quit smoking, lose weight, and get more active. About 1500 participants will either get coaching sessions or just information. The goal is to see which approach works better for improving long-term health.

This study tests a new surgical device (a metal clip) to create a second food pathway in the stomach for people with type 2 diabetes who are overweight or mildly obese (BMI 25-35). The goal is to improve blood sugar control without causing too much weight loss or needing lifelong…

The PROVE trial is testing whether a weight loss program combined with walking exercise can improve or maintain walking ability in people with peripheral artery disease (PAD) who are overweight. 212 participants will be randomly assigned to either weight loss plus exercise or exe…

This 12-week study tests whether replacing highly processed soy foods (like soy burgers) with less processed options (like tofu or edamame) can lower blood pressure and improve heart health in 300 adults with obesity, hypertension, and often type 2 diabetes. Participants use a di…

This study tests whether a dietary supplement called capsinoid, found in sweet peppers and chilies, can activate brown fat in obese adolescents. Brown fat is a type of body fat that burns calories to produce heat, which may help with weight control. The study will involve 38 teen…

This study tests whether semaglutide (Ozempic) helps people with HIV and obesity lose more weight than diet and exercise alone. About 80 participants will receive either semaglutide injections or standard lifestyle advice for 28 weeks. Researchers will also check how the drug aff…

This study tests whether resistance exercise and extra protein can help preserve muscle mass in people starting weight-loss drugs like semaglutide or tirzepatide. 232 adults with obesity will be randomly assigned to one of four groups: control, extra protein, exercise, or both. T…

This study tests if weight-loss surgery is better than standard medical treatment for making nonalcoholic steatohepatitis (NASH) with advanced liver scarring disappear without making the scarring worse. It involves 100 obese adults with NASH and significant liver fibrosis. Partic…

This study looks at whether adding a GLP-1 drug (semaglutide) to bariatric surgery helps people with severe obesity lose more weight and keep it off. About 200 adults aged 18-60 with a BMI of 35 or higher and related health issues will be followed for a year. The goal is to see i…

This study looks at whether a structured weight loss program, with or without added exercise, can improve physical function and emotional well-being in obese veterans who have had a stroke. Researchers will enroll 130 participants aged 35-85 who had a stroke at least 6 months ago…

This study looks at whether taking blood pressure medication in the morning or evening works better for obese people with high nighttime blood pressure. Obese individuals often have disrupted natural rhythms that raise their heart disease risk. Researchers will give 160 participa…

This study looks at whether adding extra protein to the diet can help adults with obesity keep their muscle while losing weight with GLP-1 medications. About 130 people aged 30-65 with a BMI over 30 will take part. Half will get standard medication alone, and the other half will …

This study tests an investigational drug called MOTS-c in 120 adults with prediabetes and overweight or obesity. The goal is to see if 12 weeks of treatment can improve how the body uses insulin, compared to a placebo. All participants also receive standard lifestyle advice. The …

This study tests whether metformin, a diabetes drug, can help adults with intellectual disabilities who have gained weight from antipsychotic medications. One hundred participants will receive either metformin or a placebo for 24 weeks, along with lifestyle advice. The goal is to…

This study looks at whether adding whole-body vibration training to a standard 3-week weight-loss program helps obese teenage boys burn more calories while resting. About 28 boys aged 13-18 will either get the vibration sessions plus the usual rehab (diet, exercise, counseling) o…

This study looks at whether a community program that teaches families about healthy eating, physical activity, and sleep can help children who are overweight or obese. About 160 children will be randomly assigned to either join the program right away or be placed on a waitlist. T…

This study is testing whether inviting friends, family, or coworkers to join a weight-loss program helps Black or Hispanic adults with obesity lose more weight. The program focuses on improving communication and problem-solving around eating and activity. Researchers will see if …

This study looks at whether adding aerobic or high-intensity interval exercise to a low-glycemic Mediterranean diet can lower inflammation better than diet alone. Researchers will enroll 90 adults aged 18-65 with obesity and non-alcoholic fatty liver disease. Participants will be…

This study tests whether a reduced-calorie Mediterranean diet plus regular exercise helps middle-aged adults (30-50 years) with metabolic syndrome lose weight and keep it off. About 106 participants will either follow this lifestyle program or receive standard care. Researchers w…

This study looks at whether adding a structured exercise program to the weight-loss drug tirzepatide can help overweight and obese women maintain muscle mass and physical function. Sixty women aged 25-50 will take tirzepatide for 20 weeks; half will also follow a progressive resi…

This study tests a program called Regulation of Cues (ROC) in 30 Latina women with prediabetes and obesity. The program teaches awareness of eating triggers and coping strategies to reduce weight and prevent type 2 diabetes. Researchers are first checking if participants find the…

This study looks at whether text messages and a program called Building Healthy Families can help lower-income families with a child who has obesity. About 600 families will be invited through their doctor's records and then offered the program, which teaches healthy eating, phys…

This study tests a once-weekly injection called tirzepatide in about 2,500 adults with obesity or overweight who do not have type 2 diabetes. Participants receive either the drug or a placebo, along with diet and exercise advice. The main goal is to see how much weight they lose …

This study tests a program called HARPP that combines proven treatments for PTSD and weight management into a single therapy for veterans. The goal is to see if this integrated approach leads to greater weight loss and PTSD symptom reduction compared to standard care. The study w…

This study tests whether giving adults with obesity and food insecurity free healthy groceries or grocery vouchers, plus behavioral weight loss counseling, helps them lose more weight than counseling alone. Researchers will enroll 300 adults and track weight loss at 24 and 52 wee…

This study tests a new once-weekly injection called retatrutide (LY3437943) to help people with obesity or overweight who also have weight-related health problems like high blood pressure or high cholesterol. About 300 adults will receive either the drug or a placebo, along with …

This study looks at whether drinking cranberry juice for 12 weeks can help overweight or obese adults improve blood sugar, insulin levels, cholesterol, and gut health. About 73 participants will be randomly assigned to receive either a cranberry drink or a placebo, then switch af…

This study compares three approaches to help pregnant women and new mothers maintain a healthy weight. About 795 participants will receive either self-management support via mobile app or mail, community-based help from health workers, or usual care. The goal is to see which meth…

This pilot study tests a new procedure called PSAM (Pylorus-Sparing Antral Myotomy) for weight loss in 30 adults with obesity. The procedure involves cutting some stomach muscles to slow down how fast food leaves the stomach, which may help people feel full longer and lose weight…

This study looks at whether a structured approach to managing heart disease risk factors (like high blood pressure, diabetes, and smoking) can improve health outcomes in adults. Researchers will follow 220 patients in a regular cardiology clinic, collecting data on their blood pr…

This study tests whether a high-phenolic olive oil can improve metabolic health better than a low-phenolic version. Over 8 weeks, 80 adults with overweight/obesity and metabolic issues will consume one of the two oils. Researchers will measure changes in blood fats, blood pressur…

This study tests whether taking a combination of Akkermansia muciniphila (a beneficial gut bacterium) and berberine (a plant compound) can improve insulin sensitivity in night-shift workers. 200 participants from healthcare and industry in Austria and Denmark will receive either …

This study tests whether a 12-month personalized exercise and diet program can reduce the amount of time spent in atrial fibrillation (an irregular heartbeat) and decrease fat around the heart in overweight or obese adults. About 158 participants will either follow the lifestyle …

This study tests whether adults aged 55 and older with obesity can follow a plant-based, high-protein diet while losing weight. Two hundred participants will receive dietary counseling for six months, focusing on cutting 500 calories per day and increasing protein intake. Half wi…

This study tests whether a drug called ACM-001.1 can help obese people keep their muscle while taking semaglutide for weight loss, and help them regain muscle after stopping semaglutide. About 120 participants will receive either ACM-001.1 or a placebo alongside semaglutide, and …

This study tests whether adding semaglutide (a drug used for diabetes and weight loss) to a standard topical cream can improve psoriasis symptoms and reduce body-wide inflammation. About 62 adults with plaque psoriasis who are overweight or have type 2 diabetes will receive eithe…

This study looks at what happens when people stop taking the weight-loss drug semaglutide. Researchers want to see if slowly reducing the dose over 16 weeks helps maintain weight loss and heart health better than stopping all at once. The study involves 98 adults with obesity who…

This study tests whether taking glutamine, an amino acid, for 8 weeks can improve insulin resistance and reduce irritable bowel syndrome (IBS) symptoms in obese patients. 110 participants will receive either glutamine or a protein powder placebo. Researchers will measure changes …

This study tests whether powerful weight loss drugs (like semaglutide or tirzepatide) can lower blood pressure enough for young adults (ages 18-40) with obesity and early-stage hypertension to stop taking daily blood pressure pills. Sixty participants will either receive the weig…

This study looks at whether tirzepatide, a drug used for weight loss, affects muscle function and structure in women with obesity. Thirty premenopausal women will receive either tirzepatide or a placebo for 24 weeks. Researchers will measure changes in body composition, muscle st…

This study tests a new magnetic device that creates a shortcut in the small intestine, aiming to help control type 2 diabetes and weight. Only 5 people will take part to see if the procedure is safe and feasible. It is an early-stage trial, so the main goal is to check if the mag…

This study looks at whether helping families with food benefits can improve weight in infants who are already overweight and at risk for food insecurity. About 228 infants aged 12 months and their parents will get $50 per week for one year, either as cash or as guided grocery sho…

This study looks at whether adding the drug semaglutide (Wegovy®) to a behavioral lifestyle program helps teenagers with obesity lose weight and adapt their metabolism. About 74 teens aged 12-17 will be split into two groups: one gets the lifestyle program alone for 6 months, the…

This phase 2 study at the Cleveland Clinic will test whether the weight-loss drug tirzepatide (Zepbound) can help people with obesity and atrial fibrillation (AFib). About 100 participants will receive weekly injections of tirzepatide or a placebo for up to 12 months. The main go…

This study tests whether a supervised exercise program after bariatric surgery helps patients maintain muscle mass and bone density. Researchers will compare two groups of 54 adults who had gastric bypass or sleeve surgery: one group will follow a structured exercise plan, the ot…

This study tests whether tirzepatide, a drug already used for diabetes and weight loss, can improve irregular periods and ovulation in women with PCOS who are overweight or have obesity. About 198 women will receive either tirzepatide or a placebo for 72 weeks, along with lifesty…

This study aims to find the best combination of strategies to help people maintain weight loss after losing at least 5% of their body weight. Over 500 participants will first lose weight through a 16-week program, then be assigned to different packages of four methods: eating few…

This study looks at whether GLP-1 drugs, used for diabetes and weight loss, can improve kidney health in people with chronic kidney disease. Researchers will measure changes in fat around the kidneys and heart, as well as kidney function. The goal is to see if these drugs reduce …

This study is testing whether placing a temporary intragastric balloon (a soft balloon in the stomach) along with diet and exercise can improve asthma control in obese people whose asthma is not well managed by inhalers. About 84 participants will be randomly assigned to get the …

This study compares two versions of Roux-en-Y gastric bypass surgery to see which one is better at putting type 2 diabetes into remission in severely obese patients. The trial will enroll 396 people with a BMI of 35 or higher and type 2 diabetes. Participants will be randomly ass…

This study tests whether metformin, a drug already used for diabetes, can help obese but non-diabetic Black Nigerians lose weight and lower their heart disease risk. Researchers will give 220 participants either metformin or a placebo for several months, tracking changes in weigh…

This study tests a new way to measure the maximum amount of insulin a person's pancreas can produce. Participants first undergo the standard hyperglycemic clamp, then take a single dose of alpelisib and consume a standardized meal to see if the simpler test gives similar results.…

This study tests whether artificial intelligence can better predict difficult airway management in 340 obese patients undergoing bariatric surgery. Researchers will compare AI predictions using standard measurements like mouth opening and neck length against actual views during i…

LiverSeek is a study testing an automated screening program for advanced liver fibrosis in people aged 50-75 with risk factors like diabetes or obesity. When a routine blood test is done, the lab system automatically calculates a fibrosis score and, if needed, orders additional t…

Researchers in Pakistan are testing whether a mobile app that uses artificial intelligence to send personalized heat-risk alerts can reduce heat-related illness symptoms in adults with chronic conditions such as hypertension, diabetes, kidney disease, heart disease, or obesity. T…

Researchers are testing whether daily cottonseed oil improves cholesterol and blood fat levels compared with oils that have a similar fat makeup. The study includes 90 adults aged 25 to 75 who have elevated cholesterol or excess weight. Participants drink a breakfast shake contai…

This trial tests whether teaching Black women with obesity to share Mediterranean diet and lifestyle tips within their social networks leads to greater weight loss and healthier habits than a standard program. Researchers will compare two groups: one that follows the diet alone a…

This study tests a program called PINPOINT that helps women with obesity or diabetes get screened for cervical cancer. About 20 women who are behind on screening will be offered options like self-collection or a Pap smear. The goal is to see if the program is practical and well-l…

This study tests a 9-session group program for parents of children aged 6 months to 3 years, focusing on healthy eating, physical activity, and sleep. About 526 families from Spain will take part, with half receiving the program and half getting usual care. The goal is to see if …

This study tests whether giving a fecal microbiota transplant to babies born by C-section can improve their gut bacteria and help prevent overweight or obesity later in life. Researchers will track the growth and gut health of 534 infants who receive the transplant shortly after …

This study adapts a diabetes prevention program for Hispanic adolescents aged 12-16 with obesity, delivering it via telehealth using a Fitbit, chatbot, and online lessons. The goal is to see if this approach is feasible and acceptable for reducing type 2 diabetes risk. Researcher…

This study tests two parenting programs for families with newborns. One program teaches parents how to recognize baby hunger and fullness cues and offers nutrition advice. The other provides safety tips like safe sleep and car seat use. Researchers will track the babies' growth a…

This study tests whether playgroups or parent education classes can help toddlers develop healthy eating and activity habits. About 300 families with toddlers aged 18-36 months will be randomly assigned to one of three groups: a playgroup, a parent education class, or continuing …

This study looks at whether taking a daily supplement made from artichoke by-products, combined with a calorie-controlled Mediterranean diet, can help prevent type 2 diabetes in people who are overweight or obese. Researchers will measure changes in insulin resistance and weight …

This study tests a program called Healthy Family Foundations for military families expecting their first child. The program includes 10 online group classes (5 before birth, 5 after) to help parents support each other with healthy eating, activity, and parenting. Researchers will…

This study tests whether a daily powder containing fiber and plant compounds (inulin, resveratrol, quercetin) can reduce brain inflammation in 120 overweight women aged 35-60 who are going through menopause. Participants take the supplement or a placebo for 6 months, and research…

This study looks at whether losing weight can help prevent or delay Alzheimer's disease in adults with Down syndrome. About 81 participants without dementia will either follow a reduced-calorie diet with monthly coaching or attend general health education sessions. Over 12 months…

This study tests whether an eHealth app that coaches parents can help lower the energy balance in children aged 2-6 who are already above the 97th BMI percentile. About 148 families will be randomly assigned to use the app or receive standard care. The goal is to see if the app c…

This study compares two approaches to help children ages 6-11 improve their sleep: one-on-one coaching with a nurse using behavioral strategies versus receiving educational handouts. The goal is to see if the coaching program is practical and acceptable for families in a primary …

This study tests whether a diet tailored to a person's unique metabolism (called a 'metabotype') can prevent type 2 diabetes better than standard healthy eating advice. Overweight or obese adults at risk for diabetes will follow either a personalized or standard diet for 12 month…

This trial tests whether a daily ubiquinol supplement, a form of Coenzyme Q10, can reduce fatigue and help maintain muscle strength in adults aged 30-65 who are taking GLP-1 weight loss medications like Wegovy or Mounjaro. About 90 participants will take either ubiquinol or a pla…

Researchers test whether a nutrition education program based on Brazil's national dietary guidelines eases menopause symptoms in overweight or obese women. The trial enrolls 74 perimenopausal or postmenopausal women aged 40 to 65 who have menopause symptoms. Both groups receive t…

Researchers at San Diego State University are testing an 8-week online program that teaches intuitive eating principles to pregnant women with obesity. The program includes weekly video modules and workbook exercises, with optional office hours. The study will compare participant…

People with treatment-resistant schizophrenia often take clozapine, a drug that can cause serious weight gain and metabolic problems. This pilot study tests whether a daily infusion made from the leaves of the Nitraria retusa plant can reduce those side effects. Thirty patients w…

Researchers are testing whether adding a lidocaine infusion to a nerve block in the chest and abdomen reduces the amount of fentanyl needed during gastric bypass surgery. The trial enrolls 100 obese adults scheduled for laparoscopic Roux-en-Y gastric bypass. Participants receive …

Researchers are testing whether a daily synbiotic supplement can improve thinking and memory in adults with obesity and mild cognitive impairment. Forty participants aged 30 to 40 will take either the supplement, which combines Lactobacillus acidophilus and agave inulin, or a con…

Researchers are studying whether the experimental drug cagrilintide can reduce bone loss in postmenopausal women with obesity who are losing weight. The trial compares cagrilintide, semaglutide, a combination of both, and placebo in 144 women aged 50 to 70. Participants receive w…

Researchers test whether placing bands on the stomach through an endoscope can help people with obesity lose weight. The procedure uses a flexible tube to place small bands in the stomach, aiming to reduce stomach space. Adults with a BMI over 27 may join. The study measures chan…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults aged 18-55 with a BMI between 25 and 35 will receive either the drug or a placebo. The main goal is to check for side effects and how the drug moves …

This study tests whether a gentle brain stimulation technique called tDCS, combined with cognitive training, can help veterans with obesity reduce impulsive behavior and lose weight. About 124 veterans will be randomly assigned to receive either real or fake stimulation during tr…

This study tests a once-daily pill called orforglipron in 800 adults with obesity or overweight who also have painful knee osteoarthritis. The goal is to see if the drug reduces knee pain and improves physical function over about 74 weeks. Participants will be randomly assigned t…

This Phase 3 study tests a once-weekly injection called eloralintide in 900 adults with osteoarthritis of the knee who are also overweight or obese. The goal is to see if it reduces knee pain and helps with weight loss compared to a placebo. Participants will be in the study for …

This study tests whether taking vitamin C daily can improve gut health and reduce inflammation in adults with obesity. Over two 2-week periods, 34 participants will take either vitamin C or a placebo, and researchers will measure gut permeability using sugar drinks and blood, uri…

This phase 3 trial tests whether ecnoglutide, a GLP-1 drug similar to semaglutide, can reduce knee pain and body weight in obese adults with knee osteoarthritis. Participants receive either ecnoglutide injections or a placebo for several months. The study measures changes in pain…

This Phase 3 study tests a once-weekly injection called NNC0487-0111 in 400 adults who are overweight or obese and have knee osteoarthritis. The goal is to see if it helps with weight loss and reduces knee pain compared to a placebo. Participants receive either the active drug or…

This Phase 3 trial tests whether a once-weekly injection called NNC0487-0111 can help people with overweight or obesity and knee osteoarthritis lose weight and feel less pain. About 400 adults will receive either the drug or a placebo for several weeks. Researchers will measure c…

This study tests whether a flexible, symptom-guided dosing plan for tirzepatide can reduce nausea and vomiting compared to the standard dosing plan in adults with obesity who do not have diabetes. Participants will be randomly assigned to one of two dosing strategies and followed…

This study tests whether a program that addresses chronic pain can help teens with obesity stay in weight management treatment. Fifty adolescents aged 12-18 with both obesity and musculoskeletal pain will either receive the Pain and Weight Treatment (PAW) plus standard care, or p…

This study tests whether early time-restricted eating (eating only during a set morning window) helps postpartum women with overweight lose weight and improve heart health. Sixty women 6-16 weeks after a healthy pregnancy will either follow this eating schedule or eat normally fo…

This study is testing whether a time-restricted eating plan (eating only during an 8-10 hour window each day) combined with a healthy plant-based diet is safe and doable for people with liver cancer, cirrhosis, or fatty liver disease. Fifty overweight or obese adults will either …

This study tests whether 10 minutes of daily brain games on a phone can help teens aged 14-17 with overweight improve their self-control around food. Over three weeks, participants play games designed to strengthen inhibitory control and receive a short nutrition lesson. The goal…

This study tests whether adding very short, intense exercise bursts (called 'exercise-snacks') to a standard weight-management program can improve physical fitness in obese adolescents. Forty-eight teens will either do six mini-exercise sessions daily for three weeks or just rece…

This study tests whether a 5-week program of aerobic and resistance exercises can improve muscle quality, body composition, and quality of life in 84 adults who recently had bariatric surgery. Participants are split into an exercise group and a usual-care group. The goal is to se…

This study looks at whether special breathing exercises (inspiratory muscle training) can improve lung function and reduce inflammation in people with obesity. Researchers will measure breathing, muscle strength, and blood markers in 40 adults aged 30-60 with a BMI of 30 or highe…

This study tests whether a synbiotic supplement (a mix of probiotics and prebiotics) can improve gut health and reduce mild stomach discomfort in adults aged 50-70 who are overweight. Participants take the supplement or a placebo daily for 8 weeks, and researchers measure changes…

This study tests whether foot reflexology can reduce nausea and vomiting in the first 24 hours after sleeve gastrectomy (a type of weight-loss surgery). About 60 adults having this surgery will be randomly assigned to receive either foot reflexology or standard care. The goal is …

This study tests whether a special food drink can help adults on popular weight loss drugs like Wegovy or Mounjaro keep their muscle while losing weight. About 144 overweight or obese adults will take the drink or a placebo for 24 weeks. Researchers will measure changes in muscle…

This study is testing whether a supplement called tributyrin, which the body turns into butyrate, can help lower blood sugar and reduce appetite in people who are overweight or obese. Twelve participants will take either tributyrin or a placebo for two weeks, then switch after a …

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

This study tests whether a 6-month mobile program can help 200 older adults (65+) with knee or hip arthritis pain become more active, lose weight, and feel less pain. Participants will join weekly group or individual coaching calls and track their steps. After the program, they w…

This study tests whether a cold water extract from saffron tepals (the flower petals) can improve blood sugar and metabolism after a meal in 20 adults with obesity or prediabetes. Participants drink either the extract or plain water before eating white bread, then have blood test…

This study tests whether replacing opioids with a non-opioid drug (dexmedetomidine) and adding person-centred care can improve recovery and reduce opioid use in 220 adults undergoing obesity surgery. Participants are randomly assigned to either the opioid-free approach or standar…

This study tests a new home-based program that uses a special treadmill and virtual reality to help children with conditions like cerebral palsy, muscle diseases, or obesity improve their walking. About 30 children aged 6 to 17 will try the program at home for at least 3 sessions…

This study tests a new method to reduce pain and nausea after laparoscopic sleeve gastrectomy, a common weight-loss surgery. About 200 adults will receive either a paragastric nerve block (injecting numbing medicine near the stomach) or a placebo during surgery. The goal is to se…

This study looks at whether teaching teens with overweight or obesity how to sleep better can help them lose more weight when combined with standard diet and exercise advice. About 126 teens aged 13 to 17 who have poor sleep will join. Half will get usual care, and the other half…

This study looks at two ways of giving a standard liquid meal to measure how the body handles sugar. One method gives everyone the same number of calories, while the other adjusts the calories based on a person's size. Researchers want to find out which method gives more consiste…

This study follows 1,500 children ages 8 to 17 over several years to learn how genes, sleep, mood, and environment affect eating behavior and overall health. Participants wear wrist monitors, answer smartphone surveys, and provide samples like blood and stool. The goal is to iden…

This study looks at how a supplement called nicotinamide riboside (NR) and a low-carb, high-fat 'ketogenic' diet affect the way the body burns fat and uses energy. Researchers will measure changes in metabolism in 100 overweight or obese adults. Participants will eat a standard d…

This early-stage study in 50 healthy women with overweight or obesity examines whether two experimental weight-loss injections, AZD6234 and AZD9550, change how the body processes a common birth control pill. Participants will receive the drugs alone and together, and researchers …

This study aims to learn how type 2 diabetes and obesity in young people affect heart and blood vessel health over time. About 930 participants aged 12 to 25, including those with diabetes, overweight but not diabetic, and healthy lean individuals, will be followed for up to 25 y…

Researchers at Pennington Biomedical Research Center are following Louisiana families over time to understand how lifestyle and environment affect the risk of developing obesity and other health conditions. The study includes children, teens, young adults, and adults who are expe…

Researchers are building a long-term health study of 150,000 children born in Victoria, Australia, and their parents. The study follows participants from birth over their lifetime, collecting data on health, development, and environment through surveys, biosamples, and linked rec…

This study tests how a single injection of HRS-4729 behaves in people with mild, moderate, or severe kidney impairment compared with healthy people. Researchers measure drug levels in the blood over time to see if kidney function affects how the body processes the drug. The trial…

This study aims to learn more about heart and blood vessel diseases by observing people who have them or are at risk. Researchers will collect samples and perform tests like imaging and stress tests on up to 5,000 participants, including healthy volunteers and relatives of affect…

This study looks at how obesity and body fat affect heart disease risk in 2,000 healthy African American men and women. Researchers will measure body fat, blood fats, and insulin function to see if risk factors differ by sex. The goal is to understand why heart disease rates are …

This study follows 1,500 pregnant women and their children for up to 18 years to understand how a mother's health, lifestyle, and environment affect her child's growth and risk for obesity, diabetes, and fatty liver. Mothers attend visits during pregnancy and after birth, while c…

This natural history study will look at how metabolism relates to body size and composition in 2,000 people aged 2 and older, including healthy volunteers and those with conditions like diabetes, obesity, or cancer. Participants will stay in the hospital for two days to undergo v…

This study tests whether people with prediabetes and obesity change their eating and activity habits when they can see their glucose levels in real time versus when the data is hidden. Thirty-four adults will wear a continuous glucose monitor during both an open and a blinded pha…

Mayo Clinic researchers are studying how chronic inflammation affects muscle function and the body's response to exercise in adults with obesity. About 120 men and women aged 20 to 45 will undergo treadmill fitness tests, strength tests, body composition scans, and small muscle a…

This study looks at whether exercising in the morning or evening helps the body handle sugar better in people with prediabetes who have an extreme natural body clock. Twenty-eight adults with prediabetes and overweight will do a single cycling session at 9 AM, 5 PM, or no exercis…

This study looks at how certain natural chemicals (endocannabinoids) influence the development of fat cells from stem cells found in belly fat. Researchers will take small fat samples from 30 people undergoing abdominal surgery, including healthy controls, people with obesity, an…

Researchers are studying whether the mix of bacteria in the gut helps explain why people with obesity and type 2 diabetes get chronic infections more often. The study follows 80 adults, some with ongoing infections and some without, for 12 months. Participants give blood, stool, …

This study follows 106 people who had weight-loss surgery using the MagDI system, a device that uses magnets to create a new connection between parts of the intestine. The main goal is to see how often internal hernias or bowel blockages happen within one year after surgery. Rese…

This study aims to see if a specially designed education module helps people with spinal cord injury (SCI) learn about their increased risk for heart disease, obesity, and metabolic problems. Researchers will enroll 250 adults with SCI and measure changes in knowledge, body weigh…

Researchers at Mudanya University are observing adults who have had sleeve gastrectomy to see whether taking collagen-containing supplements relates to differences in muscle mass, body composition, and body image. Participants choose on their own whether to use collagen supplemen…

Researchers at Ariel University are studying whether how children chew and how fast they eat relate to their weight. The trial enrolls 70 healthy children aged 6 to 11, half with obesity and half at a normal weight. Each child eats two breakfast meals of equal calories that diffe…

This early-stage trial is testing how an experimental drug called PF-08653945 enters the bloodstream when injected into different areas of the body. Researchers will give a single dose to adults who are overweight or obese and measure drug levels in the blood over time. The goal …

Researchers at George Washington University are studying how a single 30-minute aerobic exercise session affects gut bacteria and their metabolites in premenopausal women. The study includes 40 women with different fitness levels and body mass indexes, both with and without obesi…

Researchers are building a large, diverse group of adults with varying body sizes, ethnicities, and diabetes risk. They will collect blood, stool, and fat tissue samples to study how obesity relates to diabetes and other health issues. The goal is to create a rich resource for fu…

This observational study looks at how being overweight or obese, and changes in lifestyle, impact work performance, quality of life, and well-being in medical residents. Researchers will track 600 participants for 12 months, measuring body weight, lifestyle habits, and using ques…

This study aims to understand how the hormone insulin controls blood sugar in different people. Researchers will test a new procedure called the graded insulin suppression test (GIST) in 15 healthy volunteers and those at higher risk for type 2 diabetes. Participants receive medi…

This study looks at whether obese children with autism spectrum disorder differ from those without autism in fitness and heart health. Researchers will review medical records of 200 children aged 6 to 18, including step test results, handgrip strength, body measurements, and bloo…

This study is testing new magnetic resonance imaging (MRI) techniques to get clearer pictures of the heart and blood vessels without using radiation. Researchers will compare these new MRI methods to standard tests like angiography and CT scans. Up to 4,000 adults—including healt…

This study looks at how people with severe obesity perceive internal body signals (like hunger and fullness) before and after bariatric surgery. Researchers will follow 300 adults for two years to see if changes in body awareness and views on illness affect eating behaviors after…

Researchers are following 60 adults who are starting GLP-1 receptor agonist therapy for weight loss. They will measure changes in anhedonia, the loss of pleasure in activities, and emotional eating behaviors at the start of treatment and again after 6 months. The study uses quest…

This study asks how the nervous system tells blood vessels to narrow during stress, and whether obesity or high blood pressure changes that signal. Researchers will measure nerve activity and blood flow in about 100 adults, some with obesity, some with hypertension, and some with…

This study tests whether a device called an external cuirass, a plastic shell worn over the chest, can reduce the extra effort of breathing that often comes with obesity in older age. Researchers will compare older adults with and without obesity, aged 65 to 75, measuring lung fu…

This early-stage trial is testing a new drug called ACI-19764 in 78 healthy adults to see if it is safe and how the body handles it. The drug targets a protein in the brain linked to inflammation. Participants will receive either the drug or a placebo, and researchers will monito…

This study aims to describe the physical and behavioral traits of overweight and obese adults compared to lean individuals. Researchers will measure hormones, metabolism, food preferences, fitness, sleep, and thinking patterns in 2,000 participants. The goal is to better understa…

This study works with Black churches in Washington, D.C. to understand heart health risks like obesity, high blood pressure, and diabetes. About 200 adults will get a health exam, wear an activity monitor for a month, and answer health questions. The results will help design a fu…

This trial tests how two different exercise sessions, high-intensity interval exercise (HIIE) and moderate-intensity continuous exercise (MICE), affect the body's fat-burning response in young women with overweight or obesity. Researchers measure oxygen use, fat and carbohydrate …

This study follows 70 adults with severe obesity for three years after bariatric surgery, checking in before the operation and again at several points afterward. Researchers will measure psychological distress, perceived stress, and impulsivity, along with weight changes and the …

This study evaluates how well different devices—like bioelectrical impedance scales, 3D body scanners, and manual tape measurements—measure body fat and muscle compared to gold-standard methods like DXA and MRI. It will enroll 300 healthy adults with a BMI between 18.5 and 45. Th…

This study investigates whether a key channel in insulin-producing cells becomes less active as type 2 diabetes progresses. Researchers will give a single 10 mg dose of glipizide, a drug that blocks this channel, to people with and without type 2 diabetes and measure their insuli…

This trial is developing and testing a system that uses ultrasound to automatically identify spinal landmarks, helping doctors find the right spot for spinal anesthesia. The study includes people who need spinal anesthesia for surgery, with a focus on obese patients, where tradit…

This study is investigating how immune cells called macrophages in fat tissue handle fat and influence metabolism. Researchers will compare people with obesity and related metabolic issues to lean individuals, using imaging, blood tests, and tissue biopsies. The goal is to unders…

This study investigates how immune cells in fat tissue, called macrophages, handle fats and whether this affects metabolism in people with obesity. Researchers will compare adults with obesity and type 2 diabetes or fatty liver to lean individuals, using imaging, blood tests, and…

This study looks at whether taking GLP-1 weight-loss medications before pregnancy influences how much weight a woman gains during pregnancy and her pregnancy outcomes. Researchers will compare pregnant women who used these medications before conception with those who did not. Par…

This study aims to validate the accuracy and reproducibility of laboratory assays and research techniques used in metabolism research. It will involve up to 100 adults aged 18-75 with a BMI between 18.5 and 45. Participants may undergo various tests, including blood sampling, ora…

This study compares robot-assisted bariatric surgery to standard laparoscopic surgery for obesity. About 482 adults aged 18-70 who qualify for weight-loss surgery will be randomly assigned to one of the two methods. The goal is to see if the robot's higher upfront cost is offset …

This study tests whether an 8-week very-low-calorie diet (600-800 kcal/day) can alter bone marrow fat, bone health, and stem cell function in obese premenopausal women. Researchers will use MRI and biopsies to measure changes in vertebral bone marrow fat and the behavior of bone …

This study looks at whether a special digital follow-up system plus nurse-led education can help people feel better and stay active after weight-loss surgery. About 52 adults who have had bariatric surgery will take part. Half will get the extra digital support and exercise progr…

This study investigates whether genetic differences influence how people respond to semaglutide, a GLP-1 drug used for weight loss and diabetes. Overweight or obese volunteers of Amish descent will receive weekly semaglutide injections for six weeks. Before and after treatment, r…

This study investigates why some people with obesity develop insulin resistance and related diseases while others remain metabolically healthy. Researchers are examining tiny particles called exosomes, released from fat tissue, which may carry signals that affect how cells respon…

This study investigates whether proteins released by muscles, called myokines, can serve as early warning signs or even causes of muscle loss (sarcopenia) in people with metabolic or endocrine conditions like diabetes, obesity, and Cushing syndrome. Researchers will measure myoki…

This study looks at whether a person's genetic makeup can predict how much weight they will lose on the drugs semaglutide or tirzepatide. Researchers will follow 220 adults with obesity who are starting one of these medications for six months. By analyzing genetic risk scores and…

This pilot study aims to see if a new program can help people manage their weight after they stop taking anti-obesity medications. Researchers will test if the program is easy to run and acceptable to patients. About 214 participants will either receive the new program or usual c…

This study investigates what happens inside the body after an 84-hour fast. Researchers will measure peak fat oxidation (how well the body burns fat during exercise), mitochondrial coupling (energy efficiency in cells), and changes in the extracellular matrix (the scaffold around…

This study looks at how common and severe gum disease is in people with obesity. Researchers will check dental health, analyze saliva for signs of inflammation, and look at genes linked to obesity. They will also study the bacteria in dental plaque to understand the connection be…

This study looks at whether childhood trauma is linked to changes in stress hormones and inflammation in obese women. Researchers will measure cortisol levels in saliva and urine, along with other markers, in 102 women. The goal is to better understand how past experiences might …

This study looks at whether a program to reduce sitting time and increase light activity before bariatric surgery helps women with obesity achieve better weight loss and health. Seventy-two women scheduled for surgery will be guided to replace sedentary behavior with movement. Re…

This observational study will follow 10,000 adults with obesity or overweight to understand how the disease progresses and what factors predict treatment success. Researchers will analyze medical records from 2000 onward, looking at heart and metabolic complications over 5 to 10 …

This study is tracking 2,000 adults over time to understand how obesity and disruptions to the body's internal clock (circadian rhythm) influence aging and heart health. Participants will provide health data, questionnaires, and biological samples during annual check-ups. The goa…

This study will enroll 20 adults with severe obesity who are scheduled for weight-loss surgery. Researchers want to see if advanced tools like MRI and 3D body scans give a clearer picture of health changes than just measuring weight or waist size. Participants will be followed fo…

This study looks at how a person's genetics, gut microbiome, and behaviors influence how well they tolerate and respond to the weight-loss drug tirzepatide. Researchers will follow 200 overweight or obese adults for up to 12 months, tracking weight changes, side effects, and whet…

This study follows 100 obese patients starting dialysis to understand why they are less likely to receive a kidney transplant. Researchers will track health changes over two years and compare them to non-obese patients. The goal is to identify barriers and improve access to trans…

This study tracks 800 obese patients at Nîmes University Hospital to see if they develop alcohol or other addictions during obesity treatment, especially after bariatric surgery. Researchers will use questionnaires and blood tests to understand these behaviors. The goal is to imp…

This study looks at why people with obesity often regain weight after losing it through a behavioral weight loss program. About 205 adults aged 25-59 will first lose at least 7% of their body weight, then be followed for a year to track how much weight they regain. The goal is to…

This study follows 165 adults undergoing bariatric surgery to see if certain pre-surgery traits—like anxiety, depression, eating behaviors, and weight-related quality of life—can predict how their quality of life changes over the two years after surgery. Participants complete que…

This study investigates how exercise affects the structure and function of fat tissue in adults aged 18-40 with obesity or metabolic syndrome. Participants are randomly assigned to either an exercise program or a sedentary control group. All undergo a 10% weight loss phase, then …

This study is looking at whether GLP-1 receptor agonists—drugs used for type 2 diabetes and obesity—can also improve dry eye disease. Researchers will measure changes in tear stability and eye surface health in 100 patients who have not taken these drugs before. The goal is to un…

This study looks at why teens with obesity often regain weight after losing it. Researchers think hormones that control appetite might be involved. Over 35 weeks, 260 teens will follow a meal replacement plan and then be monitored for weight regain. The goal is to understand the …

This study looks at how obesity impacts the physical abilities and daily activities of people over 65. Researchers will compare obese and normal-weight seniors using fitness tests and questionnaires. The goal is to understand how excess fat, combined with age-related muscle loss,…

This study aims to understand how the body defends its weight by measuring energy use and intake after a short fast. Twelve men and women who are either underweight or have obesity will fast for two days, then eat freely for two days in a special chamber. The results will help de…

This study looks at whether a special type of high-intensity interval training can help overweight adults maintain healthy vitamin D levels during winter. Thirty participants will either exercise three times a week for 12 weeks or just follow a balanced diet. Researchers will mea…

This study tracks 420 people to see how bariatric surgery affects drinking behavior using a special device called a drinkometer. It measures things like sip size and speed, and looks at how gut hormones and sex differences play a role. The goal is to better understand why surgery…

This study looks at whether eating peanuts every day can improve bone health, metabolism, and physical function in overweight or obese adults aged 50-75 during a 6-month weight loss program. Participants will be randomly assigned to eat either a daily peanut snack or a nut-free s…

This study aims to see if a short, interval fitness test (the IFT 30-15) can reliably measure heart and lung fitness in both healthy people and those with high blood pressure or obesity. Researchers will compare results from this test with a standard treadmill test and a six-minu…

This study is recruiting 8,000 young Chinese adults with obesity (BMI 30 or higher) to investigate how genes and clinical features contribute to obesity and metabolic syndrome. Researchers aim to better understand the underlying causes, which could eventually lead to improved tre…

This study looks at how growth hormone affects beta-cells, which make insulin, in people with a family history of type 2 diabetes. Researchers will compare 30 obese adults with and without a family history of diabetes. The goal is to better understand why some people develop diab…

This study collects data from 500 children with severe, early-onset obesity to find genetic causes. Researchers will track how many kids have genetic variants linked to obesity and monitor changes in their BMI over time. The goal is to better understand the role of genetics in se…

This study looks at two blood inflammation markers, SII and SIRI, to see if they can help predict metabolic problems like insulin resistance and fatty liver in people who are overweight or have obesity. Researchers will follow 200 adults for up to 3 years, tracking their diet, la…

This study looks at why some children become overweight or obese by examining their eating habits, brain activity, and family history. Researchers will measure how kids' brains respond to food and how well they control their eating. The goal is to find early clues that could lead…

This study uses advanced heart MRI to see how bariatric surgery and cardiac rehabilitation change the heart's structure and function. Researchers will scan 150 adults before and 6-12 months after these metabolic treatments. The goal is to understand how the heart adapts to these …

This observational study looks at the bacteria in dental plaque of 170 people with obesity (BMI 30+) who are scheduled for bariatric surgery. Researchers want to see if the types and amounts of mouth bacteria differ between those with obesity (BMI 30-35) and those with morbid obe…

This study looks at how being overweight affects insulin sensitivity and heart-lung fitness in people with type 1 diabetes. Researchers will compare participants with and without diabetes, before and after a 15-week high-intensity interval training program. The goal is to underst…

This study collects blood and tissue samples from 270 severely obese patients during bariatric surgery to uncover new biological factors that lead to type 2 diabetes. Participants are grouped by their metabolic status: those with diabetes, insulin resistance, or normal insulin se…

This study looks at how obesity affects the heart and blood vessels, and how these change after bariatric surgery. Researchers will collect blood, urine, stool, and fat tissue samples from 85 adults before and after surgery. They aim to understand how fat tissue and gut bacteria …

This study looks at how weight loss (using tirzepatide) and a biologic drug (ixekizumab) affect the body in people with psoriatic arthritis who are overweight or obese. About 45 adults will receive one or both treatments. Researchers will take samples of skin, joint tissue, and f…

This early-phase study tests whether a natural odor, when inhaled, can be detected in the cerebrospinal fluid (the fluid around the brain and spine) within 30 minutes. 32 lean and obese adults who are already scheduled for a spinal tap will sniff either the odor or a placebo. The…

This study follows 2,500 adults aged 30-75 in Puerto Rico to track chronic diseases like heart disease, diabetes, and obesity. Researchers will collect data on diet, stress, and lifestyle over two years to identify trends and risk factors. The goal is to guide public health prior…

This study is looking at how the timing of meals, along with genetics, affects weight loss in a Mediterranean population. Researchers will track nearly 6,000 overweight adults to see if eating lunch later makes it harder to lose weight. The goal is to understand if when we eat is…

This study looks at how fasting insulin and insulin resistance differ based on age, sex, race/ethnicity, body weight, and PCOS diagnosis. Researchers will analyze data from 150 adults to find patterns that may explain why some groups face higher metabolic risks. The goal is to be…

This study will track 1,200 adults in semi-rural Tanzania to find out how common chronic kidney disease (CKD) is and what factors increase the risk. Participants will have blood and urine tests at the start, after 90 days, and again after one year. The goal is to create better wa…

This study looks at how different types of exercise—moderate, vigorous, or short bursts—change inflammation levels in the body. Researchers want to see if exercise can help reduce the low-grade inflammation linked to obesity and heart disease. The study is recruiting 33 overweigh…

This study looks at whether losing weight and breathing low-oxygen air (like at high altitude) can help people with obesity absorb more iron. Iron deficiency is common in obesity, possibly due to inflammation. The study will measure iron absorption before and after a 6-week progr…

This study collects information from medical records and patient visits to see how well endoscopic bariatric therapies (EBTs) work for weight loss and if they are safe. It includes adults who have had or plan to have an EBT within six months. The goal is to track weight changes a…

This study looks at how limiting eating to an 8-hour window each day (time-restricted feeding) affects the immune system of women with severe obesity. Researchers will compare two groups of women with obesity—one following the 8-hour eating schedule and one eating normally—and al…

This study looks at how two types of bariatric surgery (RYGB and SG) change bone marrow fat and bone loss in 40 postmenopausal women with obesity. Researchers will measure bone marrow fat before and after surgery and check for links to hormones, blood sugar, and bone markers. The…

This study looks at how severe obesity can lead to a type of heart failure called HFpEF, where the heart becomes stiff and has trouble filling with blood. Researchers will study 250 people with obesity using heart ultrasounds and blood tests to find early signs of heart problems.…

This study looks at whether a community program rooted in Native Hawaiian values can improve the well-being of young people aged 12-25 who have health issues like asthma, obesity, or mental health concerns. About 100 youth from the Wai'anae area will take part in cultural activit…

This study looks at what happens inside your fat tissue when you lose weight with or without exercise. 68 adults with obesity will lose 10% of their body weight through diet, with some also doing moderate exercise. Researchers will measure insulin sensitivity, fat breakdown, and …

This study follows 1,000 people who are having weight-loss (bariatric) surgery. Researchers will measure changes in weight, body fat, blood sugar, cholesterol, and other health markers before surgery and at several follow-up visits over two years. The goal is to better understand…

This study looks at whether eating dinner earlier in the evening, in sync with your body's internal clock, helps burn more fat and control blood sugar. Researchers will compare early versus late dinner in 32 adults—some healthy weight, some with obesity and prediabetes. Participa…

This study looks at how body composition (like weight and fat distribution) relates to airway tone and reactivity. Researchers will use a device called an oscillometer to measure airway resistance in 100 people who are already scheduled for a methacholine challenge test. The goal…

This study looks at how fat tissue changes when people gain weight from overeating. Researchers will ask 58 overweight adults to either maintain their weight or eat 30% more calories for a short time. By tracking fat cell growth and other changes, they hope to understand why some…

This study looks at 150 adults with obesity to see if there are differences in fat, muscle, and metabolism between those who were obese as children and those who became obese as adults. Participants will provide tissue samples, blood, and urine, and undergo a weight loss program.…

This study looks at whether bariatric surgery can change a person's biological age—a measure of how well their body is aging. Researchers will track 300 adults with obesity before and one year after surgery, checking blood markers, fat cell health, gut bacteria, and daily rhythms…

This study looks at how two natural hormones—amylin and pancreatic polypeptide—work together to control appetite and food intake. Eighteen healthy men will receive infusions of these hormones, alone or combined, and then eat a meal to see how much they consume. The goal is to bet…

This study aims to understand how people with obesity feel about their quality of life after undergoing endoscopic vertical gastroplasty (GVE), a less invasive alternative to traditional weight-loss surgery. Researchers will interview 20 Italian adults who had the procedure at le…

This study looks at how gut bacteria and the brain communicate in people with obesity, and whether this affects eating control. Researchers will study 116 adults aged 30-65, using brain scans, blood tests, and questionnaires. No treatment is given; the goal is to understand the c…

This study looks at how fat tissue and gut bacteria might influence memory and thinking in people with and without obesity. Researchers will analyze tissue, blood, and stool samples from 100 adults scheduled for surgery. The goal is to uncover new ways obesity affects the brain, …

This study looks at how 12 weeks of endurance exercise affects fat tissue quality and insulin sensitivity in 70 men and women with obesity. Researchers will take small samples of fat and muscle, and use a glucose test to measure insulin response. The goal is to understand how exe…

This study looks at how GLP-1 medications (like Ozempic) affect fat tissue in people with severe obesity who are scheduled for weight-loss surgery. Researchers will compare fat samples from 40 patients—half taking a GLP-1 drug and half not—to see changes in oxytocin and other mar…

This study looks at the best dose of a green fluorescent dye (indocyanine green) used during repeat weight-loss surgery to see blood flow. About 108 people with obesity scheduled for this surgery will get different doses of the dye. The goal is to find the smallest dose that stil…

This study looks at how exercise affects insulin resistance and heart function in people with type 2 diabetes. Researchers will have 150 participants do 15 weeks of cardiovascular exercise, 3 times a week. They will measure changes in oxygen use and insulin sensitivity to see if …

This study looks at how well young women with overweight or obesity absorb iron from their diet compared to women at a healthy weight. Researchers will track iron levels and losses over time in 70 South African women. The goal is to understand why obesity raises the risk of iron …

This study looks at how exercise and physical activity during and after pregnancy change the makeup of breast milk. Researchers want to see if these changes affect how babies use energy and grow, which could help prevent childhood obesity. The study will follow 200 mothers and th…

This study looks at why people with lower income often have a harder time losing weight in behavioral programs. Researchers will track daily experiences and decision-making in 230 adults with obesity. The goal is to understand the barriers and improve future weight loss support.

This study looks at how certain natural fats from food affect inflammation in postmenopausal women, especially those with breast cancer and obesity. Researchers will measure body fat, diet, activity, and quality of life in 60 women divided into four groups. No treatment is given—…

This study looks at how 100 children aged 6-9 with obesity eat in a lab compared to at home. Researchers want to see if eating styles observed in a lab are the same as in real life, and how the home food environment affects eating. The goal is to better understand what drives ove…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study aims to understand how obesity and aging are connected by looking at blood markers in 650 young and older adults with or without obesity. Participants will provide blood samples and undergo imaging tests to measure biological age and fat distribution. The goal is to la…

This study looks at how a molecule called NAD+ affects brown fat, which helps control weight and lowers the risk of diseases like type 2 diabetes. Researchers will compare normal-weight adults and those with obesity to understand why brown fat becomes less active with age. The go…

This study looks at 500 people who are offered prescription weight-loss drugs like Wegovy or Mounjaro. Researchers want to understand what makes someone accept or refuse these medications. They will also track those who start treatment for up to 5 years to see how well the drugs …

This study is building a biobank of DNA samples and health information from 500 adults. Researchers will use this resource to explore how genetic variations relate to heart disease, high blood pressure, diabetes, and obesity. Participants provide samples and data, but no experime…

This small study looks at how a 6-month family-focused program of healthy eating and activity affects thinking skills (like focus and planning) in teens ages 13-17 who are overweight or have obesity. Ten teens and a parent or guardian will attend group sessions and complete tests…

This study looks at whether a newer measure of body shape, called the Body Roundness Index (BRI), can better predict difficult airway placement during anesthesia in obese patients compared to standard BMI. Researchers will enroll 90 obese adults undergoing general anesthesia and …

This study tests five different group programs, all delivered remotely, to help adults with higher body weight eat healthy and be active. Some groups also include mindful eating, body image support, or finding enjoyable physical activities. The goal is to see which program people…

This study looks at how moderate wine consumption changes tiny particles called extracellular vesicles, which help cells communicate. Eight healthy adults aged 35-65 will drink red wine, white wine, or water, and researchers will analyze their blood for changes in these particles…

This study tests whether a ketone supplement can improve how the body uses insulin and burns energy. Ten overweight adults aged 55-70 will receive different combinations of growth hormone, a ketone drink, or placebos on separate days. Using advanced PET scans and tissue samples, …

This study looks at how two weight-loss medications, tirzepatide and liraglutide, affect bone health and body composition in adults with severe obesity (BMI 40 or higher). Over 6 months, researchers will measure changes in bone turnover markers, weight, and body fat. The goal is …

This study looks at how digestion works in people who have had bariatric surgery (like gastric bypass or sleeve gastrectomy) and in people living with obesity. Researchers will collect fluid samples from the stomach and small intestine, and also use a swallowable capsule that mea…

This study looks at how a 12-week running program affects energy use in 80 sedentary adults. Participants will run five times a week, with researchers measuring changes in calories burned, food intake, and activity levels. The goal is to understand why exercise doesn't always lea…

This study aims to find out why some people lose more weight than others after a minimally invasive stomach-shrinking procedure called endoscopic sleeve gastroplasty. Researchers will follow 205 obese adults for 12 months, measuring weight, blood markers, and gut bacteria changes…

This study looks at whether eating oil rich in oleic acid (like some sunflower oils) can improve how fat tissue processes cholesterol in women with obesity. Forty women scheduled for bariatric surgery will take either oleic-rich or regular sunflower oil for 13 weeks. Researchers …

This study follows 832 children from remote farming communities in Pakistan to see how their diet and nutrition affect their growth and development up to age 5. Researchers will measure body mass index, head circumference, and developmental skills using questionnaires. The goal i…

This study looks at how the liver reacts to a sugar injection during bariatric surgery in people with obesity, comparing those with and without fatty liver disease (MASLD). Forty adults will receive either a sugar solution or salt water during surgery, and small tissue samples wi…

This study looks at how exercise affects blood components and physical fitness in overweight or obese adults. Researchers will measure things like body fat, strength, and heart health, along with tiny particles in the blood. The goal is to learn more about how exercise helps the …

This study aims to improve how acyclovir is dosed in people with obesity. Researchers will measure lean body mass and kidney function in 20 healthy volunteers with different BMIs to see if these factors predict how the body clears the drug. The goal is to create better dosing gui…

This study follows 320 people who had omega gastric bypass surgery 10 years ago to compare long-term side effects between two surgical techniques (150 cm vs 200 cm loop). Researchers will check for serious complications, nutritional problems, and weight loss. The goal is to deter…

This study tests how easy and useful a new digital program called Hope-D is for managing weight during pregnancy and for 6 months after giving birth. The program includes a digital pathway, weight management plans, and coaching. 30 pregnant women with a BMI of 30 or higher will u…

This study looks at how being overweight or having early signs of type 2 diabetes affects the brains of teenagers aged 12 to 17. Researchers will use brain scans and memory tests to see which factors—like insulin resistance or inflammation—are most linked to changes in brain stru…

This study aims to understand how a person's weight and blood sugar levels influence the activity of genes in tissues that process sugar and fat. Researchers will collect tissue samples from 20,000 adults undergoing abdominal surgery. The goal is to learn more about the link betw…