Can a weekly shot help shed excess weight? a large trial aims to find out
NCT ID NCT07784725
First seen Aug 25, 2026 · Last updated Aug 26, 2026 · Updated 1 time
Summary
This clinical trial is testing an experimental drug called AZD6234, given as a weekly injection, to see if it can help adults with obesity or overweight lose weight. The study will compare the drug against a placebo (a dummy injection) to measure the change in body weight over 68 weeks. Participants will be adults with a body mass index (BMI) of 30 or higher, or 27 or higher with at least one weight-related health condition like high blood pressure or sleep apnea. The goal is to determine if AZD6234 is both effective and safe for weight management.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- AZD6234, an experimental drug given as a weekly injection
- What this could lead to
- If successful, this could provide a new treatment option for weight loss in people with obesity or overweight, potentially reducing the risk of weight-related health problems.
- What could go wrong
- The trial is still in progress, and it's unclear if AZD6234 will prove more effective than placebo or if it will have significant side effects. Results from this large phase 3 study are needed to confirm its benefits and safety.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Phase 3
Large-scale testing in a bigger group. Usually the last step before a treatment can be approved.
- Participants
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About 2,500 people
The number the study aims to enrol. It can still change while the study runs.
- Started
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Aug 2026
- Expected to finish
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May 2029
An estimate. End dates often move.
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Males \& females (inclusive of all gender identities) age ≥18 years * BMI ≥30 kg/m2 OR BMI ≥27 kg/m2 with at least one of the following weight related comorbidities (treated or untreated): hypertension, dyslipidaemia, obstructive sleep apnoea, cardiovascular disease, heart failure, chronic kidney disease, metabolic dysfunction-associated steatotic liver disease, osteoarthritis of the knee, or stress urinary incontinence * Stable body weight (≤5% body weight change) for at least 3 months prior to Randomisation * History of at least one self-reported unsuccessful attempt to lose body weight in their lifetime Exclusion Criteria: * Obesity primarily caused by other endocrine disorders * History of Type 1 or Type 2 Diabetes Mellitus, HbA1c ≥6.5% (48 mmol/mol), and/or treatment with glucose-lowering agent(s) within 3 months prior to Screening * Significant hepatobiliary disease and/or any of the following results at Screening: * ALT ≥ 3.0 × ULN * AST ≥ 3.0 × ULN * TBL \> 1.5 × ULN (except for cases of known Gilbert's Syndrome) * Has received treatment with a GLP-1 receptor agonist or GLP-1 containing medication for any indication within 3 months before Randomisation.
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Get notified about this study
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
209 sites in 16 countries. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Research Site
NOT_YET_RECRUITINGDothan, Alabama, 36305, United States
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NOT_YET_RECRUITINGHuntsville, Alabama, 35801, United States
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NOT_YET_RECRUITINGMesa, Arizona, 85206, United States
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NOT_YET_RECRUITINGEscondido, California, 92025, United States
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NOT_YET_RECRUITINGClearwater, Florida, 33765, United States
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NOT_YET_RECRUITINGJacksonville, Florida, 32205, United States
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NOT_YET_RECRUITINGStockbridge, Georgia, 30281, United States
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NOT_YET_RECRUITINGChampaign, Illinois, 61822, United States
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NOT_YET_RECRUITINGChicago, Illinois, 60640, United States
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NOT_YET_RECRUITINGAmes, Iowa, 50010, United States
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NOT_YET_RECRUITINGTroy, Michigan, 48098, United States
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NOT_YET_RECRUITINGJefferson City, Missouri, 65109, United States
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NOT_YET_RECRUITINGKansas City, Missouri, 64131, United States
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NOT_YET_RECRUITINGButte, Montana, 59701, United States
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NOT_YET_RECRUITINGLas Vegas, Nevada, 89101, United States
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NOT_YET_RECRUITINGJersey City, New Jersey, 07306, United States
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NOT_YET_RECRUITINGCortland, New York, 13045, United States
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NOT_YET_RECRUITINGStatesville, North Carolina, 28625, United States
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NOT_YET_RECRUITINGFargo, North Dakota, 58104, United States
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NOT_YET_RECRUITINGColumbus, Ohio, 43215, United States
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NOT_YET_RECRUITINGTulsa, Oklahoma, 74133, United States
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NOT_YET_RECRUITINGPortland, Oregon, 97202, United States
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NOT_YET_RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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NOT_YET_RECRUITINGSmithfield, Pennsylvania, 15478, United States
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NOT_YET_RECRUITINGKingsport, Tennessee, 37660, United States
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NOT_YET_RECRUITINGHouston, Texas, 77043, United States
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NOT_YET_RECRUITINGSan Antonio, Texas, 78231, United States
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NOT_YET_RECRUITINGSugar Land, Texas, 77478, United States
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NOT_YET_RECRUITINGWaco, Texas, 76710, United States
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NOT_YET_RECRUITINGSalt Lake City, Utah, 84124, United States
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NOT_YET_RECRUITINGArlington, Virginia, 22206, United States
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WITHDRAWNRenton, Washington, 98057, United States
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NOT_YET_RECRUITINGSeattle, Washington, 98104, United States
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NOT_YET_RECRUITINGBuenos Aires, C1425AGC, Argentina
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NOT_YET_RECRUITINGCABA, C1120AAC, Argentina
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NOT_YET_RECRUITINGCiudad de Buenos Aires, C1094AAD, Argentina
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NOT_YET_RECRUITINGMendoza, 5500, Argentina
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NOT_YET_RECRUITINGRamos Mejía, B1704ETD, Argentina
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NOT_YET_RECRUITINGRosario, S2000PBJ, Argentina
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NOT_YET_RECRUITINGSan Nicolás, B2900DMH, Argentina
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NOT_YET_RECRUITINGBotany, 2019, Australia
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NOT_YET_RECRUITINGKotara, 2289, Australia
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NOT_YET_RECRUITINGMalvern, 3144, Australia
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NOT_YET_RECRUITINGSt Albans, 3021, Australia
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RECRUITINGSt Leonards, 2065, Australia
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NOT_YET_RECRUITINGWaitara, 2077, Australia
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NOT_YET_RECRUITINGBelo Horizonte, 30150-320, Brazil
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NOT_YET_RECRUITINGBrasília, 71625-009, Brazil
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NOT_YET_RECRUITINGCampinas, 13060-904, Brazil
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NOT_YET_RECRUITINGCampinas, 13087-567, Brazil
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WITHDRAWNCuritiba, 80030-480, Brazil
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NOT_YET_RECRUITINGCuritiba, 80230-130, Brazil
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NOT_YET_RECRUITINGCuritiba, 80810-040, Brazil
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NOT_YET_RECRUITINGNatal, 59020-035, Brazil
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NOT_YET_RECRUITINGPorto Alegre, 90630-165, Brazil
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NOT_YET_RECRUITINGRio de Janeiro, 22270-060, Brazil
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NOT_YET_RECRUITINGSão José dos Campos, 12243-280, Brazil
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NOT_YET_RECRUITINGSão Paulo, 04266-010, Brazil
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NOT_YET_RECRUITINGMontana, 3400, Bulgaria
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NOT_YET_RECRUITINGPleven, 5800, Bulgaria
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NOT_YET_RECRUITINGPlovdiv, 4000, Bulgaria
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NOT_YET_RECRUITINGSofia, 1000, Bulgaria
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NOT_YET_RECRUITINGSofia, 1527, Bulgaria
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NOT_YET_RECRUITINGSofia, 1618, Bulgaria
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NOT_YET_RECRUITINGVarna, 9010, Bulgaria
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NOT_YET_RECRUITINGYambol, 8600, Bulgaria
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NOT_YET_RECRUITINGCalgary, Alberta, T3R 1W9, Canada
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NOT_YET_RECRUITINGNew Westminster, British Columbia, V3L 3W4, Canada
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NOT_YET_RECRUITINGSurrey, British Columbia, V3S 2N6, Canada
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NOT_YET_RECRUITINGVictoria, British Columbia, V8V 4A1, Canada
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NOT_YET_RECRUITINGMoncton, New Brunswick, E1G 1A7, Canada
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NOT_YET_RECRUITINGTruro, Nova Scotia, B2N 1L2, Canada
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NOT_YET_RECRUITINGBrampton, Ontario, L6T 0G1, Canada
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NOT_YET_RECRUITINGGuelph, Ontario, N1H 1B1, Canada
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NOT_YET_RECRUITINGHamilton, Ontario, L8L 5G8, Canada
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RECRUITINGMississauga, Ontario, L5K2L3, Canada
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NOT_YET_RECRUITINGNorth York, Ontario, M6B 3H7, Canada
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NOT_YET_RECRUITINGScarborough Village, Ontario, M1R 0B1, Canada
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NOT_YET_RECRUITINGStoney Creek, Ontario, L8J 3W2, Canada
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RECRUITINGStouffville, Ontario, L4A1H2, Canada
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NOT_YET_RECRUITINGToronto, Ontario, M9V 4B4, Canada
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NOT_YET_RECRUITINGMontreal, Quebec, H4N 2W2, Canada
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NOT_YET_RECRUITINGQuébec, Quebec, G1V 4T3, Canada
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NOT_YET_RECRUITINGQuébec, Quebec, G2J 0C4, Canada
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NOT_YET_RECRUITINGSaint-Charles-Borromée, Quebec, J6E 2B4, Canada
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NOT_YET_RECRUITINGSherbrooke, Quebec, J1L 0K3, Canada
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NOT_YET_RECRUITINGBeijing, 100000, China
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NOT_YET_RECRUITINGCangzhou, 061001, China
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NOT_YET_RECRUITINGChangchun, 130011, China
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NOT_YET_RECRUITINGChangchun, 130041, China
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NOT_YET_RECRUITINGChangsha, 410006, China
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NOT_YET_RECRUITINGChengdu, 610021, China
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NOT_YET_RECRUITINGDanyang, 212399, China
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NOT_YET_RECRUITINGGanzhou, 341000, China
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NOT_YET_RECRUITINGGuiyang, 550044, China
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NOT_YET_RECRUITINGHengshui, 053099, China
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NOT_YET_RECRUITINGHuizhou, 516002, China
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NOT_YET_RECRUITINGLanzhou, 730000, China
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NOT_YET_RECRUITINGPanjin, 124009, China
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NOT_YET_RECRUITINGQiqihar, 161005, China
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NOT_YET_RECRUITINGShanghai, 200032, China
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NOT_YET_RECRUITINGSuzhou, 215006, China
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NOT_YET_RECRUITINGXiamen, 361101, China
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NOT_YET_RECRUITINGXianyang, 712000, China
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NOT_YET_RECRUITINGZigong, 643000, China
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NOT_YET_RECRUITINGBenešov, 256 01, Czechia
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WITHDRAWNBrandýs nad Labem, 250 01, Czechia
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NOT_YET_RECRUITINGBrno, 602 00, Czechia
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NOT_YET_RECRUITINGHodonín, 695 01, Czechia
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NOT_YET_RECRUITINGKladno, 272 01, Czechia
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NOT_YET_RECRUITINGOstrava, 702 00, Czechia
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NOT_YET_RECRUITINGPrague, 104 00, Czechia
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NOT_YET_RECRUITINGPrague, 116 94, Czechia
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NOT_YET_RECRUITINGPrague, 140 00, Czechia
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NOT_YET_RECRUITINGPrague, 149 00, Czechia
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NOT_YET_RECRUITINGPrague, 150 00, Czechia
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NOT_YET_RECRUITINGPrague, 19800, Czechia
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NOT_YET_RECRUITINGŠtětí, 411 08, Czechia
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NOT_YET_RECRUITINGBobigny, 93000, France
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NOT_YET_RECRUITINGColmar, 68024, France
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NOT_YET_RECRUITINGDijon, 21000, France
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NOT_YET_RECRUITINGParis, 75900, France
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NOT_YET_RECRUITINGPessac, 33604, France
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NOT_YET_RECRUITINGPierre-Bénite, 69495, France
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NOT_YET_RECRUITINGThionville, 57100, France
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NOT_YET_RECRUITINGToulouse, 31059, France
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NOT_YET_RECRUITINGVénissieux, 69200, France
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NOT_YET_RECRUITINGBerlin, 10117, Germany
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NOT_YET_RECRUITINGBerlin, 10629, Germany
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NOT_YET_RECRUITINGBerlin, 10787, Germany
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NOT_YET_RECRUITINGBochum, 44789, Germany
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NOT_YET_RECRUITINGBünde, 32257, Germany
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NOT_YET_RECRUITINGDresden, 01069, Germany
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NOT_YET_RECRUITINGFrankfurt, 60590, Germany
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NOT_YET_RECRUITINGFrankfurt, 60596, Germany
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NOT_YET_RECRUITINGFreiburg im Breisgau, 79106, Germany
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NOT_YET_RECRUITINGGöttingen, 37075, Germany
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NOT_YET_RECRUITINGHamburg, 20095, Germany
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NOT_YET_RECRUITINGHamburg, 20253, Germany
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NOT_YET_RECRUITINGHanover, 30159, Germany
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NOT_YET_RECRUITINGHomburg, 66421, Germany
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NOT_YET_RECRUITINGJerichow, 39319, Germany
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NOT_YET_RECRUITINGKarlsruhe, 76137, Germany
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NOT_YET_RECRUITINGLeipzig, 04177, Germany
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NOT_YET_RECRUITINGMagdeburg, 39110, Germany
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NOT_YET_RECRUITINGMainz, 55128, Germany
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NOT_YET_RECRUITINGMünchen, 80339, Germany
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NOT_YET_RECRUITINGMünchen, 81667, Germany
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NOT_YET_RECRUITINGOffenbach, 63065, Germany
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NOT_YET_RECRUITINGSchwerin, 19055, Germany
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NOT_YET_RECRUITINGWiesbaden, 65189, Germany
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SUSPENDEDBhubaneswar, 751019, India
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NOT_YET_RECRUITINGCoimbatore, 641009, India
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NOT_YET_RECRUITINGHyderabad, 500048, India
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NOT_YET_RECRUITINGIndore, 452008, India
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NOT_YET_RECRUITINGJaipur, 302001, India
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NOT_YET_RECRUITINGJodhpur, 342005, India
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SUSPENDEDKochi, 682041, India
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NOT_YET_RECRUITINGKolkata, 700014, India
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NOT_YET_RECRUITINGNoida, 201310, India
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NOT_YET_RECRUITINGPune, 411021, India
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NOT_YET_RECRUITINGPune, 411057, India
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NOT_YET_RECRUITINGSiliguri, 734012, India
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NOT_YET_RECRUITINGSurat, 395002, India
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NOT_YET_RECRUITINGVijayawada, 520 008, India
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NOT_YET_RECRUITINGBologna, 40138, Italy
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NOT_YET_RECRUITINGMilan, 20138, Italy
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NOT_YET_RECRUITINGMilan, 20149, Italy
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NOT_YET_RECRUITINGPalermo, 90127, Italy
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NOT_YET_RECRUITINGPisa, 56100, Italy
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NOT_YET_RECRUITINGRoma, 128, Italy
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NOT_YET_RECRUITINGRozzano, 20089, Italy
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NOT_YET_RECRUITINGSesto San Giovanni, 20099, Italy
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NOT_YET_RECRUITINGTorino, 10126, Italy
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NOT_YET_RECRUITINGChūōku, 103-0025, Japan
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NOT_YET_RECRUITINGChūōku, 103-0027, Japan
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NOT_YET_RECRUITINGFukuoka, 812-0025, Japan
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NOT_YET_RECRUITINGHachioji-shi, 192-0071, Japan
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NOT_YET_RECRUITINGOsaka, 540-0001, Japan
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NOT_YET_RECRUITINGShibuya-ku, 151-0051, Japan
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NOT_YET_RECRUITINGTakatsuki-shi, 569-1192, Japan
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NOT_YET_RECRUITINGBialystok, 15-481, Poland
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NOT_YET_RECRUITINGElblag, 82-300, Poland
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NOT_YET_RECRUITINGGdynia, 81-338, Poland
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NOT_YET_RECRUITINGKatowice, 40-081, Poland
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NOT_YET_RECRUITINGKatowice, 40-772, Poland
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NOT_YET_RECRUITINGKrakow, 30-105, Poland
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NOT_YET_RECRUITINGKrakow, 31-271, Poland
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NOT_YET_RECRUITINGLegnica, 59-220, Poland
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NOT_YET_RECRUITINGLodz, 90-132, Poland
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NOT_YET_RECRUITINGLodz, 90-338, Poland
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NOT_YET_RECRUITINGPoznan, 60-354, Poland
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NOT_YET_RECRUITINGRadzionków, 41-922, Poland
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NOT_YET_RECRUITINGWarsaw, 00-719, Poland
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NOT_YET_RECRUITINGWarsaw, 03-291, Poland
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NOT_YET_RECRUITINGWroclaw, 53-673, Poland
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NOT_YET_RECRUITINGAnyang, 14068, South Korea
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NOT_YET_RECRUITINGBucheon-si, 14754, South Korea
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NOT_YET_RECRUITINGDaegu, 41944, South Korea
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NOT_YET_RECRUITINGSeoul, 02841, South Korea
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NOT_YET_RECRUITINGSeoul, 04763, South Korea
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NOT_YET_RECRUITINGSeoul, 05505, South Korea
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NOT_YET_RECRUITINGSeoul, 06591, South Korea
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NOT_YET_RECRUITINGYangsan, 50612, South Korea
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NOT_YET_RECRUITINGChanghua, 500, Taiwan
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NOT_YET_RECRUITINGChiayi City, 600, Taiwan
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RECRUITINGKaohsiung City, 80756, Taiwan
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NOT_YET_RECRUITINGNew Taipei City, 24352, Taiwan
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NOT_YET_RECRUITINGTaichung, 40705, Taiwan
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NOT_YET_RECRUITINGTainan, 704, Taiwan
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NOT_YET_RECRUITINGTaipei, 10002, Taiwan
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NOT_YET_RECRUITINGTaoyuan, 333, Taiwan
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