Basal ganglia disorder

This phase 3 trial is testing whether adding a targeted therapy called Sacituzumab tirumotecan (Sac-TMT) to standard chemotherapy and immunotherapy (pembrolizumab) can better eliminate cancer before surgery in people with high-risk, early-stage triple-negative or hormone-receptor…

This study tests whether adding a personalized mRNA vaccine (V940) to standard immunotherapy (pembrolizumab) can stop advanced melanoma from growing or spreading. About 160 people with stage III or IV melanoma that cannot be removed by surgery will receive either the vaccine plus…

This phase 3 trial tests whether adding the experimental drug sacituzumab tirumotecan (sac-TMT) to standard immunotherapy (pembrolizumab) and a targeted therapy (bevacizumab) helps people with metastatic cervical cancer live longer. About 1,000 participants whose cancer has sprea…

This study tests a new automated method to fine-tune adaptive deep brain stimulation (aDBS) for people with Parkinson's disease. aDBS uses brain signals to adjust stimulation in real time, but setting it up is complex. The trial will compare automated aDBS to standard continuous …

This phase 3 trial tests whether adding the experimental drug MK-2870 to the standard immunotherapy pembrolizumab helps people with advanced non-small cell lung cancer live longer compared to pembrolizumab alone. The study enrolls about 614 adults whose tumors have high PD-L1 lev…

This study investigates whether a homemade bottle-based breathing device can strengthen the muscles used for exhaling and improve balance in people with Parkinson's disease. Parkinson's often weakens respiratory muscles, leading to breathing and coughing problems. The trial will …

This study checks the long-term safety and lasting effects of a gene therapy called IPS101A in 6 people with severe Parkinson's disease who already received it in an earlier trial. Researchers will monitor side effects and measure changes in movement symptoms over time. The goal …

This early-stage trial tests whether implanting specially grown dopamine-producing cells into the brain is safe and can help people with Parkinson's disease. Six participants receive their own lab-grown cells placed into a brain region that controls movement. The study measures c…

This Phase 2 trial tests an oral drug called NEU-411 in 150 adults aged 40-80 with early Parkinson's disease who have a specific genetic marker (LRRK2-driven). The study is double-blind and placebo-controlled, meaning neither patients nor doctors know who gets the real drug. Rese…

This study follows 300 adults with Parkinson's disease, essential tremor, or dystonia who receive deep brain stimulation (DBS). DBS uses a device implanted in the chest to send electrical pulses to brain areas controlling movement. Researchers will track symptom severity, medicat…

This phase 3 trial tests whether a new drug (MK-2870), alone or with another drug (pembrolizumab), works better than standard treatments for people with a common type of advanced breast cancer (HR+/HER2-). About 1,200 participants whose cancer has worsened after hormone therapy w…

This Phase 2 study tests whether a single dose of AAV2-GDNF gene therapy, delivered directly into the brain, can improve motor function in adults with moderate Parkinson's disease. About 127 participants will receive either the gene therapy or a sham surgery. The main goal is to …

This study tests whether a new drug, sacituzumab tirumotecan (Sac-TMT), given alone or with pembrolizumab, helps people with advanced triple-negative breast cancer live longer or keep their cancer from growing. About 1,000 adults whose cancer has spread and who have not had prior…

This study tests a new targeted therapy pill called MK-1084, alone or with other drugs, for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. The goal is to see if the treatment is safe and can shrink tumors. About 130 participan…

This study tests whether adding an experimental mRNA vaccine (V940) to the immunotherapy drug pembrolizumab (Keytruda) can keep lung cancer from returning after surgery. It includes 680 people with stage II to IIIB non-small cell lung cancer whose tumors did not fully respond to …

This study tests several new drug combinations, with or without the immunotherapy pembrolizumab, in people with advanced esophageal cancer that has continued to grow after standard treatment. About 230 participants will receive different drug regimens to see which are safest and …

This study is testing whether stem cells taken from a person's own bone marrow and then given back through the veins and nose can improve brain and nerve function. It includes 500 people with various conditions like stroke, Parkinson's, Alzheimer's, and nerve damage. The goal is …

This study tests an adaptive deep brain stimulation (aDBS) system that automatically adjusts stimulation based on real-time brain signals. It aims to improve symptom control for 62 people with Parkinson's disease in China who already have a compatible brain implant. The main goal…

This phase 2 trial is testing whether giving the immunotherapy drug pembrolizumab (Keytruda) along with chemotherapy before surgery can eliminate all signs of cancer in people with resectable stage II to IIIB non-small cell lung cancer. About 60 participants will receive the comb…

This phase 3 trial is testing whether a targeted drug (trastuzumab deruxtecan) combined with immunotherapy (rilvegostomig or pembrolizumab) works better than standard chemotherapy plus pembrolizumab for people with advanced or recurrent endometrial cancer that has a specific prot…

This early-stage trial tests a new oral drug called MF1 in healthy adults and people with Parkinson's disease. The drug aims to block a harmful protein (alpha-synuclein) linked to Parkinson's. The main goal is to check safety and how the body processes the drug, not yet whether i…

This study follows 120 adults with advanced Parkinson's disease in Belgium who are prescribed a drug called Foslevodopa/Foscarbidopa. The drug is given as a continuous infusion under the skin to help control symptoms. Researchers will track how much 'off' time (when symptoms like…

This study tests several new drug combinations, including pembrolizumab (an immunotherapy), with or without chemotherapy, in people with advanced non-small cell lung cancer who have not had prior treatment. The goal is to see if these combinations can shrink tumors and control th…

This study compares Tai Chi and Qi-Gong, two gentle movement therapies, to see which better improves balance and motor function in people with stage I Parkinson's disease. Fifty participants aged 50 to 65 will receive either Tai Chi or Qi-Gong alongside standard physical therapy …

This Phase 2 study tests two new antibody-drug conjugates (R-DXd and I-DXd) against standard chemotherapy in 96 people with advanced nonsquamous non-small cell lung cancer that has worsened after prior immunotherapy and chemotherapy. These 'guided missiles' deliver a cancer-killi…

This study investigates whether a wrist-worn sensor (KinesiaU) can accurately measure how long people with Parkinson's disease experience 'good on-time' — periods when medication works well and symptoms are controlled without troublesome movements. Researchers are testing IPX-203…

This study tests a new type of deep brain stimulation (DBS) that automatically adjusts its settings based on real-time brain signals, unlike standard DBS which uses fixed stimulation. Sixty people with Parkinson's disease will have a special neurostimulator implanted and then exp…

This early-stage trial tests whether transplanting 10 million special nerve cells made from stem cells into the brain is safe for people with moderate Parkinson's disease. Ten participants will receive the cells in a single surgery. The main goal is to check for side effects and …

This early-stage trial is testing an experimental drug called MK-0472, alone or combined with the immunotherapy Keytruda or another experimental drug MK-1084, in people with advanced or metastatic solid tumors. The main goals are to check safety, find the right dose, and see how …

This phase 2 trial tests whether dapansutrile, a drug that targets inflammation, is safe and can reduce brain and body inflammation in people with early Parkinson's disease. 36 participants will take either the drug or a placebo daily for 6 months, with brain scans and spinal tap…

This early-phase trial is testing a new experimental drug called BNT3212, alone or with another drug (pumitamig), in 375 adults with advanced solid tumors who have no other treatment options. The main goals are to check safety, find the right dose, and get an early look at whethe…

This phase 3 study is testing whether adding an experimental pill called calderasib (MK-1084) to the immunotherapy drug pembrolizumab (Keytruda) works better than pembrolizumab alone for people with advanced non-small cell lung cancer that has a KRAS G12C mutation and high PD-L1 …

This study is testing the long-term safety of a daily drug called buntanetap in 500 people with Parkinson's disease over 36 months. It includes two groups: those who have taken buntanetap before and those who have a deep brain stimulation device. The main goal is to see if the dr…

This registry is collecting information from 1,500 people with Parkinson's disease who are receiving deep brain stimulation (DBS) with the Vercise system. The goal is to see how DBS affects quality of life in everyday practice, and to evaluate new programming tools. Participants …

This study tests a new way to give the drug rilvegostomig as a shot under the skin instead of through an IV. It is for adults with advanced solid tumors who have already tried standard treatments. The goal is to find a dose that works as well as the IV version and to check for si…

This study follows about 215 adults with advanced Parkinson's disease who are switching from a pump medication to a new intestinal gel called LECIGON®. Researchers want to see if the gel reduces daily 'off' time—when symptoms return—over 12 months. Participants continue their usu…

This study tests whether D-serine, a dietary supplement, can slow the progression of Parkinson's disease. One hundred people with early-stage Parkinson's will receive either D-serine or a placebo for 58 weeks. Researchers will measure changes in symptoms and brain scans to see if…

This study tests an experimental drug called prasinezumab in 900 people with early-stage Parkinson's disease who are already taking levodopa. The goal is to see if the drug can delay worsening of motor symptoms compared to a placebo. Participants receive the drug or placebo by IV…

This study tests a treatment called bemdaneprocel, which involves transplanting dopamine-producing nerve cells into the brains of people with Parkinson's disease. The goal is to reduce daily 'OFF' time—when symptoms return—and increase 'ON' time without uncontrolled movements. Ab…

This study is testing deep brain stimulation (DBS) surgery for people with Parkinson's disease, essential tremor, or dystonia that doesn't improve enough with medication. DBS uses a device like a pacemaker to send electrical pulses to specific brain areas that control movement. R…

This early-stage study tests a new drug called MTX325 in healthy volunteers and people with mild to moderate Parkinson's disease. The main goals are to check safety, how the body processes the drug, and whether it reaches the brain. If successful, MTX325 might one day slow the pr…

This study tests whether a daily supplement containing a specific probiotic, tryptophan, and branched-chain amino acids can slow the progression of early-stage Parkinson's disease. Researchers will recruit 120 participants and randomly assign them to receive either the supplement…

This study tests whether adding sacituzumab tirumotecan (Sac-TMT) to pembrolizumab helps people with advanced or recurrent endometrial cancer live longer without the cancer getting worse. About 1,100 participants with a specific type of endometrial cancer (pMMR) will receive eith…

This phase 2 trial is testing whether a nasal spray containing insulin and glutathione can safely improve symptoms in people with Parkinson's disease. About 56 participants will receive either the active spray or a placebo, added to their usual medications. The study focuses on c…

This study looks at how well the drug combination Foslevodopa/Foscarbidopa works for people with early advanced Parkinson's disease in everyday German clinics. About 125 adults aged 18-64 who are already prescribed this drug will be followed for up to 12 months. Researchers will …

This study tests a single intravenous dose of a gene therapy called AB-1009 in 12 adults with late-onset Pompe disease. Participants must have been on enzyme replacement therapy for at least 6 months. The main goal is to check safety and side effects, while also seeing if the tre…

This study tests new experimental drugs combined with standard chemotherapy and immunotherapy for people with advanced stomach, gastroesophageal junction, or esophageal cancer that cannot be removed by surgery or has spread. About 160 participants will receive the combination to …

This study tests a treatment called Lecigon® for people with Parkinson's disease. It is a gel given through a tube into the intestine that delivers a steady dose of medication. The goal is to see if this method reduces certain behavioral and emotional side effects better than sta…

This early-stage study tests a new drug called LY3962681 in healthy volunteers and people with Parkinson's disease. The goal is to check if the drug is safe and how the body processes it. Participants receive either the drug or a placebo injected into the spinal fluid, and are fo…

This study follows 270 Italian adults with advanced Parkinson's disease who are already prescribed Foslevodopa/Foscarbidopa, a drug given as a continuous infusion under the skin. Researchers will track how the drug affects quality of life over 12 months using a standard questionn…

This study tests two new drug combinations for people with advanced stomach, gastroesophageal junction, or esophageal cancer that has worsened after initial treatment. About 210 participants will receive either an experimental antibody-drug conjugate plus chemotherapy, or a stand…

This early-phase trial tests a new treatment called NouvNeu001 for people with advanced Parkinson's disease. It involves injecting special brain cells directly into areas of the brain that control movement. The study will enroll just 5 participants to see if the procedure is safe…

This early-phase study tests whether a supplement called gamma-glutamylcysteine (GGC) can increase levels of the brain's master antioxidant, glutathione, in people with early Parkinson's disease. Researchers will measure changes in brain chemistry, motor skills, thinking abilitie…

This early-stage trial tests a gene therapy called IPS101A in 6 people with advanced Parkinson's disease (stages 4-5) whose symptoms are not controlled by current medications. The main goal is to check safety and find the best dose. Researchers will also look for any signs that t…

This early-stage trial is testing an experimental drug called LY4006896 in healthy volunteers and people with Parkinson's disease. The main goal is to check if the drug is safe and how the body processes it. Researchers will give single or multiple doses and watch for side effect…

This early-stage trial tests an experimental oral drug called HL-400 in 86 healthy volunteers. The drug aims to block a protein (NLRP3) linked to inflammation, which may play a role in Parkinson's disease. The study focuses on safety, tolerability, and how the drug moves through …

This study tests an experimental drug called ALN-SNCA in 46 people with early Parkinson's disease. The drug is designed to lower levels of a harmful protein, alpha-synuclein, in the brain. The main goal is to check if the drug is safe and tolerable, and to see how it moves throug…

This early-stage trial is testing a new cancer vaccine called BNT116, alone or with other drugs, in people with advanced non-small cell lung cancer. The main goal is to find a safe dose and check for side effects. About 320 participants will be enrolled across several groups, inc…

This early-stage trial tests a single injection of dopamine-producing cells directly into the brain for people with multiple system atrophy (MSA), a rare and severe movement disorder. The main goal is to check safety and side effects in 9 participants aged 30 to 70. Researchers w…

This study tests whether high-intensity treadmill exercise can slow the worsening of motor symptoms in people with early-stage Parkinson's disease. 370 participants who have not yet started Parkinson's medication will be assigned to either moderate or high-intensity treadmill ses…

This program offers continued free access to the experimental drug BIA 28-6156 for people with Parkinson's disease who have a specific change in the GBA1 gene and have already completed the ACTIVATE study. Participants take one 60mg pill daily. The goal is to provide ongoing trea…

This study tests whether etoricoxib, an anti-inflammatory drug, can help control symptoms in people with Parkinson's disease when added to their usual treatment. The trial will include 60 adults with Parkinson's and measure changes in movement and daily function. The goal is to s…

This study tests a home-based fall prevention program for people with Parkinson's disease. Participants receive a home assessment, personalized recommendations, and an action plan to improve safety and accessibility. The goal is to boost confidence, reduce falls, and help people …

This early-stage study tests if implanting a small piece of the participant's own leg nerve into a key brain area is safe and feasible for people with early Parkinson's disease or Multiple System Atrophy. Seven people will take part; four will get the nerve graft and three will h…

This study tests whether a new drug called SUL-238 can improve energy production in brain cells of people with early, untreated Parkinson's disease. Forty-five participants will take either a low or high dose of SUL-238 or a placebo daily for 28 days. Researchers will use a speci…

This study tests whether varenicline (Chantix), a drug used to help people quit smoking, can reduce falls in people with Parkinson's disease. About 102 participants will take either varenicline or a placebo for one year. Researchers will measure changes in walking speed while mul…

This early-stage trial tests if transplanting a patient's own stem cells into the brain is safe for Parkinson's disease. Researchers take skin cells, turn them into dopamine-producing brain cells, and surgically place them in the brain. Only 8 people with moderate Parkinson's wil…

This registry follows 50 people with tremor-dominant Parkinson's disease who have undergone a focused ultrasound thalamotomy. The procedure uses sound waves to target a small area in the brain that causes tremors. The goal is to collect long-term safety data and measure how well …

This study tracks people with advanced Parkinson's disease who receive a treatment called Exablate, which uses focused ultrasound to target a small area in the brain. The goal is to see how well it reduces medication-resistant motor problems like shaking and stiffness. Researcher…

This early-stage trial is testing whether an experimental oral drug called AX-5006 is safe and tolerable in healthy adults and people with Parkinson's disease. The study involves 84 participants across three parts: single doses in healthy volunteers, multiple daily doses in healt…

This study is testing whether montelukast, a common asthma medication, can help control symptoms of Parkinson's disease. Researchers will enroll 60 adults with Parkinson's who are already taking levodopa. The main goal is to see if montelukast improves movement and daily living s…

This early-stage trial tests a cell therapy called DSP-1083, implanted directly into the brain, for people with Parkinson's disease. About 25 participants will either get the real implant or a sham surgery to see if it's safe and helps control symptoms. The goal is to replace dam…

This phase 2 trial tests whether etidronate, a drug used for bone disorders, can reduce calcium deposits in the brain and slow disease progression in Fahr's disease or syndrome. 98 adults will receive either etidronate or a placebo for 12 months. The study measures changes in thi…

This study tests whether using a robot to help remove large blood clots in the brain (from a hemorrhagic stroke) leads to better recovery than standard surgery. About 198 adults with a large basal ganglia hemorrhage will be randomly assigned to robot-assisted or traditional surge…

This early trial tests whether a surgically implanted device that stimulates a specific brain network (called SCAN) can improve movement problems in people with Parkinson's disease. Three adults with Parkinson's will receive the implant and be followed for 12 months. The study is…

This study tests whether playing gentle sounds during deep sleep can slow the progression of Parkinson's disease in people at high risk. Participants with REM sleep behavior disorder or early Parkinson's will wear a headband and headphones for 18 months. Researchers will track ch…

This program allows eligible people with Parkinson's disease to receive tavapadon, an experimental oral tablet, before it is officially approved. A doctor must decide if the potential benefit outweighs the risks. The program is only available in certain territories and for those …

This study tests whether exercising more frequently (5 times a week for one month, then three weeks off) is better than exercising once a week with no breaks for people with moderate Parkinson's disease. The exercise is a partnered dance program based on Argentine tango, adapted …

This early-stage study tests whether a new gene therapy called BBM-P002 is safe when injected directly into a specific brain area. It involves 18 adults who have had Parkinson's disease for at least 5 years. The main goal is to check for side effects and see how well the treatmen…

This early-phase trial tests whether a focused ultrasound device can safely open the blood-brain barrier to deliver a missing enzyme (GCase) directly into the brains of 14 people with Parkinson's disease. The goal is to see if this delivery method is safe and feasible, not yet to…

This early-stage trial tests a new treatment called RNDP-001, which involves transplanting dopamine-producing stem cells into the brains of 12 people with Parkinson's disease. The main goal is to see if the procedure is safe and tolerable. Researchers will also monitor changes in…

This study is testing a supplement made from a broccoli compound (bioactivated GRA) in 300 people with Parkinson's disease, relapsing-remitting multiple sclerosis, or certain childhood nerve diseases. Participants will take the supplement daily for 6 months. Researchers will trac…

This study tests whether a daily pill called BHV-8000 can slow the worsening of motor skills in people recently diagnosed with Parkinson's disease. About 550 adults aged 40 to 85 with early Parkinson's will receive either BHV-8000 (10 mg or 20 mg) or a placebo for up to 48 weeks.…

This study tests whether an AI-guided robotic system can improve outcomes for people with a moderate brain bleed (basal ganglia hemorrhage). About 330 adults will be randomly assigned to receive either the AI-assisted minimally invasive surgery or standard care. The goal is to se…

This large trial is testing whether AI-guided robotic surgery can improve outcomes for people with a hemorrhagic stroke (bleeding in the brain). The study will compare this new, less invasive technique to standard surgery or medical management. Researchers hope the robotic approa…

This international study is following 1,000 people who already have or are getting an Abbott deep brain stimulation (DBS) system to treat Parkinson's disease, essential tremor, or dystonia. Researchers will track how well the device controls symptoms and monitor for serious side …

This study compares deep brain stimulation (DBS) plus medication against medication alone for Parkinson's patients who also have impulse control disorders, like gambling or compulsive behaviors. About 60 participants aged 70 or younger will be randomly assigned to one of the two …

This study tests a single injection of lab-grown nerve cells made from stem cells to treat early-onset Parkinson's disease. The cells are designed to replace the dopamine-producing neurons that are lost in Parkinson's. The trial has two phases: first, a small safety test in 6-12 …

This study looks at whether a 12-month home exercise program can improve thinking skills in people with Parkinson's disease who also have mild memory or attention problems. Researchers will compare exercisers to a sedentary group and measure changes in movement, mood, and blood m…

This study tests whether a non-invasive brain stimulation technique called rTMS can improve deep sleep and slow the progression of Parkinson's disease. Researchers will give 56 people with Parkinson's either real or sham rTMS and track changes in movement and sleep. The goal is t…

This study tests whether vinpocetine, a drug thought to improve blood flow in the brain, can safely reduce Parkinson's symptoms like tremor and stiffness. Researchers will enroll 60 adults with Parkinson's who already take levodopa. The goal is to see if adding vinpocetine leads …

This study tests whether metformin, a standard diabetes medication, can safely improve movement and quality of life in people with Parkinson's disease. Researchers will enroll 60 adults aged 50 and older who are already taking levodopa/carbidopa. The main goal is to see if metfor…

This early study tests a spinal cord stimulation therapy called ARC-IM in 5 people with Parkinson's disease or related conditions who experience severe drops in blood pressure when standing (orthostatic hypotension). The main goal is to check safety, and researchers will also mea…

This study tests whether a supplement called tributyrin can improve memory, thinking, and walking in people with Parkinson's disease who also have cognitive problems. 45 participants will take either tributyrin or a placebo three times daily for about 90 days. Researchers will me…

This study looks at how genetics and aerobic exercise together might slow the progression of Parkinson's disease. Two hundred people with Parkinson's will take part in a community-based cycling program three times a week for a year. Researchers will track motor symptoms and think…

This study aims to find better ways to diagnose Parkinson's disease in its earliest stages. Researchers will use wearable devices to track movement and analyze blood samples for specific markers from nerve cells. By combining these digital and biological clues, they hope to creat…

This study tests a new radioactive tracer called 18F-mFBG to see if it can detect nerve damage in the heart caused by Lewy body diseases like Parkinson's and Lewy body dementia. About 20 adults will get a PET scan after an injection of the tracer. The goal is to see if the scan c…

This early-stage study tests a new radioactive tracer called SST001 that lights up on PET scans. Researchers want to see if it is safe and can help tell the difference between multiple system atrophy (MSA) and Parkinson's disease. The study will include 30 healthy volunteers and …

This early-phase study tests a new imaging drug called [18F]MK-0947 that works with PET scans to show where a protein called α-synuclein builds up in the brain—a hallmark of Parkinson's disease. Researchers will check safety and how well the tracer works in 22 adults (some with P…

This early-phase study tests a new radioactive tracer called [¹⁸F]MODAG-009 to see if it can safely highlight abnormal protein clumps in the brains of people with Parkinson's disease or multiple system atrophy (MSA). About 13 participants, including healthy volunteers, will recei…

This early-phase study tests a radioactive tracer called 11C-M503 to see if it can detect abnormal alpha-synuclein protein clumps in the brain, which are linked to Parkinson's disease and multiple system atrophy. About 70 adults aged 40-85 with Parkinson's, multiple system atroph…

This study is testing a non-invasive eye camera that takes pictures of the retina using different colors of light. Researchers want to see if these images can help detect signs of Alzheimer's, Parkinson's, and other neurodegenerative diseases. About 930 adults over age 30 with or…

This study is testing whether a new digital test battery, Mindmore Distance, can accurately assess thinking and memory skills in people with neurological conditions like stroke, Parkinson's, or multiple sclerosis. Researchers will compare results from home-based computer tests wi…

This study is testing a new blood test to help doctors diagnose Parkinson's disease and similar brain disorders more accurately and earlier. Researchers will use a technique called RT-QuIC to detect misfolded proteins in blood samples from 458 participants, including healthy peop…

This study is testing whether a blood test can detect Parkinson's disease early, before symptoms become severe. Researchers will measure specific proteins (α-synuclein) in tiny particles from nerve cells in the blood of 600 people with Parkinson's and 600 healthy controls. The go…

This study looks at whether a protein linked to Parkinson's disease can be found in colon tissue samples taken during a routine colonoscopy. Researchers will compare samples from people with Parkinson's, those with REM sleep behavior disorder, and healthy individuals. The goal is…

This study tests whether tissue samples taken during a routine colonoscopy can find signs of Parkinson's disease. Researchers look for a protein called alpha-synuclein in the colon of people already diagnosed with Parkinson's. If successful, this could lead to earlier detection a…

This phase 3 study is testing an improved PET/CT imaging method using a radioactive tracer called 18F-DOPA. Researchers want to see if it can better detect small lesions and reduce image artifacts in patients with conditions like congenital hyperinsulinism, neuroblastoma, neuroen…

This study is testing whether artificial intelligence can help diagnose Parkinson's disease by analyzing facial expressions and speech patterns. Researchers will record videos of 720 participants, including people with Parkinson's and similar conditions, as well as healthy volunt…

This study is testing three new radioactive tracers that light up alpha-synuclein clumps in the brain during PET/CT scans. Researchers want to see if these scans can accurately diagnose Parkinson's disease and related disorders. 500 adults with suspected or confirmed Parkinson's …

This early-phase study tests a new radioactive tracer called 18F-JSS20-183A to see if it can safely and accurately detect abnormal tau protein in the brain during PET scans. Researchers will study 90 adults aged 40-85 with tauopathies (like PSP, Alzheimer's, or Parkinson's) and h…

This study is testing a computer program called DystoniaNet that uses artificial intelligence to help doctors diagnose isolated dystonia, a movement disorder. The trial will enroll 1000 people with dystonia or other conditions that look like it, such as Parkinson's disease or ess…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This early-phase study tests a new radioactive tracer called [18F]ACI-15916, designed to detect clumps of α-synuclein protein in the brain using PET scans. These protein deposits are linked to Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. The trial …

This early-phase study tests a new radioactive tracer called 11C-HY-2-15, designed to detect abnormal alpha-synuclein protein in the brain. Researchers will scan 70 adults with multiple system atrophy, Parkinson's disease, progressive supranuclear palsy, or healthy volunteers to …

This study aims to develop computer models that can help diagnose and monitor Parkinson's disease by analyzing eye movements and walking patterns. Researchers will collect data from 100 people with Parkinson's or similar conditions using special devices. The goal is to make diagn…

This study tests whether increasing physical activity through a motivational smartphone app can slow cognitive decline in people with isolated REM sleep behavior disorder (iRBD), an early sign of Parkinson's disease and related disorders. Researchers will enroll 130 participants …

This study tests whether adding music-like sounds (sonification) to standard walking rehabilitation can improve gait, balance, and quality of life. 120 adults with Parkinson's disease, stroke, or multiple sclerosis will be randomly assigned to standard rehab or rehab with sonific…

This study is testing whether a specially designed amino acid supplement can improve nutrition, reduce oxidative stress, and boost physical and mental health in people with Parkinson's disease. Thirty adults aged 60-80 with Parkinson's will take either the supplement or a placebo…

This pilot study tests whether a single session of breathing air with slightly higher carbon dioxide and lower oxygen can improve speech, cough, and movement in people with Parkinson's disease. Participants are randomly assigned to one of two breathing patterns, each lasting abou…

This study tests whether osteopathic manipulative treatment (OMT) — a hands-on therapy using gentle techniques on the head, neck, and ribs — can improve sleep quality in people with Parkinson's disease. Participants are split into two groups: one receives OMT, the other a light t…

This study tests whether a personalized form of transcranial magnetic stimulation (TMS) can improve motor and non-motor symptoms in people with Parkinson's disease, multiple system atrophy, or progressive supranuclear palsy. Fifty participants will receive 10 days of targeted TMS…

This study tests whether a non-invasive brain stimulation technique called TMS can help with apathy—a common lack of motivation—in people with Parkinson's disease. Sixty participants will receive TMS to two different brain areas on separate visits and perform a task where they ch…

This study tests whether walking with a metronome at different speeds can improve how people with Parkinson disease walk. 45 participants will do 12 training sessions on a treadmill and overground, using slow and fast beats to encourage larger and faster steps. Researchers will m…

This study looks at whether a new pump-delivered medication (Foslevodopa/Foscarbidopa) can help improve sleep problems in people with advanced Parkinson's disease. About 103 adults in Spain will take part, and researchers will track their sleep quality over 12 weeks using a simpl…

This early study tests whether a gentle, non-invasive nerve stimulation device placed in the ear (taVNS) can improve how the body regulates heart rate and blood pressure in people with Parkinson's disease. Researchers will measure changes during simple physical tasks like deep br…

This study will test whether doing two physical tasks at the same time or combining a physical task with a thinking task can help people with Parkinson's disease move better, keep their balance, and do daily activities more easily. About 39 participants will do 45-minute exercise…

This pilot study tests whether an accelerated course of repetitive transcranial magnetic stimulation (rTMS) can improve movement and thinking in people with mild to moderate Parkinson's disease. Forty participants aged 50 to 90 will receive six sessions of high-frequency magnetic…

This study tests whether a device that gently stimulates a nerve in the ear (taVNS) can help with Parkinson's symptoms like walking and balance problems. Sixteen adults with Parkinson's will use the device at home for one hour daily over eight weeks. Researchers will check if it'…

This study tests whether a personalized diet plan from a registered dietitian can improve constipation in people with Parkinson's disease. Fifty-four participants will follow the diet for 3 months, with regular check-ins. Researchers will measure bowel movements, gut bacteria, an…

This study tests whether a 3-week cane training program can improve walking speed and confidence in people with Parkinson's disease. 26 participants will either receive cane training or do stretching exercises. The goal is to see if using a cane properly helps with gait and reduc…

This study tests whether a program of supervised eye exercises can improve physical function, balance, and reduce fear of falling in people with Parkinson's disease. 34 participants will do progressive eye movements and gaze stabilization exercises in a clinic setting. The goal i…

This early-stage study tests a single dose of SER-252 in 40 people with Parkinson's disease who experience motor fluctuations (times when symptoms worsen). The main goal is to check safety and how the drug moves through the body. Participants receive either the drug or a placebo,…

This early study tests whether a spinal cord stimulation device called ARC-IM can safely improve walking and balance in people with Parkinson's disease. Six participants will receive the therapy, and researchers will monitor side effects and measure changes in gait speed and endu…

This study tests a new, non-invasive brain stimulation method called transcranial temporal interference stimulation (tTIS) for people with Parkinson's disease. The treatment targets a deep brain area involved in movement control. 32 participants will receive either real or sham s…

This study tests a handheld device that gives gentle directional cues (haptic feedback) to help people with Parkinson's disease perform arm movements more accurately. Twenty participants will use either the haptic device or a similar non-haptic version during home sessions over 8…

This study tests whether a single dose of psilocybin, given with psychological support, can improve depression in people with Parkinson's disease. Sixty adults aged 40 to 80 with mild to moderate Parkinson's and depressive symptoms will receive either a low or high dose of psiloc…

This study is testing whether a 12-week group exercise program, designed for each person's needs, is practical and helpful for people with Parkinson's disease. The program includes strength, aerobic, balance, and cognitive exercises, done both in person and at home. Researchers w…

This study tests whether a single injection of RE104 can reduce symptoms of depression or mixed depression and anxiety in people with adjustment disorder caused by a serious medical illness like cancer, ALS, multiple sclerosis, Parkinson's disease, or idiopathic pulmonary fibrosi…

This study tests whether a four-week training program using a device called EMST can improve swallowing in people with Parkinson's disease who have trouble swallowing. Thirty participants will do breathing exercises five days a week. Researchers will use special cameras and press…

This study tests whether 8 weeks of mindfulness classes, taken together by people with Parkinson's and their family caregivers, can reduce negative emotions like stress, anxiety, and depression. About 200 Chinese patient-caregiver pairs will either take the classes or continue us…

This study tests whether dual-task training—doing cognitive tasks like counting backwards while performing hand exercises—can improve upper limb function and muscle thickness in people with Parkinson's disease. 38 participants will be assigned to either the training group or rout…

This study tests a software called CereGate that fine-tunes an already-implanted deep brain stimulator to reduce freezing of gait in Parkinson's disease. About 41 participants will have their stimulator adjusted using the software. The goal is to see if this extra tuning can make…

This study tests a robot-guided exercise program for people with mild to moderate Parkinson's disease. Participants will do exercises three times a week for three weeks, either in person or remotely. The goal is to see if the program is safe, doable, and helps improve movement an…

This study compares two non-drug therapies—trunk control exercises and mirror therapy—to see which better improves balance and posture in people with Parkinson's disease. Thirty-six participants aged 50 to 70 with mild to moderate Parkinson's will be enrolled. The goal is to find…

This study tests a new approach to help people with early Parkinson's disease who have mild memory or thinking problems. Instead of brain games, participants learn practical strategies from an occupational therapist to handle everyday challenges like remembering tasks or staying …

This study tests whether a 4-week virtual balance training program, guided by a physical therapist and monitored with wearable sensors, can improve balance and reduce fall risk in older adults with Parkinson's disease. Eighty participants aged 55-85 will complete 12 remote sessio…

This small pilot study tests whether a special rocking bed (Somnomat Casa) can improve sleep quality in people with Parkinson's disease. Fifteen participants will use the bed at home for two months, and researchers will measure how acceptable and helpful the treatment is. The goa…

This study is testing whether speech amplification devices can help people with Parkinson's disease and related conditions who have a soft, weak voice (hypophonia). Researchers will work with 100 participants to measure how well these devices improve speech loudness, clarity, and…

This study tests two different home exercise programs designed to prevent falls in people with Parkinson's disease. Thirty participants will do one of the programs for six weeks, and researchers will measure changes in balance, walking, and fear of falling. The goal is to find ou…

This study tests whether mild electrical stimulation of the ear, combined with physical and speech therapy, can improve symptoms like voice problems, swallowing, and balance in people with Parkinson's disease. 46 participants will receive either active or sham stimulation during …

This pilot study tests a new approach called 'phygital' training for people with early-stage Parkinson's disease. Instead of just using a screen, participants will play digital games while handling real objects like blocks or cups. The goal is to see if this combination improves …

This study tests two extra therapies added to standard exercise rehab for people with Parkinson's disease: robot-assisted walking training and electrical stimulation of the thigh muscle. Forty participants will be randomly assigned to one of the two groups and undergo treatment f…

This study tests whether a wearable robotic exoskeleton can improve walking, balance, and mobility in healthy older adults and people with Parkinson's disease—both groups at high risk for falls. About 26 participants will attend two lab sessions to try the device while performing…

This study is testing whether a high-intensity exercise program and a sleep-tracking headband can be used safely and effectively at home by people with Parkinson's disease. Sixteen participants in Colorado will try the remote program and give feedback. The goal is to make exercis…

This study tests a new, non-invasive brain stimulation method called temporal interference stimulation (tTIS) to see if it can improve motor symptoms in people with Parkinson's disease. 90 participants will be randomly assigned to receive either real stimulation targeting specifi…

This phase 2a trial tests an oral liquid containing low-dose carbon monoxide (HBI-002) in 36 people with Parkinson's disease. Participants take it daily for 14 days to see if it is safe and tolerable. The study is randomized and placebo-controlled, meaning some get the drug and s…

This study tests a new device that uses focused ultrasound waves on the brain to see if it can safely improve movement problems in people with Parkinson's disease. About 60 adults with Parkinson's will receive either real or fake (sham) ultrasound treatments. Researchers will mea…

This study tests whether Parkinson's patients can improve their movement by watching personalized 3D virtual reality recordings of their own smooth, fast actions. 24 participants will use VR headsets to view their own best movement sequences, aiming to retrain the brain and reduc…

This study aims to improve walking and balance in people with Parkinson's disease who already have a brain implant (deep brain stimulation). Researchers will use MRI scans and computer models to find the best settings for each person's implant. Sixty participants will test these …

This study aims to find out which type of exercise helps people with Parkinson's disease the most. Researchers will compare different supervised exercise programs to see how they affect movement, balance, endurance, and quality of life. The study involves 45 adults with mild to m…

This study tests whether psilocybin (the active ingredient in magic mushrooms) can safely reduce depression in adults with COPD, ALS, MS, or atypical Parkinson disease who have at least 6 months to live. Participants receive either two moderate-to-high doses (15mg then 25mg) or t…

This study tests whether transcranial magnetic stimulation (TMS) timed to a person's own tremor cycle can reduce shaking in Essential Tremor and Parkinson's disease. Twenty participants with each condition will receive TMS pulses over the motor cortex while their tremor is record…

This study tests whether a daily probiotic supplement can help treat depression in people with Parkinson's disease. Sixty adults with mild to moderate Parkinson's and depression will take either the probiotic or a placebo for 12 weeks. Researchers will measure changes in mood and…

This study looks at how well the drug opicapone works for people with Parkinson's disease who have early signs of motor fluctuations (times when movement symptoms change). About 200 adults in Italy will take the drug as part of their normal care. Researchers will check if patient…

This study tests a new drug called CST-3056 in 12 adults with neurogenic orthostatic hypotension (a sharp drop in blood pressure when standing) caused by Parkinson's disease or pure autonomic failure. The goal is to see if the drug can improve blood pressure and reduce symptoms l…

This study tests whether rhythmic auditory stimulation (RAS) — listening to a metronome beat — can improve walking in people with Parkinson's disease who have a deep brain stimulator (DBS). Ten participants will walk to the beat for four minutes with their DBS turned on and off. …

This study tests whether a new type of deep brain stimulation (called patterned DBS) is safe and tolerable for people with Parkinson's disease to use at home. About 60 adults who already have a DBS device will try the new stimulation pattern for two weeks. The goal is to see if t…

This study tests a non-invasive device that delivers mild electrical stimulation to the cerebellum, timed precisely to each patient's hand tremor rhythm. Ten people with Parkinson's and moderate-to-severe hand tremor will receive both real and sham stimulation to see if the real …

This study tests whether a deep brain stimulator (DBS) that automatically adjusts its settings can better control movement and sleep problems in people with Parkinson's disease. 24 adults aged 25-75 will have electrodes placed under the scalp to record brain signals. The device w…

This study tests a non-invasive brain stimulation method called temporal interference stimulation (TIS) to see if it can improve motor and speech problems in people with Parkinson's disease or secondary Parkinson's syndrome. Sixty participants will receive either real TIS or a sh…

This study tests whether a gentle electrical brain stimulation technique called tDCS can improve cognitive problems in people with Parkinson's disease who have mild memory or thinking issues. About 36 participants will receive the stimulation while their brain activity and cognit…

This study tests whether playing soft sounds during deep sleep can improve the effects of a home-based brain training program for people with Parkinson's disease and mild memory problems. Fifty participants will use a sleep device at night and complete cognitive exercises for fiv…

This study tests whether combining exercise video games (exergaming) with real-time brainwave feedback can improve balance in people with Parkinson's disease. One hundred participants will be randomly assigned to either exergaming alone or exergaming plus neurofeedback, training …

This study tests whether using walking poles during an 8-week independent walking program can improve walking, movement, and thinking in people with Parkinson's disease. Forty participants will walk at least three times a week, either with or without poles. Researchers will measu…

This study tests whether daily 30-minute sessions of transcranial pulsed electromagnetic fields (T-PEMF) can improve movement and other symptoms in people with Parkinson's disease. 90 participants will receive either real or sham treatment for the first 6 months, then all receive…

This study tests a personalized approach to brain stimulation (rTMS) for people with Parkinson's disease. The goal is to see if tailoring the stimulation to each patient's brain function improves walking better than the standard one-size-fits-all method. The study will involve 60…

This study tests a device called EarStim that gently stimulates the ear to temporarily improve movement problems in people with Parkinson's disease. About 90 adults with moderate to severe Parkinson's who experience 'off' episodes will try the device in a clinic and later at home…

This small pilot study tests a special standing desk that gently moves, prompting people with Parkinson's to take small steps while standing. Five participants will use the desk for up to 12 sessions over 6 weeks. Researchers will measure walking speed, motor symptoms, and thinki…

This study tests whether a non-invasive brain stimulation technique called rTMS can safely improve mild thinking problems in veterans with Parkinson's disease. Researchers will give real or fake rTMS sessions to 56 veterans and measure changes in executive function (like planning…

This study is testing SL-APO (Kynmobi), a fast-acting film placed under the tongue, to treat OFF episodes in people with Parkinson's disease. OFF episodes are times when Parkinson's symptoms return between medication doses. The study will enroll 90 adults and observe how doctors …

This pilot study tests a handheld device that gently stimulates the vagus nerve in the neck to see if it can improve walking and balance in veterans with Parkinson's disease. Forty participants will use the device at home while researchers measure changes in stride length and oth…

This study tests whether training the people who talk with someone with Parkinson's disease can make communication easier. Instead of focusing on the patient, researchers will teach their primary communication partners to better understand slurred or unclear speech. The goal is t…

This study tests whether a non-invasive brain stimulation technique called rTMS can reduce impulse control disorders in people with Parkinson's disease who are on dopamine therapy. Twenty participants will receive both real and sham stimulation in random order, then complete task…

This study compares two virtual reality rehab programs for people with mild to moderate Parkinson's disease. One group will do therapist-guided exercises in a shared virtual space, while the other uses a standard screen-based VR. Over 12 weeks, researchers will measure improvemen…

This study tests whether a noninvasive brain stimulation device, used at home under remote supervision, can improve motor symptoms like stiffness, slowness, and walking difficulty in people with Parkinson's disease. 68 participants with mild-to-moderate Parkinson's will receive e…

This study looks at whether combining physical exercise with a gentle, non-invasive brain stimulation technique (tDCS) can improve walking, balance, and reaction time in people with Parkinson's disease. Researchers will measure changes in movement speed and coordination in 100 pa…

This study looks at whether a 12-week supervised aerobic exercise program can improve brain blood flow, thinking skills, and walking in people with Parkinson's disease. Researchers will compare 40 participants who either do the exercise program or continue their usual care. The g…

This study tests whether a single dose of intravenous ketamine can quickly improve depression in veterans with Parkinson's disease. Researchers will also look at how ketamine affects brain flexibility and inflammation. The trial involves 80 veterans and compares ketamine to a mil…

This study tests an experimental drug called AP-472 in people with Parkinson's disease who have motor fluctuations—times when their usual levodopa medication stops working well. About 150 participants will take either a low dose, a high dose, or a placebo pill for 8 weeks, added …

This study looks at whether using a CPAP machine (a device that gently blows air through a mask) can safely lower high blood pressure when lying down at night and help reduce dizziness upon standing in people with autonomic failure. About 59 adults aged 40-80 with conditions like…

This study tests whether a non-invasive brain stimulation technique called MRI-guided transcranial direct current stimulation (tDCS) can reduce depression and apathy in people with Parkinson's disease. Forty participants will receive either real or sham stimulation, and researche…

This study tests whether a virtual reality (VR) app used at home with remote therapist guidance can improve memory, attention, and social skills in people with early memory decline (Subjective Cognitive Decline and Mild Cognitive Impairment). 480 adults aged 40-80 will either use…

This pilot study tests a personalized music therapy program to prevent delirium (sudden confusion) in hospitalized people with neurodegenerative diseases like Alzheimer's or Parkinson's. Thirty participants will receive up to five live music sessions tailored to their preferences…

This study explores whether people with Parkinson's disease can improve their quality of life, walking speed, and mobility by managing their own exercise plans at home using telerehabilitation. Researchers will compare self-managed exercise to supervised programs in 30 participan…

This study tests whether doing high-intensity exercise before virtual reality training can improve balance and brain flexibility in people with Parkinson's disease. Sixteen participants will be split into two groups: one does intense exercise plus VR, the other does stretching pl…

This study tests a new method to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals. Instead of the usual time-consuming manual adjustments, doctors will use these signals to pick the best stimulation settings. The goal is to imp…

This study tests a device that uses light, sound, and gentle touch to stimulate brain waves at a specific frequency (gamma). Researchers want to see if it is safe and can change brain activity in people with mild Parkinson's disease. 40 participants will use the device for 30-60 …

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Standard DBS helps movement but can sometimes cause thinking or mood problems. The researchers will add low-frequency stimulation to a different part of the brain while keeping the usual high-…

This study tests a new exercise method for people with Parkinson's disease. Researchers will see if partially restricting blood flow to the legs during balance-challenging strength exercises can improve symptoms. The study involves 20 participants aged 40 to 85 and focuses on whe…

This study tests whether a fast form of brain stimulation (called accelerated TMS) can help with apathy—a lack of motivation—in people with Parkinson's disease. Fifteen participants will receive 48 stimulation sessions over two weeks. Researchers will check if the treatment is sa…

This study tests whether a continuous apomorphine pump can reduce stiffness and improve comfort in Parkinson's patients who are near the end of life and can no longer take oral medications. Researchers will follow 80 patients receiving home hospital care, measuring symptoms like …

This study tests whether following a Mediterranean-style diet for 18 months is practical and beneficial for people with Parkinson's disease. Researchers will see if the diet is easy to stick with and if it leads to changes in gut bacteria or Parkinson's symptoms. About 40 partici…

This study explores whether listening to personally meaningful music can reduce apathy—a lack of motivation and emotion—in people with Parkinson's disease. Fifty participants will listen to their own chosen music or neutral podcasts for 8 weeks. Researchers will use brain scans a…

This study tests if magnetic stimulation applied to the spine and brain can improve walking and balance in people with Parkinson's disease. Thirty participants will receive 10 sessions of either neck or upper-back stimulation combined with brain stimulation. The goal is to find t…

This study tests whether an online self-management program can help people with early-stage Parkinson's disease maintain their daily activities and quality of life as well as in-person task training. One hundred participants aged 45-70 will be split into three groups: online prog…

This study is testing whether a non-invasive brain stimulation technique called repetitive transcranial magnetic stimulation (rTMS) applied to the cerebellum can improve cognitive deficits and mood in people with schizophrenia, autism, bipolar disorder, depression, or Parkinson's…

This study tests a wearable device called Cue2Walk that automatically detects freezing of gait in people with Parkinson's disease and provides rhythmic cues to help them keep walking. The study will compare the device's effectiveness and cost against usual care in 84 participants…

This early study tests whether a device that sends electrical pulses to muscles and the spinal cord can improve arm, hand, or leg movement in people with paralysis from spinal cord injury, stroke, or other nerve damage. Up to 64 participants will attend sessions five times a week…

This study tests whether a 12-week exercise program that combines balance, treadmill walking with mental tasks, and leg strengthening can improve gait and balance in people with moderate-to-advanced Parkinson's disease. 48 participants will be randomly assigned to either the exer…

This study looks at whether different types of exercise—like cardio, strength training, or a mix—can help people with Parkinson's disease sleep better. Researchers will track sleep quality and brain activity during sleep in 150 participants over 12 weeks. The goal is to find whic…

This study is testing whether a non-invasive device that sends mild electrical pulses to the spinal cord can improve walking and balance in people with Parkinson's disease. The device is placed on the skin, so no surgery is needed. Twenty adults with Parkinson's who can walk at l…

This study tests an experimental drug called IRL757 in 75 people with Parkinson's disease who also have apathy (loss of interest or motivation). The main goal is to see if the drug is safe and tolerable over 12 weeks. Researchers will also check if it helps improve apathy symptom…

This study tests whether functional rotational exercises can lower fall risk and improve mobility and balance in people with Parkinson's disease. Researchers will enroll 50 adults aged 50-70 with mild to moderate Parkinson's. Participants will perform rotational exercises, and th…

This small pilot study tests a smart shoe called NUSHU that provides gentle vibrations to see if it can help people with Parkinson's disease walk faster. Sixteen participants will complete two short walking tests—one with the vibration on and one without—to compare their speed, s…

This study tests a breathing and meditation program called SKY Breath in 40 people with early-stage Parkinson's and their care partners. Participants will learn the technique over four days and practice daily for four weeks. Researchers will use surveys to measure changes in stre…

This study tests whether atomoxetine, a medication that affects noradrenaline, can reduce freezing of gait in people with Parkinson's disease. About 60 participants will take either atomoxetine or a placebo and perform walking tests, MRI scans, and questionnaires. The goal is to …

This study tests whether pyridostigmine, a drug that stimulates the gut, can safely relieve chronic constipation in people with Parkinson's disease. Constipation is a common and bothersome symptom that often appears years before movement problems. Sixteen adults with Parkinson's …

This study tests whether electrical spinal cord stimulation is safe for people with Parkinson's disease who have a painful, bent-forward posture called camptocormia. Six participants will receive the stimulation and be monitored for side effects for about 10-11 months. The goal i…

This pilot study tests whether a smartphone app called Walking Tall can help people with Parkinson's disease improve their walking. Thirty participants will use the app at home for 6 weeks, doing walking exercises with audio cues and prompts. Researchers will measure step counts,…

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck can improve leg muscle control, walking, and balance in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) version in 75 participants. The goal i…

This study tests whether a non-invasive brain stimulation technique called patterned repetitive transcranial magnetic stimulation (prTMS) can reduce bradykinesia—slowness of movement—in people with Parkinson's disease. Researchers will apply the stimulation over a brain area invo…

This study tests whether playing a motion-sensor game called TOAP RUN at home can improve walking and balance in people with Parkinson's disease. 80 patients will be split into two groups: one does the game sessions plus usual care, the other just usual care. Researchers will che…

This study tests whether supervised pool exercises (aquatic therapy) can improve daily activities, walking, balance, posture, pain, and mood in people with Parkinson's disease. 42 participants will either do home exercises alone or add three 45-minute pool sessions per week for s…

This study tests whether adding a mild, non-invasive brain stimulation (tDCS) to a supervised Nordic walking program improves walking speed and balance in people with Parkinson's disease. Forty participants will be randomly assigned to receive either real or fake tDCS during 12 w…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve motor function and reduce fatigue in people with Parkinson's disease. Researchers will apply mild electrical current to the movement-control area of the brain over multiple sessions. The t…

This study looks at language difficulties in people with Lewy body disease (like Parkinson's or dementia with Lewy bodies) who also have mild cognitive impairment. Researchers will first compare sentence understanding between patients and healthy older adults. Then they will test…

This study looks at whether low-load or high-load resistance training works better for improving muscle strength and everyday activities in older adults with Parkinson's disease. About 60 participants with mild to moderate Parkinson's will take part. The goal is to find the most …

This study tests whether sensor-based robotic arm rehabilitation can improve both thinking skills (like memory and attention) and physical movement in adults with Parkinson's disease, multiple sclerosis, or stroke. Participants will receive 25 sessions of either robotic therapy w…

This study tests whether adding personalized music therapy to standard physical therapy can improve walking and balance in people with Parkinson's disease. About 50 participants will receive either physical therapy alone or physical therapy plus rhythmic music cues for 8 weeks. T…

This study tests whether adding visual feedback exercises—using a laser pointer—to standard physical therapy can improve balance and mobility in people with Parkinson's disease. 32 participants will be randomly assigned to either standard exercises alone or standard exercises plu…

This study tests a non-invasive device called Sphere V3.0 that delivers gentle electrical pulses to the scalp to improve movement problems in Parkinson's disease. Thirty adults with Parkinson's will use the device at home for 13 minutes each weekday for 3 weeks, then be monitored…

This study looks at whether changing the ratio of carbidopa to levodopa in standard Parkinson's medication can reduce orthostatic hypotension—a sudden drop in blood pressure when standing that causes dizziness and fainting. Researchers will give 36 patients with Parkinson's disea…

This study compares two ways of delivering deep brain stimulation (DBS) to people with Parkinson's disease: adaptive DBS, which adjusts stimulation in real time based on brain signals, and continuous DBS, which delivers constant stimulation. About 130 adults who already have a DB…

This study is testing whether fexofenadine, a common allergy medication, can improve quality of life for people with Parkinson's disease who are already on standard treatment. Researchers will enroll 46 adults aged 50 and older with mild to moderate Parkinson's. The main goal is …

This study tests whether applying gentle heat to the abdomen overnight can safely lower high blood pressure that occurs when lying down in people with autonomic failure. About 20 adults with conditions like Parkinson's or Multiple System Atrophy who have this nighttime hypertensi…

This study tests a wearable sensor that tracks neck muscle activity during swallowing exercises, providing real-time feedback to patients. Researchers want to see if adding this device to standard therapy improves swallowing more than therapy alone. The study includes 120 adults …

This study tests an 8-week online group therapy program for people diagnosed with Parkinson's disease before age 65. The therapy, called Acceptance and Commitment Therapy (ACT), helps participants cope with difficult thoughts and feelings related to their condition. Researchers w…

This study tests a digital system called NMS Assist that helps people with Parkinson's and their care partners track non-motor symptoms like pain, sleep problems, and mood changes. 30 participants will use the system for 6 months, and researchers will see if it's easy to use and …

This study tests whether a personalized brain stimulation method called rTMS, combined with walking exercises, can help people with Parkinson's disease who experience freezing of gait—a feeling of being stuck when trying to walk. Up to 15 adults aged 50-80 will receive 6 treatmen…

This study tests a smart exercise bike that adjusts its resistance based on how well a person performs, aiming to improve movement and thinking in people with Parkinson's disease. The bike is used at home and monitored remotely, so patients don't need to travel to a clinic. Resea…

This study tests a tool called PARKINSUN that helps people with Parkinson's disease communicate better with their doctors during visits. 120 participants will be split into two groups: one uses PARKINSUN during appointments, the other does not. The goal is to see if the tool impr…

This study tests whether a non-invasive brain stimulation technique called tDCS, applied while people walk, can improve motor skills like gait, speech, and eye movements. Twenty adults with progressive supranuclear palsy, corticobasal degeneration, or Parkinson's disease will rec…

This study explores whether mentally practicing a hand dexterity test can immediately improve actual performance in people with Parkinson's disease. Thirty participants will time themselves both physically and mentally performing the Nine-Hole Peg Test. The goal is to see if moto…

This early study tests whether a leg sleeve called the Cionic Neural Sleeve is safe and easy for people with Parkinson's to use at home. Ten volunteers with walking problems will try the device, which uses mild electrical pulses to help muscles move. The main goal is to see if pe…

This study is testing whether changing the strength of deep brain stimulation (DBS) during sleep can help people with Parkinson's disease sleep better. Ten participants will try three different nighttime DBS settings (off, half strength, and full strength) for two weeks each. The…

This study tests a walking meditation program called iWalk for adults with neurodegenerative diseases like multiple sclerosis. The goal is to see if it's feasible and helps improve resilience, stress regulation, and thinking skills. Researchers will enroll 90 participants and mea…

This study tests a wearable device that provides gentle vibrations timed to each step, aiming to make walking more automatic for people with Parkinson's disease. Sixty participants will be randomly assigned to receive either personalized step-synchronized cues or fixed-interval c…

This study tests whether a new type of deep brain stimulation that adapts in real time to brain activity can safely improve walking and balance problems in people with Parkinson's disease. Ten participants who already have a compatible brain implant will be enrolled. The goal is …

This study tests if whole-body light therapy (photobiomodulation) can safely improve movement and thinking in people with Parkinson's disease. Fifteen adults with mild to moderate Parkinson's will receive about 30 sessions over 10 weeks. Researchers will measure changes in motor …

This study looks at two types of anesthesia for replacing the battery of a deep brain stimulator in people with Parkinson's disease. Researchers want to see which method—general anesthesia or regional anesthesia with sedation—provides better pain control and patient satisfaction …

This study tests whether adding action observation (watching movements) and motor imagery (imagining movements) to standard physical therapy can improve balance, daily function, and quality of life for people with Parkinson's disease. About 54 participants with mild to moderate P…

This study tests whether celecoxib, an anti-inflammatory drug, can help people with Parkinson's disease. Researchers believe brain inflammation plays a role in Parkinson's, and celecoxib may reduce that inflammation. The trial will include 80 adults with Parkinson's and measure c…

This study tests whether following a Mediterranean diet for three months after deep brain stimulation surgery helps Parkinson's patients control weight gain and improve body composition. Researchers will compare a diet group to a usual-diet group using weight, appetite, and quali…

This study tests whether adding gentle electrical stimulation to the brain and spine can improve walking and balance training for people with Parkinson's disease who have trouble with gait. About 71 participants (51 with Parkinson's and 20 healthy controls) will take part. The Pa…

This study explores whether a 6-week training program in empathy and self-compassion can improve the quality of life for people with Parkinson's disease and their caregivers. Participants will practice mindfulness, writing, and poetry exercises, and fill out questionnaires before…

This study tests whether turning on an extra deep brain stimulation (DBS) electrode in a brain region called the globus pallidus externa (GPe) can help people with Parkinson's disease who have severe insomnia. Ten participants aged 40-80 will report changes in their sleep quality…

This study tests whether real-time visual feedback from the SpiroGym app helps people with Parkinson's disease perform breathing muscle exercises more effectively. Thirty participants will do the exercises with and without the app's feedback, and researchers will measure muscle a…

This study tests whether a newer 'directional' brain stimulation method works better than the standard 'ring' method for people with Parkinson's disease. Ten participants who already have deep brain stimulation electrodes implanted will try both modes. The goal is to see which on…

This study is testing a wristband that delivers gentle, personalized vibrations to the wrist to help reduce hand tremors in people with essential tremor or Parkinson's disease. About 80 participants will use the device at home over several weeks. The goal is to see if the device …

This study is testing whether a lightweight leg exoskeleton called Keeogo is safe and helpful for improving walking and preventing falls in people with Parkinson's disease. Thirty veterans with mild to advanced Parkinson's will wear the device during supervised walking sessions t…

This study is testing a smartphone app called MindTrails-Movement to see if it can help reduce anxiety in people with Huntington's or Parkinson's disease. The app uses a technique called cognitive bias modification for interpretation (CBM-I) to train users to think less negativel…

This study tests whether a temporary spinal cord stimulator can help people with advanced Parkinson's disease who experience freezing of gait—a sudden inability to move their feet—that doesn't respond to medication. Five participants will receive the device, which delivers mild e…

This study tests whether high-frequency repetitive transcranial magnetic stimulation (rTMS) can improve balance in people with Parkinson's disease. Forty participants with mild to moderate Parkinson's will receive 12 sessions over four weeks. Researchers will measure changes in s…

This study tests whether a type of brain stimulation called theta-burst transcranial magnetic stimulation (TBS) can help people who experience freezing of gait—a sudden inability to start or continue walking. Forty participants will receive TBS while researchers measure how quick…

This study tests a non-invasive device that stimulates the vagus nerve in the ear, timed with breathing, to see if it can reduce apathy (lack of motivation) in people with Parkinson's disease. 60 participants will receive either the real stimulation or a sham (fake) version for 2…

This study follows 120 people with Parkinson's disease who are using a continuous apomorphine infusion pump (ONAPGO™) to see how it works in real-world settings. Researchers will track how long it takes to find the right dose, any changes to other Parkinson's medications, and how…

This study tests whether a 6-week group program led by an occupational therapist can help people with Parkinson's disease feel more confident in managing their energy and fatigue. About 80 participants will be randomly assigned to either the group program or receive standard info…

This study uses a non-invasive brain stimulation technique called transcranial magnetic stimulation (TMS) to examine how nerve pathways from the brain to the legs and trunk are affected in people with Parkinson's disease. Researchers will measure brain activity and link it to wal…

This study explores whether a small accelerometer worn on the thigh can objectively measure how well treatments work for neurogenic orthostatic hypotension—a condition causing dizziness and fainting upon standing. Participants wear the device for one week on placebo and one week …

This study uses special PET scans to measure inflammation in the brains of people with Alzheimer's, Parkinson's, ALS, and other neurodegenerative diseases. Researchers will compare these scans to those from healthy volunteers to see if inflammation levels differ. The goal is to d…

This natural history study is collecting information from up to 4,000 people with movement disorders (like Parkinson's disease or tremor) and their family members. Participants undergo exams, blood tests, and imaging, but receive no new treatments. The goal is to gather data that…

This large study is testing many different drug combinations, including the immunotherapy pembrolizumab, in people with advanced non-small cell lung cancer. The goal is to see which treatments work best based on specific tumor features like PD-L1 levels and histology. Over 1,000 …

This study is gathering medical information and samples from up to 5,000 people with neurosurgical conditions like brain tumors, epilepsy, and Parkinson's disease. Participants receive standard care while their data is collected for future research. No new treatments are being te…

This study follows 300 people with Parkinson's disease who still have movement symptoms despite taking standard medications. Researchers will collect data over up to 5 years through questionnaires, diaries, medical records, blood samples, and a digital device. The goal is to bett…

This observational study, led by the Michael J. Fox Foundation, aims to understand how Parkinson's disease progresses over time. It will follow 4,500 people, including those with Parkinson's, those at risk, and healthy volunteers, collecting clinical, imaging, and genetic data. T…

This study follows 214 people in China with multiple system atrophy, a rare and fast-worsening brain disease that affects movement and automatic body functions. Researchers will track symptoms over time to learn how the disease progresses and what factors influence it. The goal i…

This study reviews the medical records of up to 5,000 people who have received deep brain stimulation (DBS) for Parkinson's disease, essential tremor, or dystonia. Researchers want to see how well DBS improves symptoms over time in real-world settings. No new treatments are given…

This study aims to learn more about the brain activity behind risk-taking and reward-seeking behaviors in people with Parkinson's disease. Researchers will record brain signals during deep brain stimulation surgery while participants play a gambling task. The goal is to understan…

This study aims to learn more about the brain activity behind cognitive impairment in Parkinson's disease. Researchers will record brain signals from 75 people during deep brain stimulation surgery while they perform a gambling task. The goal is to understand how certain brain ar…

This study follows 800 adults with synucleinopathies—diseases like Parkinson's, Lewy body dementia, and multiple system atrophy—to learn how they develop and change over time. Researchers will track symptoms, biological markers, and early signs like dizziness on standing or dream…

This study looks at whether a special nursing care model helps people with long-term health conditions like diabetes, heart disease, or Parkinson's work better with their advanced practice nurse. About 420 adults will take part. The goal is to see if this approach improves how pa…

This study is collecting information from 200 people with Parkinson's disease, dystonia, essential tremor, or other movement disorders who are scheduled to receive radiofrequency (RF) ablation—a procedure that uses heat to target small areas in the brain. The goal is to see how p…

This study looks at how a specific gene change (LRRK2 mutation) affects brain chemicals in people with Parkinson's disease. Researchers will compare 15 participants with the mutation to others without it using brain scans, thinking tests, and movement tests. The goal is to better…

This study looks at how deep brain stimulation (DBS) affects sleep in people with Parkinson's disease. Twenty participants who already have a DBS implant will spend two nights in a sleep lab—one night with the device on and one night with it off. Researchers will measure sleep qu…

This study looks at how deep brain stimulation (DBS) changes motivation and decision-making in people with Parkinson's disease. Researchers will have 70 participants play a tablet game that measures risky vs. safe choices while their brain activity is recorded. The goal is to und…

This study is testing a new radioactive tracer called [18F]MODAG-009 in 6 healthy adults. The goal is to see how the tracer moves through the body and how much radiation exposure it causes. Participants get one injection and then a full-body PET scan. This is an early-phase study…

This study uses a special PET scan tracer called [18F]DPA-714 to measure brain inflammation in people with early or suspected Parkinson's disease and in healthy volunteers. Researchers will scan participants at the start, after 12 months, and after 24 months to see how inflammati…

This study uses MRI scans to see how deep brain stimulation (DBS) changes brain activity in people with Parkinson's disease. Researchers will compare brain images when the stimulator is on versus off, focusing on the leg area of the brain. The goal is to understand why DBS someti…

This study looks for brain scan markers that might predict thinking and memory changes after Deep Brain Stimulation (DBS) in people with Parkinson's disease. Researchers will use MRI scans before surgery and cognitive tests after surgery in 55 Parkinson's patients, plus compare t…

This study looks at immune cells in the gut to understand how they might be linked to multiple sclerosis, Parkinson's disease, and REM sleep behavior disorder. Researchers will collect colon tissue samples from 100 adults during colonoscopy. The goal is to map these cells and the…

This study tests whether computer analysis of speech can reliably detect motor, emotional, and cognitive changes in people with Parkinson's disease. Researchers will record speech from 80 patients while they are on and off medication or deep brain stimulation. The goal is to find…

This study explores whether the gut's nervous system can reveal early signs of Parkinson's disease. Researchers will analyze gut tissue and microbiome samples from 60 people aged 45-75 during routine colonoscopies. The goal is to find biomarkers that reflect brain changes, not to…

This study is creating a large, open-access database of clinical, motor, and non-motor information from nearly 1,000 people with Parkinson's disease and healthy controls in Brazil. Researchers will collect data through questionnaires, movement tests, and clinical scales. The goal…

This study follows 450 people with Parkinson's disease for four years to learn why some become less active and what helps them stay active. Participants wear activity monitors and complete tests and questionnaires. The goal is to identify early warning signs of declining activity…

This study looks at how certain brain signals (called beta waves) affect movement in people with Parkinson's disease. Researchers will work with 25 patients already scheduled for deep brain stimulation (DBS) surgery. By using special stimulation and medication, they hope to learn…

This study tests an artificial intelligence algorithm that uses wearable sensors to detect freezing of gait—a sudden inability to walk—in people with Parkinson's disease. Researchers want to see if the AI works accurately in home environments, not just in the lab. About 126 parti…

This study aims to understand why some people with Parkinson's disease experience central pain. Researchers will use brain scans (PET and MRI) to examine the serotonin system in 34 participants. The goal is to see how serotonin relates to pain, not to test a new treatment.

This study compares two different deep brain stimulation (DBS) settings in 30 people with Parkinson's disease who already have DBS implants. The goal is to see which setting better improves walking and balance problems. Participants will try both settings, and their symptoms will…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand why falls happen more…

This study uses brain imaging (PET scans) and memory tests to understand why some people with Parkinson's disease develop dementia. Researchers will follow 320 participants over several years, using scans to look for abnormal proteins and track thinking changes. The goal is to id…

This study looks at how deep brain stimulation (DBS) changes attention and the way people with Parkinson's disease, essential tremor, or dystonia perceive emotions in others' faces. Researchers will track eye movements and ask participants to rate facial expressions before, durin…

This study uses a special PET scan tracer called DPA-714 to measure brain inflammation in people with Parkinson's disease compared to healthy volunteers. Researchers want to see if Parkinson's patients have higher levels of inflammation and how that relates to their symptoms. The…

This study looks at how blood pressure changes when standing affect thinking and brain blood flow in people with Parkinson's disease. About 60 participants, with and without orthostatic hypotension (low blood pressure on standing), will take thinking tests while lying down and st…

This study creates a registry to collect real-world information on the safety and effectiveness of ambroxol, a common cough medicine, when used at higher doses for Gaucher disease or GBA-related Parkinson disease. Researchers aim to gather data from 300 patients worldwide who are…

This study follows 640 participants—including people with Parkinsonism, those with REM sleep behavior disorder, and healthy volunteers—for 5 years. Researchers will use brain scans, movement tests, voice analysis, and other tools to track how the disease progresses and improve di…

This study follows 150 people with early-stage Parkinson's disease to see if the condition starts in the brain or the body first. Researchers will track symptoms like walking problems and thinking changes over 5 years using tests, scans, and questionnaires. The goal is to better …

This study observes 280 people with Parkinson's disease or multiple system atrophy to understand how pain and automatic body functions (like blood pressure and digestion) affect their lives. Participants will undergo standard rehabilitation and be assessed with questionnaires. Th…

This study looks at whether the position a person is in during a urodynamic exam (a test that measures bladder function) affects the diagnosis of an overactive bladder in people with multiple sclerosis or Parkinson's disease. Researchers will compare results from tests done while…

This study follows 650 people with early Parkinson's disease or a sleep condition called idiopathic REM sleep behavior disorder (iRBD). Researchers use brain scans, heart tests, and fluid samples to track changes over time. The goal is to better understand how these conditions de…

This study aims to develop new ways to measure how much energy people with Parkinson's use during dance classes. Researchers will use cameras, wearable activity monitors, and questionnaires to track movement and intensity. The goal is to better understand the relationship between…

This study uses advanced MRI scans to look at a newly discovered brain network, called SCAN, in people with Parkinson's disease and healthy volunteers. Researchers want to see if this network is linked to the movement problems in Parkinson's. The goal is to find a specific brain …

This study aims to understand how different brain circuits affect movement and thinking in people with Parkinson's disease who already have a deep brain stimulation (DBS) device. Researchers will measure brain activity patterns during rest and movement, and link them to motor and…

This study follows nearly 3,000 people, including healthy adults and those with memory or movement problems, to learn how brain diseases like Alzheimer's and Parkinson's develop. Researchers use advanced brain scans and tests to track changes over time. The goal is to improve ear…

This study uses a new ultra-high-resolution PET scanner to take detailed pictures of the brain and spinal cord in 300 healthy volunteers and people with conditions like Alzheimer's, Parkinson's, ALS, and psychotic disorders. The goal is to understand how small brain regions chang…

This study is gathering information from 4500 people who have or will have brain surgery for conditions like aneurysms, tumors, epilepsy, and Parkinson's disease. The goal is to find patterns that help doctors predict how well someone will recover. By standardizing how outcomes a…

This study aims to find early markers of Parkinson's disease, multiple system atrophy, and Lewy body dementia by analyzing samples from the nose, blood, and urine. Researchers will compare results from 180 people with these conditions and healthy volunteers. The goal is to improv…

This study is creating a national biobank of blood samples and health data from 230 people with Parkinson's disease or a related sleep disorder (REM sleep behavior disorder). Researchers will analyze the complete DNA of each participant to find rare genetic changes that may cause…

This study looks at how deep brain stimulation (DBS) affects the ability to stop actions in people with Parkinson's disease. Researchers will measure brain waves and behavior during impulse control tasks before, during, and after DBS surgery. The goal is to understand how stimula…

This study looks at how Parkinson's disease impacts breathing, muscle strength, and physical fitness. Researchers will compare 100 people aged 50-80 with Parkinson's to healthy volunteers. Participants will do breathing tests, fitness assessments, and disease severity evaluations…

This study aims to learn more about how the brain controls speech in people with Parkinson's disease, essential tremor, or dystonia. Researchers will record brain activity during speech tasks while participants undergo deep brain stimulation (DBS) surgery. The study does not test…

This study looks at how thinking skills and brain activity relate to walking in people with Parkinson's disease and healthy older adults. Researchers will measure walking patterns, brain waves, and mental tests in 70 participants. The goal is to better understand why walking beco…

This study looks at whether recording brain signals (called local field potentials) can help doctors pick the best deep brain stimulation (DBS) contacts for people with Parkinson's disease. About 40 participants will have these recordings done during routine care. The goal is to …

This study investigates why people with Parkinson's disease sometimes freeze while walking or turning. Researchers will use gentle electrical stimulation to the balance system and brain wave recordings to understand the signals involved. The goal is to find biological markers tha…

This study looks at brain activity in people with Parkinson's disease or essential tremor who are already scheduled for deep brain stimulation (DBS) surgery. Researchers want to understand how the brain handles both movement problems and non-motor issues like memory loss or depre…

This study collects information from 500 children worldwide who have both epilepsy and movement disorders caused by specific gene changes. Researchers will analyze medical records to find patterns linking symptoms to genetics. The goal is to create a shared database that helps do…

This study looks at how changes in muscles and the brain are linked in aging and diseases like ALS, Alzheimer's, and Parkinson's. Researchers will compare healthy older adults with those who have these conditions to find early signs of disease. The goal is to better understand ri…

This study watches brain activity in 25 Parkinson's patients during their planned DBS surgery. Researchers place a thin sensor strip on the brain's surface to record signals while stimulating deep brain areas. The goal is to understand how movement-related brain pathways work, wh…

This study uses a special PET scan with a radioactive tracer called [18F]F-DOPA to measure dopamine production in the brains of people with autonomic failure (problems with automatic body functions like blood pressure). The goal is to see if changes in dopamine levels can predict…

This study records brain activity from people with movement disorders like Parkinson's disease, essential tremor, and dystonia. Researchers use scalp electrodes or existing deep brain stimulators to measure electrical signals. The goal is to find patterns linked to symptoms, whic…

This study is looking for new, less invasive ways to diagnose and track Parkinson's disease, Alzheimer's disease, and type 2 diabetes. Researchers will study 500 participants using blood tests, brain scans, and genetic analysis to find early signs of these conditions. The goal is…

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study aims to find the brain areas responsible for depression in people with Parkinson's disease. Researchers will use brain scans to compare 120 participants aged 40-80 who have both conditions. The goal is to identify targets for future treatments, not to test a new therap…

This study is gathering information from 700 people with Parkinson's disease or similar conditions who experience freezing of gait—a sudden inability to move their feet while walking. Researchers will track symptoms, walking patterns, and falls over three years using questionnair…

This study looks at why people with Lewy body dementia have sudden changes in attention and thinking, called cognitive fluctuations. Researchers will use skin biopsies, brain scans, and EEG monitoring in 120 participants to link these symptoms to damage in a key brain chemical sy…

This study is following 700 people with Parkinson's disease or multiple system atrophy in Shanghai. Researchers will collect medical history, brain scans, blood samples, and other data every six months. The goal is to find early signs of these diseases and better predict how they…

This study looks at sleep problems in people with Parkinson's disease and those with a sleep disorder called REM sleep behavior disorder (iRBD). Researchers will compare sleep quality among these groups and healthy volunteers using overnight sleep tests. The goal is to better und…

This study tests whether a non-invasive brain stimulation technique called temporal interference stimulation (TIS) can temporarily improve language processing in people with mild cognitive impairment due to Parkinson's disease, Lewy body disease, or amnestic MCI. Seventy particip…

This study looks at how deep brain stimulation (DBS) affects walking and other movements that don't improve with standard Parkinson's medication. About 36 adults with Parkinson's who already have a Medtronic Percept DBS implant will wear sensors and use a smartphone app to track …

This study looks at how deep brain stimulation (DBS) — a device already used to control movement in Parkinson's disease — affects sleep. Researchers will monitor brain activity and sleep quality in 64 adults with Parkinson's who have or will get DBS implants. The goal is to under…

This study uses two special scanners (HR-pQCT and pQCT) to take detailed pictures of bone and muscle in 1,000 people with conditions that raise the risk of bone loss, like osteoporosis, arthritis, or kidney disease. The goal is to see if these scanners can spot tiny changes in bo…

This study looks at why some people with Parkinson's disease suddenly feel like their feet are glued to the floor, known as freezing of gait. Researchers will use special brain recordings from already-implanted devices to compare brain activity in people with and without this sym…

BLAAC PD is a research study that aims to understand what Parkinson's disease looks like for Black and African American communities. Researchers will collect genetic and health information from 2,000 participants across the U.S. to explore risk factors and genetic causes of Parki…

This study is testing whether wearable sensors can accurately measure how people climb stairs. Researchers will compare sensor data to traditional stopwatch timing in healthy volunteers and people with conditions like cerebral palsy, Parkinson's disease, and stroke. The goal is t…

This study uses a powerful 7-Tesla MRI scanner to measure brain chemicals in people newly diagnosed with Parkinson's disease who have not yet started medication, and compares them to healthy volunteers. The goal is to better understand how brain metabolism changes early in the di…

This study looks at how different types of treadmill training affect the gut bacteria and symptoms of people with Parkinson's disease. Sixty participants will be split into three groups: one doing standard physiotherapy, one using a C-Mill treadmill, and one using the C-Mill with…

This study is looking for clues in the blood that might tell doctors ahead of time whether deep brain stimulation (DBS) surgery will work well for a person with Parkinson's disease. Researchers will collect blood and leftover brain tissue from 30 people who are already scheduled …

This study looks at how balance problems, walking difficulties, physical activity, and sleep quality are related in people with Parkinson's disease. Researchers will compare 34 Parkinson's patients to healthy adults of similar age to see which issues are due to Parkinson's and wh…

This study tests whether a mild electrical pulse to the ear—called transcutaneous auricular vagus nerve stimulation—can improve decision-making and problem-solving. Researchers will compare results in healthy adults, people with mild cognitive impairment, and those with Parkinson…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study uses small motion sensors to detect internal tremors—a common but hard-to-measure symptom—in people with Parkinson's disease. Researchers will compare 60 participants (30 with Parkinson's and 30 healthy volunteers) to see if a specific 4-6 Hz rhythm can be identified. …

This study is looking at a gene called csgA found in gut bacteria of people with Parkinson's disease. Researchers want to see how common this gene is and how it changes over time. The goal is to learn more about the link between gut health and Parkinson's, which could help develo…

This study looks at how people with Parkinson's disease learn to understand speech and how that relates to their own speaking ability. Researchers will have 50 participants with Parkinson's do listening and speaking tasks to measure speech perception and production. The goal is t…

This study looks at how the brain processes optimistic and pessimistic signals related to dopamine, a chemical that helps control movement and mood. Researchers will compare 70 people with Parkinson's disease and 70 healthy volunteers using brain scans while they play a reward-ba…

This study looks at brain activity in 30 people with Parkinson's disease who have deep brain stimulation (DBS) implants. Researchers want to understand the brain signals behind motor and mood changes that happen when medication wears off. By recording brain waves and stimulation …

This study translates a questionnaire about stomach and bowel problems (GIDS-PD) into Italian for people with Parkinson's disease. Researchers will test the translated version with 190 Italian-speaking patients to make sure it works correctly. The goal is to give doctors a reliab…

This study looks at how Parkinson's disease changes social behavior and quality of life. Researchers will compare 500 adults with Parkinson's to healthy adults of the same age. Participants will answer questions about their daily activities, mood, memory, and social interactions.…

This study is testing whether special smart socks (DANU) can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare the socks' readings to standard lab equipment. The goal is to see if these socks can help predict falls. The study invo…

This observational study tests whether DANU Smart Socks can accurately measure walking and balance in people with Parkinson's disease. Researchers will compare data from 60 participants (30 with Parkinson's and 30 healthy older adults) during a single lab visit. The goal is to se…

This study uses non-invasive eye scans (OCT and OCTA) to look for changes in the retina that might be linked to brain diseases like Alzheimer's, Parkinson's, and multiple sclerosis. Researchers aim to find early markers that could help diagnose or track these conditions. The stud…

This study tests a new PET scan tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 healthy volunteers and patients to see if…

This study is testing whether artificial intelligence (AI) can analyze brain scans to help diagnose Parkinson's disease and related conditions like multiple system atrophy. Researchers will also see if the scans can predict how fast the disease will progress. The study involves 9…

This study looks at how deep brain stimulation (DBS) affects brain activity in 30 people with Parkinson's disease. Researchers will measure brain signals during movement and thinking tasks, with and without DBS or medication. The goal is to understand how different brain areas wo…

This study looks at how the exact placement of deep brain stimulation (DBS) electrodes in the brain affects movement problems in people with Parkinson's disease. Researchers will study 24 participants who already have DBS implants to see which stimulation locations improve sympto…

This study collects information and samples from 1,000 people with or at risk for brain diseases like Alzheimer's, ALS, and frontotemporal degeneration. Researchers will track changes in thinking, language, and brain scans over time. The goal is to build a resource for future stu…

This study is looking for simple ways to detect early signs of multiple sclerosis and Parkinson's disease in people who drive. Researchers will test 200 drivers with these conditions using computer-based attention and reaction tests. The goal is to find quick, easy tests that cou…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…

This study looks at how a brain area called the Posterior Parietal Cortex helps people with Parkinson's disease transfer walking skills from a treadmill to the ground. Researchers will use mild brain stimulation (rTMS) in 24 participants to see if it improves stride length and ot…

This study collects DNA from up to 1,000 adults with progressive supranuclear palsy (PSP), corticobasal syndrome (CBS), multiple system atrophy (MSA), or related conditions, plus their family members. Researchers will sequence participants' whole genomes to find genetic variants …

This study looks at how the brain handles sensory information in people with Parkinson's disease. Researchers will measure brain activity and arm movements in 30 participants during deep brain stimulation surgery. The goal is to understand the brain's role in movement problems, w…

This study collects blood and optional spinal fluid samples from 350 people with Parkinson's, ALS, glioblastoma, certain cancers, or rheumatoid arthritis. The goal is to find new genetic markers that could lead to better diagnostic tests for autoimmune encephalitis and paraneopla…

This study looks at whether combining patient ratings with brain signal recordings can make deep brain stimulation (DBS) programming faster and more personalized for people with Parkinson's disease. Researchers will measure brain activity from implanted electrodes and compare it …

This observational study looks at how gut bacteria relate to brain structure and function in healthy aging and in people with early Alzheimer's, Parkinson's, or multiple sclerosis. Researchers will use brain scans, stool samples, blood tests, and cognitive assessments in 200 part…

This study is testing whether a new, low-cost type of brain scan can find early signs of Alzheimer's and Parkinson's disease. Researchers will compare brain scans from 120 people, including those at risk for Alzheimer's, those with Parkinson's, and healthy volunteers. The goal is…

This study follows 20 people with Parkinson's disease who receive a brain treatment called focused ultrasound to stop tremors. Researchers want to understand why some patients' tremors return within two years. Participants will have brain scans and regular check-ups to find clues…

This study is testing whether new brain imaging techniques can better diagnose diseases like Parkinson's, multiple system atrophy, and frontotemporal dementia. Researchers will use MRI scans and neurological exams in about 94 adults aged 40-85. The goal is to improve how doctors …

This study looks at how deep brain stimulation (DBS) affects the ability to align and focus both eyes on objects at different depths in people with Parkinson's disease. Researchers will use eye-tracking and brain models to find the best stimulation settings. The goal is to improv…

This study uses ultrasound to measure the thickness of abdominal breathing muscles in people with Parkinson's disease. Researchers want to see if muscle thickness is linked to disease severity and how strong a person's exhale is. The study will include 36 Parkinson's patients at …

This early-phase study tests a new radioactive tracer called [11C]SY08 to see if it can detect clumps of alpha-synuclein protein in the brain using PET scans. Researchers will scan 40 volunteers, including healthy people and those with Parkinson's disease, multiple system atrophy…

This observational study looks at whether long-term use of immunosuppressive drugs (taken for other conditions) can slow the onset or progression of Parkinson's disease. Researchers will compare 80 people with Parkinson's—half on immunosuppressants, half not—by tracking motor sym…

This study uses a non-invasive brain stimulation technique called TMS to measure brain activity in 52 people with Parkinson's disease. The goal is to see if these measurements can tell the difference between normal thinking, mild cognitive impairment, and dementia, and predict fu…

This study looks at why swallowing problems happen in Parkinson's disease, a common issue that can lead to serious health risks like pneumonia. Researchers will study 100 people with Parkinson's using swallowing tests, brain scans, and blood tests to understand the underlying cau…

This study looks at how Parkinson's disease affects the brain's ability to control actions, like stopping or switching tasks. Researchers will have 50 people with Parkinson's do joystick tasks while on their usual dopamine medication. The goal is to better understand these brain …

This study is looking at hearing in people with early-stage Alzheimer's or Parkinson's disease, compared to healthy volunteers. Researchers will use detailed hearing tests to find out how common different types of hearing loss are, especially 'hidden hearing loss' where standard …

This study is collecting nerve samples and biofluids from 400 people with ALS or peripheral neuropathies to find biological markers for early diagnosis and disease tracking. By analyzing individual cells, researchers hope to identify molecular changes that happen before symptoms …

This study is testing whether a special PET scan using a tracer called [18F] AV-133 can track changes in the brain of people with early, or 'prodromal,' Parkinson's disease. About 100 participants will be scanned at the start, after 12 months, and after 24 months. The goal is to …

This study records brain activity during deep brain stimulation (DBS) surgery in 140 people with Parkinson's disease or essential tremor. Researchers aim to understand brain networks linked to non-motor symptoms like depression, attention problems, and slow thinking. Participants…

This study looks at how deep brain stimulation (DBS) for Parkinson's disease affects speech. Researchers will record voices of 60 participants before and after surgery to measure changes in clarity, emotion, and word choice. The goal is to better understand the benefits and risks…

This study aims to find new biological markers for neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS. Researchers will analyze genetic, protein, and metabolic data from 1,200 patients to improve diagnosis, predict disease course, and monitor treatment response. Th…

This study is looking for 500 people with early dementia or mild cognitive impairment to help develop a way to predict how their disease will progress. Researchers will use blood tests and other models to better understand each person's outlook. The goal is to give patients and d…

This study looks at whether allowing people with Parkinson's disease to make choices during practice helps them learn new motor skills. Researchers will compare two groups: one that can choose when to receive feedback and one that cannot. The goal is to see if autonomy improves l…

This study looks at whether clozapine, a drug used to treat psychosis in Parkinson's disease, weakens the immune system over time. Researchers will measure immune markers in 24 patients before and after 6 and 12 months of treatment. The goal is to understand infection risks in th…

This study looks at how deep brain stimulation (DBS) changes movement in people with conditions like Parkinson's disease or essential tremor. About 60 people scheduled for DBS surgery will have extra temporary electrodes placed on the brain to measure muscle activity during stimu…

This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new…

This study is looking at how deep brain stimulation (DBS) affects brain activity in people with Parkinson's disease. Researchers will record brain signals during DBS surgery to better understand which areas to stimulate and how to set the device for each person. The goal is to ma…

This study looks at how midodrine and droxidopa, two drugs used for low blood pressure upon standing, affect the veins in the abdomen of people with autonomic failure. About 34 adults aged 40-80 with conditions like multiple system atrophy or Parkinson's disease will participate.…

This study looks at why deep brain stimulation (DBS) for Parkinson's disease can sometimes cause thinking problems. Researchers will scan the brains of 55 people with DBS implants while their device is on or off. The goal is to understand how stimulation affects brain networks, w…

This study uses advanced brain scans (PET, SPECT, and MRI) to find markers of Parkinson's disease in people with certain genetic mutations. Researchers will look at changes in brain chemicals and structure. The goal is to better understand the disease and help develop new treatme…

This study aims to understand how inflammation in the brain works in Parkinson's disease. Researchers will give a mild inflammatory compound (LPS) to 30 volunteers—some with Parkinson's, some with a sleep disorder linked to Parkinson's, and some healthy—and use special PET-MR bra…

This study uses special brain scans (PET, SPECT, and MRI) to look for a marker that shows how Parkinson's disease changes over time. Researchers will scan 44 people with Parkinson's to see if a compound called BU99008 can highlight brain cell activity linked to the disease. The g…