New drug combo targets Hard-to-Treat lung cancer mutation
NCT ID NCT07252739
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new targeted therapy pill called MK-1084, alone or with other drugs, for people with advanced non-small cell lung cancer that has a specific genetic change called KRAS G12C. The goal is to see if the treatment is safe and can shrink tumors. About 130 participants will be enrolled in this Phase 2 trial.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
MK-1084 (a targeted therapy pill for KRAS G12C mutations) combined with pembrolizumab (Keytruda), cetuximab, carboplatin, or pemetrexed
What this could lead to
If successful, this could provide a new first-line treatment option for people with a specific genetic subtype of lung cancer, potentially shrinking tumors and delaying progression.
What could go wrong
This is an early Phase 2 study with a small number of participants, so results may not apply broadly. The drug combination may cause side effects or fail to improve outcomes compared to existing therapies.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Bangkok Metropolitan Administration Medical College and Vajira Hospital ( Site 0351)
RECRUITINGBangkok, Bangkok, 10300, Thailand
Contact Phone: •••-•••-••••
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Baskent University Dr. Turgut Noyan Research and Training Center ( Site 0141)
RECRUITINGAdana, 1250, Turkey (Türkiye)
Contact Phone: •••-•••-••••
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COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 0139)
RECRUITINGCherkasy, Cherkasy Oblast, 18009, Ukraine
Contact Phone: •••-•••-••••
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Centro de Oncología de Precisión ( Site 0160)
RECRUITINGSantiago, Region M. de Santiago, 7560908, Chile
Contact Phone: •••-•••-••••
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Clermont Oncology Center ( Site 0041)
RECRUITINGClermont, Florida, 34711, United States
Contact Phone: •••-•••-••••
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Communal Non-Commercial Enterprise "Prykarpatski Clinical On-Surgery department #2 ( Site 0132)
RECRUITINGIvano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Contact Phone: •••-•••-••••
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Communal Noncommercial Enterprise "Podillia Regional Oncolog-Cardiothoracic department ( Site 0131)
RECRUITINGVinnitsya, Vinnytsia Oblast, 21029, Ukraine
Contact Phone: •••-•••-••••
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Deventer Ziekenhuis ( Site 0272)
RECRUITINGDeventer, Overijssel, 7416 SE, Netherlands
Contact Phone: •••-•••-••••
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Erciyes University ( Site 0145)
RECRUITINGTalas, Kayseri, 38039, Turkey (Türkiye)
Contact Phone: •••-•••-••••
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Fondazione IRCCS Istituto Nazionale Dei Tumori ( Site 0175)
RECRUITINGMilan, Lombardy, 20133, Italy
Contact Phone: •••-•••-••••
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Fundacion Arturo Lopez Perez ( Site 0167)
RECRUITINGSantiago, Region M. de Santiago, 7500921, Chile
Contact Phone: •••-•••-••••
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HYKS Syöpätautien klinikka ( Site 0260)
RECRUITINGHelsinki, Uusimaa, 00290, Finland
Contact Phone: •••-•••-••••
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Hacettepe Universite Hastaneleri ( Site 0140)
RECRUITINGAnkara, 6230, Turkey (Türkiye)
Contact Phone: •••-•••-••••
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Hong Kong Integrated Oncology Centre ( Site 0232)
RECRUITINGCentral, 0000, Hong Kong
Contact Phone: •••-•••-••••
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Hong Kong United Oncology Centre ( Site 0231)
RECRUITINGKowloon, Hong Kong
Contact Phone: •••-•••-••••
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Hospital Universitario Virgen de la Macarena ( Site 0093)
RECRUITINGSeville, 41009, Spain
Contact Phone: •••-•••-••••
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Koç Üniversitesi Hastanesi ( Site 0142)
RECRUITINGAdana, 34010, Turkey (Türkiye)
Contact Phone: •••-•••-••••
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Kuopion Yliopistollinen Sairaala ( Site 0261)
RECRUITINGKuopio, Northern Savonia, 70200, Finland
Contact Phone: •••-•••-••••
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LIMITED LIABILITY COMPANY "MEDICAL CENTER "DOBROBUT-CLINIC" ( Site 0138)
RECRUITINGKyiv, 03151, Ukraine
Contact Phone: •••-•••-••••
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Leids Universitair Medisch Centrum ( Site 0273)
RECRUITINGLeiden, South Holland, 2333 ZA, Netherlands
Contact Phone: •••-•••-••••
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Limited Liability Company Ukrainian Center of Tomotherapy-Department of Chemotherapy ( Site 0467)
RECRUITINGKropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine
Contact Phone: •••-•••-••••
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Liv Hospital Ankara ( Site 0146)
RECRUITINGAnkara, 06680, Turkey (Türkiye)
Contact Phone: •••-•••-••••
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Lviv Territorial Medical Union Multidisciplinary Clinical Hospital ( Site 0133)
RECRUITINGLviv, Lviv Oblast, 79059, Ukraine
Contact Phone: •••-•••-••••
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Medical Center "Mriya Med-Service"-Clinical Research Department ( Site 0465)
RECRUITINGKryvyi Rih, Dnipropetrovsk Oblast, 50000, Ukraine
Contact Phone: •••-•••-••••
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Queen Mary Hospital ( Site 0230)
RECRUITINGPokfulam, Hong Kong
Contact Phone: •••-•••-••••
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Sanford Cancer Center Oncology Clinic ( Site 0038)
RECRUITINGSioux Falls, South Dakota, 57104, United States
Contact Phone: •••-•••-••••
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Sanford Health Roger Maris Cancer Center ( Site 0039)
RECRUITINGFargo, North Dakota, 58102, United States
Contact Phone: •••-•••-••••
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Severance Hospital Yonsei University Health System ( Site 0080)
RECRUITINGSeoul, 03722, South Korea
Contact Phone: •••-•••-••••
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Turku University Hospital ( Site 0262)
RECRUITINGTurku, Southwest Finland, 20520, Finland
Contact Phone: •••-•••-••••
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Uzhhorod Municipal Multidisciplinary Clinical Hospital of Uzhhorod City Council ( Site 0137)
RECRUITINGUzhhorod, Zakarpattia Oblast, 88000, Ukraine
Contact Phone: •••-•••-••••
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VISION PARTNER Medical Centre ( Site 0135)
RECRUITINGKyiv, 03022, Ukraine
Contact Phone: •••-•••-••••
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Vaasan Keskussairaala ( Site 0263)
RECRUITINGVaasa, Pohjanmaa, 65130, Finland
Contact Phone: •••-•••-••••
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West China Hospital, Sichuan University ( Site 0315)
RECRUITINGChengdu, Sichuan, 610066, China
Contact Phone: •••-•••-••••