Basal ganglia disorder

This Phase 2 trial tests a combination of pembrolizumab (Keytruda) and quavonlimab against other drug combos in 302 people with stage IV colorectal cancer that has a specific genetic feature (MSI-H or dMMR). The goal is to see if the new combo shrinks tumors better and for longer…

This study tests whether a new drug called zanidatamab, combined with chemotherapy and sometimes another drug (tislelizumab), works better than the current standard treatment for advanced HER2-positive stomach and esophageal cancers. About 920 adults whose cancer has spread or ca…

This phase 3 trial tests whether a new drug combination (MK-7684A) plus chemoradiotherapy helps people with stage III non-small cell lung cancer live longer than the current standard treatment. About 611 participants will receive either the new combo or durvalumab. The study is a…

This phase 2 trial tests the safety and effectiveness of avelumab, an immunotherapy drug, in people with thymoma or thymic carcinoma that has progressed after platinum-based chemotherapy. About 56 participants will receive avelumab intravenously every two weeks. The study aims to…

This phase 2 trial tests whether prasinezumab, given as an IV infusion every 4 weeks, can slow motor decline in people with early Parkinson's disease. The study includes 586 participants who are already on stable Parkinson's medication. Researchers are measuring how long it takes…

This study tests a one-time gene therapy called CAP-003 in adults with Parkinson's disease caused by a GBA1 gene mutation. The goal is to see if it is safe and if it can help control the disease. Participants receive a single IV infusion and are monitored for two years.

This study tests whether a low dose of lithium (20 mg/day) can slow disease-related changes in the brain and blood of people with early-stage Parkinson's disease. Twenty participants will receive either lithium or a placebo for a period, and researchers will use MRI scans and blo…

This early study at Mayo Clinic tests whether ultra-low, anti-inflammatory doses of radiation can slow Parkinson's disease. Twenty people with early-stage Parkinson's will receive five daily radiation treatments guided by special brain scans. The main goal is to see if the treatm…

This early study tests a new treatment called UX-DA001 for people with Parkinson's disease. The treatment uses the patient's own cells, which are turned into dopamine-producing cells and implanted into the brain during surgery. The main goal is to check safety, but researchers wi…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (with or without radiation) after surgery can help prevent high-risk endometrial cancer from coming back. About 990 participants who had surgery to remove their uterus and ovaries will r…

This study tests new drugs, alone or combined with pembrolizumab, in people with extensive-stage small cell lung cancer that has stopped responding to initial therapy. About 110 participants will receive experimental treatments to see if they are safe and can shrink tumors. The g…

This trial will test whether deep brain stimulation (DBS) surgery improves movement, balance, and daily function in 40 people with Parkinson's disease. Participants will have their walking speed, balance, muscle strength, and activity levels measured before and after surgery. The…

This early-stage study tests a new long-acting injection called HNC364, which turns into the Parkinson's drug rasagiline in the body. Researchers want to see how much of the drug gets into the bloodstream compared to taking rasagiline pills daily. The study involves 30 healthy ad…

This phase 3 trial tests whether adding pembrolizumab (an immunotherapy) and olaparib (a targeted drug) to standard chemotherapy and radiation can help people with limited-stage small cell lung cancer live longer. About 672 participants will receive either the drug combo or a pla…

This study tests an experimental drug called BIIB122 in 50 people who have a specific genetic form of Parkinson's disease (LRRK2-PD). The main goal is to check the drug's safety and how it affects certain markers in the blood and urine over 12 weeks. Participants are randomly ass…

This study compares the immunotherapy drug pembrolizumab with standard chemotherapy in about 100 Chinese patients whose advanced colorectal cancer has a specific genetic feature (MSI-H or dMMR). The goal is to see if pembrolizumab can slow cancer growth or improve survival better…

This clinical trial is testing several new combinations of drugs for people with advanced kidney cancer that has spread. The study includes about 400 participants who have not had any prior treatment for their advanced disease. The goal is to see if these combinations are safe an…

This study tests an experimental drug called BIA 28-6156 in people with Parkinson's disease who have a specific change in the GBA1 gene. The goal is to see if the drug can delay the worsening of movement-related daily living skills over 78 weeks. About 237 participants will recei…

This early-stage trial tests whether implanting a person's own lab-grown dopamine cells into their brain is safe for Parkinson disease. Nine participants aged 40-75 with Parkinson for at least 4 years will receive the injection. The goal is to see if the cells can replace lost do…

This phase 3 trial tests whether adding belzutifan to standard pembrolizumab after kidney cancer surgery can delay or prevent the cancer from coming back. About 1800 participants with clear cell renal cell carcinoma are randomly assigned to receive either belzutifan plus pembroli…

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab (Keytruda) to standard chemoradiotherapy helps people with esophageal cancer live longer and delay recurrence. About 700 participants who cannot have surgery will receive either pembrolizumab or a placeb…

This study tests whether adding the drugs pembrolizumab and olaparib to standard chemoradiation helps people with stage III non-small cell lung cancer live longer without their cancer growing. About 870 participants will receive one of three treatments: pembrolizumab with chemora…

This study follows 250 adults with advanced Parkinson's disease who are prescribed ABBV-951 by their doctors. The goal is to see how safe and effective the drug is in everyday use over 52 weeks. Participants continue their normal care with no extra visits required.

This phase 3 trial tests whether adding the immunotherapy drug pembrolizumab before and after surgery can help people with advanced head and neck cancer stay cancer-free longer. About 714 participants receive either pembrolizumab plus standard radiation (with or without chemo) or…

This Phase 3 trial compares the immunotherapy drug pembrolizumab (Keytruda) to standard chemotherapy in 280 women with advanced or recurrent endometrial cancer that has a specific genetic feature (dMMR). The goal is to see if pembrolizumab can better delay cancer growth and impro…

This study tests a procedure called focused ultrasound (Exablate) that uses sound waves to target a small area in the brain involved in Parkinson's disease. It involves 67 people with early-stage Parkinson's who will either receive the ultrasound treatment or continue with standa…

This study tests if adding another drug (belzutifan or quavonlimab) to a standard two-drug treatment can help people with advanced clear cell kidney cancer live longer or stop their cancer from growing. About 1,650 adults who have not had prior treatment for advanced disease will…

This study is testing experimental combinations of drugs for people with advanced kidney cancer (clear cell type) that has gotten worse after initial treatment. The goal is to see if these combinations are safe and can shrink tumors. About 370 participants will be enrolled in thi…

This study tests whether adding the immunotherapy drug pembrolizumab to standard BCG treatment helps people with high-risk non-muscle invasive bladder cancer stay cancer-free longer. About 1,400 participants will receive either BCG alone or BCG plus pembrolizumab. The goal is to …

This early-phase study tests a new type of deep brain stimulation that adapts in real time to a person's movements, aiming to improve walking and motor skills in Parkinson's disease. Ten patients already scheduled for standard DBS surgery will receive this adaptive stimulation an…

This study tests a new way to use deep brain stimulation (DBS) for Parkinson's disease. Instead of constant stimulation, the device automatically switches settings when the person starts walking, aiming to improve gait and balance. Six people who already have a special DBS implan…

This study follows about 427 adults with advanced Parkinson's disease who are receiving ABBV-951, a continuous infusion under the skin. Researchers want to see how well it controls symptoms like tremors and stiffness over three years in everyday medical practice. Participants att…

This phase 2a trial tests whether the drug TB006 can safely improve motor function in people with early-stage Parkinson's disease. About 62 participants will receive either TB006 or a placebo by IV infusion. The study is double-blind, meaning neither patients nor doctors know who…

This study follows about 300 adults with advanced Parkinson's who are already using Lecigon, a gel given through a pump to control movement problems. Researchers will track how well it works and what side effects occur over up to two years in everyday medical care. The goal is to…

This Phase 3 study tests an experimental drug called CVN424 in 330 people with Parkinson's disease who experience motor complications. Participants take either 75 mg, 150 mg, or a placebo pill once daily for 12 weeks. The main goal is to see if CVN424 can reduce the daily hours o…

This early-phase study tests a new drug called MK-2870, either alone or with the immunotherapy pembrolizumab, in Japanese patients with advanced solid tumors or a type of lung cancer. The main goal is to check the safety and side effects of these treatments. About 30 people will …

This study tests a new gene therapy called VGN-R09b in 39 people with Parkinson's disease. The goal is to see if it is safe and can help control motor symptoms like tremors and stiffness. Participants must be between 40 and 75 years old and have at least 2.5 hours of poor movemen…

This study tests a new drug called rilvegostomig (AZD2936) in people with advanced or metastatic non-small cell lung cancer. The drug is designed to boost the immune system's ability to fight cancer by blocking two targets (TIGIT and PD-1). The trial will check for safety, side e…

This study tests a non-invasive treatment using focused ultrasound to target a small area in the brain that controls movement. It is for people with advanced Parkinson's disease whose medication no longer controls their involuntary movements or motor fluctuations. The goal is to …

This study tests an experimental drug called prasinezumab in 316 people with early Parkinson's disease. The drug is an antibody designed to target and remove clumps of a protein linked to Parkinson's. Participants receive either the drug or a placebo for 52 weeks, with an option …

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy can help people with a common type of advanced breast cancer (HR+/HER2-) live longer without their cancer getting worse. About 340 participants who have already tried hormone therapy wil…

This study tests a new gene therapy called LY3884961 in 32 people with moderate to severe Parkinson's disease who have a specific genetic change (GBA1 mutation). The treatment is given as a single injection into the fluid around the brain and spinal cord. The main goal is to chec…

This study aimed to see if a special nutritional supplement (AMS2434) could help people with Parkinson's disease build stronger muscles and improve brain function. It was designed for adults aged 55 and older with mild to moderate Parkinson's. However, the study was withdrawn bef…

This study tests a new medicine called exidavnemab in people with mild to moderate Parkinson's disease or multiple system atrophy. The main goal is to check if the drug is safe and how the body processes it. Participants will receive either the drug or a placebo, and researchers …

This study tests a precise, non-invasive radiation treatment (frameless virtual cone radiosurgery) to reduce severe tremors in people with essential tremor or Parkinson's disease who cannot have deep brain stimulation. About 40 participants will receive a single focused dose of r…

This study tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy (paclitaxel, with or without bevacizumab) can slow the growth of ovarian cancer that has become resistant to platinum-based treatments. About 643 adults with recurrent ovarian, fallopian…

This study looks at whether terazosin, a drug usually used for high blood pressure, can slow the progression of Parkinson's disease. Researchers are tracking changes in heart and brain scans of 15 people who are either in early stages or at high risk for Parkinson's. The goal is …

This phase 2 trial tests whether carvedilol, a drug usually used for heart conditions, can slow the loss of dopamine transporters in the brain and delay Parkinson's symptoms. It follows 15 people with REM sleep behavior disorder and other early Parkinson's risk factors over three…

This study looks at how well a drug called foslevodopa-foscarbidopa works for people with advanced Parkinson's disease in France. About 250 adults whose doctors have already prescribed this drug will be followed for up to 12 months. The goal is to see if the treatment improves th…

This early-stage study is testing a combination of three drugs—sacituzumab tirumotecan, enfortumab vedotin, and pembrolizumab—in people with advanced bladder cancer that has spread or cannot be surgically removed. The trial has two parts: first, to find safe doses of the two-drug…

This study tests a new approach to deep brain stimulation (DBS) for people with Parkinson's disease. Instead of the usual single electrode, researchers are placing electrodes in two brain areas and using a system that adjusts stimulation based on real-time brain signals. The goal…

This study tests a new drug combination (pembrolizumab plus berahyaluronidase alfa) given as a shot under the skin for Japanese patients with advanced squamous cell skin cancer that has spread or cannot be removed by surgery. The main goal is to see if the treatment can shrink tu…

This phase 2 trial is testing an injectable form of the immunotherapy drug pembrolizumab (combined with hyaluronidase to help absorption) in 66 adults with classical Hodgkin lymphoma or primary mediastinal large B-cell lymphoma that has returned or not responded to prior treatmen…

This early-stage trial tests a gene therapy called AAV2-GDNF for multiple system atrophy (MSA), a rare and serious brain disorder. Nine adults with MSA will receive either the gene therapy or a sham surgery. The main goal is to check safety, but researchers will also look for any…

This study tests whether adding a personalized cancer vaccine (V940) to standard immunotherapy (pembrolizumab) can prevent high-risk bladder cancer from coming back after surgery. About 230 adults with muscle-invasive bladder cancer will receive either the vaccine plus immunother…

This early-phase study tests an experimental drug called MK-6837, given alone or with another drug (pembrolizumab), in people with advanced solid tumors that have not responded to standard treatments. The main goals are to check safety, find the right dose, and see if the drug sh…

This study tests a smart wearable airbag that detects when someone is falling and inflates to cushion the impact. It is designed for people at high risk of falling, such as those with stroke, Parkinson's disease, or a leg amputation. The goal is to see if the device can reduce fa…

This study tests whether adding sacituzumab govitecan to the immunotherapy drug pembrolizumab helps people with advanced non-small cell lung cancer live longer or delay cancer growth compared to pembrolizumab alone. About 614 adults whose tumors have high levels of a protein call…

This study tests whether adding lenvatinib to pembrolizumab and chemotherapy helps people with metastatic esophageal cancer live longer. About 864 participants receive either the new three-drug combo or standard care. The goal is to improve overall survival, but this is not a cur…

This first-in-human trial tests a stem cell therapy called STEM-PD for Parkinson's disease. Eight participants with moderate Parkinson's will have dopamine-producing cells transplanted into a brain region affected by the disease. The main goal is to check safety over 12 months, w…

This study tests whether a daily dose of tocotrienols (a type of vitamin E) can slow the worsening of motor symptoms in Parkinson's disease. One hundred adults with Parkinson's will take either the supplement or a placebo for two years. Researchers will track movement, thinking, …

This study tests a vaccine called ACI-7104.056 in 150 people with early-stage Parkinson's disease. The goal is to see if it is safe and helps the body fight a protein linked to Parkinson's. Participants must already be on stable low-dose levodopa. This is not a cure, but may help…

This study is testing whether low-dose lithium aspartate, a dietary supplement, can slow the progression of Parkinson's disease. It involves 35 people who have already completed a lithium trial, and they will take lithium for another 24 weeks. Researchers will use brain scans and…

This Phase 3 trial tests whether adding belzutifan or quavonlimab to a standard immunotherapy (pembrolizumab) and targeted therapy (lenvatinib) works better for advanced clear cell kidney cancer. About 249 Chinese patients who haven't had prior treatment will be randomly assigned…

This early-stage trial tests whether implanting a small piece of a patient's own nerve tissue into the brain during deep brain stimulation (DBS) surgery is safe and feasible. Ten people with Parkinson's disease will receive the implant, and researchers will monitor them for a yea…

This study is testing whether implanting a small piece of a patient's own nerve tissue into the brain during deep brain stimulation (DBS) surgery is safe and doable for people with Parkinson's disease. The nerve tissue contains cells that produce growth factors, which might help …

This study tests whether the immunotherapy drug pembrolizumab (Keytruda) combined with radiation works better than the standard chemotherapy drug cisplatin with radiation for patients with a certain type of head and neck cancer (p16-positive). About 126 adults with advanced or in…

This study tests whether a combination of stereotactic (computer-guided) surgery and a clot-dissolving drug can help people recover from a deep brain hemorrhage. The trial enrolls 380 adults with small-to-moderate bleeds in the basal ganglia who have significant disability. The g…

This program gave 10 people with Parkinson's disease, aged 76 to 95, multiple infusions of their own stored stem cells to check if it is safe. The treatment used 200 million cells given through an IV over 18 weeks, followed by 6 weeks of monitoring. The goal was safety, not a cur…

This expanded access program provides multiple intravenous infusions of a patient's own stem cells (HB-adMSCs) to up to 11 people with Parkinson's disease who were eligible for but not randomized into a related Phase 2 trial. The goal is to evaluate safety and effectiveness in co…

This study looks at whether adding physiotherapy to deep brain stimulation (DBS) can improve how people with Parkinson's disease move around their community. DBS helps with stiffness and tremors, but past studies found it didn't improve mobility and even increased falls. The tria…

This study tests a brain-computer interface that records brain activity and delivers stimulation to stop freezing of gait in people with Parkinson's disease. Ten participants who are already scheduled for deep brain stimulation surgery will have an additional electrode placed on …

This phase 2 trial tests the immunotherapy drug pembrolizumab (Keytruda) in people with 15 types of advanced solid tumors that have worsened after standard treatments. About 1,600 participants receive the drug to see if their tumors shrink or stop growing. The study also looks fo…

This study tests whether the antibiotic ceftriaxone can improve thinking and memory in people with mild to moderate Parkinson's disease dementia. About 100 participants will receive either ceftriaxone or a placebo intravenously twice a week. The main goal is to see if ceftriaxone…

This early-stage trial tests a single dose of a gene therapy called AAV2-GDNF, delivered directly into the brain, for people with Parkinson's disease. The main goal is to check safety in 11 adults aged 35-75. Researchers will also look at whether it improves motor symptoms.

This early-stage trial tests whether transplanting dopamine neurons made from a patient's own stem cells into the brain is safe for Parkinson's disease. Six people aged 55 to 80 with Parkinson's for at least 5 years will receive the cells in a single surgery. The main goal is to …

This phase 2 trial tests two experimental immunotherapy drugs, botensilimab and balstilimab, alone or together, against standard chemotherapy in 234 people with metastatic colorectal cancer that has not responded to prior treatments. The goal is to see if these drugs can shrink t…

This study explores whether altering gut bacteria with an antibiotic (rifaximin) can improve motor symptoms and medication response in people with Parkinson's disease. Researchers will first analyze how gut bacteria relate to symptoms, then give some participants rifaximin and ot…

This phase 2 trial is testing whether adding an experimental mRNA vaccine (V940) to standard immunotherapy (pembrolizumab) can prevent kidney cancer from coming back after surgery. About 272 people with high-risk kidney cancer will receive either the vaccine plus immunotherapy or…

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests an AI tool called AIDP that analyzes MRI scans to help diagnose Parkinson's disease and two similar conditions (MSA and PSP). Researchers at 21 sites will compare the AI's diagnosis to that of movement disorder specialists. The goal is to see if the tool can impr…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This study tests a new PET imaging technique that uses 10 to 100 times less radiation than standard scans. Researchers will inject 200 healthy volunteers and patients with a radioactive tracer and use a high-sensitivity scanner to see if image quality remains good enough for dete…

This study is looking for better ways to diagnose Parkinson's disease using samples that are easy to collect, like blood, skin, and nasal swabs. Researchers will compare these samples from 340 people, including those with Parkinson's, Alzheimer's, and healthy volunteers. The goal…

This study tests whether an AI tool can help radiologists read brain CT and MRI scans more accurately and quickly. Researchers will compare how well doctors, AI alone, and doctors using AI together can spot abnormalities, urgent findings, and classify diseases. The goal is to red…

This study uses a special brain scan called DaTscan to look at how certain brain diseases affect the brain. Researchers will scan 500 adults with conditions like Parkinson's disease, dementia, mild cognitive impairment, or REM sleep behavior disorder. The goal is to see if DaTsca…

This study tests a special bed called SuPerSense that senses how a person lies on it and gives feedback to help improve posture and balance. People with Parkinson's disease who have trouble with balance or posture will either do standard rehab exercises or use the smart bed plus …

This study tests a new functional drink made with chicory inulin, B-vitamins, and vitamin D to see if it can improve constipation and overall well-being in people with Parkinson's disease. About 56 participants will drink either the active supplement or a placebo twice daily for …

This study investigates whether whole-body vibration (WBV) therapy, added to standard exercise, can improve balance, walking, thinking, and the ability to do two things at once in people with Parkinson's disease. Participants will be randomly assigned to receive either low-freque…

This study tests whether alternating between high and low frequencies of deep brain stimulation (DBS) can improve walking and balance in people with Parkinson's disease. Twelve participants who already have DBS implants will try different stimulation patterns while their gait and…

This phase 2 trial tests whether fasudil, a drug already used in Japan for blood vessel spasms, is safe and can help symptoms in people with early Parkinson's disease. 75 participants will take either fasudil or a placebo for 3 weeks. The study focuses on safety and tolerability,…

This study is testing whether a 6-month program of online exercise classes, guided meditation, and nutrition advice can improve thinking, sleep, and overall health in people with Parkinson's disease. 60 participants aged 40 to 85 will take part, with some starting the program rig…

This study tests whether adding cognitive training to balance and gait exercises helps people with Parkinson's disease improve their balance, walking, and thinking. Fourteen participants will undergo 12 sessions of combined training. The goal is to see if this approach eases move…

This study tests a personalized workplace intervention for 124 Dutch workers with Parkinson's disease, cerebellar ataxia, hereditary spastic paraparesis, or slowly progressive neuromuscular/mitochondrial disorders. A trained facilitator helps employees and their managers identify…

This study looks at whether adding resistance (strength) exercises to standard aerobic and balance training can improve quality of life, daily activities, thinking skills, and muscle health in people with early-stage Parkinson's disease. About 34 adults aged 40-70 with mild to mo…

This study tests a remote speech therapy program for 32 Korean-speaking people with Parkinson's disease and their families. The therapy includes 16 sessions over four weeks, plus daily home practice, to improve speech clarity. The goal is to see if this culturally adapted approac…

This study tests whether a 'social prescription' program can reduce loneliness in people with Parkinson's disease who already attend group exercise classes. About 40 participants who feel lonely will work with an occupational therapist to choose from 11 social activities, like sp…

This study tests whether adding motor imagery—mentally practicing movements without actually moving—to standard physical therapy can improve balance and reduce fear of movement in people with Parkinson's disease. Forty-two participants will be randomly assigned to receive either …

This study tests whether an 8-week aquatic high-intensity interval training (HIIT) program can improve balance, physical function, and muscle health in people with Parkinson's disease. Fifty-six participants with mild to moderate Parkinson's will do Tabata-style exercises in a po…

This study tests whether a non-invasive magnetic brain stimulation technique, called rTMS, can help ease depression in people with Parkinson's disease. Fifty adults with mild to moderate depression will be randomly assigned to receive either real rTMS or a sham (fake) treatment f…

This study tests whether an immersive virtual reality program can improve balance in people with Parkinson's disease. Fifty participants in Spain will either receive the VR program or standard physical therapy. The goal is to see if VR can help with balance and reduce fall risk.

This study tests whether adaptive deep brain stimulation (DBS) can reduce or prevent freezing of gait in 20 people with Parkinson's disease. Participants already have DBS implants, and the device will adjust stimulation in real time based on brain signals. Freezing episodes will …

This study tests a drug called bezisterim (NE3107) in 60 people with early Parkinson's disease who have not yet started standard treatment. The goal is to see if it can improve movement symptoms like stiffness and slowness. Participants take the drug or a placebo twice daily for …

This study tests special gloves that vibrate in a pattern to help people with moderate Parkinson's disease move more easily. Thirty participants wear the gloves at home for months. Researchers measure changes in movement scores to see if the vibration therapy works.

This study tests a wearable device that delivers gentle vibrations to the skin to improve motor function in people with Parkinson's disease. The treatment can be used alongside regular medication and aims to delay the need for higher doses. Thirty participants with moderate-stage…

This study tests a device called NervioX-2400 that uses weak electrical currents to stimulate specific brain areas without surgery. Researchers want to see if it can improve movement problems like tremors and stiffness in 100 people with early-to-mid stage Parkinson's disease. Ea…

This study tests whether a gentle electrical current applied to the back of the head (cerebellar tDCS) can improve both movement and mood in people with mild to moderate Parkinson's disease. Twenty-five participants will use a portable device at home for 8 days. Researchers will …

This study tests whether a dietary fiber called resistant maltodextrin is safe and tolerable for people with Parkinson's disease. Half of the 30 participants will take the fiber, and the other half will take a control substance. Researchers will check for side effects and see if …

This study tests whether home-based physical and cognitive exercises, delivered via telemedicine, can reduce chronic pain in people with Parkinson's disease. 166 Veterans will use a stationary bike or smartphone cognitive games from home. The goal is to find an easy, affordable w…

This study tests whether a combination of two sedatives (ketamine and dexmedetomidine, called Ketodex) works better than dexmedetomidine alone for keeping patients comfortable during awake deep brain stimulation surgery. The surgery is used for movement disorders like Parkinson's…

This study tests whether a personalized lifestyle program focusing on stress, exercise, nutrition, sleep, and self-management can improve quality of life for people with Parkinson's disease. 256 participants will be randomly assigned to either work on their goals independently or…

This study tests whether a 4-week telerehabilitation program can improve balance and quality of life in 36 people with multiple sclerosis or Parkinson's disease. Participants do balance exercises at home while monitored by a hospital physiotherapist. The results are compared to s…

This study tests whether mindfulness-based cognitive therapy (MBCT) can reduce psychological distress in people with Parkinson's disease. 174 participants with mild-to-moderate stress symptoms will either receive MBCT or continue usual care. The main goal is to see if MBCT lowers…

This study tests whether a drug called crisugabalin can safely reduce pain in people with Parkinson's disease who have a type of pain called nociplastic pain. About 166 adults will take either the drug or a placebo twice a day for 12 weeks. Researchers will measure pain levels an…

This study tests two types of memory training in 120 people with Parkinson's disease and mild cognitive impairment. Participants complete 8 weekly sessions of either process or strategy training. The goal is to see if these exercises improve remembering to do tasks in daily life,…

This study tests whether manual therapy (specialized hands-on techniques by experienced physiotherapists) can improve both movement and non-movement symptoms in 60 people with Parkinson's disease. Participants receive up to two sessions per week for six weeks, alongside their usu…

This study looks at whether a gentle electrical stimulation to the ear (auricular vagus nerve stimulation) combined with standard physical therapy can improve balance, walking, and other symptoms in people with Parkinson's disease. About 20 adults with mild to moderate Parkinson'…

This study looks at whether online community support and telemedicine can improve quality of life for people with Parkinson's disease, Lewy body dementia, and related conditions, as well as their caregivers. About 632 participants will receive palliative care training for their d…

This study tests whether daily exposure to a flickering gamma light is safe and tolerable for people with Parkinson's disease who experience freezing of gait—a sudden inability to step forward. Researchers will monitor side effects and see if the light therapy reduces freezing ep…

This study tests a set of virtual reality exergames in the Metaverse to help people with neurological conditions like multiple sclerosis, Parkinson's disease, stroke, and traumatic brain injury improve their cognitive skills. 25 participants will try games like virtual cooking an…

This study tests an experimental drug called KDT-3594 in 150 people with advanced Parkinson's disease who already take levodopa. The goal is to see if the drug can improve movement and daily living skills during their 'on' times (when medication is working). Participants take esc…

This study tests whether combining two types of brain stimulation (tDCS and TUS) with physical therapy can improve balance in people with Parkinson's disease. Forty participants will receive either real or sham stimulation during therapy sessions over two weeks. The goal is to se…

This study tests whether a non-invasive brain stimulation technique called tDCS can improve depression and other non-motor symptoms in people with Parkinson's disease. About 80 participants will receive either real or fake (sham) stimulation for 30 minutes over 10 sessions. The g…

This study explores whether wearing prismatic goggles that shift vision can improve emotional awareness (alexithymia) and visual-spatial abilities in people with Parkinson's disease. Researchers will also use brain scans and tear tests to understand how the brain adapts and to fi…

This study tests whether using advanced brain imaging to guide deep brain stimulation (DBS) can better control tremor in people with Parkinson's disease while avoiding side effects like involuntary movements. Twenty adults who already have DBS implants will have their stimulation…

This study tests whether a non-invasive brain stimulation technique called iTBS can reduce pain and other symptoms in people with Parkinson's disease. Researchers will compare two different stimulation patterns in 90 adults aged 40-80 who have had Parkinson's for at least 3 years…

This study is testing a device called MemorEM, which is a cap that sends low-level electromagnetic waves to the head. The goal is to get feedback from 1,000 patients with neurological diseases like Alzheimer's or Parkinson's, and their caregivers, on how easy the device is to use…

This study tests whether a high-intensity interval training (HIIT) program can improve cognitive function and quality of life in people with Parkinson's disease. Researchers will enroll 30 participants aged 40 and older to exercise regularly for 3 to 6 months. The goal is to see …

This phase 2 trial tests whether taking 10 mg of melatonin daily for 12 weeks can reduce oxidative stress and improve symptoms in 70 people with mild-to-moderate Parkinson's disease who are already on levodopa. Participants will be randomly assigned to receive melatonin or a plac…

This study tests whether partnered dance aerobic exercise can reduce 'OFF-time' (when Parkinson's medication stops working well) and improve thinking skills. Researchers will enroll 82 people with Parkinson's who experience OFF-time. Participants will take dance classes twice a w…

This study is testing whether a daily supplement made from baker's yeast can improve digestion and reduce gut symptoms in healthy adults aged 50 to 99. Participants take 15 grams of the supplement each day and report any changes in how their stomach feels. The goal is to see if t…

This pilot study tests whether a Parkinson's-specific Tai Chi program can improve movement and non-movement symptoms like balance, fatigue, and mood. Thirty adults with mild to moderate Parkinson's will either take Tai Chi classes plus usual care or just usual care for 12 weeks. …

This pilot study tests whether a home-based program called HOBSCOTCH, originally designed for epilepsy, can be adapted for people with Parkinson's disease. Ten participants will work one-on-one with a coach in nine virtual sessions to learn problem-solving strategies and memory a…

This study tests a non-invasive device that stimulates a nerve in the ear to see if it can improve movement, mood, sleep, and motivation in people with Parkinson's disease. Thirty participants will try three different stimulation patterns over several weeks. The goal is to find t…

This study tests whether a 7-week ballroom dance program, called Parkinson Ballroom Fitness, can improve walking, balance, and quality of life in people with Parkinson's disease. About 50 participants will be randomly assigned to dance or usual care. The program uses waltz, swing…

This study tests a special exercise program called TURN-IT for people with Parkinson's disease who have fallen in the past year. The program focuses on improving turning ability through targeted exercises. 55 participants will either do the program or continue usual care, and res…

This study tests whether a special light therapy device can improve quality of life and movement for people with Parkinson's disease. About 350 participants who are already on standard Parkinson's medication will use the light at home. The goal is to see if adding this light ther…

This study tests whether bright light therapy can help with sleep and alertness issues in people with Parkinson's disease. Researchers will measure sleep quality, daytime sleepiness, and other non-motor symptoms in 65 participants. The goal is to see if light exposure can improve…

This study tests whether a special shoulder rehabilitation program can improve arm and shoulder movement in people with Parkinson's disease. Twenty-eight participants will receive either the shoulder-focused rehab or a standard upper extremity program. The goal is to see if this …

This study aims to identify genetic, biochemical, and clinical factors linked to disease severity in people with Gaucher disease and other lysosomal storage disorders. Researchers will evaluate up to 1,000 participants, including patients, carriers, and healthy controls, to bette…

This study follows 125 people with Parkinson's disease or related conditions over two years. Researchers use special brain scans to measure changes in a chemical called acetylcholine, which is linked to walking problems, falls, and thinking skills. The goal is to understand how t…

This study aimed to see if Alzheimer's disease affects the nerves in the gut, similar to what happens in Parkinson's disease. Researchers planned to take extra colon biopsies during routine colonoscopies from people with Alzheimer's, Parkinson's, and healthy individuals to compar…

This study aims to improve how doctors test for autonomic failure, a condition where the body's automatic functions like blood pressure control don't work properly. Researchers will use advanced imaging, sweat tests, and skin biopsies in up to 89 adults with Parkinson's disease, …

This long-running study follows nearly 100,000 French women, mostly teachers, since 1990 to understand what factors influence their risk of cancer, heart disease, diabetes, and other major illnesses. Participants fill out questionnaires every few years about their lifestyle, medi…

This study aims to identify biomarkers—biological clues in the body—that can help distinguish between Parkinson's disease and similar conditions like progressive supranuclear palsy and multiple system atrophy. Researchers will follow people with early-stage parkinsonism and healt…

This study investigates how genetic, lifestyle, and biological factors relate to memory and thinking problems in people over 60 with Alzheimer's disease, Parkinson's disease, or mild cognitive impairment. Researchers will use brain scans, spinal fluid and blood tests, and data fr…

This study tracks brain activity in 160 Parkinson's patients who have or will receive deep brain stimulation (DBS). Researchers record signals from the brain during memory tasks, with the stimulator on and off, to find patterns linked to cognitive side effects. The goal is to ide…

This study tests a new type of brain implant that can both sense brain activity and deliver stimulation in real time. It involves 25 people with Parkinson's disease or dystonia who already need deep brain stimulation. The goal is to see if closed-loop stimulation (which adjusts a…

This study tracks the exercise habits of 288 people with Parkinson's disease over one year using activity trackers and a phone app. Researchers want to see if different types of exercise advice—like standard care, written guidance from a neurologist, or physical therapy—help peop…

This study enrolls 500 adults with a sleep condition called REM sleep behavior disorder (RBD), which often leads to Parkinson's disease or related brain disorders. Researchers will track symptoms like thinking, movement, and smell to develop a rating scale. The goal is to prepare…

This study looks at how thinking, memory, and movement change in older adults with conditions like dementia or Parkinson's disease. Researchers will use tests, brain scans, and lab samples to find clues for earlier diagnosis and better care. About 260 people, including healthy vo…

This study uses a special brain scan called PIB PET to look at different types of dementia in people with Parkinson's disease. The goal is to find out who might develop dementia and what causes it. Researchers will study 320 participants to better understand these brain changes.

This study collects movement data from 250 people with stroke, Parkinson's disease, or leg amputations using wearable sensors and video. The goal is to build an online database that researchers can use to study how people move and recover. No treatments are being tested—this is p…

This study is observing up to 198 people with rapid-onset dystonia-parkinsonism (RDP) or related genetic mutations. Researchers aim to identify affected individuals, document how common the disease is, and track its progression over time. Participants undergo assessments of sympt…

This early-phase study tests whether a new type of PET scan can measure inflammation in the brains of people with Parkinson's disease. Researchers will compare scans from 11 participants (both with Parkinson's and healthy volunteers) to see if the imaging drug 18F-NOS can help di…

This study looks at whether the Parkinson's drug Levodopa-Benserazide affects gum health and inflammation. Researchers will measure gum health and saliva markers in 136 people, including Parkinson's patients with and without gum disease, and healthy controls. The goal is to under…

This study aimed to understand how blood pressure changes when standing up affect thinking abilities and brain blood flow in people with Parkinson's disease. Researchers planned to compare participants with and without orthostatic hypotension (low blood pressure upon standing) us…

This study looks at how things like social support, income, and health habits are linked to mental health and brain diseases such as depression, Alzheimer's, and Parkinson's. Researchers will collect surveys, blood samples, and optional brain scans from over 1,300 adults in Europ…

This study follows 100 people aged 60-85 with mild memory or movement problems to see if losing smell, hearing, or balance speeds up cognitive decline. Researchers will test these senses and track thinking skills and quality of life for 5 years. The goal is to understand which se…

This study follows 200 people with Parkinson's disease or multiple sclerosis over one year to see how active they are. Participants use a smartphone app called Datos Health to track steps, workouts, and heart rate. A physical therapist sets personalized exercise goals. The goal i…

This study follows 32 people with Parkinson's disease, some with a specific gene change (GBA mutation), to see how their brain activity patterns change over time. Researchers use brain scans to measure these changes. The goal is to understand if the gene mutation leads to faster …

This early-phase study uses advanced MRI to visualize the brain's lymphatic system, which may help clear waste linked to Parkinson's and other brain diseases. Researchers will compare images from 140 people with and without Parkinson's to see if this system works differently in t…

This study looks at how different patterns of deep brain stimulation (DBS) affect movement symptoms and brain activity in people with Parkinson's disease, essential tremor, multiple sclerosis, or dystonia. Researchers will test non-regular stimulation patterns to find ways to mak…

This observational study follows 36 people with neurologic conditions like traumatic brain injury, cerebral palsy, multiple sclerosis, or Alzheimer's who are already receiving intranasal MuSE stem cell or exosome therapy as part of their routine care. Researchers track safety and…

This study looks at whether small amounts of brain inflammation contribute to movement and thinking problems in people with Parkinson disease. Researchers will use a new radioactive tracer called [11C]-CS1P1 in PET scans to measure inflammation in the brain. The study includes 80…

This study aimed to collect brain signals related to speech from people with Parkinson's disease during deep brain stimulation (DBS) surgery. The goal was to better understand how the brain controls speech in these patients. However, the study was withdrawn before enrolling any p…

This study looks at how tiredness affects daily life and muscle function in older adults (65+) and people with Parkinson's disease. Researchers will use questionnaires and simple exercises like handgrip and leg movements to measure fatigue. The goal is to better understand fatigu…

This study was designed to test a wearable sensor system that tracks how people walk on different surfaces like grass, pavement, and stairs. It aimed to include healthy volunteers and people with conditions such as Parkinson's disease, dementia, stroke, multiple sclerosis, or low…

This study looks at data from 1 million adults worldwide to see if eating nuts is linked to a lower risk of diseases like diabetes, heart disease, cancer, and dementia. Researchers will combine information from many past studies to get clearer answers. The goal is to understand i…

This study records brain activity from 125 Parkinson's patients during deep brain stimulation (DBS) surgery. Participants perform tasks that involve making decisions, stopping actions, or switching between actions. The goal is to understand how brain circuits control movement and…

This study translates a scale that measures how thinking difficulties affect daily life in people with Parkinson's disease into Turkish. Researchers will test the translated version in 60 Turkish-speaking Parkinson's patients to see if it is valid and reliable. The goal is to giv…

This study follows 60 adults with Parkinson's disease who are scheduled for deep brain stimulation (DBS) surgery. Researchers will track their brain activity, movement, and thinking skills over time to learn how DBS affects the brain. The goal is to gather information, not to tes…

This observational study will enroll 100,000 people over age 45 to track early signs of Alzheimer's and Parkinson's using smartphone-based tests, genetic data, and brain scans. Researchers aim to develop better ways to identify who is at risk before symptoms worsen. Participants …

This study is testing whether adding action observation and motor imagery (watching and imagining exercises) to standard dual-task gait training can improve walking and balance in people with Parkinson's disease who have trouble with posture and walking. 80 participants will be r…

This study looks at whether carvedilol, a drug used for heart failure, can reverse early heart changes seen in people with a sleep disorder that puts them at high risk for Parkinson's disease. Fifteen participants with REM sleep behavior disorder or reduced sense of smell will ta…

This study looks at whether terazosin, a drug used for high blood pressure, can change heart nerve activity in people at high risk for Parkinson's disease. Researchers are studying 15 adults with REM sleep behavior disorder (a strong early sign of Parkinson's) to see if the drug …

This study is analyzing blood samples from 1,799 people with Alzheimer's, dementia, depression, bipolar disorder, schizophrenia, or Parkinson's disease. Researchers want to see if certain substances in the blood can help doctors diagnose and manage these conditions more accuratel…

This study looks at balance and movement problems in people with stroke, Parkinson's disease, or multiple sclerosis. Researchers will use special devices to measure how well participants can keep their balance and walk. The goal is to learn more about these issues so that rehabil…

This study looks at why some people with Parkinson's disease suddenly freeze while walking. Researchers will record brain activity from implanted devices as 36 participants walk in a virtual reality setup. The goal is to better understand what happens in the brain during freezing…

This study uses a small skin sample to measure levels of a protein linked to Parkinson's disease and REM sleep behavior disorder. Researchers will follow 100 participants for 18 months to see if changes in the protein match disease progression. The goal is to develop a simple bio…

This study aims to develop a new way to measure arm and hand function in people with brain disorders like stroke or Parkinson's disease. Researchers will use a smart board and smart glove to collect movement data and compare it with standard tests. The goal is to create a more pr…

This study aims to build a research group of 100 people with neurological diseases like stroke, Parkinson's, epilepsy, or dementia. Researchers will use overnight sleep tests and questionnaires to measure sleep patterns, breathing, and heart rate during sleep. The goal is to bett…

This study looks at whether a device called GYKO can reliably measure balance in people with Parkinson's disease during walking tests. Twenty-five participants will perform two common balance tasks while wearing the device, and their results will be compared between two raters an…

The Brain Health Registry is an online project that collects information about memory, mood, sleep, diet, and exercise from adults over 18. Participants also take simple cognitive tests online. The goal is to build a large database to speed up research into brain diseases like Al…

This study looks at how certain cues (like visual or sound signals) help people with Parkinson's disease move more easily. Researchers will use EEG and MRI to watch brain activity while participants perform movement tasks. The goal is to find brain patterns that could lead to new…

This study will collect brain scans from over 10,000 healthy people in China to create standard brain charts. These charts will show what a normal brain looks like at different ages. Doctors can then compare a patient's brain scan to these charts to help diagnose diseases like mu…

This study tests a new high-density microelectrode designed to record activity from individual brain cells and groups of cells. Ten Parkinson's patients already scheduled for deep brain stimulation surgery will have the electrode used during their procedure. The main goals are to…

This study follows 96 people with moderate Parkinson's disease for up to 24 months. Participants take their usual medications, and doctors may adjust them as needed. Researchers will track motor symptoms using standard rating scales to better understand how the disease progresses…

This study is testing whether rehabilitation that combines physical and mental exercises (called dual-task training) can help people with stroke, multiple sclerosis, Parkinson's disease, or long COVID. Researchers will design and try out different dual-task strategies in small gr…

This study records brain activity in 40 Parkinson's patients during deep brain stimulation (DBS) surgery. While awake, patients perform movement tasks with sensory or motivational cues. The goal is to understand how the brain improves movement with these cues, which could guide f…

This study aims to learn more about diseases that affect the brain, such as Parkinson's disease and different types of dementia. Researchers will follow 500 adults with symptoms of these conditions over time, using brain scans and genetic tests to see how the diseases progress. T…

This study aims to see if a special camera pill can safely take pictures of the esophagus in people with Parkinson's disease. Researchers want to find out if nerve changes in the gut can be seen and compared to healthy people. About 20 adults with Parkinson's will swallow a tiny …

This study follows 150 people with early Parkinson's disease or Multiple System Atrophy (MSA) for up to 18 months. Researchers will measure changes in motor symptoms, quality of life, and biomarkers to better understand how these diseases progress. The goal is to gather informati…

This study follows 132 people with Parkinson's disease or multiple system atrophy who previously received the gene therapy AB-1005. Researchers will track safety and how well the treatment works over the long term. No new treatments are given; it's purely observational.

This study tests whether two online educational sessions can help Parkinson's patients better understand deep brain stimulation (DBS) surgery. Sixty patients and their caregivers will attend virtual classes with expert talks and patient testimonials. The goal is to see if this im…

This study planned to use brain scans to measure how a meditation technique called OM affects dopamine and stress markers in people with Parkinson's disease. It was withdrawn before enrolling any participants, so no results are available. The goal was to better understand meditat…

This study explores whether low-intensity ultrasound can safely and precisely stimulate deep brain regions in people with Parkinson's disease or dystonia. Ten participants who already have deep brain stimulation (DBS) implants will receive ultrasound pulses while researchers reco…

This study is testing whether mobile EEG headsets, smartwatches, and other wearable devices can reliably measure sleep problems and disease progression in people with Parkinson's disease. About 82 participants will use these devices at home and complete tasks through a mobile app…

This study looks at whether prolactin (a hormone) and certain inflammation markers in the blood are linked to how severe Parkinson's disease is. Researchers will measure these in 300 people with Parkinson's and compare them to standard disease severity scores. The goal is to find…

This study follows 30 people with Parkinson's disease who are scheduled to receive deep brain stimulation (DBS). Researchers will test whether brain scans, thinking tests, and other measures can predict who might experience cognitive decline after surgery. Participants complete t…

This study tests whether a wrist-worn movement recorder, called the Personal KinetiGraph (PKG), helps doctors make better treatment decisions for people with Parkinson's disease. About 231 participants will be split into two groups: one where the doctor sees the PKG data during t…

This study gathers MRI, CT, and ultrasound images from 300 adults—some healthy, some with kidney or brain disease—to build a collection for future not-for-profit research. No new treatments are being tested; the goal is to make medical images available to scientists for advancing…