New Dual-Action drug shows promise in early lung cancer trial

NCT ID NCT04995523

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Jun 23, 2026 · Updated 33 times

Summary

This study tests a new drug called rilvegostomig (AZD2936) in people with advanced or metastatic non-small cell lung cancer. The drug is designed to boost the immune system's ability to fight cancer by blocking two targets (TIGIT and PD-1). The trial will check for safety, side effects, and whether the drug can shrink tumors. About 212 participants will take part in this early-stage research.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Research Site

Chicago, Illinois, 60637, United States
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Rochester, Minnesota, 55905, United States
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Fairfax, Virginia, 22031, United States
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Melbourne, 3000, Australia
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Anderlecht, 1070, Belgium
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Leuven, 3000, Belgium
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Florianópolis, 88034-000, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90035903, Brazil
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Rio de Janeiro, 20231-050, Brazil
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São Paulo, 01246-000, Brazil
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Chengdu, 610041, China
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Chongqing, 400030, China
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Copenhagen, 2100, Denmark
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Dijon, 21079, France
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Toulouse, 31059, France
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Tbilisi, 0112, Georgia
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Kashiwa, 227-8577, Japan
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Niigata, 951-8566, Japan
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Sendai, 981-0914, Japan
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Tokyo, 104-0045, Japan
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Kuala Lumpur, 59100, Malaysia
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Kuching, 93586, Malaysia
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Chisinau, MD-2025, Moldova
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Groningen, 9713 GZ, Netherlands
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Leiden, 2333 ZA, Netherlands
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Utrecht, 3584 CX, Netherlands
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Seoul, 03082, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Barcelona, 08035, Spain
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Madrid, 28027, Spain
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Madrid, 28041, Spain
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Taichung, 40201, Taiwan
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Taichung, Taiwan
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Tainan, 70403, Taiwan
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Taipei, 110, Taiwan
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Bangkok, 10700, Thailand
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Chanthaburi, 22000, Thailand
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Muang, 50200, Thailand

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

rilvegostomig (AZD2936), a bispecific antibody that targets two immune checkpoints (TIGIT and PD-1)

What this could lead to

If successful, this could provide a new treatment option for advanced lung cancer by helping the immune system attack cancer cells more effectively.

What could go wrong

This is an early-phase trial (Phase 1/2) with a small number of participants, so safety and effectiveness are not yet proven. The drug may cause immune-related side effects or not work for all patients.

Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 Neoplasm Metastasis non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-SMALL CELL LUNG CARCINOMA NON-SMALL CELL LUNG CARCINOMA