Lung cancer hope: drug combo aims to boost survival in Early-Stage disease

NCT ID NCT04624204

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether adding pembrolizumab (an immunotherapy) and olaparib (a targeted drug) to standard chemotherapy and radiation can help people with limited-stage small cell lung cancer live longer. About 672 participants will receive either the drug combo or a placebo alongside standard treatment. The study is active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

pembrolizumab and olaparib

What this could lead to

If successful, this combination could extend survival for people with limited-stage small cell lung cancer, offering a new standard treatment option.

What could go wrong

This is an early-phase trial, and the added drugs may cause more side effects without improving outcomes. Results may not apply to all patients.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for SMALL CELL LUNG CANCER are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A O U Policlinico di Modena ( Site 1503)

    Modena, Emilia-Romagna, 41125, Italy

  • AZ Delta ( Site 1000)

    Roeselare, West-Vlaanderen, 8800, Belgium

  • Affiliated Cancer Hospital of Shandong First Medical University ( Site 3100)

    Jinan, Shandong, 250117, China

  • Aichi Cancer Center ( Site 4010)

    Nagoya, Aichi-ken, 464-8681, Japan

  • Amethyst Radiotherapy Center-Oncologie Medicala ( Site 2805)

    Florești, Cluj, 407280, Romania

  • Ankara Bilkent Sehir Hastanesi ( Site 2007)

    Ankara, 06800, Turkey (Türkiye)

  • Anti-Cancer Hospital of Thessaloniki Theagenio ( Site 1204)

    Thessaloniki, Central Macedonia, 54007, Greece

  • Asan Medical Center ( Site 3308)

    Songpagu, Seoul, 05505, South Korea

  • Austin Health-Austin Hospital ( Site 3006)

    Heidelberg, Victoria, 3084, Australia

  • Azienda Ospedaliera Spedali Civili di Brescia ( Site 1512)

    Brescia, 25123, Italy

  • Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento-Oncology Unit ( Site 1513)

    Verona, Veneto, 37126, Italy

  • Azienda Ospedaliero Universitaria Careggi ( Site 1509)

    Florence, Firenze, 50134, Italy

  • Bacs-Kiskun Megyei Korhaz-Onkoradiologiai Kozpont ( Site 1306)

    Kecskemét, Bács-Kiskun county, 6000, Hungary

  • Barts Health NHS Trust ( Site 2409)

    London, London, City of, EC1A 7BE, United Kingdom

  • Beijing Cancer Hospital ( Site 3127)

    Beijing, Beijing Municipality, 130021, China

  • Beijing Cancer hospital-Oncology Radiotherapy Department ( Site 3140)

    Beijing, Beijing Municipality, 100142, China

  • C.H. de Saint Quentin ( Site 1111)

    Saint-Quentin, Aisne, 02321, France

  • C.I.U. Hopital Ambroise Pare ( Site 1001)

    Mons, Hainaut, 7000, Belgium

  • CHU Grenoble -Hop Michallon ( Site 1102)

    Grenoble, Isere, 38043, France

  • CHU UCL Namur Site de Godinne ( Site 1004)

    Yvoir, Namur, 5530, Belgium

  • CHU de Bordeaux Hop St ANDRE ( Site 1115)

    Bordeaux, Aquitaine, 33075, France

  • CIUSSS Ouest de l Ile - St-Mary s Hospital ( Site 0202)

    Montreal, Quebec, H3T 1M5, Canada

  • CIUSSS de la Mauricie et du Centre du Quebec ( Site 0200)

    Trois-Rivières, Quebec, G8Z 3R9, Canada

  • Cabinet Medical Oncomed ( Site 2802)

    Timișoara, Timiș County, 300239, Romania

  • Calvary Mater Newcastle ( Site 3000)

    Waratah, New South Wales, 2298, Australia

  • Campbelltown Hospital ( Site 3002)

    Campbelltown, New South Wales, 2560, Australia

  • Cancer Hospital Chinese Academy Of Medical Sciences. Shenzhen Center ( Site 3113)

    Shenzhen, Guangdong, 518116, China

  • Cancer Hospital Chinese Academy of Medical Sciences ( Site 3104)

    Beijing, Beijing Municipality, 100021, China

  • Cancer Institute Hospital of JFCR ( Site 4006)

    Tokyo, 135-8550, Japan

  • Chaim Sheba Medical Center ( Site 1400)

    Ramat Gan, 5262000, Israel

  • Chongqing Cancer Hospital ( Site 3135)

    Chongqing, Chongqing Municipality, 400030, China

  • Cleveland Clinic - Hillcrest Hospital-Hillcrest Hospital Cancer Center ( Site 0140)

    Mayfield Heights, Ohio, 44124, United States

  • Cleveland Clinic Main ( Site 0139)

    Cleveland, Ohio, 44195, United States

  • Clinic of National Cancer Institute ( Site 2101)

    Kyiv, Kyivska Oblast, 03022, Ukraine

  • Clinique Clairval ( Site 1108)

    Marseille, Bouches-du-Rhone, 13009, France

  • Communal Noncommercial Enterprise "Podillia Regional Oncolog-Chemotherapy Department ( Site 2114)

    Vinnytsia, Vinnytsia Oblast, 21029, Ukraine

  • Cross Cancer Institute ( Site 0206)

    Edmonton, Alberta, T6G 1Z2, Canada

  • Daping Hospital,Third Military Medical University ( Site 3136)

    Chongqing, Chongqing Municipality, 400042, China

  • Ege Universitesi Tip Fakultesi Hastanesi ( Site 2001)

    Izmir, 35040, Turkey (Türkiye)

  • Fairview Hospital-Moll Cancer Center ( Site 0141)

    Cleveland, Ohio, 44111, United States

  • Fort Wayne Medical Oncology and Hematology ( Site 0034)

    Fort Wayne, Indiana, 46804, United States

  • Frankston Hospital-Oncology and Haematology ( Site 3007)

    Frankston, Victoria, 3199, Australia

  • Fujian Provincial Cancer Hospital ( Site 3126)

    Fuzhou, Fujian, 350014, China

  • Georgetown University ( Site 0017)

    Washington D.C., District of Columbia, 20007, United States

  • Gold Coast University Hospital ( Site 3003)

    Southport, Queensland, 4215, Australia

  • Grand Hopital de Charleroi ( Site 1003)

    Gilly, Hainaut, 6060, Belgium

  • Grigoriev Institute for medical Radiology NAMS of Ukraine ( Site 2110)

    Kharkiv, Kharkiv Oblast, 61024, Ukraine

  • Groote Schuur Hospital ( Site 5002)

    Cape Town, Western Cape, 7925, South Africa

  • Guy s & St Thomas NHS Foundation Trust ( Site 2408)

    London, London, City of, SE1 9RT, United Kingdom

  • Göztepe Prof. Dr. Süleyman Yalçın Şehir Hastanesi-oncology ( Site 2003)

    Istanbul, 34722, Turkey (Türkiye)

  • H.I.A. Sainte-Anne ( Site 1101)

    Toulon, Var, 83800, France

  • Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0212)

    Hamilton, Ontario, L8V 5C2, Canada

  • Hangzhou Cancer Hospital ( Site 3129)

    Hanghzou, Zhejiang, 310002, China

  • Harry & Jeanette Weinberg Cancer Institute ( Site 0045)

    Baltimore, Maryland, 21237, United States

  • Henan Cancer Hospital ( Site 3105)

    Zhengzhou, Henan, 450008, China

  • Henry Dunant Hospital ( Site 1205)

    Athens, Attica, 115 26, Greece

  • Hopital Avicenne ( Site 1106)

    Bobigny, Seine-Saint-Denis, 93000, France

  • Hopitaux Universitaires Paris Centre-Hopital Cochin ( Site 1105)

    Paris, Île-de-France Region, 75014, France

  • Hospital Civil de Guadalajara Fray Antonio Alcalde ( Site 0401)

    Guadalajara, Jalisco, 44280, Mexico

  • Hospital Duran i Reynals ( Site 1903)

    L'Hospitalet de Llobregat, Barcelona, 08908, Spain

  • Hospital Regional Universitario de Malaga ( Site 1905)

    Málaga, 29010, Spain

  • Hospital Universitari Vall d Hebron ( Site 1904)

    Barcelona, 08035, Spain

  • Hospital Universitario "Dr. Jose Eleuterio Gonzalez" ( Site 0404)

    Monterrey, Nuevo León, 64460, Mexico

  • Hospital Universitario 12 de Octubre ( Site 1902)

    Madrid, 28041, Spain

  • Hospital Universitario Central de Asturias ( Site 1900)

    Oviedo, Principality of Asturias, 33011, Spain

  • Hospital Universitario Virgen Macarena-Unidad de Investigación Oncológica ( Site 1907)

    Seville, 41009, Spain

  • Hubei Cancer Hospital ( Site 3120)

    Wuhan, Hubei, 430079, China

  • Hunan Cancer Hospital ( Site 3133)

    Changsha, Hunan, 410013, China

  • IRCCS Istituto Oncologico Veneto ( Site 1506)

    Padova, 35128, Italy

  • IRCCS Ospedale San Raffaele ( Site 1500)

    Milan, 20132, Italy

  • Inje University Haeundae Paik Hospital ( Site 3307)

    Busan, Pusan-Kwangyokshi, 48108, South Korea

  • Inst. Portugues de Oncologia de Lisboa Francisco Gentil EPE ( Site 1705)

    Lisbon, 1099-023, Portugal

  • Institut De Cancerologie De L Ouest ( Site 1110)

    Saint-Herblain, Loire-Atlantique, 44805, France

  • Institut de Cancerologie de l Ouest Site Paul Papin ( Site 1103)

    Angers, Maine-et-Loire, 49000, France

  • Institut za plucne bolesti Vojvodine Sremska Kamenica ( Site 2991)

    Kamenitz, Sremski Okrug, 21204, Serbia

  • Institute for Oncology and Radiology of Serbia ( Site 2995)

    Belgrade, Beograd, 11000, Serbia

  • Instituto Portugues de Oncologia Do Porto Francisco Gentil E.P.E. ( Site 1701)

    Porto, 4200-072, Portugal

  • Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2803)

    Cluj-Napoca, Cluj, 400015, Romania

  • Ironwood Cancer & Research Centers ( Site 0007)

    Chandler, Arizona, 85224, United States

  • Istanbul Universitesi Cerrahpasa Tip Fakultesi ( Site 2009)

    Istanbul, 34098, Turkey (Türkiye)

  • Istituto Europeo di Oncologia ( Site 1501)

    Milan, 20141, Italy

  • Istituto Nazionale dei Tumori ( Site 1504)

    Milan, 20133, Italy

  • Jiangsu Cancer Hospital ( Site 3139)

    Nanjing, Jiangsu, 210000, China

  • John Theurer Cancer Center ( Site 0064)

    Hackensack, New Jersey, 07601, United States

  • Juntendo University Hospital ( Site 4008)

    Tokyo, 113-0033, Japan

  • Kanagawa Cancer Center ( Site 4001)

    Yokohama, Kanagawa, 241-8515, Japan

  • Kansai Medical University Hospital ( Site 4009)

    Hirakata, Osaka, 573-1191, Japan

  • Keimyung University Dongsan Hospital CRC room 1 ( Site 3302)

    Daegu, Taegu-Kwangyokshi, 42601, South Korea

  • Kobe Minimally Invasive Cancer Center ( Site 4003)

    Kobe, Hyōgo, 650-0046, Japan

  • Kyiv City Clinical Oncology Center ( Site 2100)

    Kyiv, 03115, Ukraine

  • LISOD. Hospital ( Site 2111)

    Pliuty, Kyiv Oblast, 08720, Ukraine

  • LSMUL Kauno Klinikos ( Site 2301)

    Kaunas, 50161, Lithuania

  • Loma Linda University Cancer Center ( Site 0011)

    Loma Linda, California, 92350, United States

  • MD Anderson Cancer Center ( Site 0100)

    Houston, Texas, 77030, United States

  • MHAT "Uni Hospital" OOD ( Site 2507)

    Panagyurishte, Pazardzhik, 4500, Bulgaria

  • MROI n.a. P.A. Herzen - branch of FSBI NMICR of MoH of Russia ( Site 1800)

    Moscow, Moscow, 125284, Russia

  • Main Military Clinical Hospital n.a. N.N.Burdenko ( Site 1812)

    Moscow, Moscow, 105094, Russia

  • McGill University Health Centre ( Site 0210)

    Montreal, Quebec, H4A 3J1, Canada

  • Medical Center Verum ( Site 2106)

    Kyiv, Kyivska Oblast, 03039, Ukraine

  • Medical Center of Yuriy Spizhenko LLC.-Clinical Trial ( Site 2104)

    Kapitanivka Village, Kyivska Oblast, 08111, Ukraine

  • Medical Oncology Associates, PS ( Site 0142)

    Spokane, Washington, 99208, United States

  • Medipol Universite Hastanesi ( Site 2005)

    Istanbul, 34214, Turkey (Türkiye)

  • Memorial Sloan Kettering - Basking Ridge ( Site 0133)

    Basking Ridge, New Jersey, 07920, United States

  • Memorial Sloan Kettering - Bergen ( Site 0130)

    Montvale, New Jersey, 07645, United States

  • Memorial Sloan Kettering - Monmouth ( Site 0135)

    Middletown, New Jersey, 07748, United States

  • Memorial Sloan Kettering - Nassau ( Site 0131)

    Uniondale, New York, 11553, United States

  • Memorial Sloan Kettering - Westchester-Thoracic Oncology ( Site 0134)

    Harrison, New York, 10604, United States

  • Memorial Sloan Kettering Cancer Center ( Site 0069)

    New York, New York, 10021, United States

  • Memorial Sloan Kettering- Commack ( Site 0132)

    Commack, New York, 11725, United States

  • Millennium Research & Clinical Development ( Site 0143)

    Houston, Texas, 77090, United States

  • Moffitt Cancer Center ( Site 0137)

    Tampa, Florida, 33612, United States

  • Moscow Regional Oncological Dispensary-Oncology (thoracic surgery) Department №1 ( Site 1815)

    Balashikha, Moscow Oblast, 143900, Russia

  • Multicare Institute For Research And Innovation ( Site 0108)

    Tacoma, Washington, 98405, United States

  • Municipal non-profit Enterprise "Khmelnytskyi Regional Antitumor Center" ( Site 2115)

    Khmelnytskyi, Khmelnytskyi Oblast, 29009, Ukraine

  • Nacionalinis Vezio Institutas ( Site 2300)

    Vilnius, Vilniaus Miestas, 08660, Lithuania

  • National Cancer Center ( Site 3306)

    Goyang-si, Kyonggi-do, 10408, South Korea

  • National Cancer Center Hospital ( Site 4015)

    Tokyo, 104-0045, Japan

  • National Hospital Organization Kyushu Cancer Center ( Site 4000)

    Fukuoka, 811-1395, Japan

  • Nepean Hospital ( Site 3001)

    Kingswood, New South Wales, 2747, Australia

  • Niigata Cancer Center Hospital ( Site 4004)

    Niigata, 951-8566, Japan

  • Ninewells Hospital and Medical School ( Site 2401)

    Dundee, Dundee City, DD1 9SY, United Kingdom

  • Nizhniy Novgorod Region Oncology Dispensary ( Site 1811)

    Nizhny Novgorod, Nizhny Novgorod Oblast, 603081, Russia

  • Okayama University Hospital ( Site 4012)

    Okayama, 700-8558, Japan

  • Omsk Clinical Oncology Dispensary ( Site 1806)

    Omsk, Omsk Oblast, 644013, Russia

  • Oncology Hematology West, PC dba Nebraska Cancer Specialists ( Site 0061)

    Omaha, Nebraska, 68130, United States

  • Orszagos Koranyi Pulmonologiai Intezet ( Site 1301)

    Budapest, 1121, Hungary

  • Orszagos Onkologiai Intezet ( Site 1310)

    Budapest, 1122, Hungary

  • Osaka International Cancer Institute ( Site 4005)

    Osaka, 541-8567, Japan

  • Osaka Medical and Pharmaceutical University Hospital ( Site 4007)

    Takatsuki, Osaka, 569-8686, Japan

  • Overton Brooks VAMC ( Site 0041)

    Shreveport, Louisiana, 71101, United States

  • Peking Union Medical College Hospital ( Site 3102)

    Beijing, Beijing Municipality, 100006, China

  • Peking University Shenzhen Hospital ( Site 3118)

    Shenzhen, Guangdong, 518036, China

  • Penn State Hershey Cancer Institute ( Site 0081)

    Hershey, Pennsylvania, 17033, United States

  • Petz Aladar Megyei Oktato Korhaz ( Site 1312)

    Győr, Győr-Moson-Sopron, 9024, Hungary

  • Policlinico Universitario Agostino Gemelli ( Site 1505)

    Roma, 00168, Italy

  • Providence Regional Cancer Partnership ( Site 0106)

    Everett, Washington, 98201, United States

  • Rambam Health Care Campus-Oncology Division ( Site 1401)

    Haifa, 3109601, Israel

  • Reformatus Pulmonologiai Centrum ( Site 1304)

    Törökbálint, Pest County, 2045, Hungary

  • Republican Clinical Oncology Dispensary-Chemotherapy #1 ( Site 1814)

    Kazan', Tatarstan, Respublika, 420029, Russia

  • Royal Infirmary Aberdeen ( Site 2403)

    Aberdeen, Aberdeen City, AB25 2ZN, United Kingdom

  • Rutgers Cancer Institute of New Jersey ( Site 0123)

    New Brunswick, New Jersey, 08901, United States

  • S.C.Focus Lab Plus S.R.L ( Site 2804)

    Bucharest, 022548, Romania

  • SA Pohja-Eesti Regionaalhaigla ( Site 2201)

    Tallinn, Harju, 13419, Estonia

  • SA Tartu Ulikooli Kliinikum ( Site 2200)

    Tartu, Tartu, 50406, Estonia

  • Saint Francis Cancer Center ( Site 0087)

    Greenville, South Carolina, 29607, United States

  • Saint-Luc UCL ( Site 1005)

    Brussels, Bruxelles-Capitale, Region de, 1200, Belgium

  • Samsung Medical Center ( Site 3300)

    Seoul, 06351, South Korea

  • Second Xiangya Hospital of Central-South University ( Site 3128)

    Changsha, Hunan, 410011, China

  • Seoul National University Bundang Hospital ( Site 3301)

    Seongnam-si, Kyonggi-do, 13620, South Korea

  • Severance Hospital Yonsei University Health System ( Site 3304)

    Seoul, 03722, South Korea

  • Shanghai Chest Hospital ( Site 3107)

    Shanghai, Shanghai Municipality, 200030, China

  • Shanghai Pulmonary Hospital ( Site 3101)

    Shanghai, Shanghai Municipality, 200443, China

  • Shizuoka Cancer Center ( Site 4014)

    Nakatogari, Shizuoka, 411-8777, Japan

  • Showa Medical University Hospital ( Site 4002)

    Tokyo, 142-8666, Japan

  • Sotiria Regional Chest Diseases Hospital of Athens ( Site 1200)

    Athens, Attica, 115 27, Greece

  • Spitalul Municipal Ploiesti ( Site 2801)

    Ploieşti, Prahova, 100337, Romania

  • St. Vincent Healthcare Frontier Cancer Center ( Site 0056)

    Billings, Montana, 59102, United States

  • Steve Biko Academic Hospital ( Site 5000)

    Pretoria, Gauteng, 0002, South Africa

  • Sverdlovsk Regional Oncology Hospital ( Site 1807)

    Yekaterinburg, Sverdlovsk Oblast, 620036, Russia

  • Takarazuka City Hospital ( Site 4013)

    Takarazuka, Hyōgo, 665-0827, Japan

  • Taunton and Somerset Hospital ( Site 2404)

    Taunton, England, TA1 5DA, United Kingdom

  • Texas Oncology - Dallas (Presbyterian)_McIntyre ( Site 0098)

    Dallas, Texas, 75231, United States

  • Texas Oncology - Dallas (Sammons) ( Site 0093)

    Dallas, Texas, 75246, United States

  • The 1st Affil Hosp of College of Medicine, Zhejiang Univ ( Site 3131)

    Hangzhou, Zhejiang, 310003, China

  • The Catholic University of Korea St. Vincent s Hospital ( Site 3303)

    Suwon, Kyonggi-do, 16247, South Korea

  • The Christie NHS Foundation Trust ( Site 2405)

    Manchester, M20 4GJ, United Kingdom

  • The First Affiliated Hospital of Xiamen University ( Site 3121)

    Xiamen, Fujian, 361003, China

  • The First Hospital of Jilin University ( Site 3132)

    Changchun, Jilin, 130021, China

  • The Second Affiliated Hospital of Nanchang University ( Site 3106)

    Nanchang, Jiangxi, 330006, China

  • The University of Tennessee Medical Center ( Site 0116)

    Knoxville, Tennessee, 37920, United States

  • Tianjin Medical University Cancer Institute & Hospital ( Site 3103)

    Tianjin, Tianjin Municipality, 300060, China

  • Tokyo Metropolitan Komagome Hospital ( Site 4011)

    Tokyo, 113-8677, Japan

  • Tongji Medical College Huazhong University of Science and Technology ( Site 3138)

    Wuhan, Hubei, 430030, China

  • UZ Leuven ( Site 1002)

    Leuven, Vlaams-Brabant, 3000, Belgium

  • Unidade Local de Saude de Santa Maria - Hospital Pulido Valente ( Site 1704)

    Lisbon, Lisbon District, 1769-001, Portugal

  • Union Hospital, Tongji Medical College of HUST ( Site 3123)

    Wuhan, Hubei, 430048, China

  • University General Hospital of Herakleion ( Site 1202)

    Heraklion, Irakleio, 711 10, Greece

  • University General Hospital of Larisa ( Site 1201)

    Larissa, Thessaly, 411 10, Greece

  • University of Chicago Medical Center ( Site 0136)

    Chicago, Illinois, 60637, United States

  • University of Kentucky Chandler Medical Center ( Site 0138)

    Lexington, Kentucky, 40536, United States

  • Uzsoki Utcai Korhaz ( Site 1303)

    Budapest, 1145, Hungary

  • VA Ann Arbor Healthcare System ( Site 0050)

    Ann Arbor, Michigan, 48105, United States

  • Virginia Mason Memorial- North Star Lodge Cancer Center ( Site 0112)

    Yakima, Washington, 98902, United States

  • West China Hospital of Sichuan University ( Site 3114)

    Chengdu, Sichuan, 510115, China

  • Western Health-Sunshine Hospital ( Site 3004)

    St Albans, Victoria, 3021, Australia

  • Xiangya Hospital of Central South University ( Site 3137)

    Changsha, Hunan, 410008, China

  • Zhejiang Cancer Hospital ( Site 3108)

    Hangzhou, Zhejiang, 310022, China