New drug combo aims to extend life in advanced lung cancer

NCT ID NCT05298423

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 3 trial tests whether a new drug combination (MK-7684A) plus chemoradiotherapy helps people with stage III non-small cell lung cancer live longer than the current standard treatment. About 611 participants will receive either the new combo or durvalumab. The study is active but no longer recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

MK-7684A (vibostolimab and pembrolizumab combination)

What this could lead to

If successful, this could offer a new treatment option that helps people with advanced lung cancer live longer without their cancer growing.

What could go wrong

This is an early-stage trial comparing against an existing treatment, so it may not show better results. Side effects from the drug combination could be serious.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • A. C. Camargo Cancer Center-CAPEC ( Site 0102)

    São Paulo, 01509-010, Brazil

  • Abraham Oncology ( Site 2303)

    Richards Bay, KwaZulu-Natal, 3900, South Africa

  • Actualidad Basada en la Investigación del Cáncer-Lung Cancer ( Site 1505)

    Guadalajara, Jalisco, 44680, Mexico

  • Affiliated Hospital of Jiangsu University ( Site 0305)

    Zhenjiang, Jiangsu, 212001, China

  • Ajou University Hospital-Hematology-Oncology ( Site 2402)

    Suwon, Kyonggi-do, 16499, South Korea

  • Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 0706)

    Athens, Attica, 115 28, Greece

  • Amethyst Radiotherapy Center ( Site 2102)

    Florești, Cluj, 407280, Romania

  • Ankara City Hospital-Medical Oncology ( Site 2601)

    Ankara, 06800, Turkey (Türkiye)

  • Ankara Gülhane Eitim ve Aratrma Hastanesi-Oncology ( Site 2602)

    Ankara, 06010, Turkey (Türkiye)

  • Arké SMO S.A. de C.V. ( Site 1504)

    Mexico City, Mexico City, 06700, Mexico

  • Army Medical Center of People's Liberation Army-Oncology Department ( Site 0321)

    Chongqing, Chongqing Municipality, 400042, China

  • Azienda Ospedaliera Spedali Civili di Brescia ( Site 1105)

    Brescia, 25123, Italy

  • Ballarat Health Services-Medical Oncology ( Site 0002)

    Ballarat Central, Victoria, 3350, Australia

  • Baskent University Dr. Turgut Noyan Research and Training Center-ONCOLOGY ( Site 2607)

    Adana, 01250, Turkey (Türkiye)

  • Beijing Cancer hospital-Oncology Radiotherapy Department ( Site 0309)

    Beijing, Beijing Municipality, 100142, China

  • Beijing Cancer hospital-intrathoratic deparmtment II ( Site 0328)

    Beijing, Beijing Municipality, 100142, China

  • Beijing Peking Union Medical College Hospital-pneumology department ( Site 0300)

    Beijing, Beijing Municipality, 100730, China

  • Biocenter ( Site 0208)

    Concepción, Biobio, 4070196, Chile

  • Boston Medical Center ( Site 2829)

    Boston, Massachusetts, 02118, United States

  • Bradfordhill ( Site 0200)

    Santiago, Region M. de Santiago, 8420383, Chile

  • CANCERCARE LANGENHOVEN DRIVE ONCOLOGY CENTRE ( Site 2304)

    Port Elizabeth, Eastern Cape, 6055, South Africa

  • CHUS - Hospital Clinico Universitario-Servicio de Oncologia ( Site 2502)

    Santiago de Compostela, La Coruna, 15706, Spain

  • CIMCA ( Site 0501)

    San José, Provincia de San José, 10103, Costa Rica

  • Cabinet Medical Oncomed ( Site 2101)

    Timișoara, Timiș County, 300239, Romania

  • Canberra Hospital ( Site 0010)

    Canberra, Australian Capital Territory, 2605, Australia

  • Cancer Institute Hospital of JFCR ( Site 1202)

    Koto, Tokyo, 135-8550, Japan

  • Cape Town Oncology Trials ( Site 2306)

    Cape Town, Western Cape, 7570, South Africa

  • Central Texas Veterans health care-Oncology & Hematology ( Site 2819)

    Temple, Texas, 76504, United States

  • Centro Medico Integral De Cancerología (CEMIC) ( Site 0805)

    Quetzaltenango, 09002, Guatemala

  • Centro Oncologico de Chihuahua-Unidad de Investigacion Clinica ( Site 1507)

    Chihuahua City, 31217, Mexico

  • Centro Regional de Sub Especialidades Médicas SA ( Site 0801)

    Quetzaltenango, 09001, Guatemala

  • Centro de Investigacion Clinica de Oaxaca ( Site 1501)

    Oaxaca City, 68020, Mexico

  • Centro de Oncología de Precisión ( Site 0209)

    Santiago, Region M. de Santiago, 7560908, Chile

  • Centrul Medical Medicover Victoria ( Site 2106)

    Bucharest, Bucharest, 010626, Romania

  • Centrul Medical Neolife- Baneasa ( Site 2110)

    Bucharest, 077190, Romania

  • Centrul de Oncologie "Sfântul Nectarie" ( Site 2100)

    Craiova, Dolj, 200542, Romania

  • Champalimaud Foundation ( Site 2003)

    Lisbon, Lisbon District, 1400-038, Portugal

  • Charité Campus Virchow-Klinikum-Department of Infectious Diseases and Pulmonary Medicine ( Site 0603)

    Berlin, 13353, Germany

  • Chungbuk National University Hospital-Internal medicine ( Site 2400)

    Cheongju-si, North Chungcheong, 28644, South Korea

  • Clinica Adventista Belgrano ( Site 3601)

    Caba., Buenos Aires F.D., C1430EGF, Argentina

  • Communal Noncommercial Enterprise "Podillia Regional Oncology Center Of Vinnytsia Regional Council" ( Site 2900)

    Vinnytsia, Vinnytsia Oblast, 21029, Ukraine

  • Cox Medical Center North-Cox Medical Center/Hulston Cancer Center/ Radiation Oncology ( Site 2837)

    Springfield, Missouri, 65807, United States

  • Ege University Medicine of Faculty-Chest Diseases Department ( Site 2603)

    Bornova, İzmir, 35100, Turkey (Türkiye)

  • Errikos Dunant Hospital Center-Second Department of Oncology and Clinical Trials Unit ( Site 0703)

    Athens, Attica, 115 26, Greece

  • European Interbalkan Medical Center ( Site 0701)

    Thessaloniki, 570 01, Greece

  • FALP-UIDO ( Site 0205)

    Santiago, Region M. de Santiago, 7500921, Chile

  • Fakultni nemocnice Ostrava-Klinika onkologicka ( Site 3502)

    Ostrava, Moravian-Silesian Region, 708 52, Czechia

  • Fondazione IRCCS Istituto Nazionale dei Tumori ( Site 1100)

    Milan, Lombardy, 20133, Italy

  • Fondazione IRCCS Policlinico San Matteo ( Site 1103)

    Pavia, 27100, Italy

  • Fourth Hospital of Hebei Medical University ( Site 0331)

    Shijiazhuang, Hebei, 050035, China

  • Franciscan St. Francis Health ( Site 2812)

    Indianapolis, Indiana, 46237, United States

  • Frankston Hospital-Oncology and Haematology ( Site 0009)

    Frankston, Victoria, 3199, Australia

  • Fudan University Shanghai Cancer Center ( Site 0304)

    Shanghai, Shanghai Municipality, 200032, China

  • Fujian Medical University Union Hospital-1 Bingfanglou ( Site 0330)

    Fuzhou Fujian, Fujian, 350001, China

  • Fujian Provincial Cancer Hospital ( Site 0316)

    Fuzhou, Fujian, 350014, China

  • General Oncology Hospital of Kifissia "Agioi Anargiroi"-2nd Department of Medical Oncology ( Site 0705)

    Nea Kifissia, Attica, 136 77, Greece

  • HOSPITAL CLÍNIC DE BARCELONA-ICHMO- Clinic Institut of Haematological and Oncological diseases ( Site 2503)

    Barcelona, Catalonia, 08036, Spain

  • HOSPITAL UNIVERSITARIO QUIRONSALUD MADRID-ONCOLOGIA MEDICA ( Site 2504)

    Pozuelo de Alarcón, Madrid, Comunidad de, 28223, Spain

  • Hacettepe Universitesi-oncology hospital ( Site 2605)

    Ankara, 06230, Turkey (Türkiye)

  • Hangzhou Cancer Hospital-Medical Oncology ( Site 0302)

    Hangzhou, Zhejiang, 310002, China

  • Henan Cancer Hospital ( Site 0333)

    Zhengzhou, Henan, 450008, China

  • Hospital CUF Descobertas ( Site 2006)

    Lisbon, Lisbon District, 1998-018, Portugal

  • Hospital Kuala Lumpur-Radiotherapy and Oncology ( Site 1401)

    Kuala Lumpur, 50586, Malaysia

  • Hospital Metropolitano - Sede Lindora ( Site 0503)

    Santa Ana, Provincia de San José, 10903, Costa Rica

  • Hospital Nossa Senhora da Conceição ( Site 0111)

    Porto Alegre, Rio Grande do Sul, 91350-200, Brazil

  • Hospital Pulau Pinang ( Site 1400)

    George Town, Pulau Pinang, 10450, Malaysia

  • Hospital Universitari Vall d'Hebron ( Site 2501)

    Barcelona, Catalonia, 08035, Spain

  • Hubei Cancer Hospital ( Site 0311)

    Wuhan, Hubei, 430079, China

  • Hunan Cancer Hospital ( Site 0307)

    Changsha, Hunan, 410013, China

  • I.E.U. Medical Point Hastanesi-Oncology ( Site 2612)

    Izmir, 35575, Turkey (Türkiye)

  • Icahn School of Medicine at Mount Sinai ( Site 2821)

    New York, New York, 10029, United States

  • Icon Cancer Centre Hobart ( Site 0003)

    Hobart, Tasmania, 7000, Australia

  • Instituto Médico Río Cuarto ( Site 3600)

    Río Cuarto, Córdoba Province, X5800, Argentina

  • Instituto Português de Oncologia do Porto Francisco Gentil, EPE ( Site 2001)

    Porto, 4200-072, Portugal

  • Instituto de Educação, Pesquisa e Gestão em Saúde ( Site 0105)

    Rio de Janeiro, 22793-080, Brazil

  • Instituto de Oncologia ( Site 3003)

    Santo Domingo, Nacional, 10102, Dominican Republic

  • Istituto Nazionale Tumori IRCCS Fondazione Pascale-Oncologia medica Toraco-Polmonare ( Site 1107)

    Naples, Campania, 80131, Italy

  • James Lind Centro de Investigacion del Cancer ( Site 0202)

    Temuco, Araucania, 4800827, Chile

  • Jilin Cancer Hospital-oncology department ( Site 0319)

    Changchun, Jilin, 130012, China

  • Kaiser Permanente Northwest-Central Interstate--Oncology ( Site 2816)

    Portland, Oregon, 97227, United States

  • Kanagawa Cancer Center ( Site 1204)

    Yokohama, Kanagawa, 241-8515, Japan

  • Kansai Medical University Hospital ( Site 1207)

    Hirakata, Osaka, 573-1191, Japan

  • Klinikum Chemnitz-Klinik für Innere Medizin IV ( Site 0607)

    Chemnitz, Saxony, 09116, Germany

  • Kobe Minimally Invasive Cancer Center ( Site 1210)

    Kobe, Hyōgo, 650-0046, Japan

  • Kurume University Hospital ( Site 1212)

    Kurume, Fukuoka, 830-0011, Japan

  • Lancaster General Hospital - Ann B Barshinger Cancer Institute ( Site 2827)

    Lancaster, Pennsylvania, 17601, United States

  • Limited Liability Company Ukrainian Center of Tomotherapy-Department of Chemotherapy ( Site 2905)

    Kropyvnytskyi, Kirovohrad Oblast, 25011, Ukraine

  • LungenClinic Grosshansdorf-Onkologie ( Site 0602)

    Großhansdorf, Schleswig-Holstein, 22927, Germany

  • MEDI-K ( Site 0807)

    Guatemala City, 01009, Guatemala

  • MFSMC-HJWCI ( Site 2804)

    Baltimore, Maryland, 21237, United States

  • Masarykuv onkologicky ustav ( Site 3500)

    Brno, Brno-mesto, 656 53, Czechia

  • Medipol Mega Universite Hastanesi-oncology ( Site 2611)

    Stanbul, Istanbul, 34214, Turkey (Türkiye)

  • Memorial Ankara Hastanesi-Medical Oncology ( Site 2609)

    Ankara, 06520, Turkey (Türkiye)

  • Metropolitan Hospital ( Site 0702)

    Athens, Attica, 185 47, Greece

  • Mid Florida Hematology and Oncology Center ( Site 2800)

    Orange City, Florida, 32763, United States

  • Millennium Oncology Research Clinic ( Site 2801)

    Hollywood, Florida, 33024, United States

  • Millennium Research & Clinical Development ( Site 2811)

    Houston, Texas, 77090, United States

  • Miyagi Cancer Center ( Site 1200)

    Natori-shi, Miyagi, 981-1293, Japan

  • Moffitt Cancer Center ( Site 2818)

    Tampa, Florida, 33612, United States

  • MultiCare Health System ( Site 2817)

    Tacoma, Washington, 98405, United States

  • Municipal non-profit enterprise "Lviv Territorial Medical Union "Multidisciplinary Clinical Hospital ( Site 2920)

    Lviv, Lviv Oblast, 79059, Ukraine

  • National Hospital Organization Shikoku Cancer Center ( Site 1211)

    Matsuyama, Ehime, 791-0280, Japan

  • Niigata Cancer Center Hospital ( Site 1205)

    Niigata, Niigata, 951-8566, Japan

  • ONCOCENTRO APYS-ACEREY ( Site 0203)

    Viña del Mar, Valparaiso, 2520598, Chile

  • Onconet ( Site 3002)

    Distrito Nacional, Santo Domingo Province, 10148, Dominican Republic

  • Osaka International Cancer Institute ( Site 1209)

    Osaka, 541-8567, Japan

  • Osaka Medical and Pharmaceutical University Hospital ( Site 1208)

    Takatsuki, Osaka, 569-8686, Japan

  • Ospedale San Gerardo-ASST Monza-Oncologia ( Site 1102)

    Monza, Lombardy, 20900, Italy

  • Ospedale San Raffaele. ( Site 1104)

    Milan, 20132, Italy

  • PROCLINICAL Pharma ( Site 0504)

    San José, Provincia de San José, 11303, Costa Rica

  • Policlinico Universitario Campus Bio-Medico-Radiation Oncology ( Site 1101)

    Rome, Lazio, 00128, Italy

  • Private Practice- Dr. Rixci Augusto Lenin Ramírez ( Site 0802)

    Guatemala City, 01010, Guatemala

  • Qingdao Central Hospital-Endocrinology ( Site 0332)

    Qingdao, Shandong, 266042, China

  • Rabin Medical Center ( Site 1004)

    Petah Tikva, 4941492, Israel

  • Radiology Therapeutic Center ( Site 2108)

    Otopeni, Ilfov, 075100, Romania

  • Rambam Health Care Campus-Oncology ( Site 1001)

    Haifa, 3109601, Israel

  • Rivne Regional Clinical Hospital ( Site 2919)

    Rivne, Rivne Oblast, 33007, Ukraine

  • Rutgers Cancer Institute of New Jersey ( Site 2805)

    New Brunswick, New Jersey, 08901, United States

  • Saitama Prefectural Cancer Center ( Site 1201)

    Ina-machi, Saitama, 362-0806, Japan

  • Sanatorio Parque ( Site 3602)

    Rosario, Santa Fe Province, S2000DSV, Argentina

  • Sendai Kousei Hospital ( Site 1213)

    Sendai, Miyagi, 981-0914, Japan

  • Severance Hospital, Yonsei University Health System-Lung Cancer Center ( Site 2403)

    Seoul, 03722, South Korea

  • Shaare Zedek Medical Center ( Site 1003)

    Jerusalem, 9103102, Israel

  • Shandong Provincial Hospital ( Site 0326)

    Jinan, Shandong, 250001, China

  • Shanghai Chest Hospital-Radiotherapy Department ( Site 0306)

    Shanghai, Shanghai Municipality, 200030, China

  • Shanghai Pulmonary Hospital-Radiotherapy department ( Site 0335)

    Shanghai, Shanghai Municipality, 200433, China

  • Shanxi Cancer Hospital-Pulmonology ( Site 0322)

    Taiyuan, Shanxi, 030000, China

  • Sheba Medical Center-ONCOLOGY ( Site 1000)

    Ramat Gan, 5265601, Israel

  • Showa Medical University Hospital ( Site 1203)

    Shinagawa, Tokyo, 142-8666, Japan

  • Sotiria Thoracic Diseases Hospital of Athens ( Site 0704)

    Athens, Attica, 11527, Greece

  • Sourasky Medical Center ( Site 1002)

    Tel Aviv, 6423906, Israel

  • Southern Medical University Nanfang Hospital-Department of Oncology ( Site 0336)

    Guangzhou, Guangdong, 510515, China

  • St Vincent's Hospital-Oncology Clinical Trials ( Site 0005)

    Melbourne, Victoria, 3065, Australia

  • TC Saglik Bakanligi Goztepe Prof. Dr. Suleyman Yalcin Sehir Hastanesi-oncology ( Site 2610)

    Istanbul, 34722, Turkey (Türkiye)

  • THE MEDICAL CITY-Cancer Research Center ( Site 3200)

    Pasig, National Capital Region, 1605, Philippines

  • The Catholic University Of Korea St. Vincent's Hospital-Medical Oncology ( Site 2401)

    Suwon, Kyonggi-do, 16247, South Korea

  • The First Affiliated hospital of Xiamen University-oncology ( Site 0317)

    Xiamen, Fujian, 361003, China

  • The Oncology Centre ( Site 2300)

    Durban, KwaZulu-Natal, 4091, South Africa

  • The Second Affiliated Hospital of Soochow University ( Site 0314)

    Suzhou, Jiangsu, 215004, China

  • The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0301)

    Hangzhou, Zhejiang, 310009, China

  • Thomas Jefferson University - Clinical Research Institute ( Site 2813)

    Philadelphia, Pennsylvania, 19107, United States

  • Tianjin Cancer Hospital ( Site 0329)

    Tianjin, Tianjin Municipality, 300060, China

  • Unidade Local de Saude de Santo António - Hospital Santo António ( Site 2004)

    Porto, 4099-001, Portugal

  • Union Hospital Tongji Medical College Huazhong University of Science and Technology ( Site 0315)

    Wuhan, Hubei, 430000, China

  • Universal Clinic Oberig-Oncology Center ( Site 2916)

    Kyiv, 03057, Ukraine

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel-Medizinische Klinik II, Hämatologie und Onkolo ( Site 0609)

    Kiel, Schleswig-Holstein, 24105, Germany

  • University General Hospital of Heraklion-Internal Medicine-Oncology ( Site 0700)

    Heraklion, Irakleio, 715 00, Greece

  • University Malaya Medical Centre-Clinical Oncology ( Site 1402)

    Lembah Pantai, Kuala Lumpur, 59100, Malaysia

  • University of Chicago Medical Center ( Site 2828)

    Chicago, Illinois, 60637, United States

  • University of Massachusetts Chan Medical School ( Site 2815)

    Worcester, Massachusetts, 01655, United States

  • University of Missouri Hospital ( Site 2839)

    Columbia, Missouri, 65212, United States

  • VA Long Beach Healthcare System ( Site 2831)

    Long Beach, California, 90822, United States

  • VA West Los Angeles Medical Center ( Site 2808)

    Los Angeles, California, 90073, United States

  • Veterans Memorial Medical Center-Section of Oncology ( Site 3201)

    Quezon City, National Capital Region, 1100, Philippines

  • Volyn Regional clinical hospital. Regional Medical Oncology Centre. Oncology chemotherapy department ( Site 2918)

    Lutsk, Volyn Oblast, 43018, Ukraine

  • West China Hospital of Sichuan University ( Site 0324)

    Chengdu, Sichuan, 610041, China

  • White Plains Hospital ( Site 2835)

    White Plains, New York, 10601, United States

  • Wilgers Oncology Centre ( Site 2301)

    Pretoria, Gauteng, 0040, South Africa

  • Xiangya Hospital Central South University-Oncology department ( Site 0310)

    Changsha, Hunan, 410008, China

  • Zhejiang Cancer Hospital ( Site 0308)

    Hangzhou, Zhejiang, 310022, China