Lung cancer umbrella study aims to match treatments to tumor type

NCT ID NCT04165798

Recruiting now Knowledge-focused Sponsor: Merck Sharp & Dohme LLC Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 31, 2026 · Updated 3 times

Summary

This large study is testing many different drug combinations, including the immunotherapy pembrolizumab, in people with advanced non-small cell lung cancer. The goal is to see which treatments work best based on specific tumor features like PD-L1 levels and histology. Over 1,000 participants will be enrolled, and the study is currently recruiting.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: pembrolizumab (immunotherapy) plus various investigational drugs and chemotherapy
What this could lead to: If successful, this study could help identify which drug combinations work best for different types of advanced lung cancer, potentially leading to more personalized treatment plans.
What could go wrong: This is an early-phase umbrella study testing many combinations at once, so most may not prove effective. Results are exploratory and not a guarantee of new treatments.

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Conditions

The condition(s) this trial relates to.

autosomal dominant Parkinson disease 4 non-small cell lung carcinoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CARCINOMA, NON-SMALL-CELL LUNG

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

Abramson Cancer Center of the University of Pennsylvania ( Site 0010)
RECRUITING

Philadelphia, Pennsylvania, 19104, United States
Azienda Ospedaliera Universitaria Careggi ( Site 0173)
COMPLETED

Florence, Firenze, 50134, Italy
Banner MD Anderson Cancer Center ( Site 0001)
COMPLETED

Gilbert, Arizona, 85234, United States
COMMUNAL NONPROFIT ENTERPRISE CLINICAL CENTER OF ONCOLOGY, HEMATOLOGY, TRANSPLANTOLOGY AND PALLIATI ( Site 0463)
RECRUITING

Cherkasy, Cherkasy Oblast, 18009, Ukraine
Chaim Sheba Medical Center ( Site 0070)
RECRUITING

Ramat Gan, 5262000, Israel
Chang Gung Medical Foundation-Linkou Branch ( Site 0182)
RECRUITING

Taoyuan, 33305, Taiwan
Changhua Christian Hospital ( Site 0181)
RECRUITING

Changhua, 50006, Taiwan
City of Hope ( Site 0014)
COMPLETED

Duarte, California, 91010, United States
Cleveland Clinic Main ( Site 0006)
COMPLETED

Cleveland, Ohio, 44195, United States
Communal Non-Commercial Enterprise "Prykarpatski Clinical Oncological Center" of Ivano-Frankivsk Reg ( Site 0460)
RECRUITING

Ivano-Frankivsk, Ivano-Frankivsk Oblast, 76018, Ukraine
Dana Farber Cancer Institute ( Site 0002)
COMPLETED

Boston, Massachusetts, 02215, United States
Dartmouth Hitchcock Medical Center ( Site 0016)
RECRUITING

Lebanon, New Hampshire, 03766, United States
Georgetown University ( Site 0036)
COMPLETED

Washington D.C., District of Columbia, 20007, United States
Hospital Clinic de Barcelona ( Site 0092)
RECRUITING

Barcelona, 08008, Spain
Hospital Universitario Quiron Madrid ( Site 0091)
COMPLETED

Madrid, 28223, Spain
ICO L Hospitalet ( Site 0090)
COMPLETED

L'Hospitalet de Llobregat, Barcelona, 08907, Spain
IRCCS Ospedale San Raffaele ( Site 0171)
COMPLETED

Milan, 20132, Italy
John Theurer Cancer Center at Hackensack University Medical Center ( Site 0037)
COMPLETED

Hackensack, New Jersey, 07601, United States
Jász-Nagykun-Szolnok Vármegyei Hetényi Géza Kórház ( Site 0061)
COMPLETED

Szolnok, Jász-Nagykun-Szolnok, 5004, Hungary
Laura and Isaac Perlmutter Cancer Center at NYU Langone Health ( Site 0034)
COMPLETED

New York, New York, 10016, United States
ME RIVNE REGIONAL ANTITUMOR CENTER ( Site 0461)
RECRUITING

Rivne, Rivne Oblast, 33010, Ukraine
Massachusetts General Hospital ( Site 0003)
COMPLETED

Boston, Massachusetts, 02114, United States
MedStar Franklin Square Medical Center ( Site 0033)
COMPLETED

Baltimore, Maryland, 21237, United States
Meir Medical Center ( Site 0071)
COMPLETED

Kfar Saba, 4428132, Israel
Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - P-Klinika Nowotworow Pluca i Klatki Pier ( Site 0151)
COMPLETED

Warsaw, Masovian Voivodeship, 02-781, Poland
Ohio State University Comprehensive Cancer Center ( Site 0015)
RECRUITING

Columbus, Ohio, 43210, United States
Oncology Hematology West, PC DBA Nebraska Cancer Specialists ( Site 0031)
COMPLETED

Omaha, Nebraska, 68130, United States
Orszagos Koranyi Pulmonologiai Intezet ( Site 0060)
COMPLETED

Budapest, 1121, Hungary
Petz Aladar Megyei Oktato Korhaz ( Site 0062)
COMPLETED

Győr, Győr-Moson-Sopron, 9024, Hungary
Policlinico Gemelli di Roma ( Site 0174)
COMPLETED

Roma, 00168, Italy
Rabin Medical Center ( Site 0074)
COMPLETED

Petah Tikva, 4941492, Israel
Rambam Health Care Campus-Oncology ( Site 0076)
COMPLETED

Haifa, 3109601, Israel
Samsung Medical Center ( Site 0082)
COMPLETED

Seoul, 06351, South Korea
Sanford Cancer Center ( Site 0038)
RECRUITING

Sioux Falls, South Dakota, 57104, United States
Sanford Fargo Medical Center ( Site 0039)
RECRUITING

Fargo, North Dakota, 58102, United States
Seoul National University Bundang Hospital ( Site 0081)
COMPLETED

Seongnam-si, Kyonggi-do, 13620, South Korea
Severance Hospital ( Site 0080)
COMPLETED

Seoul, 03722, South Korea
Shaare Zedek Medical Center ( Site 0075)
RECRUITING

Jerusalem, 9103102, Israel
Soroka Medical Center ( Site 0072)
COMPLETED

Beersheba, 8457108, Israel
Sourasky Medical Center ( Site 0077)
COMPLETED

Tel Aviv, 6423906, Israel
Szpital Wojewódzki im. Mikoaja Kopernika w Koszalinie-Oddzial Dzienny Chemioterapii ( Site 0152)
ACTIVE_NOT_RECRUITING

Koszalin, West Pomeranian Voivodeship, 75-581, Poland
Taipei Medical University Hospital ( Site 0180)
RECRUITING

Taipei, 110301, Taiwan
The University of Texas MD Anderson Cancer Center ( Site 0009)
RECRUITING

Houston, Texas, 77030, United States
UCSF Medical Center at Mission Bay ( Site 0007)
COMPLETED

San Francisco, California, 94158, United States
University of Kentucky Markey Cancer Center ( Site 0019)
COMPLETED

Lexington, Kentucky, 40536-0293, United States
Uniwersyteckie Centrum Kliniczne-Early Clinical Trials Unit ( Site 0150)
COMPLETED

Gdansk, Pomeranian Voivodeship, 80-952, Poland
Uzhhorod Multispecialty City Clinical Hospital ( Site 0462)
RECRUITING

Uzhhorod, Zakarpattia Oblast, 88017, Ukraine

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