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Scientists hunt for Parkinson's clues in newly found brain network

NCT ID NCT07024875

Knowledge-focused Sponsor: Washington University School of Medicine Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study uses advanced MRI scans to look at a newly discovered brain network, called SCAN, in people with Parkinson's disease and healthy volunteers. Researchers want to see if this network is linked to the movement problems in Parkinson's. The goal is to find a specific brain circuit that could be targeted by future treatments like deep brain stimulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could identify a specific brain circuit as a target for future treatments like deep brain stimulation for Parkinson's disease.
What could go wrong
This is an early-stage observational study, not a treatment trial. It may not lead directly to new therapies, and results may not apply to all Parkinson's patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

About 120 people

The number the study aims to enrol. It can still change while the study runs.

Started

Aug 2025

Expected to finish

Jan 2031

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

1. Parkinson's Disease (PD) Patients * 70 non-demented individuals with clinically definite PD * Must be 40 years of age or older * Both male \& female * Must not meet dementia criteria 2. Age-matched Healthy Controls * 50 individuals with normal neurological exams and cognition * No first-degree relatives with PD * Also, must be 40 years of age or older

Ages

40 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Must meet specific health and cognitive criteria depending on the group. For PD participants * Clinical diagnosis of Parkinson's Disease * Must not meet dementia criteria For Healthy Control Participants * Normal or benign neurological exam * Normal cognition * No first-degree relatives with Parkinson's Disease Exclusion Criteria: 1. Neurological Disorders (other than PD) \- Any other neurological condition 2. Significant Head Injury * Head injury with loss of consciousness \>5 minutes * Or any neurological sequelae 3. Psychiatric Disorders * Schizophrenia * Bipolar Disorder * Epilepsy 4. Serious Medical Conditions * End-stage organ failure * Ongoing cancer treatment 5. Cognitive Impairment * Diagnosis of dementia * MMSE score \<24 or MoCA score \<21 6. MRI contraindications * Metal implants * claustrophobia * Weight over 300 lbs (due to weight restrictions of the MRI scanner)

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Parkinsons disease (PD)

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • East Imaging Building

    RECRUITING

    St Louis, Missouri, 63110, United States

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