New PET tracer aims to light up tau tangles in the brain
NCT ID NCT06932809
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This early-phase study tests a new radioactive tracer called 18F-JSS20-183A to see if it can safely and accurately detect abnormal tau protein in the brain during PET scans. Researchers will study 90 adults aged 40-85 with tauopathies (like PSP, Alzheimer's, or Parkinson's) and healthy volunteers. The goal is to improve diagnosis of these brain diseases by measuring where the tracer goes and how long it stays.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
18F-JSS20-183A (a radioactive tracer for PET scans)
What this could lead to
If successful, this could lead to a more accurate way to diagnose tau-related brain diseases like PSP and Alzheimer's using a simple PET scan.
What could go wrong
This is a very early, small study focused on safety and imaging, not treatment. The tracer may not clearly distinguish between diseases or may have unexpected side effects.
Disclaimer
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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University of California
RECRUITINGSan Francisco, California, 94143, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Email: •••••@•••••
Contact