New imaging tool could spot Parkinson's years before symptoms worsen

NCT ID NCT07265596

Recruiting now Knowledge-focused Sponsor: Michael J. Fox Foundation for Parkinson's Research Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study is testing whether a special PET scan using a tracer called [18F] AV-133 can track changes in the brain of people with early, or 'prodromal,' Parkinson's disease. About 100 participants will be scanned at the start, after 12 months, and after 24 months. The goal is to see if this imaging method can measure disease progression and predict when motor symptoms will appear.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: [18F] AV-133 (a radioactive tracer for PET imaging)
What this could lead to: If successful, this could lead to better ways to detect Parkinson's disease early and track its progression, helping future treatment trials.
What could go wrong: This is a small, early-phase imaging study, not a treatment trial. The tracer may not reliably predict clinical decline, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PRODROMAL PARKINSONS DISEASE

Contacts and locations

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Locations

Institute for Neurodegenerative Disorders
RECRUITING

New Haven, Connecticut, 06510, United States
Newcastle University
RECRUITING

Newcastle upon Tyne, Tyne and Wear, NE45PL, United Kingdom
Philipps-University of Marburg
NOT_YET_RECRUITING

Hessen, 35043, Germany
Queen Mary University of London
RECRUITING

London, Britain, EC1M 6BQ, United Kingdom
Radboud University
NOT_YET_RECRUITING

Nijmegen, Gelderland, 6525 GC, Netherlands

Contact Email: •••••@•••••
Tel Aviv Sourasky Medical Center
NOT_YET_RECRUITING

Tel Aviv, 64239, Israel
Toronto Western Hospital
NOT_YET_RECRUITING

Toronto, Ontario, M5T2S8, Canada
University of Pennsylvania
RECRUITING

Philadelphia, Pennsylvania, 19107, United States

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