New imaging tool could spot Parkinson's years before symptoms worsen
NCT ID NCT07265596
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study is testing whether a special PET scan using a tracer called [18F] AV-133 can track changes in the brain of people with early, or 'prodromal,' Parkinson's disease. About 100 participants will be scanned at the start, after 12 months, and after 24 months. The goal is to see if this imaging method can measure disease progression and predict when motor symptoms will appear.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
[18F] AV-133 (a radioactive tracer for PET imaging)
What this could lead to
If successful, this could lead to better ways to detect Parkinson's disease early and track its progression, helping future treatment trials.
What could go wrong
This is a small, early-phase imaging study, not a treatment trial. The tracer may not reliably predict clinical decline, and results may not apply to all patients.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institute for Neurodegenerative Disorders
RECRUITINGNew Haven, Connecticut, 06510, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Newcastle University
RECRUITINGNewcastle upon Tyne, Tyne and Wear, NE45PL, United Kingdom
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Philipps-University of Marburg
NOT_YET_RECRUITINGHessen, 35043, Germany
Contact Email: •••••@•••••
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Queen Mary University of London
RECRUITINGLondon, Britain, EC1M 6BQ, United Kingdom
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Radboud University
NOT_YET_RECRUITINGNijmegen, Gelderland, 6525 GC, Netherlands
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Contact Email: •••••@•••••
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Tel Aviv Sourasky Medical Center
NOT_YET_RECRUITINGTel Aviv, 64239, Israel
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Toronto Western Hospital
NOT_YET_RECRUITINGToronto, Ontario, M5T2S8, Canada
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Contact Phone: •••-•••-••••
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University of Pennsylvania
RECRUITINGPhiladelphia, Pennsylvania, 19107, United States
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Contact Phone: •••-•••-••••