New PET tracer aims to spot Parkinson's protein in the brain
NCT ID NCT06891703
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This early-phase study tests a new radioactive tracer called [18F]ACI-15916, designed to detect clumps of α-synuclein protein in the brain using PET scans. These protein deposits are linked to Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. The trial will include 46 people—both healthy volunteers and those with suspected α-synuclein-related conditions—to check if the tracer is safe and can reliably show differences in protein buildup between groups.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- [18F]ACI-15916 (a radioactive imaging agent)
- What this could lead to
- If successful, this could lead to a reliable brain scan to diagnose diseases like Parkinson's and Lewy body dementia earlier and more accurately.
- What could go wrong
- This is a very early Phase 1 study with only 46 participants. The tracer may not bind well to α-synuclein or may cause side effects. Results may not apply to all patients.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Karolinska Institutet
RECRUITINGSolna, Sweden
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