PARKINSON'S DISEASE (PD)

This study is testing whether a 6-month program combining exercise, mindfulness, and healthy eating can improve brain health and potentially slow the progression of Parkinson's disease. It will involve 60 people aged 40-85 who have been diagnosed with Parkinson's or a related sle…

This study is testing whether a gentle, focused ultrasound beam can safely calm overactive brain areas in people with movement disorders like Parkinson's or essential tremor, and conditions like epilepsy or addiction. Researchers will measure changes in brain activity and symptom…

This study aims to check if a combination of two existing drugs, febuxostat and inosine, is safe for people with Parkinson's disease. It will involve 24 adults with early-stage Parkinson's who will take the pills twice daily for 12 weeks. The main goal is to see how the body hand…

This study is testing an investigational drug called TB006 in people with early-stage Parkinson's disease. The main goals are to see if TB006 is safe and if it can improve movement symptoms like tremors and stiffness. About 62 participants will be randomly assigned to receive eit…

This study aims to check the long-term safety of buntanetap, an experimental drug for Parkinson's disease, over three years. It will include 500 participants, some who have tried buntanetap before and others who use deep brain stimulation devices. The main goal is to monitor for …

This study aims to see how well an already-approved Parkinson's drug (ABBV-951) works over three years in real-world medical settings. It will follow 450 adults with advanced Parkinson's who are receiving the drug as part of their normal care. Researchers will track changes in da…

This study is testing a new method to program deep brain stimulation (DBS) devices for Parkinson's disease. It aims to use the brain's own electrical signals to find the best settings faster than the current manual process. Researchers will compare this new approach to the standa…

This study aims to improve how doctors program deep brain stimulation devices for people with Parkinson's disease. Researchers will compare patients' own ratings of how well their treatment is working with electrical signals recorded from their brain implants. The goal is to find…

This is the first human study testing a new oral medication called VT-5006 for Parkinson's disease. Researchers want to see if the drug is safe and how it moves through the body in both healthy volunteers and people with Parkinson's. The study involves taking single or multiple d…

This early-stage study is testing a new type of brain scan to see if it can safely and reliably detect clumps of a protein called alpha-synuclein in the brain. These protein clumps are involved in Parkinson's disease, Lewy body dementia, and multiple system atrophy. Researchers w…

This study is testing if a quick, non-invasive scan of the back of the eye (the retina) can help doctors diagnose Parkinson's disease in its early stages. Researchers will compare the eye scan's accuracy to a more complex and expensive brain scan currently used for diagnosis. The…

This study is testing if the drug atomoxetine can help reduce 'freezing of gait'—a sudden, temporary inability to move the feet—in people with Parkinson's disease. Researchers will compare atomoxetine to a placebo (inactive pill) in 60 participants to see if it decreases how ofte…

This small study is testing whether a special shoe that vibrates can help people with Parkinson's disease walk faster and more steadily. Sixteen participants will try walking with and without the shoe's vibration during short tests to see if it makes a difference. The goal is to …

This study is testing a new online group therapy program designed to help people with young-onset Parkinson's disease. The program uses Acceptance and Commitment Therapy (ACT) to help participants cope with the emotional and psychological challenges of living with the disease. Ov…

This study is testing whether magnetic stimulation applied to the spine, combined with brain stimulation, can improve walking and balance in people with Parkinson's disease. Researchers will compare whether stimulating the neck or the upper back is more effective. Participants wi…

This study aims to understand why Parkinson's disease affects leg muscle control and walking. Researchers will test if a brief, non-invasive stimulation of a nerve in the neck can improve muscle activity and balance. The study involves 75 participants, including people with Parki…

This study is testing a new type of brain scan to measure levels of a specific protein called Hsp90. Researchers will compare scans from healthy volunteers to those from people with Alzheimer's disease, Parkinson's disease, or ALS. The goal is to see if this scan can help underst…

This study aims to build a detailed picture of Parkinson's disease and a related condition called Multiple System Atrophy. Researchers will follow 700 patients in Shanghai over time, collecting health data, brain scans, and biological samples. The goal is to find better ways to s…

This study aims to see if recordings of the brain's electrical activity can help doctors choose the best settings for deep brain stimulation (DBS) devices in Parkinson's disease. Researchers will compare settings chosen using these brain signals to the settings doctors normally p…

This study aims to understand how different types of dementia develop and progress over time. Researchers are following over 1,500 people aged 50-90, including those with various dementia types and healthy individuals, across Canada. Participants undergo regular brain scans, memo…

This early research study is testing a new imaging drug called [18F]MK-0947 that helps doctors see protein buildup in the brains of people with Parkinson's disease. The study will enroll 22 participants, including people with Parkinson's and healthy volunteers, to check if the tr…

This study will examine how two important brain circuits - one involving the subthalamic nucleus (STN) and one involving the ventral intermediate nucleus of the thalamus (VIM) - contribute to learning and producing speech sequences. Participants will include two groups: 1. indivi…