PARKINSON'S DISEASE (PD)

This study is testing the long-term safety of a daily drug called buntanetap in 500 people with Parkinson's disease over 36 months. It includes two groups: those who have taken buntanetap before and those who have a deep brain stimulation device. The main goal is to see if the dr…

This early-stage study tests a new drug called MTX325 in healthy volunteers and people with mild to moderate Parkinson's disease. The main goals are to check safety, how the body processes the drug, and whether it reaches the brain. If successful, MTX325 might one day slow the pr…

This study tests whether a new drug called SUL-238 can improve energy production in brain cells of people with early, untreated Parkinson's disease. Forty-five participants will take either a low or high dose of SUL-238 or a placebo daily for 28 days. Researchers will use a speci…

This early-stage trial is testing whether an experimental oral drug called AX-5006 is safe and tolerable in healthy adults and people with Parkinson's disease. The study involves 84 participants across three parts: single doses in healthy volunteers, multiple daily doses in healt…

This early-stage study tests a new radioactive tracer called SST001 that lights up on PET scans. Researchers want to see if it is safe and can help tell the difference between multiple system atrophy (MSA) and Parkinson's disease. The study will include 30 healthy volunteers and …

This early-phase study tests a new imaging drug called [18F]MK-0947 that works with PET scans to show where a protein called α-synuclein builds up in the brain—a hallmark of Parkinson's disease. Researchers will check safety and how well the tracer works in 22 adults (some with P…

This study is testing a new, non-invasive eye scan to see if it can detect Parkinson's disease in its early stages. Researchers will compare the eye scan results with standard brain imaging in 200 participants, including people with early Parkinson's, related movement disorders, …

This early-phase study tests a new radioactive tracer called [18F]ACI-15916, designed to detect clumps of α-synuclein protein in the brain using PET scans. These protein deposits are linked to Parkinson's disease, multiple system atrophy, and dementia with Lewy bodies. The trial …

This study will test whether doing two physical tasks at the same time or combining a physical task with a thinking task can help people with Parkinson's disease move better, keep their balance, and do daily activities more easily. About 39 participants will do 45-minute exercise…

This study tests a new, non-invasive brain stimulation method called transcranial temporal interference stimulation (tTIS) for people with Parkinson's disease. The treatment targets a deep brain area involved in movement control. 32 participants will receive either real or sham s…

This study tests a handheld device that gives gentle directional cues (haptic feedback) to help people with Parkinson's disease perform arm movements more accurately. Twenty participants will use either the haptic device or a similar non-haptic version during home sessions over 8…

This study tests whether a four-week training program using a device called EMST can improve swallowing in people with Parkinson's disease who have trouble swallowing. Thirty participants will do breathing exercises five days a week. Researchers will use special cameras and press…

This study tests whether a wearable robotic exoskeleton can improve walking, balance, and mobility in healthy older adults and people with Parkinson's disease—both groups at high risk for falls. About 26 participants will attend two lab sessions to try the device while performing…

This study tests whether transcranial magnetic stimulation (TMS) timed to a person's own tremor cycle can reduce shaking in Essential Tremor and Parkinson's disease. Twenty participants with each condition will receive TMS pulses over the motor cortex while their tremor is record…

This study tests a non-invasive device that delivers mild electrical stimulation to the cerebellum, timed precisely to each patient's hand tremor rhythm. Ten people with Parkinson's and moderate-to-severe hand tremor will receive both real and sham stimulation to see if the real …

This study tests a new method to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals. Instead of the usual time-consuming manual adjustments, doctors will use these signals to pick the best stimulation settings. The goal is to imp…

This study tests if magnetic stimulation applied to the spine and brain can improve walking and balance in people with Parkinson's disease. Thirty participants will receive 10 sessions of either neck or upper-back stimulation combined with brain stimulation. The goal is to find t…

This small pilot study tests a smart shoe called NUSHU that provides gentle vibrations to see if it can help people with Parkinson's disease walk faster. Sixteen participants will complete two short walking tests—one with the vibration on and one without—to compare their speed, s…

This study tests whether atomoxetine, a medication that affects noradrenaline, can reduce freezing of gait in people with Parkinson's disease. About 60 participants will take either atomoxetine or a placebo and perform walking tests, MRI scans, and questionnaires. The goal is to …

This study tests whether a handheld device that gently stimulates the vagus nerve in the neck can improve leg muscle control, walking, and balance in people with Parkinson's disease. Researchers will compare real stimulation to a sham (fake) version in 75 participants. The goal i…

This study tests an 8-week online group therapy program for people diagnosed with Parkinson's disease before age 65. The therapy, called Acceptance and Commitment Therapy (ACT), helps participants cope with difficult thoughts and feelings related to their condition. Researchers w…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand why falls happen more…

This study looks at whether recording brain signals (called local field potentials) can help doctors pick the best deep brain stimulation (DBS) contacts for people with Parkinson's disease. About 40 participants will have these recordings done during routine care. The goal is to …

This study looks at how two brain areas—the subthalamic nucleus and the ventral intermediate nucleus of the thalamus—help us learn and produce speech. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 people with Parkinson's disease or essential tremo…

This study is following 700 people with Parkinson's disease or multiple system atrophy in Shanghai. Researchers will collect medical history, brain scans, blood samples, and other data every six months. The goal is to find early signs of these diseases and better predict how they…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse. Researchers will use brain recordings and movement tests to see if the ultra…

This study tests a new PET scan tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan 48 healthy volunteers and patients to see if…

This study follows 1,573 adults aged 50 to 90 across Canada, including people with different types of dementia and those with healthy memory. Researchers will use memory tests, brain scans, and blood samples to track how thinking and memory change over time. The goal is to better…

This study looks at whether combining patient ratings with brain signal recordings can make deep brain stimulation (DBS) programming faster and more personalized for people with Parkinson's disease. Researchers will measure brain activity from implanted electrodes and compare it …

This early-phase trial will test the safety of combining two drugs—febuxostat (used for gout) and inosine (a natural substance)—in 24 adults with early-stage Parkinson's disease. Participants will take one of four dose combinations twice daily for 12 weeks, with regular blood tes…