PARKINSON'S DISEASE (PD)

This study looks at the long-term safety of a drug called buntanetap in 500 people with Parkinson's disease. Participants include those who have taken buntanetap before and those with a deep brain stimulation device. The study lasts 36 months and tracks side effects to see if the…

This study looks at whether a 6-month program combining exercise, mindfulness, and nutrition can improve thinking, sleep, inflammation, and other health markers in people with Parkinson's disease. 60 adults aged 40 to 85 will take part. Everyone gets the program, but some start r…

This early-stage trial tests the safety of combining two oral drugs, febuxostat and inosine, in 24 adults with early Parkinson's disease. Participants take the medication twice daily for 12 weeks while researchers monitor blood changes and side effects. The study does not promise…

This early-phase study tests whether a new radioactive tracer called [18F]ACI-15916 can safely and reliably detect harmful alpha-synuclein protein clumps in the brain using PET scans. About 46 people—including healthy volunteers and those with suspected Parkinson's disease, multi…

This study explores whether a non-invasive eye scan can detect Parkinson's disease in its early stages. Researchers will compare the scan's accuracy to standard PET imaging in 200 participants, including people with early Parkinson's, related conditions, and healthy volunteers. I…

This early study tests a new imaging drug called [18F]MK-0947 that works with a PET scan to show clumps of a protein called alpha-synuclein in the brain, which are linked to Parkinson's disease. The goal is to see if the drug is safe and can help doctors better diagnose and track…

This study tests whether a new oral drug, AX-5006, is safe and tolerable in healthy adults and people with Parkinson's disease. It involves three parts: single doses, multiple doses over a week, and daily doses for 28 days. The goal is to gather safety data before larger trials.

This study tests a new way to program deep brain stimulation (DBS) for Parkinson's disease using the brain's own electrical signals. Instead of the usual slow, manual process, doctors will use local field potentials to pick the best stimulation settings. The goal is to improve mo…

This study is testing whether a wearable robotic exoskeleton can improve mobility, balance, and walking in healthy older adults and people with Parkinson's disease. About 26 participants will attend two lab sessions to try the device and perform tasks like walking and standing. T…

This study tests a new online group therapy program for people diagnosed with Parkinson's disease before age 65. The therapy, called Acceptance and Commitment Therapy (ACT), helps participants cope with difficult thoughts and feelings so they can focus on what matters most. Resea…

This small study tests a smart shoe called NUSHU that gives gentle vibrations to see if it can help people with Parkinson's disease walk faster. Sixteen participants will do two short walks, one with the vibration on and one without, to compare speed and safety. It's an early, lo…

This study tests whether atomoxetine, a medication that affects the brain chemical noradrenaline, can reduce freezing of gait in people with Parkinson's disease. Sixty participants will receive either atomoxetine or a placebo and will complete walking tests, MRI scans, and questi…

This study tests if magnetic stimulation on the neck or back, combined with brain stimulation, can improve walking and balance in people with Parkinson's disease. 30 participants will receive 10 treatment sessions. The goal is to find the best spot to stimulate to help with mobil…

This study looks at whether electrical signals from deep brain areas can guide doctors in selecting the best stimulation contacts for Parkinson's disease. About 40 people who are already scheduled for deep brain stimulation (DBS) will have their brain signals recorded during rout…

This study looks at how well people can control their hip muscles and whether that affects their balance and walking. Researchers will compare healthy young, middle-aged, and older adults, as well as people with Parkinson's disease. The goal is to understand which muscle factors …

This study looks at how two brain circuits involved in movement and speech work when people learn new sound sequences. Researchers will temporarily turn deep brain stimulation (DBS) on or off in 80 adults with Parkinson's disease or essential tremor while they perform speech task…

This study is testing whether low-intensity focused ultrasound (LIFUS) can safely change brain activity in people with conditions like Parkinson's disease, essential tremor, epilepsy, or substance abuse disorder. Researchers will measure brain responses and any changes in movemen…

This study follows 1,573 Canadians aged 50–90 with various types of dementia or normal memory to track how brain health changes over time. Participants complete memory tests, brain scans, and provide blood samples. The goal is to better understand different forms of dementia, not…

This study tests a new PET imaging tracer to measure levels of a protein called Hsp90 in the brain. Hsp90 helps proteins fold correctly, and problems with this process are linked to Alzheimer's, Parkinson's, and ALS. Researchers will scan healthy volunteers and patients to see if…

This study tests a new drug called SUL-238 in people with early, untreated Parkinson's disease. The goal is to see if the drug can improve how brain cells make energy, measured with a special MRI scan. 45 participants will take either SUL-238 or a placebo daily for 28 days, with …

This study is creating a detailed database of 600 people with Parkinson's disease and 100 with multiple system atrophy in Shanghai. Participants will provide medical history, undergo tests (like brain scans and memory assessments), and give blood samples. Researchers will track t…

This study aims to make deep brain stimulation (DBS) programming faster and more personalized for people with Parkinson's disease. Researchers will compare patients' own ratings of how well the stimulation works with electrical signals recorded from the brain. By finding the best…

This study looks at why people with Parkinson's disease have trouble activating their leg muscles. Researchers will test if stimulating a nerve in the neck (vagus nerve) can improve muscle activation, walking, and balance. The study involves 75 participants and aims to better und…