PARKINSON'S DISEASE (PD)

This study investigates whether upper extremity exercise training delivered via tele-rehabilitation (synchronous or asynchronous) can improve motor symptoms, hand dexterity, and daily living activities in people with Parkinson's disease. Participants will receive either remote or…

This phase 2 trial tests whether ENERGI-F705 tablets, taken twice daily alongside standard Parkinson's medications, can improve motor function and safety in people aged 40–75 with idiopathic Parkinson's disease. Participants are randomly assigned to receive a high dose, low dose,…

This early-stage study will test a new way of using deep brain stimulation (DBS) for Parkinson's disease. Instead of the usual constant high-frequency pulses, this 'Coordinated Reset' approach uses lower-power, patterned stimulation. Researchers want to see if it's safe and can i…

This early-stage study tests a single injection of special brain cells (NouvNeu001) in 10 people with moderate-to-advanced Parkinson's who have already had deep brain stimulation surgery. The main goal is to check safety, but researchers will also track movement and daily functio…

This early-phase trial tests a new gene therapy for Parkinson's disease. Six participants will receive a virus-based treatment injected into a specific brain area during surgery. Afterward, they take a drug to control abnormal brain activity and improve movement. The main goal is…

This Phase 2 trial tests whether terazosin, a drug already used for high blood pressure, can improve energy production in the brains of people with Parkinson's disease. Researchers will measure changes in a key energy molecule (ATP) in 120 participants over 1.5 years. If it works…

This study will screen 600 adults aged 55 and older in U.S. communities to find early signs of mild cognitive impairment (MCI). Participants will receive a combination of stem cell therapy, a wearable brain-computer interface device, and wellness coaching to see if these treatmen…

This early-stage trial tests a gene therapy called AAV2-hAADC in 9 adults with young-onset Parkinson's disease. The therapy delivers a gene directly to two brain regions (putamen and caudate) to help convert levodopa into dopamine more efficiently. The main goal is to check safet…

This phase 2 trial tests whether a single dose of psilocybin, the active ingredient in magic mushrooms, can improve depression in people with Parkinson's disease. Forty participants will receive a low to high dose with psychological support. The study measures changes in depressi…

This study tests whether a non-invasive device that gently stimulates a nerve on the forehead (external trigeminal nerve stimulation, or eTNS) can immediately improve walking and other movement problems in people with Parkinson's disease. Thirty participants will each try two dif…

This study tests an automated programming method for deep brain stimulation (DBS) in people with Parkinson's disease. Fifteen participants who recently had DBS surgery will try the new algorithm and perform motor tasks like walking and finger tapping. The goal is to see if the au…

This study will compare two types of physical therapy—strategy training (using mental cues and visual guides) and proprioceptive neuromuscular facilitation (a stretching and movement technique)—to see which one improves balance, walking, and daily independence in people with Park…

This study will test a robotic device called BackHug that delivers deep back massages to 30 adults with mild-to-moderate Parkinson's disease. The goal is to see if it improves walking, balance, back pain, and sleep quality. Participants will receive 40-minute sessions over a set …

This study tests whether an AI-powered smart electric vehicle can help people with Parkinson's disease or dementia improve their walking and reduce falls. The vehicle monitors gait, gives real-time feedback, and adapts to the user. Researchers will enroll 120 participants aged 50…

This study looks at how abnormal proteins, like alpha-synuclein and tau, build up and affect brain function in people with Parkinson's disease. Researchers will use brain scans, blood tests, and skin biopsies to track these changes. The goal is to find better ways to diagnose and…

This study looks at how doing mental tasks—like naming objects or remembering words—changes the way people with Parkinson's disease walk. Researchers will compare 30 people with Parkinson's to healthy adults of the same age and sex. The goal is to find out which type of thinking …

This study looks at gut changes in people with untreated Parkinson's disease compared to healthy adults. Researchers will measure gut permeability, microbiome, and transit time using stool samples, X-rays, and optional endoscopy. The goal is to better understand early gut involve…