PARKINSON'S DISEASE (PD)

This study aims to find better ways to catch early signs of memory loss in community settings and test if new treatments can slow it down. It will involve 600 adults aged 55 and older in the U.S. who have mild cognitive impairment. Researchers will compare standard care against w…

This study is testing whether a drug called Terazosin, already used for other conditions, can improve how brain cells produce energy in people with Parkinson's disease. Researchers will enroll 120 participants to see if taking the drug increases a key energy molecule in the blood…

This study is testing whether a new oral drug called SUL-238 can improve the energy function of brain cells in people with early, untreated Parkinson's disease. Researchers will compare two doses of SUL-238 against a placebo in 45 participants over a 28-day treatment period. The …

This study is testing a new automated computer program, called Illumina 3D, designed to help set up deep brain stimulation (DBS) devices for people with Parkinson's disease. It will involve 15 people who have just had a DBS implant. Researchers will compare how well participants …

This early-stage study is testing whether a gene therapy delivered directly to the brain is safe and might help people with young-onset Parkinson's disease. The therapy uses a modified virus to deliver a gene that helps brain cells produce more dopamine, the chemical that's low i…

This early-stage study is testing a new way to use deep brain stimulation (DBS) for Parkinson's disease. It will see if a gentler, patterned electrical signal is safe and can help control movement symptoms like slowness, stiffness, and tremor. The study will involve 24 people who…

This study is testing whether using an AI-powered smart electric vehicle for walking (gait) training is safe and helpful for people with Parkinson's disease or dementia. About 120 participants aged 50-85 will use the vehicle for training sessions 2-3 times per week for 2 to 12 we…

This study will compare two different physical therapy approaches to see which one better helps people with Parkinson's disease improve their balance, walking, and ability to do daily tasks independently. It will involve 42 participants who will be randomly assigned to receive ei…

This study is testing a new remote system designed to help people with Parkinson's disease do physical therapy exercises at home. The system uses handheld devices that provide gentle touch-like guidance to help improve arm movements. Researchers will see if this approach is easy …

This small pilot study is testing whether a robotic device called BackHug can help people with Parkinson's disease. The device gently massages the back and spine to try to reduce stiffness, improve movement, lessen pain, and help with sleep. Thirty adults with mild to moderate Pa…

This study aims to understand how specific proteins build up and spread in the brains of people with Parkinson's disease and related conditions. Researchers will examine 160 participants, including people with Parkinson's, people with a sleep disorder linked to Parkinson's, and h…

This study aims to understand how Parkinson's disease affects the gut before patients start any medication. Researchers will compare 100 people with untreated Parkinson's to healthy volunteers, looking at gut bacteria, intestinal function, and digestion speed. The findings won't …