Breast neoplasm

This pilot study tests a device that uses short, high-frequency electrical pulses to shrink or destroy soft tissue tumors in people with metastatic breast cancer. The trial will enroll 20 adults with tumors near the skin that are at least 1 cm but no larger than 5 cm. The main go…

This early-stage trial tests whether a stool transplant (FMT) can help cancer patients who develop severe diarrhea or colon inflammation from immune-checkpoint inhibitor drugs. About 40 patients with various cancers will receive the transplant via colonoscopy. The main goal is to…

This phase 3 trial is testing whether adding the targeted drug ribociclib to standard hormone therapy can help prevent invasive breast cancer from returning in people with HR+ HER2- early breast cancer. About 1,400 participants will receive the combination for up to 3 years. The …

This study tests a new drug, TER-2013, in people with advanced solid tumors (like breast, ovarian, or lung cancer) that have specific genetic changes in the AKT/PI3K/PTEN pathway. The goal is to see if the drug is safe and can shrink tumors. About 205 participants will receive th…

This study tests two experimental drugs, BNT323 and BNT327, together in people with advanced breast cancer that has spread or cannot be removed. The goal is to see if the combination can shrink tumors and control the disease. About 380 adults with various types of breast cancer (…

This phase 2 trial is testing an experimental drug called patritumab deruxtecan (HER3-DXd) in 740 people with advanced solid tumors, including melanoma, lung, breast, and other cancers. The drug is given by IV every three weeks. The main goal is to see if the drug shrinks tumors.…

This early-stage trial is testing a new drug called IM-1617 in people with advanced solid tumors (cancers that have spread or can't be removed by surgery). The study has two parts: first, finding a safe dose, then testing that dose in more people to see how well it works and how …

This phase 3 trial tests whether adding the experimental drug BNT327 to standard chemotherapy helps people with advanced triple-negative breast cancer (TNBC) live longer without their cancer growing. Participants have TNBC that cannot be treated with current PD(L)1 immunotherapie…

This study tests a technique called systematic margin shaving during breast-conserving surgery for breast cancer. The idea is to remove a thin extra layer of tissue around the tumor right after the main lump is taken out, based on a pathologist's check. Researchers want to see if…

This study is for women aged 51 or older whose breast cancer has returned or who have a new cancer in the same breast. The goal is to see if giving a focused, short course of radiation before surgery is safe and effective enough to allow breast-conserving treatment instead of mas…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study tests the immunotherapy drug atezolizumab in 200 people with advanced solid tumors (breast, lung, GI, and others). Researchers use each person's tumor DNA to see if it predicts a response. Participants get the same dose every 3 weeks. The goal is to see if DNA analysis…

This study looks at whether eating a Mediterranean diet (rich in vegetables, fruits, nuts, fish, and olive oil) can improve gut health, quality of life, and treatment outcomes for women with early breast cancer undergoing chemotherapy. About 105 participants will be randomly assi…

This study tests an experimental oral drug called zongertinib, which blocks HER2, a protein that fuels cancer growth. It is given alone or with other cancer drugs to adults with advanced HER2+ breast, stomach, or colorectal cancer that has spread and not responded to prior treatm…

This phase 2 trial tests whether specially selected immune cells taken from a patient's own tumor, grown in large numbers in the lab, and given back along with the drug pembrolizumab (Keytruda) can shrink tumors in people with metastatic colorectal, pancreatic, ovarian, breast, o…

This trial tests whether adding an experimental drug called culmerciclib to standard hormone therapy can shrink tumors more effectively in women with early-stage, hormone-receptor-positive, HER2-negative breast cancer. Participants receive either the combination or hormone therap…

This study tests a device called SAVI Scout MD, which uses tiny radar reflectors placed in the breast before surgery to help surgeons locate and remove tumors more precisely. The goal is to see if this method leads to complete tumor removal with clear margins, potentially reducin…

This Phase 3 trial tests whether elacestrant, a new hormone therapy, can prevent distant metastasis better than standard hormone therapies in 220 patients with ER+/HER2- breast cancer whose blood tests show signs of cancer DNA (ctDNA) but no visible spread. Participants are rando…

This study tests a new drug called elacestrant against standard hormone therapy in people with a certain type of early breast cancer (ER+/HER2-) that has spread to lymph nodes and has a high chance of returning. About 4,220 participants will be randomly assigned to receive either…

This study tests a new drug called rezatapopt (PC14586) in people with advanced solid tumors that have a specific TP53 Y220C mutation. The drug is designed to reactivate the p53 protein, which normally helps stop cancer growth. The trial will also test rezatapopt combined with th…

This early-phase trial tests SL-28, a cell therapy made from donor immune cells, in 60 people with advanced solid tumors (like lung, pancreatic, or breast cancer) that haven't responded to standard treatments. The study aims to find a safe dose and see if the therapy can shrink t…

This study compares a new experimental drug, BL-M07D1, to an approved therapy (DS-8201) in people with a common form of advanced breast cancer (HR-positive, HER2-low). The goal is to see if the new drug can delay cancer growth or improve survival. About 120 women aged 18 to 75 wi…

Researchers are testing whether adding stereotactic ablative radiotherapy (SABR) to standard systemic therapy helps people with oligometastatic breast cancer, meaning cancer that has spread to only a few sites. The trial enrolls adults with 1 to 5 metastases in up to two organs. …

This phase 2 trial tests whether adding cediranib or ceralasertib to olaparib can overcome resistance in BRCA-mutated advanced breast cancer. About 60 participants with HER2-negative, BRCA-positive tumors that have progressed on prior therapy will receive one of the two drug comb…

This early-phase trial is testing a new drug called BGB-21447, which blocks a protein that helps cancer cells survive. It is given together with standard hormone therapy (fulvestrant) and sometimes another targeted drug (BGB-43395). The study involves 120 adults with HR+/HER2- me…

This phase 3 trial is testing a daily pill called giredestrant in 300 people with ER+/HER2- early breast cancer who had to stop standard aromatase inhibitors due to side effects. The study will track how well patients stick with the treatment, their quality of life, and any side …

Inavolisib treats certain PIK3CA-mutated, HR-positive, HER2-negative breast cancers but can raise blood sugar. Researchers at Tianjin Medical University Cancer Institute and Hospital are studying whether matching blood sugar monitoring and preventive metformin to each patient's r…

This study tests a new drug called BMS-986507, alone or with other cancer medicines, in adults with advanced lung or breast cancer that has spread. The goal is to check safety, side effects, and how well the drugs work. About 416 participants will receive different combinations t…

This early-phase trial tests whether freezing a tumor (cryoablation) can boost the immune response to the drug pembrolizumab in people with metastatic or locally advanced triple negative breast cancer. About 30 participants will be randomly assigned to receive either the combinat…

This study follows 138 adults in Bulgaria and Slovenia with HER2-low advanced breast cancer who are taking trastuzumab deruxtecan (T-DXd), a targeted therapy. Researchers will track how long patients go before needing a different treatment or dying. The goal is to see how well T-…

This study compares two types of radiation therapy for women with early-stage breast cancer who have had a lumpectomy. One group receives radiation to the whole breast, the other only to the area where the cancer was removed. Both treatments are given once a day for about one wee…

This study tests a new drug called AZD8205, alone or with another drug (rilvegostomig), in people with advanced solid tumors like breast, ovarian, and lung cancers. The trial has two phases: first to find the safest dose, then to see if it shrinks tumors. About 460 adults whose c…

This early-phase study tests a new drug called BGB-43395 in people with advanced HR+/HER2- breast cancer and other solid tumors. The drug blocks a protein (CDK4) that helps cancer cells grow. Researchers want to find the safest and most effective dose, either alone or combined wi…

This study tests whether a new quarterly injection of letrozole delivers the same amount of medicine into the body as the standard daily pill. It involves 120 postmenopausal women who have already completed at least 4-5 years of hormone therapy for early breast cancer. The goal i…

This phase 3 trial is testing whether adding a targeted therapy called Sacituzumab tirumotecan (Sac-TMT) to standard chemotherapy and immunotherapy (pembrolizumab) can better eliminate cancer before surgery in people with high-risk, early-stage triple-negative or hormone-receptor…

This phase 2 trial is testing whether adding a targeted drug called patritumab deruxtecan to standard immunotherapy and chemotherapy can improve outcomes for people with high-risk early-stage triple-negative or hormone receptor-low positive breast cancer. About 372 participants w…

This Phase 1 trial tests a new drug called BL-M07D1 in 280 adults with advanced HER2-positive cancers, including breast, lung, and stomach cancers. The study aims to find safe doses and check for early signs of tumor shrinkage. Participants must have tried at least two prior trea…

This early-stage trial is testing an investigational drug called SI-B036, a bispecific antibody designed to target cancer cells in people with locally advanced or metastatic breast cancer and other solid tumors. The study aims to find the safest dose and understand how the drug b…

This study is testing many different drug combinations in people with metastatic breast cancer that has spread or cannot be removed by surgery. Researchers are looking at which combinations work best for different cancer types, such as triple-negative or hormone receptor-positive…

This trial is testing an oral drug called elacestrant in Japanese patients with a specific type of advanced breast cancer (ER+/HER2-) that has a mutation in the ESR1 gene and has progressed after prior endocrine therapy including a CDK4/6 inhibitor. The study aims to see if elace…

This early-stage trial tests a new drug called M7437 in people with advanced solid tumors that have not responded to standard treatments. M7437 is an antibody-drug conjugate designed to deliver chemotherapy directly to cancer cells that have a specific marker (Ly6E). The study ai…

This study tests a combination of two drugs, elacestrant and abemaciclib, in people with a specific type of breast cancer (ER-positive, HER2-negative) that has spread to the brain. The goal is to see if the combination can shrink or control brain tumors. The trial involves about …

This study is a safety check required by Korean health authorities after capivasertib was approved for breast cancer. Researchers will watch for side effects and see how well the drug works in everyday medical practice. About 130 patients in Korea who are already prescribed the d…

This Phase 1 trial is testing ZOLADEX (goserelin), a hormone-blocking implant, in 88 premenopausal women with HR+/HER2- advanced breast cancer. The goal is to see if it can temporarily shut down ovarian function, which may help control the cancer. Participants receive two injecti…

This early-stage study tests a new drug called BBO-10203 in people with advanced solid tumors (breast, lung, or colorectal cancer) that have not responded to standard treatments. The drug is designed to block two cancer-driving proteins (PI3K and RAS). Researchers will check safe…

Researchers are testing whether a single, concentrated dose of radiation to the tumor site can replace the usual weeks of daily radiation after breast-conserving surgery. The trial enrolls 250 women with early-stage, low-risk breast cancer that has not spread to lymph nodes. Doct…

This study tracks how well freezing breast tumors (cryoablation) works together with hormone therapy for women aged 70 and older with low-risk, early-stage breast cancer. Researchers will follow 400 participants for up to 5 years to see how often the cancer comes back. The goal i…

This early-stage trial tests AGX101, a drug that delivers chemotherapy directly to cancer cells by targeting a protein called TM4SF1. About 80 adults with advanced solid tumors (like breast, prostate, or pancreatic cancer) who have run out of standard options will receive the dru…

This early-stage trial tests a new drug called IAM1363 in adults with advanced cancers that have HER2 alterations, including breast, lung, and stomach cancers that have spread to the brain. The study aims to find the safest dose and see if the drug can shrink tumors. About 383 pa…

This study tests whether adding AGuIX gadolinium-based nanoparticles to standard brain radiation can better control brain metastases that are at high risk of coming back. About 134 adults with certain cancers (like melanoma, lung, breast, or colorectal) that have spread to the br…

This phase 2 trial tests whether adding the experimental drug evexomostat (SDX-7320) to standard chemotherapy (eribulin) works better than chemotherapy alone for people with metastatic triple-negative breast cancer who also have metabolic dysfunction (like insulin resistance). Th…

This early-stage study tests a new drug called LOXO-783 in people with advanced breast cancer or other solid tumors that have a specific change in the PIK3CA gene. The main goals are to find the safest dose and check for side effects. About 193 participants will take the drug alo…

This study looks at how well the drug inavolisib works for people with a certain type of advanced breast cancer that has a PIK3CA gene change and has stopped responding to hormone therapy. About 500 participants in China will receive inavolisib as part of their regular care. Rese…

This phase 2 trial is testing whether adding a drug called inavolisib to two standard treatments (ribociclib and fulvestrant) can shrink tumors or slow cancer growth in people with advanced hormone-receptor-positive, HER2-negative breast cancer that has a specific genetic change …

This study tests a new drug called GDC-4198, alone or combined with another drug (giredestrant), against a standard treatment (abemaciclib plus giredestrant) in people with advanced ER+/HER2- breast cancer that has worsened after prior CDK4/6 inhibitor therapy. The trial has two …

This study tests whether adding a new drug (LY4064809) to standard hormone therapy and CDK4/6 inhibitors can better control advanced HR+ HER2- breast cancer with a PIK3CA mutation. About 920 adults who have not had prior treatment for advanced disease will participate. The goal i…

This phase 3 trial is testing two oral drugs, camizestrant and ribociclib, as a first treatment for people with ER-positive, HER2-negative advanced breast cancer. The goal is to see if the combination can delay the need for next cancer therapy. About 150 participants will take th…

This early-phase trial tests a new radioactive drug, 177Lu-INN805, in 10 people with advanced solid tumors (like head & neck, lung, breast, or sarcoma) that haven't responded to standard treatments. The main goals are to find a safe dose and check for side effects. Researchers wi…

This early-phase study tests a new radioactive drug, LY4337713, in people with advanced cancers that have high levels of a protein called FAP. The cancers include certain types of ovarian, breast, pancreatic, colorectal, esophageal, stomach, and bile duct cancers. The study aims …

This study tests a new drug, LY4257496, that delivers radiation directly to cancer cells with a specific protein (GRPR). It is for adults with advanced solid tumors like breast, prostate, or colorectal cancer that have not responded to other treatments. The goal is to see if the …

This study tests a new oral drug called imlunestrant in premenopausal women with estrogen receptor-positive, HER2-negative breast cancer. Some participants will also receive a drug to suppress ovarian function. The effects on tumor cells and ovaries will be compared with those of…

This study tests a new drug, LY4170156, designed to attack cancer cells with a specific marker (folate receptor alpha). It is for people with advanced solid tumors like ovarian, lung, or breast cancer that have not responded to other treatments. The trial has two parts: first fin…

This study tests two oral drugs, AMXT 1501 and DFMO, given alongside standard treatments for people with advanced solid tumors (breast cancer or melanoma) that have worsened after prior therapies. The goal is to find a safe dose and see if the combination helps shrink tumors or s…

This trial tests an experimental oral drug called ORIC-114 in people with advanced solid tumors that have specific changes in the EGFR or HER2 genes. The study has two parts: first, finding a safe and effective dose, and second, seeing how well the drug works alone or with chemot…

This study tests two different doses of inavolisib combined with fulvestrant in people with a specific type of advanced breast cancer (PIK3CA-mutated, HR-positive, HER2-negative). About 80 participants whose cancer worsened after prior treatment will receive the drug combo. The g…

This early-phase trial tests two radioactive drugs, [177Lu]Lu-A9-0631 and [225Ac]Ac-A9-0642, in people with advanced solid tumors that have a protein called GRPR on their surface. These cancers include certain breast, prostate, and colorectal cancers that have stopped responding …

This phase 2 trial is testing whether adding a CDK4/6 inhibitor (palbociclib, abemaciclib, or ribociclib) to elacestrant works better than elacestrant alone for people with advanced ER+/HER2- breast cancer that has already been treated with a CDK4/6 inhibitor. The study will enro…

This study tests whether adding the drug inavolisib to standard hormone therapy and a CDK4/6 inhibitor can help people with a specific type of advanced breast cancer (PIK3CA-mutated, HR+, HER2-). About 450 adults whose cancer has not been treated yet in the advanced setting will …

This phase II trial is testing whether giving a shorter, stronger course of radiation before breast surgery is safer and works better than giving it after surgery for people with non-metastatic breast cancer. The study will enroll 120 participants with different breast cancer typ…

This study tests a new, ultra-short radiation schedule for early-stage breast cancer. Instead of the usual 3 weeks, patients receive 5 radiation sessions over one week, with an extra boost to the tumor site given at the same time. The goal is to see if this approach is safe, redu…

This study tests whether giving a different antibody-drug conjugate (ADC) to people with advanced breast cancer who have already tried an ADC can still shrink tumors or slow the disease. About 160 participants will receive one of several ADCs or a targeted pill. The goal is to se…

This Phase 2 trial tests an oral drug called BAY 2927088 (sevabertinib) in about 111 adults with advanced solid tumors that have HER2 gene mutations. The drug aims to block the abnormal HER2 protein and stop cancer growth. Participants take a 20 mg tablet daily in 3-week cycles u…

This study tests whether adding tocilizumab, an anti-inflammatory drug, to standard chemotherapy improves outcomes for people with metastatic triple-negative or ER-low breast cancer. Researchers will compare the combination to chemotherapy alone in 168 Black and non-Black patient…

This study compares two drug combinations for people with a type of advanced breast cancer (HR+/HER2-) that has a specific genetic change (PIK3CA mutation) and has worsened after prior treatment. About 540 adults will receive either the experimental drug RLY-2608 plus fulvestrant…

This phase 2 trial is testing whether giving a combination of three drugs—neratinib, an aromatase inhibitor (letrozole or anastrozole), and trastuzumab—before surgery can completely eliminate invasive breast cancer in postmenopausal women with ER-positive, HER2-positive breast ca…

This phase 3 trial tests whether a new drug (MK-2870), alone or with another drug (pembrolizumab), works better than standard treatments for people with a common type of advanced breast cancer (HR+/HER2-). About 1,200 participants whose cancer has worsened after hormone therapy w…

This pilot study tests whether adjusting chemotherapy based on early PET scan results can improve outcomes for people with stage 2 or 3 triple negative breast cancer. Participants receive four cycles of chemotherapy plus the immunotherapy drug pembrolizumab. A PET scan after the …

This study looks at whether adding chemotherapy to standard hormone therapy (which suppresses ovarian function) can better prevent breast cancer from coming back in premenopausal women with early-stage, hormone-sensitive breast cancer. About 3,960 participants will be randomly as…

This early-phase study tests a new drug, ASP2998, that targets a protein called TROP2 found on many solid tumors. The drug is given alone or with standard treatments like pembrolizumab or carboplatin. The main goals are to check safety and find the right dose. About 428 adults wi…

This phase I/II platform trial tests several drug combinations, including evorpacept, trastuzumab deruxtecan, zanidatamab, tucatinib, and TTX-MC138, in people with advanced solid tumors, especially metastatic breast cancer. The goal is to find safe and promising regimens that cou…

This phase 1 trial tests whether adding the experimental antibody axatilimab to the standard drug olaparib is safe and tolerable for people with HER2-negative breast cancer that has spread and is linked to BRCA1, BRCA2, or PALB2 gene changes. Researchers will enroll about 20 part…

This study tests whether a new treatment called Bria-IMT, given with an immunotherapy drug, helps people with advanced metastatic breast cancer live longer compared to standard chemotherapy. About 404 adults whose cancer has not responded to other treatments will participate. The…

This study is testing whether shorter courses of radiation therapy can work as well as standard treatment for people with breast cancer that has spread to lymph nodes. About 768 participants who have had surgery will receive either a very short (ultrahypofractionated) or moderate…

This early-phase study tests an experimental therapy called FT836, a ready-made CAR T-cell treatment, in people with advanced solid tumors like lung, colorectal, breast, ovarian, endometrial, or head and neck cancers that have not responded to prior treatments. The main goals are…

This early-stage study tests a new treatment called NT-175 for people with advanced solid tumors (like lung, colon, or breast cancer) that have a specific mutation (TP53 R175H) and a certain immune marker (HLA-A*02:01). NT-175 is made from a patient's own immune cells, which are …

This trial tests whether adding pyrotinib to the standard pre-surgery drug combination can better shrink HER2-positive breast tumors. Women with early or locally advanced breast cancer receive either the standard combination of pertuzumab, trastuzumab, and docetaxel, or the same …

This study is testing whether a simple blood test that looks for cancer DNA can help doctors decide when to start a targeted therapy (CDK4/6 inhibitor) in people with intermediate-risk HR+ HER2- breast cancer. About 725 participants will have their blood tested every 3 months for…

This Phase 3 study tests whether a new drug, inavolisib, combined with fulvestrant works better than the current standard alpelisib plus fulvestrant for people with a specific type of advanced breast cancer (HR-positive, HER2-negative, with a PIK3CA mutation). The trial enrolled …

This study tests whether combining the drug inavolisib with other treatments can safely shrink or eliminate early-stage breast tumors that have a specific genetic change (PIK3CA mutation). About 60 people with untreated stage II-III breast cancer will receive the drug combination…

This trial tests an experimental oral drug called MBQ-167 in people with advanced breast cancer who have exhausted standard treatments. The drug targets two proteins, Rac and Cdc42, that cancer cells use to grow and spread. Researchers are looking for the highest safe dose and ch…

This phase 2 trial is testing whether using a biomarker test (MammaPrint/BluePrint) to guide treatment choices can improve outcomes for people with early-stage HER2-positive breast cancer. Participants receive standard chemotherapy (paclitaxel, nab-paclitaxel, or docetaxel) combi…

This study compares two methods of breast reconstruction in women who had a mastectomy and radiation for breast cancer: autologous fat transfer (AFT) and DIEP flap surgery. About 280 participants will be randomly assigned to one of the two procedures. The main goal is to see if A…

This trial tests whether a personalized exercise program, done at home before breast cancer surgery, can improve physical fitness and influence the body's immune and inflammatory responses. Women with newly diagnosed luminal B or triple-negative breast cancer who are about to rec…

This early-phase study tests a new drug called HLD-0117 in about 33 women with a type of advanced breast cancer (ER-positive) that has spread and stopped responding to standard therapies. The main goals are to check the drug's safety and find the right dose, while also seeing if …

This study is testing a program called WeCan-Rural for breast cancer survivors living in rural, underserved areas. The program includes 12 weekly video sessions to help manage symptoms like pain and fatigue, and build healthy habits around eating, exercise, and weight. The goal i…

This phase 3 trial tests whether adjusting tamoxifen doses based on individual metabolism can reduce the number of breast cancer patients who stop treatment early due to side effects. About 1,100 premenopausal or perimenopausal women with hormone-sensitive breast cancer will rece…

This study looks at whether adding a tumor bed boost to standard whole breast radiation after breast-conserving surgery helps women with HER2-positive breast cancer. It will track recurrence, survival, and side effects over seven years. The goal is to see if the extra radiation d…

This trial is testing an oral form of the chemotherapy drug paclitaxel, given alongside standard anti-HER2 therapies (trastuzumab and pertuzumab), for people with HER2-positive breast cancer. The goal is to find the safest and most effective dose of the oral paclitaxel when used …

This trial is testing a new way to deliver radiation therapy for early-stage breast cancer. Instead of the usual weeks of daily radiation after surgery, this approach gives a shorter, more intense course of radiation before the tumor is removed. The study aims to find the safest …

This study tests whether a negative pressure wound dressing (PICO) can reduce the risk of seroma—a common fluid buildup—after mastectomy for breast cancer. About 76 women will be randomly assigned to get either the standard dressing or the PICO device, which they wear for a week.…

This phase 3 trial is testing whether patients with early-stage triple-negative breast cancer who have a complete response to standard chemotherapy plus the immunotherapy drug pembrolizumab can safely stop pembrolizumab early instead of continuing it for an additional six months.…

This pilot study is testing whether partial breast irradiation alone — without first removing or sampling lymph nodes from the armpit — is safe for women age 40 and older with early-stage invasive breast cancer. All participants have had a lumpectomy but no sentinel node biopsy o…

This study investigates whether patients with HER2-positive metastatic breast cancer who have had their disease controlled for at least two years on anti-HER2 therapy can safely stop that treatment. Participants must also have no detectable cancer DNA in their blood (ctDNA-negati…

This study tracks 108 patients with HR-positive, HER2-negative advanced breast cancer who are receiving abemaciclib combined with hormone therapy. Researchers are collecting real-world data on how long patients live without their cancer worsening, overall survival, and side effec…

This study tests whether postmenopausal women with a very low-risk type of breast cancer (HR+ HER2-) can safely take hormone therapy for only 2-3 years instead of the standard 5 years. The goal is to maintain protection against cancer spread while reducing side effects and improv…

This trial investigates whether women aged 60 and older with a very small, low-risk type of breast cancer can safely avoid hormone therapy after surgery. Participants will not receive standard drugs like tamoxifen or letrozole, and researchers will track cancer recurrence for up …

This trial investigates whether a single, high dose of MRI-guided radiation given before surgery can completely eliminate low-risk breast cancer. Women aged 50 and older with small, early-stage tumors receive one radiation dose, then wait 6 to 12 months before surgery to see if t…

This trial investigates whether combining high-intensity focused ultrasound (HIFU) with the immunotherapy drug toripalimab and standard chemotherapy can improve outcomes for people with ER+/HER2- breast cancer before they undergo surgery. The study enrolls women aged 18-75 with i…

This phase 2 trial tests a personalized approach for early-stage, hormone receptor-positive breast cancer. Participants receive a combination of CDK4/6 inhibitors and endocrine therapy before surgery. A blood test (ctDNA) is used to monitor tumor DNA and may help decide if chemot…

This study tests whether a blood test (ctDNA) can identify women with early-stage, hormone-positive breast cancer who can safely avoid chemotherapy. Instead of chemo, they receive a targeted pill (dalpiciclib) plus hormone therapy before surgery. The goal is to reduce side effect…

This study is for people with a type of breast cancer called triple-negative that has come back after treatment. The researchers want to see if adding a drug called bevacizumab to the usual combination of pembrolizumab and paclitaxel works better. About 44 adults who have already…

This phase 3 trial is testing whether premenopausal women with a common type of breast cancer (HR+/HER2-) can safely skip chemotherapy if their tumor responds well to hormone therapy before surgery. About 950 women will be randomly assigned to either standard surgery first or hor…

This study tests whether adding a precise local treatment—like focused radiation or ablation—can help people whose cancer has a few new or growing spots while on standard therapy. Participants continue their usual medication while the resistant tumors are treated directly. The go…

This study compares a one-week ultra-hypofractionated radiation regimen (26 Gy in 5 fractions) to the standard three-week moderate hypofractionated regimen (40 Gy in 15 fractions) for treating lymph nodes after breast cancer surgery. The goal is to see if the shorter course is ju…

This trial tests a new approach to breast reconstruction after cancer surgery. Doctors take a patient's own fat and mix it with a substance made from their blood (platelet-rich fibrin) to create a 'lipobolus' that fills the gap left by tumor removal. The goal is to see how much o…

This study is testing two different radiation schedules for women with early breast cancer who have had a lumpectomy. One group gets radiation over one week, the other over two weeks with an extra boost to the tumor site. Researchers will compare side effects, breast appearance, …

This study tests a new radiation approach for early breast cancer that uses real-time MRI guidance to deliver just three high-dose sessions over one week, instead of the usual several weeks. The goal is to see if this shorter treatment is safe, preserves the breast's appearance, …

This phase 3 trial tests whether tamoxifen or letrozole works better for preserving fertility in women with estrogen-sensitive breast cancer before starting chemotherapy. About 309 participants will take one of the two drugs during ovarian stimulation to freeze their eggs. The ma…

This phase 2 trial tests whether delivering high-dose chemotherapy directly to the liver (using a special system) followed by standard cancer drugs works better than standard drugs alone for people with breast cancer that has spread mainly to the liver. About 90 participants will…

This Phase 2 trial at Fudan University tests several targeted drug combinations given before surgery for early-stage breast cancer. The goal is to see which combinations best eliminate all signs of cancer (pathological complete response) based on each tumor's specific subtype. Ab…

This study is for women aged 65 and older with low-risk breast cancer who have had a lumpectomy. It compares two follow-up treatments: a short course of targeted radiation (5 sessions) versus 5 years of hormone pills. The main goal is to see which approach gives a better quality …

This phase II trial tests whether two oral drugs, abemaciclib (a targeted cancer therapy) and hydroxychloroquine (an older malaria drug), can eliminate leftover cancer cells hiding in the bone marrow of breast cancer patients. About 44 people with a history of breast cancer and d…

This early-phase trial is testing a new type of cell therapy called p95HER2.CAR-TECH2Me for people with advanced HER2-positive breast, gastric, or endometrial cancers that have spread. The treatment uses a patient's own immune cells, which are modified in a lab to better recogniz…

This study is for adults with certain cancers (like breast, lung, or ovarian) that are in complete remission but have persistently low platelet counts from past chemotherapy. It tests whether adding a vitamin A derivative (ATRA) to a standard platelet-boosting drug works better t…

This phase 2 trial is testing whether combining two hormone-blocking drugs, elacestrant and exemestane, can help people with a certain type of advanced breast cancer (HR+/HER2-) that has stopped responding to initial treatments. The study uses a special PET scan to select partici…

This study follows about 300 women with HER2-positive breast cancer that has spread. They are getting a three-drug combination (tucatinib, capecitabine, trastuzumab) as part of their normal care. The goal is to see how well the treatment works and how safe it is in everyday medic…

This study is for women with early-stage breast cancer that has spread to 1-2 lymph nodes. It tests whether skipping radiation to the lymph nodes can reduce side effects and improve quality of life without increasing the risk of cancer coming back. About 1,350 participants will b…

This study looks at whether women over 59 with a specific low-risk type of early breast cancer (luminal A) can safely skip sentinel lymph node biopsy, a standard surgical procedure to check if cancer has spread. The goal is to see if avoiding this biopsy leads to the same low rat…

This study tests whether eating one avocado daily for 4 months can slow biological aging in 120 female breast cancer survivors. The researchers will measure changes in telomere length (a marker of cellular aging) and other health indicators like inflammation and heart disease ris…

This study tests a precise, high-dose radiation technique called SBRT as an alternative to surgery for breast cancer in patients over 70 who are too frail for an operation. The goal is to find the safest highest dose that can be given in one to five sessions. If it works, it coul…

This study looks at whether using a mobile app helps people with HR+ HER2- stage II or III breast cancer stick to their prescribed ribociclib and aromatase inhibitor therapy for a full year. The app provides reminders and information about side effects and relapse risks. About 24…

This study tests if axelopran, a drug used for opioid-induced constipation, can slow tumor growth in people with advanced breast, lung, pancreas, or prostate cancer. About 34 adults whose cancer has worsened after standard treatment will take axelopran daily for up to a year. Res…

This study tests whether dapagliflozin, a diabetes drug, can prevent heart damage caused by anthracycline chemotherapy in breast cancer patients. About 70 women aged 18-70 with low to medium heart risk will take either dapagliflozin or standard care during their chemo. The goal i…

This study tests whether taking an oral chemotherapy (paclitaxel) along with a fixed-dose injection of two targeted drugs (pertuzumab and trastuzumab) can eliminate all signs of HER2-positive breast cancer before surgery. About 112 adults with early-stage HER2+ breast cancer will…

This phase 2 trial is testing whether the drug elacestrant, given alone or with triptorelin (which temporarily stops ovary hormone production), can slow or shrink hormone-sensitive breast tumors in premenopausal women. About 96 women will take the pills daily for 30 days before t…

This phase 2 trial is testing whether a fasting-mimicking diet (a low-calorie, plant-based diet) can improve the effectiveness of standard chemoimmunotherapy for early or locally advanced triple-negative breast cancer. About 80 women aged 18 to 70 will follow the diet for five da…

This study tests a new drug, evexomostat, added to two standard treatments for a common type of advanced breast cancer (HR+, HER2-). The goal is to see if the triple combination is safe and can reduce high blood sugar side effects often caused by the standard drugs. About 52 adul…

This study tests whether freezing early-stage breast cancer tumors (cryoablation) can safely and effectively destroy them in postmenopausal women. Participants will have the frozen tumor removed afterward to check for any remaining cancer cells. The goal is to see if this less in…

This study looks at whether proton therapy can safely treat cancers that return after standard radiation. Proton beams are more targeted than traditional X-rays, so they may deliver stronger doses to the tumor while sparing healthy tissue. Researchers will track side effects and …

This study tests a combination of two drugs, eribulin and anlotinib, for people with HER2-negative breast cancer that has spread or come back. Participants have already tried other treatments without success. The goal is to see if this combo can slow cancer growth and improve sur…

This study is for people with early-stage ER+ breast cancer who still have hidden cancer cells in their bone marrow after surgery and standard therapy. It tests whether adding drugs like hydroxychloroquine or avelumab, with or without palbociclib, can clear those leftover cells a…

This study tests a more personalized chemotherapy plan for women with early-stage triple-negative breast cancer. The treatment is adjusted based on immune system activity in the tumor and imaging results. The goal is to see if a lighter chemo can still be effective, reducing side…

This study tests the drug trastuzumab deruxtecan (T-DXd) as a first treatment for people with HER2-positive breast cancer that has spread. About 300 participants will take the drug and use digital tools like a smartwatch and pulse oximeter to catch side effects early. The goal is…

This early-stage trial is testing a new daily oral medication called ETX-19477 in about 120 adults with advanced solid tumors, including breast, ovarian, prostate, and other cancers. The drug blocks a protein called PARG to interfere with cancer cells' ability to repair themselve…

This study tests a new treatment using specially engineered immune cells (CAR-NK cells) to fight advanced breast cancer, including HER2-positive and triple-negative types. About 60 adults whose cancer has not responded to standard treatments will receive cells tailored to their t…

This study is testing whether personalizing the dose and schedule of radiation therapy after breast cancer surgery can reduce long-term side effects like scarring (fibrosis) and radiation-induced cancers, while still preventing the cancer from coming back. The trial will enroll 8…

This phase 3 trial is testing whether giving radiation only to the lower armpit lymph nodes works as well as giving radiation to a larger area of lymph nodes in breast cancer patients who have 1-2 positive sentinel nodes. The study plans to enroll 1608 women with early-stage brea…

This study explores whether women with recurrent breast cancer can safely have breast-conserving surgery and a second round of radiation instead of full mastectomy. It will enroll 60 patients who had prior radiation at least 3 years ago and have small, localized tumors. The goal …

This study compares a freezing technique called cryoablation to standard lumpectomy surgery in people with low-risk, early-stage breast cancer. The goal is to see if freezing the tumor offers similar disease control with fewer complications and better quality of life. About 120 p…

This study tests whether adding an antifungal drug (posaconazole) to standard immunotherapy and chemotherapy can help more women with triple-negative breast cancer achieve a complete response before surgery. About 72 women with early-stage, high-risk disease will be randomly assi…

This study tests a new approach using immune cells from healthy donors, engineered to recognize and attack cancer cells. The target is chosen based on each participant's tumor profile. The trial includes 85 adults with advanced solid tumors that have not responded to standard tre…

This study tests a new treatment called EBNK-001, made from donor immune cells (natural killer cells), in people with advanced solid tumors that have not responded to standard therapies. Participants receive the cells after chemotherapy to prepare the body, along with low-dose in…

This study tests whether tirzepatide, a weight-loss medication, combined with standard hormone therapy can help clear tiny amounts of cancer DNA from the blood of people with obesity or overweight who have had hormone-positive, HER2-negative, node-positive early breast cancer. Th…

This early-stage trial tests a new combination treatment for people with advanced HER2-positive solid tumors (like breast, lung, or stomach cancer). Participants receive an injection of a special virus directly into one tumor to help the immune system attack cancer, followed by a…

This study looks at how different group exercise programs affect fitness and body composition in women who have finished breast cancer treatment. About 15 women will try one of four supervised resistance training regimens. The goal is to see which approach best improves heart-lun…

This early-stage trial is testing a combination of two chemotherapy drugs (melphalan and BCNU) plus vitamins B12b and C, followed by an infusion of the patient's own stem cells. The goal is to see if this approach is safe for people with metastatic pancreatic or breast cancer, es…

This study tests whether women with breast cancer who have no signs of cancer in their armpit lymph nodes after chemotherapy can safely skip armpit surgery. About 464 participants will be randomly assigned to either have or skip the surgery. The goal is to see if skipping surgery…

This phase II trial is testing a combination of two drugs—Sac-TMT (a targeted chemotherapy) and KL-A167 (an immunotherapy)—given before surgery to 40 people with triple-negative breast cancer. The goal is to see if the combo can eliminate or shrink tumors enough to improve long-t…

This study looks at whether women who had breast cancer come back after earlier lumpectomy and radiation can avoid a mastectomy by getting a second round of targeted radiation. About 120 women with small, isolated recurrences will receive partial or whole breast radiation dependi…

This phase 2 trial is testing a new approach for post-menopausal women with HR+HER2- breast cancer. Participants receive standard hormone therapy plus focal radiation, and some also get the immunotherapy drug pembrolizumab and an immune booster (CDX-301). The goal is to see if th…

This study tests whether a program of physical exercise, nutritional guidance, and psychological support during chemotherapy can help women with early-stage breast cancer respond better to treatment. About 214 women will be randomly assigned to either the program or standard care…

Researchers are testing whether a small implantable marker called Magseed, along with a handheld magnetic probe called Sentimag, can help surgeons locate and remove a specific axillary lymph node in breast cancer patients who have had chemotherapy before surgery. The study enroll…

This study is testing whether a breath test can detect breast cancer in women aged 40 to 74. Researchers will collect breath samples from over 5,000 women before their standard biopsy or MRI and compare the chemical patterns between those found to have cancer and those who do not…

Researchers are testing a new PET imaging tracer called 18F-HER2 Affibody to see how well it detects HER2-expressing breast cancer. The study includes 40 adults with confirmed or suspected HER2-positive breast cancer. Participants receive the tracer and then undergo a PET scan. T…

Researchers compare two tracers, indocyanine green (ICG) and blue patent dye, for locating lymph nodes during targeted axillary dissection in breast cancer patients who have received chemotherapy before surgery. The trial measures how often each tracer successfully identifies the…

This study is testing a new 3D automated ultrasound system called ATUSA to see how well it can image suspicious breast lesions. Up to 800 women with suspicious findings on standard imaging will get an ATUSA scan before their biopsy. The goal is to collect images and compare them …

This study looks at whether adding an MRI to the yearly mammogram can help find breast cancer earlier in women with dense breasts. Participants will have a mammogram and a risk score calculated from it. Those with a high risk score will be offered an MRI. The goal is to see if th…

Researchers are testing a system called Magseed Pro and Sentimag Gen3 to help surgeons find breast tumors and suspicious lymph nodes during surgery. The study enrolls 224 adults with breast cancer who need these areas marked and removed. Doctors place a small magnetic marker into…

This study is testing whether routine brain MRIs can find brain metastases in stage IV breast cancer patients who have no neurological symptoms. Researchers will scan 170 participants at the start and again at 6 months or when their cancer first progresses. The goal is to see how…

The COGNITION study is a molecular diagnostic platform that collects tumor and blood samples from up to 2,000 adults with early breast cancer, including those receiving chemotherapy before surgery. Researchers perform comprehensive genomic sequencing on samples taken before and a…

Researchers are studying whether a blood test called Guardant360 can measure how well cancer treatment is working in people with advanced lung, colorectal, or breast cancer. The test looks for tumor DNA that cancer cells release into the bloodstream. Participants give blood sampl…

This study tests a new imaging agent called pHLIP ICG that makes breast cancer cells glow during surgery. The goal is to help surgeons see and remove all cancerous tissue more accurately. The trial involves 55 adults with early-stage breast cancer who have not had prior treatment…

This study is testing a new blood test that uses laser technology and artificial intelligence to help doctors tell apart high-risk and low-risk breast cancer patients. About 330 people with breast cancer will give a blood sample before treatment. The test looks at tiny particles …

This trial tests an experimental imaging agent called [68Ga]Ga-DWJ155 in adults with advanced cancers of the breast, lung, or stomach. The agent is designed to attach to tumor cells and show up on PET scans, helping doctors see where cancer has spread. Researchers will measure ho…

This study is testing whether a new blood test can screen for many types of cancer at once. Researchers will enroll 24,000 adults aged 45-75 who do not have cancer. Participants will be randomly assigned to one of two blood test groups or a control group. The goal is to see how w…

This study enrolls 400 women at high risk for breast cancer to see if a shorter, abbreviated MRI scan works as well as a full-length MRI for early detection. Participants will get MRI scans every 6 months. The goal is to develop faster, personalized screening that could make regu…

This study tests whether a special PET/MRI scan using a radioactive tracer (18F-FFNP) can detect early signs that hormone therapy is working in breast cancer. About 53 postmenopausal women with a certain type of breast cancer will get the scan before and after taking anastrozole …

This trial tests whether a simplified heart ultrasound is as good as the standard comprehensive exam for detecting heart problems caused by breast cancer treatment. About 250 breast cancer patients will be randomly assigned to one of the two monitoring approaches. The study also …

This trial is testing whether a new radioactive tracer, called 68Ga-SorB, can help doctors see certain solid tumors on PET/CT scans. The tracer targets sortilin, a protein that is often found on cancer cells. About 50 adults with melanoma, liver, lung, breast, pancreatic, or ovar…

This study evaluates a rapid test called Methylscape that measures DNA methylation patterns in body fluids like blood, urine, or saliva. The goal is to see if it can detect a cancer signal and even predict where the cancer started, using a single sample. Researchers will compare …

This study is testing whether a special type of mammogram called contrast-enhanced spectral mammography (CESM) can find breast cancers better than the standard 3D mammogram (digital breast tomosynthesis, or DBT) in women with dense breast tissue. About 2,000 women with dense brea…

This study tests a new type of PET/CT scan that uses a special tracer to see if HER2-positive breast cancer has been completely eliminated after chemotherapy and targeted therapy. The goal is to see if the scan can accurately predict which patients have no cancer left, potentiall…

This study looks at whether artificial intelligence can help detect breast cancer using standard chest CT scans that don't require a special dye. Researchers will compare the AI's accuracy to mammograms and breast MRIs in 5,000 women. The goal is to see if this approach could off…

This study tests a new imaging approach for people with advanced breast or prostate cancer. It uses two radioactive tracers to find tumors that have a specific protein (GRPR). The goal is to see if this method is safe and can help doctors see where the cancer is in the body. Abou…

This study is testing a new method called BRAVE that uses sound waves to measure breast tissue stiffness, aiming to find cancer without X-rays or painful compression. Researchers will enroll 300 adults who have a breast mass and a recent mammogram. The goal is to see how well thi…

This study tests a new imaging method called FAPI-PET/MRI to see if it can detect hidden invasive breast cancer in 30 people diagnosed with ductal carcinoma in situ (DCIS), a common pre-stage of breast cancer. Participants receive a weakly radioactive drug and lie in a scanner fo…

This study tests a new type of PET/CT scan that uses a radioactive tracer called 68Ga-ABS011 to detect HER2, a protein found on some cancer cells. The goal is to see if this scan can more accurately determine HER2 status in people with metastatic breast cancer or other solid tumo…

This study aims to see if a new test, using trained dogs and artificial intelligence, can detect breast cancer from a person's breath. About 1,200 women scheduled for routine breast cancer screening or biopsy will provide a breath sample by breathing into a mask. The results from…

This study tests a new PET imaging method that uses a radioactive tracer to spot HER2 proteins on breast cancer cells. The goal is to see if the scan can predict how well patients will respond to antibody-drug conjugate therapy. Researchers will enroll 50 adults with HER2-positiv…

Women with extremely dense breasts have a higher risk of breast cancer, and tumors are harder to see on standard mammograms. This large study of 36,000 women aged 50-75 will test two extra screening methods—contrast-enhanced mammography and a shorter MRI—to see if they can find c…

This study compares contrast-enhanced mammography (CEM) to the standard MRI plus digital mammography for screening women at high risk of breast cancer. About 2200 women aged 35-60 with a 5-year risk of 5% or higher will be randomly assigned to one of the two screening methods ove…

This study tests a new handheld device that uses light and artificial intelligence to check for leftover cancer cells right after a breast lump is removed. The goal is to help surgeons remove all cancer in one go, avoiding a second surgery. About 104 women having breast-conservin…

This study is testing a blood test called NovaGray RILA Breast® to see if it can predict severe capsular contracture (hardening and tightening of scar tissue around a breast implant) after radiotherapy. Researchers will enroll 250 breast cancer patients who have had a mastectomy …

This study tests whether non-experts using AI-supported ultrasound can effectively screen for breast cancer in communities with limited access to radiologists. About 4,800 women, both with and without symptoms, will receive a clinical breast exam and AI-guided ultrasound. The goa…

This study compares two ways of reading mammograms for breast cancer screening. The standard method uses two radiologists to review each image. The new method uses one radiologist with the help of artificial intelligence (AI). The goal is to see if the AI-assisted single reading …

This study aims to create a blood test (liquid biopsy) that can detect two key genetic mutations, ESR1 and gBRCA, in patients with a common type of metastatic breast cancer (HR+/HER2-). The test would help doctors choose the most effective treatments without needing a tissue biop…

This study is testing a new device called SPCTRone that uses light to analyze tissue during breast cancer surgery. The goal is to see if it can accurately tell surgeons whether all cancer has been removed, right in the operating room. About 100 women having breast-conserving surg…

This study in Indonesia will test whether a portable ultrasound device can help doctors quickly decide if a breast lump found during a physical exam is likely benign or possibly cancerous. 600 women with breast lumps will get an ultrasound at a primary care clinic. The goal is to…

This study tests if a safe green dye (indocyanine green) can help surgeons find lymph nodes that might contain cancer during a mastectomy, without needing a separate cut under the arm. About 90 women with early-stage breast cancer will receive the dye and a standard radioactive t…

This pilot study is testing a new radioactive tracer called [18F]F-GLN for PET/CT scans in people with breast cancer. The goal is to see how well this tracer highlights tumors and to gather safety information. Up to 40 adults with known or suspected breast cancer will receive one…

This study is testing a blood test that looks for DNA signals from 20 different cancers, including lung, breast, and colon cancer. Researchers will see if the test can find cancer early, detect any cancer left after treatment, and catch a relapse before it shows up on scans. The …

This study tests whether giving people a personalized report about their cancer risk and screening options helps them complete recommended cancer tests. Adults aged 45 to 74 who are at high risk for lung, breast, colorectal, upper gastrointestinal, or liver cancer are invited to …

This early-stage trial tests a cream made from inactivated Akkermansia muciniphila bacteria to prevent skin injury in 40 breast or head/neck cancer patients receiving radiation. The cream is applied three times daily to the radiation area. The main goal is to see if it is safe an…

This study tests whether adding a polygenic risk score (PRS) — a measure based on 313 genetic markers — to the standard CanRisk model can improve breast cancer risk prediction and prevention. About 100 women at increased risk will receive genetic counseling, a blood draw, and the…

This study tests a virtual program that includes webinars and online visits to help women at high risk for breast cancer adopt healthier lifestyles. The goal is to see if women will stick with the program and whether it helps them reduce their risk. About 1,500 women from a large…

This study tests whether a personalized prevention plan helps female night shift workers reduce their breast cancer risk. Night shift work is linked to higher cancer risk due to disrupted sleep cycles. One hundred women at a Paris hospital will receive tailored advice on diet, ex…

This study tests whether a smartphone app, combined with nutrition education, can help people at high risk for cancer eat healthier and reduce their cancer risk. About 170 participants will either get the app or standard advice, and researchers will measure changes in diet qualit…

This study tests whether a home-based telerehabilitation program, starting 10 days after breast cancer surgery, can prevent common complications like pain, shoulder stiffness, and swelling. 155 women who had a mastectomy or quadrantectomy will be randomly assigned to either the t…

This study tests whether wearing tight-fitting surgical gloves and compression knee socks during chemotherapy can prevent nerve damage (neuropathy) in breast cancer patients. The idea is that compression narrows blood vessels, reducing the amount of chemo drugs reaching the hands…

This study tests whether a personalized home exercise routine can prevent joint and muscle pain in early breast cancer patients who are starting a common hormone therapy (aromatase inhibitors). About 200 participants will be randomly assigned to either the exercise program or usu…

This study compares two approaches for breast cancer patients who still have cancer in their sentinel lymph node after chemotherapy: removing the underarm lymph nodes (surgery) or treating them with radiation. The goal is to see if radiation can reduce the risk of arm swelling (l…

Researchers test whether an AI-supported mobile app helps breast cancer patients manage chemotherapy symptoms, feel more confident, and enjoy a better quality of life. Seventy women receiving chemotherapy for the first time join the study. Half use the app to report daily symptom…

This study tests three treatments—a nerve block (SPB), Botox, and capsaicin—to see which works best for chronic nerve pain after mastectomy. 123 women whose pain is not controlled by standard medicines will be randomly assigned to one of the three groups. The main goal is to meas…

Researchers are studying whether a supervised exercise program can protect the heart and improve fitness in women receiving chemotherapy for breast cancer. The trial enrolls women who are scheduled for chemotherapy before or after breast cancer surgery. Participants attend exerci…

This study looks at whether combining resistance and aerobic arm exercises can improve arm strength, function, and quality of life in breast cancer patients. About 40 women who are at least 15 months past surgery and not currently active will participate. The goal is to find bett…

This trial tests whether personalized acupuncture—chosen together by the patient and clinician—can ease psychosomatic symptoms like anxiety, depression, sleep problems, and fatigue in women with breast cancer. Participants are divided into groups based on their symptom patterns a…

This study tests whether doing physiotherapy and using a mechanical stimulation device before breast reconstruction surgery can reduce shoulder pain and improve movement afterward. About 72 women scheduled for a specific type of breast reconstruction (using a back muscle flap) wi…

This study tests whether a personalized exercise program, tracked by a smartwatch, can help reduce fatigue in people who have finished chemotherapy for certain cancers (breast, colorectal, ovarian, pancreatic, or gastric). About 98 participants will be randomly assigned to either…

This study is testing whether a mobile app called Mighty Pro can help young women with breast cancer feel less distressed. The trial will include 120 women aged 18 to 45 who are patients at a specific cancer center. Participants will use the app for 26 weeks, and researchers will…

Cancer treatment often leaves patients with a deep, lasting tiredness that few treatments can fix. Researchers are testing whether guarana, a caffeine-rich Amazonian plant, can reduce that fatigue and improve daily life. The study gives 60 people with breast, lung, colorectal, ce…

This trial tests whether pharmacopuncture, a treatment that injects small amounts of herbal medicine into acupuncture points, can reduce joint pain in women with breast cancer who take aromatase inhibitors. These drugs often cause joint pain, and the study compares pharmacopunctu…

This Spanish trial tests whether a 6-month exercise program (combining resistance and aerobic training) can improve quality of life in 74 early breast cancer patients taking hormone therapy. Half the participants will do the exercise program three times a week, while the other ha…

This study tests whether using a special dye (ICG) to map the arm's lymph vessels can make daily arm massage more effective at preventing lymphedema (swelling) after breast cancer surgery. 30 women will be randomly assigned to either ICG-guided massage or traditional massage, and…

This study tests whether a community-based exercise program can improve memory, attention, and brain health in women who have had breast cancer. About 160 survivors, aged 50 and older, will either take part in aerobic exercise or health education sessions. The goal is to see if p…

This early-phase study tests whether psilocybin (the active ingredient in magic mushrooms) combined with talk therapy can reduce fear of cancer returning in 20 women with early-stage breast or ovarian cancer who are currently in remission. Participants receive a moderately high d…

This study tests a laser treatment for vaginal dryness in breast cancer survivors. Many survivors experience this side effect from cancer treatments like chemotherapy or hormone therapy. The trial will compare the laser to no treatment in 250 women to see if it improves symptoms.

This study tests two types of nerve blocks to see which one works better for pain after breast cancer surgery. 50 women having a mastectomy will get either a newer or a standard block. The goal is to find a way to reduce the need for strong painkillers like morphine and help pati…

This study tests whether a specific nerve block (SPSIP block) can reduce pain and the need for strong painkillers after mastectomy and lymph node removal. About 50 women with breast cancer will receive either the nerve block or a placebo before surgery. The goal is to improve rec…

This study tests a virtual group lifestyle program for women with metastatic breast cancer. The goal is to see if more support helps them stick with healthy habits like diet and exercise. One hundred women will take part, and researchers will track safety and how well they follow…

This pilot study tests a remotely delivered physical activity program designed to help breast cancer survivors increase their weekly exercise. Participants are assigned to either an affect-based or effort-based exercise prescription and receive coaching sessions. Those who are no…

This Phase 3 trial tests whether Nuvastatic 300 mg capsules can reduce the crushing fatigue that often comes with chemotherapy. About 250 women with metastatic triple-negative breast cancer will take either the supplement or a placebo three times daily for 60 days while continuin…

This trial tests whether a topical blend of essential oils can reduce the painful, tingling, or numb sensations caused by chemotherapy-induced neuropathy in breast cancer patients treated with paclitaxel. The study enrolls women with bothersome nerve symptoms that standard medica…

This trial tests whether water-only fasting for 24 to 48 hours around each chemotherapy session can help people with early-stage breast cancer tolerate treatment better. Participants will fast during four cycles of standard chemotherapy, either before or after surgery. The study …

This study tests whether megestrol acetate, a drug often used for appetite loss, can prevent or reduce severe tiredness in 132 women with advanced breast cancer who are starting a treatment called trastuzumab deruxtecan (T-DXd). Participants will receive either megestrol acetate …

This trial tests whether a 12-week slow jogging program can help breast cancer survivors sleep better, feel less tired, and enjoy a better quality of life. Women who have finished primary treatment for hormone receptor-positive breast cancer will either jog slowly three times a w…

This study tests whether cancer patients can complete a supervised exercise program from home using video calls. The program includes resistance training with dumbbells and aerobic exercise. Researchers want to see if this approach is practical and helps patients maintain functio…

This trial tests whether adding a nurse-led education and support program to standard care helps women with non-metastatic breast cancer better manage side effects from hormone therapy. Participants will attend an educational session and receive personalized guidance and phone fo…

This trial tests whether a combination of two ultrasound-guided nerve blocks (PECS II and superficial PIP) can provide pain relief and recovery quality comparable to the standard thoracic paravertebral block after mastectomy. The standard block is effective but carries a risk of …

This study tests a minimally invasive technique called endoscopic nipple-sparing mastectomy for women with breast cancer or high genetic risk. Surgeons remove breast tissue through a small side incision using a camera, then reconstruct the breast immediately with an implant. The …

This study looks at whether a telehealth exercise program with protein support can help women aged 65 and older with breast cancer receive all their planned chemotherapy at the right dose. Participants will either do resistance exercises and take protein or receive health educati…

This study is testing a virtual program called Mindful After Cancer (MAC) to help breast and gynecologic cancer survivors with sexual health and body image concerns. The program combines mindfulness training, educational materials, and group support over 8 weeks via video calls. …

This study looks at whether a structured 12-week exercise program can improve fitness and recovery in women who have had DIEP flap breast reconstruction after mastectomy. Half of the 78 participants will follow the exercise program, while the other half will receive standard care…

This study compares two types of nerve blocks given before modified radical mastectomy to see which provides better pain relief and reduces the need for strong painkillers. Eighty women scheduled for surgery will receive one of the two blocks, and researchers will track their pai…

This study tests whether a program of exercise and personalized nutrition before breast cancer treatment (called prehabilitation) can help women recover faster and feel better. Researchers will measure fitness, strength, and quality of life in 66 women with early-stage breast can…

This study tests whether a non-invasive device that gently stimulates a nerve in the ear can help prevent nausea caused by chemotherapy in breast cancer patients. Participants use the device twice daily around their chemo sessions, alongside standard anti-nausea medication. The g…

This study tests whether a virtual exercise and education program can help breast cancer patients maintain their fitness, heart health, and quality of life while undergoing chemotherapy. About 120 patients with stage I-III breast cancer will be enrolled. Participants will attend …

This study looks at whether starting resistance exercise training before breast cancer surgery can help reduce common side effects like fatigue, muscle loss, and reduced strength. The study involves 68 postmenopausal women with breast cancer who are scheduled for chemotherapy bef…

This pilot study is testing a new, less invasive breast surgery called endoscopic video-assisted nipple-sparing mastectomy (E-NSM) for women with early-stage breast cancer or those at high risk. The goal is to see if this technique can reduce surgical trauma and improve cosmetic …

This study tests whether watching augmented reality (AR) health education videos can help reduce anxiety and depression in women after breast cancer surgery. 60 female patients will be randomly assigned to receive either standard education alone or standard education plus AR vide…

This study tests whether an Enhanced Recovery After Surgery (ERAS) protocol can reduce opioid prescriptions and pain after breast conserving surgery. 260 breast cancer patients will be randomly assigned to receive either the ERAS protocol or standard care. The ERAS protocol inclu…

This study tests a remote coaching program called PRISM for people recently diagnosed with metastatic breast cancer. The program teaches stress management, goal setting, and coping skills through video sessions. Researchers want to see if it improves resilience and quality of lif…

This study looks at whether a 4-month yoga program can reduce joint pain and stiffness in women with breast cancer who are on hormone therapy. About 140 women who have joint pain from their treatment will either take yoga classes twice a week plus home practice, or join a waiting…

This study looks at whether extending the nightly fasting period (not eating for a longer stretch each night) can improve sleep, thinking, and quality of life in breast cancer survivors. Researchers will compare this approach to health education alone. The study involves 60 femal…

This pilot study is testing whether an AI-powered smartphone app called ASSIST can help people with breast cancer, lymphoma, or colorectal cancer manage symptoms while on systemic therapy. Sixty participants will either use the app for 12 weeks or receive standard care. The main …

This study tests whether a home-based exercise and nutrition program, called prehabilitation, can improve physical function in adults aged 65 and older with breast cancer before they have surgery. The program includes strength, balance, and flexibility exercises tailored to each …

This study tests whether a special spa therapy can improve skin-related quality of life in people who have skin hardening (fibrosis) after radiation for breast or head/neck cancer. About 110 adults who finished radiation at least 6 months ago will be randomly assigned to receive …

This study is testing a new surgical technique for breast cancer called endoscopic nipple-sparing mastectomy, done through just one small cut in the armpit. The goal is to remove breast tissue while sparing the nipple and avoiding a large scar on the breast. Ten women with early-…

This study tests whether a new care pathway called AMADeuS, which includes awake surgery, same-day discharge, and telemedicine follow-up, is as safe and effective as standard hospital care for women having mastectomy with immediate breast reconstruction. One hundred women aged 18…

This study tests a three-stage mental health plan for breast cancer survivors in Pakistan who also have depression. Over 26,000 women will start with guided self-help, then move to therapy or medication if needed. The goal is to see if this step-by-step approach can reduce depres…

This study is testing a magnetic tracer called Magtrace for sentinel lymph node biopsy in women with breast cancer who are having a lumpectomy. The main goal is to see how often skin discoloration happens and how it affects patients' quality of life. Researchers will follow 184 p…

This study tests whether a program of targeted exercise and psychological support before cancer treatment (called prehabilitation) can help patients with solid tumors recover better physically and emotionally. Researchers will compare this program to standard care in 125 adults w…

This study tests a new type of radiation therapy that adapts to changes in the body during treatment, aiming to reduce side effects like skin burns and scarring. It includes 500 women with breast cancer who are at high risk of fibrosis (hardening of breast tissue). The goal is to…

This study compares two exercise programs for women who have finished breast cancer treatment. One group does supervised resistance and relaxation exercises at a facility, while the other follows a home-based resistance routine. The goal is to see which approach better improves m…

This study tests whether the order in which mammogram images are taken affects pain and satisfaction in women who have had breast cancer. 400 women who had breast-conserving surgery will be randomly assigned to one of four view sequences during their annual surveillance mammogram…

This study tests if treating insomnia first helps breast cancer survivors lose more weight. 250 women with early-stage breast cancer who are overweight and have insomnia will either get a sleep therapy (CBT-I) or sleep education before starting a weight loss program. Researchers …

About half of women stop taking aromatase inhibitors early due to side effects, raising the risk of cancer returning. This study tests whether switching to a different hormone drug or using other symptom-relief methods works better at managing those side effects. Researchers will…

This study is testing whether resistance training combined with a post-workout protein drink can help women with breast cancer maintain muscle and reduce fat gain while they undergo chemotherapy. Thirty women will be randomly assigned to receive either 20 or 60 grams of whey prot…

This study looks at whether a weekly cycling exercise program can help breast cancer patients maintain their physical fitness during chemotherapy. About 156 women with early-stage breast cancer will either do the cycling program or receive standard care. The goal is to see if the…

This study compares two approaches for breast cancer patients who need a mastectomy and radiation. The experimental group gets radiation before surgery with immediate breast reconstruction, while the standard group gets radiation after surgery with delayed reconstruction. The goa…

This study tests whether a digital support program can help people with breast, prostate, or colorectal cancer reduce the time they spend sitting during their treatment. The goal is to improve their well-being and lower future health risks. About 172 participants will use an acti…

This study tests a non-drug light treatment called photobiomodulation to see if it can improve memory and thinking problems (chemobrain) in women who had chemotherapy for breast cancer. About 200 women who finished chemo within the past year and have ongoing cognitive complaints …

This phase 3 trial is testing whether the corticosteroid dexamethasone can reduce hand-foot syndrome—a painful skin reaction—caused by liposomal doxorubicin chemotherapy in breast cancer patients. 182 participants will receive either high-dose, standard-dose, or no dexamethasone …

This study collects spinal fluid, blood, saliva, and tumor samples from 139 adults with HER2-positive or triple-negative breast cancer that has spread to other organs but not yet to the brain. Researchers will analyze these samples for tumor DNA that might predict when the cancer…

This study is for people with metastatic breast cancer, including estrogen receptor-positive and triple-negative types. It uses biomarkers from tumors and blood to guide treatment choices, comparing how long the cancer stays controlled on the new therapy versus the previous one. …

This study is testing whether a less invasive procedure called target axillary dissection (TAD) can accurately check for cancer spread in the lymph nodes of people with locally advanced breast cancer after chemotherapy. The goal is to see if TAD can replace more extensive lymph n…

This study is testing an online tool called MyMammogram that helps women ages 39-49 decide whether to get a mammogram. The tool also shares the woman's risk and preferences with her doctor before the visit. The goal is to see if this approach works well in rural healthcare settin…

This study follows 100 women with early-stage breast cancer who are receiving standard chemotherapy or anti-HER2 therapy. Researchers will use heart ultrasounds and blood tests to look for early signs of heart damage. The goal is to find better ways to detect cardiac side effects…

This study aims to understand why breast cancer risk and outcomes vary among different people. Researchers will collect blood, tissue, and survey data from 800 adults in South Florida, including those with suspicious breast findings or newly diagnosed breast cancer. By analyzing …

Surgeons use imaging-guided techniques to locate breast tumors they cannot feel, aiming to remove the cancer completely while sparing healthy tissue. This large observational study compares several methods, including wire-guided localization, intraoperative ultrasound, magnetic s…

This study is testing a new PET-CT scanner that takes high-resolution images of tissue removed during cancer surgery. Researchers want to see if these images match lab results and help surgeons make better decisions. The study will include 850 people with prostate, breast, head a…

This international registry follows people who took part in GBG clinical trials for early breast cancer, collecting health information long after those trials end. Researchers track survival, late side effects, and issues related to pregnancy, fertility, and quality of life. The …

Researchers are comparing three ways to check lymph nodes after chemotherapy in people with breast cancer that had spread to the lymph nodes but turned negative with treatment. The study follows 3,000 patients across multiple countries who receive either full lymph node removal, …

Researchers are testing whether breast cancer patients who give consent digitally can reliably report complications after surgery using questionnaires. The study includes 50 women with early invasive breast cancer who are having breast-conserving surgery and a sentinel lymph node…

This study is testing whether a probiotic called BIOHM can change the community of bacteria and fungi (the microbiome) in the breast and gut of people with breast cancer. Researchers will measure certain biomarkers in 100 participants to see if the probiotic has an effect. The go…

Researchers are studying whether blood and tissue samples can show when metastatic breast cancer stops responding to standard first-line treatment with an aromatase inhibitor and a CDK4/6 inhibitor. The study enrolls women with ER-positive, HER2-negative metastatic breast cancer …

This study enrolls 3,300 women with invasive breast cancer living in 59 North Carolina counties. It aims to understand how tumor biology, healthcare access, and patient behavior together affect outcomes. All participants receive a structured program to improve communication with …

This study is auditing a surgical technique called Targeted Sentinel Node Biopsy (TSNB) for breast cancer patients who have a small number of cancer cells in their lymph nodes. The goal is to see if this less invasive procedure can accurately identify cancer spread while causing …

This study is collecting blood samples from 170 people with metastatic breast cancer to look for ESR1 gene mutations, which can make cancer resistant to hormone therapy. Researchers will compare these blood-based results with standard tissue tests. The goal is to better understan…

This study is observing about 800 adults with advanced breast cancer (HER2-positive, low, or ultralow) who are receiving the drug trastuzumab deruxtecan as part of their normal care in Germany. Researchers are tracking how long patients stay on the drug before switching treatment…

This international registry collects data on women who have breast reconstruction with implants placed in front of the chest muscle (pre-pectoral) after mastectomy for breast cancer. Researchers follow participants for surgical complications, aesthetic results, cancer outcomes, a…

This study is testing whether it is safe for women aged 70 and older with small, screen-detected, ER+/HER2- breast cancers to simply monitor the tumor with regular ultrasounds instead of undergoing immediate treatment like surgery or radiation. The main goal is to see how many tu…

This study looks at people who have a gene variant (called a secondary finding) that was found during genetic testing for another reason. Researchers want to understand how these variants affect health, how people respond to the news, and whether they follow medical advice. Up to…

This study tests a new way to mark the area where a breast tumor was removed, so radiation therapy can be more accurately aimed afterward. About 50 adults with early-stage breast cancer or a precancerous condition called DCIS will take part. The goal is to see if this marking hel…

This observational study in Vietnam looks at archived tumor samples from patients with several solid cancers, including liver, colorectal, gastric, breast, lung, endometrial, melanoma, and pancreatic cancer. Researchers will measure the presence of two proteins, ENPP1/cGAS and FA…

This study looks at how bacteria inside tumors and the immune cells around them affect how well triple-negative breast cancer responds to chemotherapy and immunotherapy. Researchers will collect tumor, blood, and stool samples from 30 women before and during treatment. They want …

This study looks at whether starting with a lower dose of CDK4/6 inhibitor pills (palbociclib or ribociclib) and gradually increasing the dose helps older adults (age 65+) with metastatic breast cancer tolerate side effects better and stay on treatment longer. About 500 participa…

This study aims to understand why some breast cancers become resistant to therapy. Researchers will analyze tumor and blood samples from 320 people with HER2-positive, hormone receptor-positive, or triple-negative breast cancer. The goal is to identify changes in cancer cells tha…

This study follows post-menopausal women with breast cancer who have stopped taking aromatase inhibitors and denosumab, two medications that affect bone. Researchers will monitor bone turnover markers, fractures, and overall bone health over 24 months through clinic visits and bl…

This study follows 500 women with early-stage invasive breast cancer who had breast-conserving surgery without sentinel lymph node biopsy or other axillary surgery. All participants receive adjuvant radiotherapy as part of their routine care. Researchers will track cancer recurre…

This study aims to screen 450 early-stage breast cancer survivors for prediabetes, diabetes, high cholesterol, and heart disease risk. Participants complete surveys and provide lab results, and those with risk factors are directed to community resources. The goal is to catch and …

This study tests a decision aid called BREASTChoice in 20 breast cancer patients who had breast surgery. Participants use the tool on their phones and share their thoughts in interviews. Researchers measure how much patients learn about reconstruction options using a knowledge su…

This study is building a large registry of up to 200,000 people in the U.S. who have had breast cancer. The goal is to collect a wide range of data—from medical records to personal experiences—that reflects the country's diverse patient population. Researchers will use this de-id…

This study is looking at whether a simple blood test can find tiny bits of cancer DNA left in the body after breast cancer treatment. These leftover cells, called minimal residual disease (MRD), can sometimes cause the cancer to come back. The study will follow 900 breast cancer …

This study looks at whether a blood test can find tiny bits of tumor DNA left after breast cancer surgery. It includes 100 women with early-stage breast cancer that spread to 1-3 lymph nodes. The goal is to see if this test can help predict which patients are more likely to have …

This study collects blood and tissue samples from 2000 people—some with cancer and some without—to create a blinded reference set. Researchers will use these samples to evaluate how well new blood tests can detect many types of cancer early. The goal is to improve the accuracy of…

This study is creating a registry for people with a rare type of breast cancer called invasive lobular carcinoma that has spread. Researchers will collect data from about 12 participants to develop a new tool that better measures how well treatments are working. The goal is to im…

This study tests whether a new type of adaptive radiotherapy can reduce radiation exposure to the ovaries in young women (ages 18-50) receiving pelvic radiation for cancers like uterine, rectal, or cervical cancer. Using advanced imaging and an AI treatment planning system, resea…

This study looks at whether women with a certain type of breast cancer (hormone-sensitive, HER2-negative, with 1-3 positive lymph nodes and a low RecurIndex score) can safely avoid radiation therapy to the lymph nodes. Researchers will follow 635 participants over time to see how…

This study collects blood and other biospecimens from adults with cancer to analyze immune-suppressing cells and genetic changes. Up to 1,750 participants will provide samples before and after chemotherapy. The goal is to better understand how cancer affects the immune system, bu…

This study investigates whether adding environmental exposure risk assessments to standard care is useful and acceptable for women at average or high risk of breast cancer, as well as those diagnosed with early-onset breast cancer. Researchers will survey patients and providers a…

This study collects blood or cheek swab samples from 1,100 cancer patients at the National Cancer Institute to analyze genetic differences that may influence how their bodies process cancer treatments. The goal is to understand why some patients experience more side effects or le…

This large Swedish study collects tumor samples from 20,000 people with breast cancer to map their genetic profiles. Researchers will analyze RNA and DNA to link gene patterns with patient outcomes, such as survival and response to therapy. The goal is to develop new molecular di…

This study looks at whether medical imaging can predict the growth patterns of liver metastases from colorectal and breast cancer. Researchers will take removed liver tumors and map them in 3D, comparing the tissue details with CT and MRI scans taken before surgery. The goal is t…

This study enrolls 7,000 people with various cancers who have had or will have treatment aimed at a cure. Researchers collect blood, tissue, urine, and saliva samples over time to look for tiny bits of cancer DNA left behind. The goal is to find any remaining cancer as early as p…

This pilot study will test a decision support tool called COAST, available as a booklet and website, designed to help people with stage IV breast cancer have better conversations with their doctors about treatment options. About 100 patients will use the tool and fill out surveys…

This observational study is following about 2,400 adults with non-small cell lung cancer or breast cancer to see how biomarkers, including whole-genome sequencing, relate to their outcomes. Participants receive their usual cancer care, and researchers track progression-free survi…

This study is testing a new web and mobile app called SHIELD, designed to support women with hormone receptor-positive breast cancer who are on long-term hormone therapy. The goal is to see if the app is easy to use and helpful for managing treatment. About 30 women will particip…

This study will follow about 109 women in Gulf Cooperation Council (GCC) countries who have a certain type of advanced breast cancer (HR-positive, HER2-low or ultra-low) and are taking the drug trastuzumab deruxtecan after hormone therapy stopped working. Researchers want to see …

This trial tests a new imaging method called ultrasound optical tomography (UOT), which combines ultrasound and laser light to create images of tissues inside the body. The goal is to see how deep the technique can image and how well it can measure tissue oxygenation in healthy v…

The AURORA study is collecting tumor and blood samples from 1,300 people with metastatic breast cancer across Europe. By analyzing genetic changes in both the original and metastatic tumors, researchers hope to understand why some patients respond well to therapy while others do …

This study follows premenopausal women with a common type of early breast cancer to see how well different treatments work over time. Participants either receive hormone therapy (with or without ovarian suppression) or chemotherapy followed by hormone therapy. The goal is to unde…

This study looks at how imaging settings and biological factors affect texture features in mammograms. Researchers will use an AI tool to analyze mammograms from 200 women undergoing mastectomy. The goal is to understand these influences to make AI-based breast cancer detection m…

This study is a large registry that will follow about 2,000 adults in China with a type of advanced breast cancer called HR+/HER2- (including HER2-low, HER2-ultralow, and HER2-null). The goal is to describe the patients' characteristics, genetic testing, treatment patterns, and o…

This trial asks whether five advanced AI models can match the treatment recommendations of expert tumor boards for cancer patients. Using 100 standardized synthetic cases across breast, lung, urological, digestive, and gynecological cancers, each AI and two independent tumor boar…

This study aims to see if a simple finger-prick blood test can accurately measure levels of certain breast cancer drugs (CDK4/6 inhibitors) compared to standard blood draws from a vein. About 90 breast cancer patients currently taking these drugs will provide both types of blood …

This study tests whether measuring calcium buildup in heart arteries from routine radiotherapy planning CT scans can identify breast cancer patients at risk for heart disease. Researchers will share this personalized risk information with patients and their doctors to see if it i…

This study tests whether having a specialist review genetic test results and guide treatment decisions can increase the use of targeted therapies for people with advanced solid tumors, including breast, lung, colorectal, and bladder cancers. Participants will have their tumor or …

This study looks at the bacteria living in the mouth, stool, and tumors of Colombian adults with advanced cancers of the stomach, colon, breast, cervix, or head and neck who are starting immunotherapy as standard care. Researchers will compare these microbial profiles to those of…

This study uses ultra-high frequency ultrasound (UHFUS) and a green dye to map lymphatic channels in the arms of breast cancer patients scheduled for lymph node surgery. The goal is to better understand normal lymphatic anatomy, which could help reduce the risk of lymphedema (arm…

This study investigates clonal hematopoiesis (CH) — small mutations in blood cells that can arise naturally or after cancer treatment — in adults receiving chemotherapy or radiation for solid tumors like breast, lung, or colorectal cancer. Researchers will collect blood, saliva, …

This study is building a huge registry of information and biological samples from adults with or at risk for many types of cancer, as well as healthy volunteers. Researchers will use this resource to study what causes cancer and how to better prevent, detect, and treat it. The re…

This study follows 500 postmenopausal women with advanced ER+ HER2- breast cancer that has an ESR1 mutation. Participants receive elacestrant as part of their normal care. Researchers will track quality of life, side effects, and how the cancer responds over time. The goal is to …

The MILES Study is tracking 100 women recently diagnosed with early-stage breast cancer to see how their diet and physical activity change over time. Participants fill out surveys and provide urine samples, which researchers analyze for chemical markers. The goal is to develop si…

This study looks at breast cancer that has spread to the brain. Researchers want to understand how much of the drug trastuzumab deruxtecan gets into the fluid around the brain and spinal cord, and whether that amount relates to how well the drug shrinks brain tumors. About 60 adu…

This study looks at whether breast cancer patients on HER2-targeted therapy can safely have fewer heart tests. Currently, patients get heart scans every three months, but most don't change treatment. Researchers will test a personalized schedule based on heart risk, comparing it …

This study is collecting detailed genetic and health information from 500 people with various cancers, including breast, lung, and leukemia. The goal is to create a shared database that helps researchers develop more personalized treatments. Participants provide samples and data,…

This study is testing whether using an MRI scan before radiation therapy can help doctors plan treatment more accurately for breast cancer. About 20 people will take part. The main goal is to see if adding an MRI to the usual planning process is practical and works well.

This study is following over 6,000 breast cancer patients in Germany to see what treatments they actually receive in routine care and how they fare over time. Researchers are collecting data on treatment patterns, survival, and quality of life from patients with early and advance…

This study aims to collect and analyze tumor samples from 10,000 adults with advanced solid cancers (like breast, lung, or colon cancer) to create a province-wide gene database. The goal is to help doctors identify which targeted drugs or clinical trials might work best for each …

This study is for people with metastatic triple-negative breast cancer who are already receiving the drug sacituzumab govitecan as part of their routine care. Researchers want to see how well the drug works in everyday practice and find biological markers (biomarkers) that predic…

This observational study will analyze tumor tissue from 100 people with BRCA1 or BRCA2 mutations and HR-positive, HER2-negative breast cancer. Researchers want to see if different molecular subtypes are linked to how well patients respond to hormone therapy or CDK4/6 inhibitors. …

This study looks at whether women who finished treatment for early-stage breast cancer can safely reduce their hospital follow-up visits from five years to just two years, while still getting yearly mammograms. About 560 women will take part, with half following the usual schedul…

This study compares three different blood tests (CellSearch, Parsortix, and SmartCatch) to see which one best detects circulating tumor cells in patients with metastatic breast or prostate cancer. Researchers will take blood samples from 54 patients before they start a new treatm…

This study looks at whether a family history screening program can help more women in rural public health clinics get tested for genetic risks linked to breast and ovarian cancer. About 3,200 women over age 25 will take part. The goal is to see if the program increases the number…

This study gathers information from over 42,000 people with metastatic breast cancer treated at 18 French cancer centers since 2008. Researchers will look at how treatments have changed over time and how they affect survival. The goal is to learn from real-world data to improve f…

This pilot study is testing whether a 7-day integrative oncology retreat called 'Via Shalva' is practical and helpful for women who have finished primary treatment for breast or gynecologic cancer. Thirty participants will either attend the retreat or receive usual follow-up care…

This observational study tracks 800 people with metastatic breast cancer to see if differences in HER2 levels across tumors affect how well trastuzumab deruxtecan works. Researchers will compare progression-free and overall survival based on HER2 patterns. The goal is to better u…

This study is developing an AI system that tracks tumors and organs during radiation therapy without needing physical markers. Researchers will use existing patient data to train and test the AI. If it works, it could help doctors target radiation more accurately. The study invol…

This study reviews medical records of 600 people with HER2+ or triple-negative breast cancer who had chemotherapy and still had cancer in their lymph nodes. The goal is to see if skipping additional lymph node removal (axillary dissection) leads to more cancer coming back in the …

This pilot study tests whether a fluorescent dye called indocyanine green (ICG) can effectively identify sentinel lymph nodes in breast cancer patients, potentially replacing the standard radioactive tracer. Forty women with early-stage breast cancer will receive both methods, an…

This study is a worldwide registry that follows 5,000 adults with breast cancer, blood cancers, or those on immune checkpoint inhibitors. Researchers collect medical records, lab results, and imaging to identify who is at risk for heart problems during or after cancer treatment. …

This study is for people with advanced cancers who are taking long-term targeted treatments. Researchers want to learn about their experiences through interviews. The goal is to find better ways to support these patients. The study is currently recruiting 75 participants.

This study looks at how well standard chemotherapy works in people with triple-negative breast cancer, an aggressive type that lacks targeted treatments. Researchers will also measure tiny molecules called microRNAs and tumor DNA in the blood to see if changes can signal when the…

This study looks at whether women who finished breast cancer treatment can safely have fewer in-person check-ups after two years, while still getting yearly mammograms. Researchers want to see if this simpler plan improves quality of life without increasing the risk of cancer com…

This study aims to understand why some breast cancer patients experience 'chemobrain'—problems with memory, concentration, and thinking after chemotherapy. Researchers will track 50 patients before, during, and after chemo using brain scans, blood tests, and thinking tests. They …

This study is testing new drug combinations for breast cancer to see which ones work best for different tumor types. It involves up to 5,000 people with early-stage or locally advanced breast cancer. Researchers use MRI scans and tissue samples before surgery to predict treatment…

This study takes tumor samples from people with triple-negative breast cancer, colorectal cancer, or ovarian cancer and grows them in mice. Researchers then test different drugs on these mouse tumors to see which ones might work best for each person. The goal is to provide person…

This study looks at how common and severe menopause-like symptoms (like vaginal dryness and pain) are in breast cancer survivors compared to healthy women. Researchers will ask 264 women to fill out questionnaires about their symptoms, quality of life, and mental health. The goal…

This study is testing whether tiny particles in the blood, called extracellular vesicles, can predict nerve damage caused by chemotherapy. Researchers will follow 120 adults with various cancers who are receiving specific chemo drugs. Participants give blood samples and answer qu…

This study follows 1,000 young women with breast cancer to learn more about preserving fertility and having healthy pregnancies. It collects data on which fertility treatments patients choose, how well they work, and the safety of cancer treatment during pregnancy. The goal is to…

This study is looking at how the immune system responds to breast and ovarian cancers. Researchers will analyze tumor and blood samples from 160 women before surgery to understand immune cell activity and find markers that might predict survival. The goal is to learn more about h…

This study aims to understand the current state of breast cancer care by surveying both patients and doctors. The goal is to identify gaps in communication and time management, and to develop new, patient-focused care models. About 2000 adults with breast cancer and their physici…

This study is testing a device called ScreenCell that counts circulating tumor cells (CTCs) in a blood sample from breast cancer patients. Researchers want to see if changes in CTC numbers over time can help track how the cancer is progressing. The study will include 93 women wit…

This study tests a decision-making toolkit for women aged 80 and older who have had breast cancer. The toolkit provides clear information to help them and their doctors decide whether to continue yearly mammograms. Researchers will track how many mammograms participants get over …

This observational study is following 1,000 people with HER2-positive breast cancer who are receiving a pertuzumab biosimilar as part of their routine care. The goal is to see how doctors are using the drug and how well it works in both neoadjuvant (before surgery) and first-line…

This study uses online surveys to learn about the real-life experiences of people diagnosed with cancer and their caregivers. Researchers want to understand the emotional, physical, social, and financial challenges they face. The goal is to use this information to improve support…

This study explores whether using alternative and complementary therapies, like turmeric supplements, affects how well early-stage breast cancer patients stick to their tamoxifen treatment. Researchers will follow 200 patients for one day to measure medication adherence and tamox…

This study is for 500 adults with non-metastatic breast cancer who are about to start treatment like chemotherapy or targeted therapy before surgery. Researchers will collect tumor tissue, blood, and sometimes stool samples and MRI scans during treatment. The goal is to learn why…

This study looks at how a 13-week physical activity program influences motivation and psychological well-being in 80 women undergoing breast cancer treatment. Participants will complete questionnaires about their attitudes, confidence, and mood. The goal is to understand what hel…

This study is a registry that collects information from 1867 people with advanced breast cancer that cannot be removed by surgery or has spread. Researchers will track different breast cancer subtypes and patient characteristics to better understand the disease in real-world sett…

This study tests whether a decision aid and training for surgeons can help women aged 70 and older with low-risk stage I breast cancer make better treatment choices. About 402 participants will be split into two groups: one where surgeons get shared decision-making training and p…

This study tests whether a new 3D imaging method used during breast cancer surgery helps surgeons remove all cancer cells the first time. About 314 women having breast-conserving surgery will be randomly assigned to either standard 2D imaging or the new 3D imaging. The goal is to…

This study looks at whether it's possible to routinely scan the brains of people with HER2-positive metastatic breast cancer to find cancer spread early. About 69 participants will get a baseline brain MRI, and if no brain tumors are found, they'll be randomly assigned to either …

This study is collecting medical data, blood samples, and lifestyle information from 300 people with early breast cancer. The goal is to create a computer algorithm that can predict whether a patient will have a complete response to chemotherapy before they start treatment. This …

This study looks at the fluid around the brain (cerebrospinal fluid) in people with breast cancer that has spread to the brain or its lining. Researchers collect this fluid to study the cancer's genetic material without needing surgery. The goal is to better understand why breast…

This study will test how well artificial intelligence (AI) can interpret breast ultrasound images using the latest BI-RADS criteria. Researchers will collect over 1,300 past ultrasound images with confirmed diagnoses and have expert radiologists annotate them. Then, various AI mo…

This study will analyze the genes of 25,000 adults who have cancer or are at risk for it. Researchers will use advanced testing to find genetic changes linked to cancer and track health records over time. The goal is to learn more about cancer biology and discover new ways to per…

This study looks at whether a deep inspiration breath-hold (DIBH) technique during radiation therapy for breast cancer keeps the radiation dose on target and protects nearby organs. About 25 women who have had breast cancer surgery will be observed. The goal is to see if the plan…

This study collects tumor and blood samples from 100 breast cancer patients to grow mini-tumors (organoids) in the lab. Researchers will then test whether specially engineered immune cells called CAR-macrophages can destroy these mini-tumors. The goal is to see if this new cell t…

This study tests whether tattooing the skin over a breast tumor before chemotherapy can help surgeons later remove the cancer completely while saving as much healthy breast tissue as possible. Thirty women with breast cancer will get their tumor edges marked with tattoo ink, then…

This pilot study looks at how social determinants of health—like housing, food, and transportation—relate to inflammation in women newly diagnosed with breast cancer. Participants fill out surveys and give a blood sample at a single visit. The goal is to understand these connecti…

This study is looking at a genomic test called EndoPredict that analyzes tumor genes to predict the risk of breast cancer returning. The goal is to see if women with a low-risk score can safely skip chemotherapy and only take hormone therapy. Researchers will follow 1,000 patient…

This study looks at whether it is possible to take multiple tissue samples (biopsies) from different tumor sites in people with metastatic breast cancer at different times during treatment. The goal is to learn how cancers change and become resistant to therapy. About 200 adults …

This study is looking for better ways to predict who might develop or have a return of certain cancers, including breast, colon, ovarian, melanoma, and lung cancer. Researchers will collect blood samples from 850 participants to study genetic and other biological markers. The goa…

This study looks at how certain natural fats from food affect inflammation in postmenopausal women, especially those with breast cancer and obesity. Researchers will measure body fat, diet, activity, and quality of life in 60 women divided into four groups. No treatment is given—…

This study is a large registry that will follow about 8,000 cancer patients who receive radiation therapy using a special machine called an MR-Linac, which combines an MRI scanner with a radiation beam. The goal is to learn how well this technology works for different cancers, in…

This study will follow 319 women with early-stage, hormone-sensitive, HER2-negative breast cancer to see how well they take their prescribed aromatase inhibitors, with or without the added drug abemaciclib. Researchers will measure adherence using pill counts and questionnaires a…

This study tests a magnetic tracer and clip to mark lymph nodes before chemotherapy in breast cancer patients. The goal is to see if this method can reliably find the sentinel lymph node during surgery after chemo. About 459 adults with breast cancer will take part. The approach …

This study looks at the genetic makeup of breast cancer tumors from 1,600 people to find changes that could help doctors choose more targeted therapies. It uses a special test to analyze over 500 cancer-related genes. The goal is to see if this testing can identify more treatment…

This study is collecting tumor and blood samples from 120 people with advanced, HER2-negative breast cancer who have a BRCA1/2 mutation. Researchers want to see if certain DNA repair proteins (POLQ, Shieldin complex, 53BP1) can predict whether a tumor will resist PARP inhibitor d…

This study looks at how breast density affects mammogram accuracy in women aged 45 to 75. Dense breast tissue can make cancers harder to see, leading to missed tumors or unnecessary follow-up tests. Researchers will review past mammograms and test a software tool that automatical…

This study is for people with high-risk early breast cancer, including inflammatory breast cancer. Researchers want to see if clusters of tumor cells found in the blood can help predict how well treatment works and the chances of survival. About 130 participants will give blood s…

This study is testing whether educational videos and brochures can help Spanish-speaking Latinx patients with breast or prostate cancer better understand their radiation therapy and clinical trials. About 194 participants will watch videos or read brochures, then answer questions…

This study looks at whether a precise type of radiation called SBRT can help people with breast cancer that has spread to only a few spots in the body (oligometastatic). Researchers will review medical records from 300 patients to see if SBRT improves how long the cancer stays un…

This study follows 2000 people with early-stage, hormone-sensitive breast cancer to see how doctors decide on treatments, especially when using a test called EndoPredict. The goal is to track long-term outcomes like cancer return and survival over 5 to 10 years. No new treatments…

This study looks at people with a specific genetic change in the CTNNA1 gene, which may increase the risk of stomach and breast cancers. Researchers will collect family health histories from 100 participants to better understand these risks. The goal is to improve cancer screenin…

This study looks at whether a protein called SGLT2 is linked to heart damage caused by a common type of breast cancer chemotherapy. Researchers will measure SGLT2 levels in blood and cells from 50 women with localized breast cancer before and after treatment. The goal is to find …

This study looks at whether giving doctors the molecular subtype of a patient's metastatic breast cancer helps them pick more effective treatments. It involves 500 adults with metastatic breast cancer who are starting or have had one prior treatment. The main goal is to see how o…

The CATCH trial is a large observational study for people with metastatic breast cancer. It uses advanced genetic testing on tumor biopsies to find unique biomarkers and drug targets. The goal is to create a precision medicine platform that helps guide patients toward the most pr…

This study looks at how common severe fear of cancer recurrence is among people treated for breast or lung cancer. Researchers will survey 200 patients and interview 40 of them to understand their experiences and what kind of support they need. The goal is to find better ways to …