Can a hormone shot help fight advanced breast cancer? new trial begins
NCT ID NCT07310420
First seen Jun 25, 2026 · Last updated Jul 15, 2026 · Updated 4 times
Summary
This Phase 1 trial is testing ZOLADEX (goserelin), a hormone-blocking implant, in 88 premenopausal women with HR+/HER2- advanced breast cancer. The goal is to see if it can temporarily shut down ovarian function, which may help control the cancer. Participants receive two injections over 12 weeks, and researchers will measure hormone levels and menstrual changes.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- ZOLADEX (goserelin implant)
- What this could lead to
- If successful, this could show that ZOLADEX effectively suppresses ovarian function, helping manage hormone-sensitive advanced breast cancer in premenopausal women.
- What could go wrong
- This is an early Phase 1 trial with only 88 participants, so results are preliminary. It focuses on hormone suppression, not tumor shrinkage, and may not lead to improved outcomes.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for ADVANCED BREAST CANCER are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Study contacts
-
Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
-
Cancer Centers of Florida
RECRUITINGOcoee, Florida, 34761, United States
Contact
-
Duly Health and Care
RECRUITINGLisle, Illinois, 60532, United States
Contact
-
Genesis Cancer and Blood Institute
RECRUITINGHot Springs, Arkansas, 71913, United States
Contact
-
Guthrie Medical Group
RECRUITINGSayre, Pennsylvania, 18840, United States
Contact
-
MedStar Heart & Vascular Institute (MHVI) - MedStar Washington Hospital Center
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact
-
Montefiore Medical Center
RECRUITINGEast Syracuse, New York, 13057, United States
Contact
-
NorthShore University HealthSystem - Evanston Hospital
RECRUITINGEvanston, Illinois, 60201, United States
Contact
-
Oncology Consultants PA
RECRUITINGHouston, Texas, 77030, United States
Contact
-
Orchard Healthcare Research
RECRUITINGSkokie, Illinois, 60077, United States
Contact
-
Profound Research LLC at Michigan Hematology and Oncology Consultants
RECRUITINGRoyal Oak, Michigan, 48073, United States
Contact
-
San Juan Oncology Associates
RECRUITINGFarmington, New Mexico, 87401, United States
Contact
-
St. Vincent Frontier Cancer Center (SVFCC) - Billings (Frontier Cancer Center and Blood Institute)
RECRUITINGBillings, Montana, 59102-6746, United States
Contact
-
Summit Cancer Care
RECRUITINGSavannah, Georgia, 31405, United States
Contact
-
The Blavatnik Family, Chelsea Medical Center at Mount Sinai
RECRUITINGMount Sinai, New York, 10011, United States
Contact
-
The Mark H. Zangmeister Center-Mid Ohio Oncology/Hematology, Inc.
RECRUITINGColumbus, Ohio, 43219, United States
Contact
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Blood tests could reveal hidden resistance in breast cancer
- Triple threat: three new targeted drugs join forces with immunotherapy to attack Hard-to-Treat breast cancer
- New drug sequence aims to outsmart advanced breast cancer
- Could a pill replace an IV for advanced breast cancer treatment?
- Blood test timing could unlock secrets of advanced breast cancer
- Oral chemotherapy pill tested for advanced breast cancer