Could thousands of women skip hormone therapy after breast cancer?
NCT ID NCT07661927
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This trial investigates whether women aged 60 and older with a very small, low-risk type of breast cancer can safely avoid hormone therapy after surgery. Participants will not receive standard drugs like tamoxifen or letrozole, and researchers will track cancer recurrence for up to five years. The goal is to see if skipping treatment maintains a low relapse rate while improving quality of life and reducing side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
no endocrine therapy (omission of tamoxifen, letrozole, anastrozole, or exemestane)
What this could lead to
If successful, this could spare many older women the side effects of hormone therapy while maintaining a low risk of cancer returning.
What could go wrong
This is a single-arm Phase 2 trial, so results are compared to historical data. It may show that skipping therapy increases relapse risk or that the selected population is not as low-risk as assumed.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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CH Annecy Genevois
Épagny, France
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CH Aunay-Bayeux
Bayeux, France
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CH Boulogne sur mer
Boulogne-sur-Mer, France
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CH de Bligny
Briis-sous-Forges, France
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CHCB
Bayonne, France
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CHD Vendée
La Roche-sur-Yon, France
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CHI de Mont-de-Marsan
Mont-de-Marsan, France
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CHP Sainte Marie
Osny, France
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CHU Orleans
Orléans, France
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CHU Tours
Tours, France
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CHU de Limoges
Limoges, France
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CHU de Saint Etienne
Saint-Priest-en-Jarez, France
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Centre Antoine Lacassagne
Nice, France
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Centre Eugène Marquis
Rennes, France
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Centre Francois Baclesse
Caen, France
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Centre Georges François Leclerc
Dijon, France
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Centre Guillaume le Conquérant
Le Havre, France
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Centre Henri Becquerel
Rouen, France
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Centre Jean Perrin
Clermont-Ferrand, France
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Centre Leonard de Vinci
Dechy, France
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Centre Léon Bérard
Lyon, France
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Centre Oscar Lambret
Lille, France
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Centre de lutte contre le cancer - Paul Strauss
Strasbourg, France
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Clinique Pasteur Lanroze
Brest, France
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Clinique Tivoli
Bordeaux, France
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Groupe Hospitalier Bretagne Sud
Lorient, France
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Groupe Hospitalier Paris Saint Joseph
Paris, France
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Groupe UNEOS-Hôpital Robert Schuman
Vantoux, France
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Hôpital Privé Clairval
Marseille, France
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Hôpital privé Jean Mermoz
Lyon, France
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Hôpitaux du Léman
Thonon-les-Bains, France
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IUCT-Oncopole
Toulouse, France
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Ico Angers
Angers, France
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Ico Saint Herblain
Saint-Herblain, France
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Institut Bergonié
Bordeaux, France
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Institut Curie
Paris, France
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Institut Curie
Saint-Cloud, France
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Institut Paoli-Calmettes
Marseille, France
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Institut de Cancérologie de Lorraine
Vandœuvre-lès-Nancy, France
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Pole Sante Leonard de Vinci- Roc37
Chambray-lès-Tours, France
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Sainte Catherine, Institut du Cancer Avignon-Provence
Avignon, France
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