Could thousands of women skip hormone therapy after breast cancer?

NCT ID NCT07661927

Recruiting now Disease control Sponsor: UNICANCER Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 17, 2026 · Updated 1 time

Summary

This trial investigates whether women aged 60 and older with a very small, low-risk type of breast cancer can safely avoid hormone therapy after surgery. Participants will not receive standard drugs like tamoxifen or letrozole, and researchers will track cancer recurrence for up to five years. The goal is to see if skipping treatment maintains a low relapse rate while improving quality of life and reducing side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: no endocrine therapy (omission of tamoxifen, letrozole, anastrozole, or exemestane)
What this could lead to: If successful, this could spare many older women the side effects of hormone therapy while maintaining a low risk of cancer returning.
What could go wrong: This is a single-arm Phase 2 trial, so results are compared to historical data. It may show that skipping therapy increases relapse risk or that the selected population is not as low-risk as assumed.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER, EARLY BREAST CANCER

Contacts and locations

Locations

CH Annecy Genevois
ACTIVE_NOT_RECRUITING

Épagny, France
CH Aunay-Bayeux
NOT_YET_RECRUITING

Bayeux, France
CH Boulogne sur mer
NOT_YET_RECRUITING

Boulogne-sur-Mer, France
CH de Bligny
NOT_YET_RECRUITING

Briis-sous-Forges, France
CHCB
NOT_YET_RECRUITING

Bayonne, France
CHD Vendée
NOT_YET_RECRUITING

La Roche-sur-Yon, France
CHI de Mont-de-Marsan
ACTIVE_NOT_RECRUITING

Mont-de-Marsan, France
CHP Sainte Marie
NOT_YET_RECRUITING

Osny, France
CHU Orleans
NOT_YET_RECRUITING

Orléans, France
CHU Tours
NOT_YET_RECRUITING

Tours, France
CHU de Limoges
NOT_YET_RECRUITING

Limoges, France
CHU de Saint Etienne
NOT_YET_RECRUITING

Saint-Priest-en-Jarez, France
Centre Antoine Lacassagne
NOT_YET_RECRUITING

Nice, France
Centre Eugène Marquis
NOT_YET_RECRUITING

Rennes, France
Centre Francois Baclesse
NOT_YET_RECRUITING

Caen, France
Centre Georges François Leclerc
NOT_YET_RECRUITING

Dijon, France
Centre Guillaume le Conquérant
ACTIVE_NOT_RECRUITING

Le Havre, France
Centre Henri Becquerel
NOT_YET_RECRUITING

Rouen, France
Centre Jean Perrin
NOT_YET_RECRUITING

Clermont-Ferrand, France
Centre Leonard de Vinci
NOT_YET_RECRUITING

Dechy, France
Centre Léon Bérard
ACTIVE_NOT_RECRUITING

Lyon, France
Centre Oscar Lambret
ACTIVE_NOT_RECRUITING

Lille, France
Centre de lutte contre le cancer - Paul Strauss
NOT_YET_RECRUITING

Strasbourg, France
Clinique Pasteur Lanroze
NOT_YET_RECRUITING

Brest, France
Clinique Tivoli
NOT_YET_RECRUITING

Bordeaux, France
Groupe Hospitalier Bretagne Sud
RECRUITING

Lorient, France
Groupe Hospitalier Paris Saint Joseph
NOT_YET_RECRUITING

Paris, France
Groupe UNEOS-Hôpital Robert Schuman
NOT_YET_RECRUITING

Vantoux, France
Hôpital Privé Clairval
NOT_YET_RECRUITING

Marseille, France
Hôpital privé Jean Mermoz
NOT_YET_RECRUITING

Lyon, France
Hôpitaux du Léman
NOT_YET_RECRUITING

Thonon-les-Bains, France
IUCT-Oncopole
NOT_YET_RECRUITING

Toulouse, France
Ico Angers
NOT_YET_RECRUITING

Angers, France
Ico Saint Herblain
NOT_YET_RECRUITING

Saint-Herblain, France
Institut Bergonié
NOT_YET_RECRUITING

Bordeaux, France
Institut Curie
ACTIVE_NOT_RECRUITING

Paris, France
Institut Curie
NOT_YET_RECRUITING

Saint-Cloud, France
Institut Paoli-Calmettes
NOT_YET_RECRUITING

Marseille, France
Institut de Cancérologie de Lorraine
NOT_YET_RECRUITING

Vandœuvre-lès-Nancy, France
Pole Sante Leonard de Vinci- Roc37
NOT_YET_RECRUITING

Chambray-lès-Tours, France
Sainte Catherine, Institut du Cancer Avignon-Provence
NOT_YET_RECRUITING

Avignon, France

More trials for these conditions

Other studies related to the condition(s) this trial covers.