New pill aims to keep breast cancer from coming back

NCT ID NCT05952557

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Aug 11, 2026 · Updated 3 times

Summary

This Phase 3 trial is testing a new daily pill called camizestrant against standard hormone therapies (like tamoxifen or aromatase inhibitors) in 5,500 people with ER+/HER2- early breast cancer who have a moderate-to-high risk of the cancer returning. Participants take the drug for up to 7 years after completing initial treatments like surgery and chemotherapy. The goal is to see if camizestrant is better at preventing the cancer from coming back, either in the breast or elsewhere in the body.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: camizestrant (oral selective estrogen receptor degrader)
What this could lead to: If successful, camizestrant could offer a more effective way to prevent breast cancer from coming back after initial treatment, potentially reducing the need for longer or stronger therapies.
What could go wrong: This is a large Phase 3 trial, but results are not yet known. Camizestrant may not prove better than current hormone therapies, and side effects could be similar or worse. The study requires 7 years of treatment, so long-term adherence and tolerability are key concerns.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast cancer breast neoplasm estrogen-receptor positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST CANCER, EARLY BREAST CANCER

Contacts and locations

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Dothan, Alabama, 36303, United States
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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85745, United States
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Fayetteville, Arkansas, 72703, United States
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Duarte, California, 91010, United States
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Fountain Valley, California, 92708, United States
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Irvine, California, 92618, United States
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La Jolla, California, 92093, United States
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Los Angeles, California, 90017, United States
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Walnut Creek, California, 94598, United States
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West Hollywood, California, 90048, United States
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Aurora, Colorado, 80045, United States
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Littleton, Colorado, 80120, United States
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Littleton, Colorado, 80129, United States
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New Haven, Connecticut, 06510, United States
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Newark, Delaware, 19713, United States
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Clearwater, Florida, 33756, United States
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Fort Myers, Florida, 33901, United States
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Gainesville, Florida, 32610, United States
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Jacksonville, Florida, 32224, United States
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Pembroke Pines, Florida, 33028, United States
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Plantation, Florida, 33322, United States
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Plantation, Florida, 33324, United States
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St. Petersburg, Florida, 33705, United States
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St. Petersburg, Florida, 33709, United States
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Tallahassee, Florida, 32308, United States
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West Palm Beach, Florida, 33401, United States
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Atlanta, Georgia, 30318, United States
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Marietta, Georgia, 30060, United States
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Thomasville, Georgia, 31792, United States
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Chicago, Illinois, 60637, United States
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Elmhurst, Illinois, 60126, United States
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Naperville, Illinois, 60540, United States
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Urbana, Illinois, 61801, United States
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Fort Wayne, Indiana, 46804, United States
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Des Moines, Iowa, 50309, United States
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Louisville, Kentucky, 40202, United States
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New Orleans, Louisiana, 70121, United States
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Scarborough, Maine, 04074, United States
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Annapolis, Maryland, 21401, United States
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Bethesda, Maryland, 20817, United States
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Towson, Maryland, 21204, United States
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Boston, Massachusetts, 02111, United States
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Boston, Massachusetts, 02115, United States
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Detroit, Michigan, 48202, United States
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Ypsilanti, Michigan, 48197, United States
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Minneapolis, Minnesota, 55416, United States
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Rochester, Minnesota, 55905, United States
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Kansas City, Missouri, 64111, United States
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St Louis, Missouri, 63110, United States
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St Louis, Missouri, 63131, United States
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Lincoln, Nebraska, 68506, United States
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Omaha, Nebraska, 68124, United States
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Hooksett, New Hampshire, 03106, United States
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Manchester, New Hampshire, 03103, United States
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New Brunswick, New Jersey, 08901, United States
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Albuquerque, New Mexico, 87109, United States
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Farmington, New Mexico, 87401, United States
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Bay Shore, New York, 11706, United States
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East Syracuse, New York, 13057, United States
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Greenlawn, New York, 11740, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10029, United States
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New York, New York, 10065, United States
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Stony Brook, New York, 11794, United States
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White Plains, New York, 10601, United States
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Charlotte, North Carolina, 28204, United States
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Pinehurst, North Carolina, 28374, United States
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Raleigh, North Carolina, 27607, United States
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Winston-Salem, North Carolina, 27103, United States
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Cincinnati, Ohio, 45255, United States
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Cleveland, Ohio, 44106, United States
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Columbus, Ohio, 43212, United States
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Portland, Oregon, 97210, United States
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Portland, Oregon, 97213, United States
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Portland, Oregon, 97225, United States
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Gettysburg, Pennsylvania, 17325, United States
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Hershey, Pennsylvania, 17033, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15213, United States
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Sayre, Pennsylvania, 18840, United States
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York, Pennsylvania, 17403, United States
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Charleston, South Carolina, 29425, United States
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Rock Hill, South Carolina, 29732, United States
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Spartanburg, South Carolina, 29303, United States
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Aberdeen, South Dakota, 57401, United States
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Sioux Falls, South Dakota, 57105, United States
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Knoxville, Tennessee, 37909, United States
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Knoxville, Tennessee, 37920, United States
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Memphis, Tennessee, 38120, United States
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Nashville, Tennessee, 37203, United States
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Nashville, Tennessee, 37232, United States
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Austin, Texas, 78731, United States
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Dallas, Texas, 75246, United States
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El Paso, Texas, 79902, United States
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Flower Mound, Texas, 75028, United States
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Houston, Texas, 77024, United States
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San Antonio, Texas, 78217, United States
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Tyler, Texas, 75702, United States
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Charlottesville, Virginia, 22908, United States
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Fairfax, Virginia, 22031, United States
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Midlothian, Virginia, 23114, United States
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Norfolk, Virginia, 23502, United States
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Roanoke, Virginia, 24014, United States
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Winchester, Virginia, 22601, United States
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Puyallup, Washington, 98373, United States
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Spokane, Washington, 99202, United States
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Vancouver, Washington, 98684, United States
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Morgantown, West Virginia, 26505, United States
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Appleton, Wisconsin, 54911, United States
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Madison, Wisconsin, 53792, United States
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CABA, C1061, Argentina
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Capital Federal, 1118, Argentina
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Ciudad de Buenos Aires, 1426, Argentina
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Ciudad de Buenos Aires, C1025ABI, Argentina
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Ciudad de Buenos Aires, C1426ANZ, Argentina
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Córdoba, 5001, Argentina
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Córdoba, X5800HHW, Argentina
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La Plata, 1900, Argentina
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Rosario, 2123, Argentina
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San Juan, 5400, Argentina
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San Miguel de Tucumán, 4000, Argentina
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Viedma, R8500ACE, Argentina
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Bankstown, 2200, Australia
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Bendigo, 3550, Australia
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Bowral, 2576, Australia
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Brighton, 3186, Australia
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Clayton, 3168, Australia
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Coffs Harbour, 2450, Australia
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Fitzroy, 3065, Australia
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Frankston, 3199, Australia
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Garran, 2605, Australia
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Gateshead, 2290, Australia
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Heidelberg, 3084, Australia
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Liverpool, 2170, Australia
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Melbourne, 3004, Australia
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Murdoch, WA6150, Australia
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Randwick, 2031, Australia
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Richmond, 3121, Australia
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Shepparton, 3630, Australia
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South Brisbane, 4101, Australia
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St Leonards, 2065, Australia
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Subiaco, 6008, Australia
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Wangaratta, 3677, Australia
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Waratah, 2298, Australia
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Warnnambool, 3280, Australia
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Wollongong, 2500, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Linz, 4010, Austria
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Linz, 4021, Austria
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Salzburg, 5020, Austria
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Sankt Veit an der Glan, 9300, Austria
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Steyr, 4400, Austria
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Vienna, 1090, Austria
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Vienna, 1130, Austria
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Vienna, 1160, Austria
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Wels, 4600, Austria
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Wiener Neustadt, 2700, Austria
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Aalst, 9300, Belgium
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Anderlecht, 1070, Belgium
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Brasschaat, 2930, Belgium
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Brussels, 1200, Belgium
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Charleroi, 6000, Belgium
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Edegem, 2650, Belgium
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Ghent, 9000, Belgium
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Leuven, 3000, Belgium
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Namur, 5000, Belgium
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Wilrijk, 2610, Belgium
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Alfenas, 37130-000, Brazil
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Belo Horizonte, 30130-100, Brazil
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Blumenau, 89010-340, Brazil
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Brasília, 71615-907, Brazil
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Curitiba, 80730-380, Brazil
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Curitiba, 80810-050, Brazil
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Fortaleza, 60135-237, Brazil
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Fortaleza, 60430-230, Brazil
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Goiânia, 74000-000, Brazil
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Itajaí, 88301-220, Brazil
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João Pessoa, 58013-140, Brazil
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Natal, 59075-740, Brazil
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Porto Alegre, 90035-001, Brazil
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Porto Alegre, 90050-170, Brazil
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Porto Alegre, 90610000, Brazil
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Porto Velho, 76834-899, Brazil
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Pouso Alegre, 37554-216, Brazil
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Recife, 50070-480, Brazil
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Ribeirão Preto, 14015-130, Brazil
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Rio de Janeiro, 20560-120, Brazil
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Rio de Janeiro, 22793-080, Brazil
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Salvador, 40170-110, Brazil
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Santo André, 09060-650, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01327-001, Brazil
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São Paulo, 01409-902, Brazil
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São Paulo, 03102-006, Brazil
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Taubaté, 12030-200, Brazil
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Teresina, 64049-200, Brazil
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Três Lagoas, 79601-001, Brazil
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Vitória, 29043-260, Brazil
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Dobrich, 9300, Bulgaria
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Haskovo, 6300, Bulgaria
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Plovdiv, 4002, Bulgaria
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Plovdiv, 4004, Bulgaria
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Shumen, 9700, Bulgaria
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Sofia, 1330, Bulgaria
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Sofia, 1404, Bulgaria
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Vratsa, 3000, Bulgaria
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La Serena, 1720430, Chile
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Santiago, 7620157, Chile
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Santiago, 8150215, Chile
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Santiago, 8330032, Chile
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Santiago, 8330336, Chile
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Temuco, 4810218, Chile
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Viña del Mar, 2520000, Chile
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Changchun, 130021, China
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Changsha, 410008, China
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Chengdu, 610042, China
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Chengdu, 610072, China
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Chifeng, 024000, China
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Foshan, 528000, China
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Fuzhou, 350014, China
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Haikou, 570311, China
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Hangzhou, 310000, China
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Hangzhou, 310009, China
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Hangzhou, 310016, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Hefei, 230001, China
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Hefei, 230012, China
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Hefei, 230022, China
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Hefei, 230601, China
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Hohhot, 010017, China
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Huizhou, 516001, China
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Krakow, 31-501, Poland
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Lodz, 90-302, Poland
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Opole, 45-061, Poland
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Rzeszów, 35-021, Poland
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Rzeszów, 35-055, Poland
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Warsaw, 02-781, Poland
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Wroclaw, 53-413, Poland
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Amadora, 2720-276, Portugal
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Braga, 4710-243, Portugal
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Lisbon, 1649-035, Portugal
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Lisbon, 1998-018, Portugal
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Porto, 4100-180, Portugal
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Porto, 4200-072, Portugal
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Vila Nova de Gaia, 4434-502, Portugal
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Vila Real, 5000-508, Portugal
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Rio Piedras, 00935, Puerto Rico
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Bucharest, 011171, Romania
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Bucharest, 013812, Romania
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Cluj-Napoca, 400015, Romania
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Craiova, 200094, Romania
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Craiova, 200385, Romania
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Craiova, 200542, Romania
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Floreşti, 407280, Romania
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Otopeni, 075100, Romania
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Ovidiu, 905900, Romania
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Piteşti, 110283, Romania
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Timișoara, 300239, Romania
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Riyadh, 12713, Saudi Arabia
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Riyadh/MENA, 11426, Saudi Arabia
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Belgrade, 11000, Serbia
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Belgrade, 11080, Serbia
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Kragujevac, 34000, Serbia
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Niš, 18000, Serbia
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Novi Sad, 21000, Serbia
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Valjevo, 14000, Serbia
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Zrenjanin, 23000, Serbia
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Cape Town, 7925, South Africa
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George, 6529, South Africa
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Johannesburg, 2193, South Africa
Research Site

Johannesburg, 2196, South Africa
Research Site

Pietermaritzburg, 3245, South Africa
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Port Elizabeth, 6045, South Africa
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Pretoria, 31, South Africa
Research Site

Cheonan-si, 31151, South Korea
Research Site

Daegu, 41404, South Korea
Research Site

Goyang-si, 10408, South Korea
Research Site

Seongnam-si, 13620, South Korea
Research Site

Seoul, 02841, South Korea
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Seoul, 03080, South Korea
Research Site

Seoul, 03722, South Korea
Research Site

Seoul, 06273, South Korea
Research Site

Seoul, 06351, South Korea
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Seoul, 06591, South Korea
Research Site

Seoul, 5505, South Korea
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A Coruña, 15006, Spain
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A Coruña, 15009, Spain
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Albacete, 02006, Spain
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Alicante, 03010, Spain
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Badalona, 08916, Spain
Research Site

Barakaldo, 48903, Spain
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Barcelona, 08003, Spain
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Barcelona, 08035, Spain
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Barcelona, 08036, Spain
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Barcelona, 08041, Spain
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Burgos, 09006, Spain
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Castellon, 12002, Spain
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Cáceres, 10003, Spain
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Córdoba, 14004, Spain
Research Site

Donostia / San Sebastian, 20014, Spain
Research Site

El Palmar, 30120, Spain
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Elche(Alicante), 03202, Spain
Research Site

Fuenlabrada, 28942, Spain
Research Site

Girona, 17007, Spain
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Granada, 18012, Spain
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Granada, 18016, Spain
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Jerez de la Frontera, 11407, Spain
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La Laguna (Tenerife), 38320, Spain
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León, 24008, Spain
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Lleida, 25198, Spain
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Madrid, 28007, Spain
Research Site

Madrid, 28009, Spain
Research Site

Madrid, 28033, Spain
Research Site

Madrid, 28034, Spain
Research Site

Madrid, 28040, Spain
Research Site

Madrid, 28041, Spain
Research Site

Madrid, 28050, Spain
Research Site

Manresa, 08243, Spain
Research Site

Málaga, 29010, Spain
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Málaga, 29016, Spain
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Murcia, 30008, Spain
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Palma de Mallorca, 07120, Spain
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Reus, 43204, Spain
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Sabadell, 08208, Spain
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Salamanca, 37007, Spain
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Sant Joan Despí, 08970, Spain
Research Site

Seville, 41009, Spain
Research Site

Seville, 41014, Spain
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Seville, 41015, Spain
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Toledo, 45007, Spain
Research Site

Valencia, 46009, Spain
Research Site

Valencia, 46010, Spain
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Valencia, 46015, Spain
Research Site

Vigo, 36312, Spain
Research Site

Zaragoza, 50009, Spain
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Baden, CH-5405, Switzerland
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Basel, 4031, Switzerland
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Bellinzona, 6500, Switzerland
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Chur, 7000, Switzerland
Research Site

Frauenfeld, 8501, Switzerland
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La Chaux-de-Fonds, 2300, Switzerland
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Lausanne, 1011, Switzerland
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Lucerne, 6000, Switzerland
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Lucerne, 6006, Switzerland
Research Site

Sankt Gallen, 9016, Switzerland
Research Site

Winterthur, 8401, Switzerland
Research Site

Zurich, 8008, Switzerland
Research Site

Hsinchu, 300, Taiwan
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Kaohsiung City, 833589, Taiwan
Research Site

New Taipei City, 23561, Taiwan
Research Site

Taichung, 40705, Taiwan
Research Site

Tainan, 70403, Taiwan
Research Site

Taipei, 10048, Taiwan
Research Site

Taipei, 11259, Taiwan
Research Site

Yongkang District, 71004, Taiwan
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Bangkok, 10210, Thailand
Research Site

Bangkok, 10330, Thailand
Research Site

Bangkok, 10400, Thailand
Research Site

Bangkok, 10700, Thailand
Research Site

Hat Yai, 90110, Thailand
Research Site

Khon Kaen, 40002, Thailand
Research Site

Ankara, 06010, Turkey (Türkiye)
Research Site

Ankara, 06200, Turkey (Türkiye)
Research Site

Ankara, 06530, Turkey (Türkiye)
Research Site

Antalya, 07100, Turkey (Türkiye)
Research Site

Bursa, 16059, Turkey (Türkiye)
Research Site

Çiğli, 35620, Turkey (Türkiye)
Research Site

Istanbul, 34093, Turkey (Türkiye)
Research Site

Istanbul, 34180, Turkey (Türkiye)
Research Site

Istanbul, 34457, Turkey (Türkiye)
Research Site

Samsun, 55200, Turkey (Türkiye)
Research Site

Abu Dhabi, 11241, United Arab Emirates
Research Site

Al Ain City, 15258, United Arab Emirates
Research Site

Dubai, 0000, United Arab Emirates
Research Site

Dubai, 505004, United Arab Emirates
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Aberdeen, AB25 2ZN, United Kingdom
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Burton-on-Trent, DE13 0RB, United Kingdom
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Cambridge, CB2 2QQ, United Kingdom
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Derby, DE22 3NE, United Kingdom
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Guildford, GU27XX, United Kingdom
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Ipswich, IP4 5PD, United Kingdom
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Lancaster, LA1 4RP, United Kingdom
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Leeds, LS9 7TF, United Kingdom
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Leicester, LE1 5WW, United Kingdom
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London, EC1M 6BQ, United Kingdom
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London, NW3 2QG, United Kingdom
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London, SE1 9RT, United Kingdom
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London, SW2 6JJ, United Kingdom
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Manchester, M20 4BX, United Kingdom
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Northampton, NN1 5BD, United Kingdom
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Shrewsbury, SY3 8XQ, United Kingdom
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Sutton, SM2 5PT, United Kingdom
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Sutton in Ashfield, NG17 4JL, United Kingdom
Research Site

Taunton, TA1 5DA, United Kingdom
Research Site

Whitchurch, CF14 2TL, United Kingdom

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