Blood test could spare thousands from unnecessary breast cancer treatment

NCT ID NCT07214532

Recruiting now Disease control Sponsor: Natera, Inc. Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Aug 14, 2026 · Updated 2 times

Summary

This study is testing whether a simple blood test that looks for cancer DNA can help doctors decide when to start a targeted therapy (CDK4/6 inhibitor) in people with intermediate-risk HR+ HER2- breast cancer. About 725 participants will have their blood tested every 3 months for up to 4 years. If the test finds cancer DNA, they start the targeted drug plus hormone therapy; if not, they continue hormone therapy alone. The goal is to see if this approach works as well as treating everyone upfront, while avoiding unnecessary side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CDK4/6 inhibitor (ribociclib or abemaciclib) plus endocrine therapy
What this could lead to: If successful, this approach could allow doctors to start targeted therapy only when cancer DNA appears in the blood, potentially sparing many patients from unnecessary treatment while still controlling the disease.
What could go wrong: This is an early-stage study comparing results to historical data, not a randomized trial. The ctDNA test may not catch all recurrences, and the added therapy carries risks like fatigue and low blood counts.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

breast ductal adenocarcinoma breast neoplasm hormone receptor-positive breast cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BREAST NEOPLASMS CARCINOMA, DUCTAL, BREAST RECEPTORS, ESTROGEN (FOR ER-POSITIVE REQUIREMENT)

Contacts and locations

Locations

Allegheny (AHN)
NOT_YET_RECRUITING

Pittsburgh, Pennsylvania, 15212, United States
Atrium Levine Cancer Institute
NOT_YET_RECRUITING

Charlotte, North Carolina, 28204, United States
Baptist MD Anderson
RECRUITING

Jacksonville, Florida, 32207, United States
Cancer & Hematology Centers
NOT_YET_RECRUITING

Grand Rapids, Michigan, 49504, United States
Cancer and Blood Research Center
NOT_YET_RECRUITING

Los Alamitos, California, 90720, United States
Cleveland Clinic
NOT_YET_RECRUITING

Cleveland, Ohio, 44195, United States
Cooper Health
NOT_YET_RECRUITING

Camden, New Jersey, 08103, United States
Fred Hutch Cancer Center
NOT_YET_RECRUITING

Seattle, Washington, 98109, United States
Hartford Healthcare Institute
NOT_YET_RECRUITING

Hartford, Connecticut, 06102, United States
Honor Health Research Institute
NOT_YET_RECRUITING

Scottsdale, Arizona, 85258, United States
Houston Methodist Hospital
NOT_YET_RECRUITING

Houston, Texas, 77030, United States
Indiana University
NOT_YET_RECRUITING

Indianapolis, Indiana, 46202, United States
Inova
NOT_YET_RECRUITING

Fairfax, Virginia, 33021, United States
Intermountain Health
NOT_YET_RECRUITING

Grand Junction, Colorado, 81501, United States
Jupiter Medical Cancer
RECRUITING

Jupiter, Florida, 33458, United States
Kaiser Permanente NorCal
NOT_YET_RECRUITING

Vallejo, California, 94589, United States
Karmanos Cancer Center - Wayne State University
NOT_YET_RECRUITING

Detroit, Michigan, 48201, United States
Loma Linda University
NOT_YET_RECRUITING

Loma Linda, California, 92354, United States
Marin Cancer Care
NOT_YET_RECRUITING

Greenbrae, California, 94904, United States
Massachusetts General Hospital
NOT_YET_RECRUITING

Boston, Massachusetts, 02114, United States
Mayo Clinic
NOT_YET_RECRUITING

Rochester, Minnesota, 55905, United States
Mayo Clinic Arizona
NOT_YET_RECRUITING

Phoenix, Arizona, 85054, United States
Mayo Clinic Florida
NOT_YET_RECRUITING

Jacksonville, Florida, 32224, United States
Mercy Health - Pratt Cancer Center
NOT_YET_RECRUITING

St Louis, Missouri, 63141, United States
Mercy Health - Sindelar Cancer Center
NOT_YET_RECRUITING

St Louis, Missouri, 63128, United States
MultiCare Cancer Institute
RECRUITING

Tacoma, Washington, 98405, United States
Munson Medical Center Cowell Family Cancer Center
NOT_YET_RECRUITING

Traverse City, Michigan, 49684, United States
NYU Langone Health
NOT_YET_RECRUITING

New York, New York, 10016, United States
New England Cancer Specialists
NOT_YET_RECRUITING

Westbrook, Maine, 04092, United States
New Mexico Oncology & Hematology Consultants
NOT_YET_RECRUITING

Albuquerque, New Mexico, 87109, United States
New York Cancer and Blood Specialists
RECRUITING

Babylon, New York, 11702, United States
Northwest Cancer Center
RECRUITING

Dyer, Indiana, 46311, United States
Northwest Medical Specialties, PLLC
RECRUITING

Puyallup, Washington, 98373, United States
Northwestern University
NOT_YET_RECRUITING

Chicago, Illinois, 60611, United States
Ocala Oncology
RECRUITING

Ocala, Florida, 34474, United States
Rutgers
NOT_YET_RECRUITING

New Brunswick, New Jersey, 08901, United States
Sanford Health
NOT_YET_RECRUITING

Sioux Falls, South Dakota, 57104, United States
Stockton Hematology Oncology Medical Group
RECRUITING

Stockton, California, 95204, United States
Stony Brook Cancer Center
NOT_YET_RECRUITING

Stony Brook, New York, 11794, United States
UCLA David Geffen School of Medicine
NOT_YET_RECRUITING

Santa Monica, California, 90404, United States
University of Arizona Cancer Center
NOT_YET_RECRUITING

Tucson, Arizona, 85719, United States
University of Rochester (URMC)
NOT_YET_RECRUITING

Rochester, New York, 14642, United States
University of Wisconsin
NOT_YET_RECRUITING

Madison, Wisconsin, 53792, United States
Vanderbilt
NOT_YET_RECRUITING

Nashville, Tennessee, 37232, United States
Werheim Cancer Institute
NOT_YET_RECRUITING

Miami, Florida, 33176, United States
West Cancer Center
NOT_YET_RECRUITING

Germantown, Tennessee, 38138, United States
West Virginia University
NOT_YET_RECRUITING

Morgantown, West Virginia, 26506, United States
Yale Cancer Center
NOT_YET_RECRUITING

New Haven, Connecticut, 06520, United States

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