Skeletal system disorder

This study looks at the long-term safety of imatinib, a daily pill for certain cancers like GIST and CML. It includes 250 patients who were already benefiting from imatinib in a previous Novartis trial and continue taking it. The main goal is to track side effects over time, with…

This study compares two treatments for severe shoulder arthritis: total shoulder replacement surgery followed by rehab, versus a 12-week exercise program with a physiotherapist. Researchers want to see if surgery leads to better pain relief and function than exercise alone. The t…

This early-phase trial tested whether giving patients their own natural killer (NK) cells, boosted by the drug bortezomib, is safe for treating advanced cancers like leukemia, lung, and pancreatic cancer. Thirty-five adults whose cancers had not responded to standard treatments r…

This trial studies a device called coflex, a small implant placed in the spine after decompression surgery for lumbar spinal stenosis (a narrowing of the spinal canal that causes back and leg pain). The study includes 40 adults with moderate to severe stenosis and low back pain. …

This study tests whether a device called BB-02, which delivers pulsed electromagnetic fields, can slow cartilage damage in people with early knee osteoarthritis. Researchers will use MRI scans to measure changes in cartilage and track pain levels. The goal is to find a non-surgic…

This trial tests whether custom-fitted supportive socks with built-in insoles, combined with a foot exercise program, can improve foot posture, walking ability, and comfort in children aged 5 to 12 with flexible flat feet. One group wears the socks for 6-8 hours daily plus exerci…

This study tests a weekly injection called TransCon CNP in children aged 2 to 10 with achondroplasia, the most common form of dwarfism. The goal is to see if it can safely improve growth over one year. Half the children receive the drug and half receive a placebo, and all childre…

This study compares different exercise programs for adolescents with idiopathic scoliosis who have undergone spinal fusion surgery. Participants are divided into three groups: one doing body awareness therapy plus core stabilization, one doing core stabilization alone, and a cont…

This study tested a program to help people with opioid use disorder stay on their medication after being hospitalized for serious infections like endocarditis or bone infections. Forty adults took part to see if the program was practical and helpful. The goal is to improve long-t…

This study tests whether leaving a tooth's root canal unfilled and using a blood clot to trigger natural healing works as well as the standard root canal filling. The trial involves 48 men with infected but still living upper premolars. One group gets the standard gutta-percha fi…

This study compares standard Schroth exercises with a virtual reality version of the same exercises in teens aged 10–15 with mild adolescent idiopathic scoliosis (curves of 10–30 degrees). The goal is to see if adding VR improves spinal alignment, trunk rotation, and mobility mor…

This study tested whether adding photodynamic therapy (a light-activated treatment) to standard sodium hypochlorite irrigation better kills bacteria in root canals. 64 adults needing root canal treatment were randomly assigned to receive either sodium hypochlorite alone or with p…

This study tests a new drug, AZD9829, in people with blood cancers that have come back or not responded to other treatments. The drug targets a protein called CD123 found on cancer cells. The main goals are to find a safe dose and check for side effects. About 56 adults will take…

This trial investigates whether non-surgical gum treatment can improve early signs of blood vessel dysfunction in people with periodontitis who have no known heart disease. Sixty participants will receive one of two types of deep cleaning procedures. Researchers will measure chan…

This trial investigates whether doxercalciferol, a form of vitamin D, can prevent bone loss in the spine and thigh bone in postmenopausal women with low bone density. Participants take either doxercalciferol or a placebo daily for two years, with bone density measured at the star…

This study tests whether a mobile-friendly gamified app, called Game-App-KNEE, can improve functional outcomes and recovery for people who have had total knee replacement surgery. Participants use the app daily for three months after discharge, while a control group receives only…

This study tests whether a nasal spray containing adelmidrol can reduce inflammation and shrink nasal polyps in people with chronic sinusitis. Participants are adults aged 18 to 70 who are scheduled for sinus surgery. Half receive standard care plus the adelmidrol spray, while th…

This study investigates whether combining high-intensity focused electromagnetic therapy with foot core training can improve foot function in adults with flatfoot (pronated foot). Participants receive either the combined therapy, electromagnetic therapy alone, or a sham treatment…

This study tests whether whole-body vibration therapy, alone or combined with exercise, can improve bone health and physical function in women with low bone density who have had a total knee replacement. Forty-eight women will be randomly assigned to vibration only, vibration plu…

This trial tests whether adding a sticky bone graft to a standard gum flap procedure helps cover exposed tooth roots better than the flap alone. It includes 30 adults with mild-to-moderate gum recession. The study measures how much the gum covers the root and how thick the gum ti…

This study looks at how well the SAGITTA EVL R hip implant works over the long term—7 to 10 years after surgery. Researchers are checking how many implants survive without needing another revision, how satisfied patients are, and what complications arise. The study includes adult…

This study tests whether giving full-strength chemotherapy (either CPX-351 or a combination called CLAG-M) can help medically less-fit adults with acute myeloid leukemia live longer and achieve remission. About 60 participants will receive one of the two treatments. The goal is t…

This study investigates whether changing diet can reduce disease activity in people with psoriatic arthritis. Participants are randomly assigned to one of two diets: one focusing on which foods are eaten, and another limiting daily calorie intake. The trial lasts 24 weeks and inc…

This study compares two minimally invasive treatments for deep gum disease bone defects: a non-surgical approach (MINST) and a surgical one (MIST). Researchers want to see if the non-surgical method can achieve similar bone and gum attachment improvements as surgery, but with les…

This study tests a drug called FT-2102 (olutasidenib) in people with acute myeloid leukemia or myelodysplastic syndrome whose cancers have a specific IDH1 gene mutation. The drug is given alone or combined with standard chemotherapy drugs (azacitidine or cytarabine). The goal is …

This study looked at whether using a soft hip brace (abduction splint) for two months in one-month-old babies with mild hip dysplasia (stable hips but abnormal ultrasound) improves hip development. 90 infants were enrolled. The goal was to see if the brace makes hip ultrasound me…

This study looked at whether taking oral azacitidine (Onureg) as maintenance therapy can help older adults with acute myeloid leukemia (AML) stay in remission longer after treatment with CPX-351 chemotherapy. The study included 100 patients aged 65 and older who had achieved remi…

This study tested a drug called pexidartinib (TURALIO) in 9 Japanese adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in the joints that causes pain and limits movement. The goal was to see if the drug is safe and can shrink tumors in people whose tu…

This pilot study tested whether memantine, a drug used for dementia in adults, could help prevent memory and thinking problems in children receiving brain radiation for tumors like glioma or craniopharyngioma. 41 children aged 6-21 took either memantine or a placebo during radiat…

This study tested a chemotherapy drug called CPX-351 in 59 adults aged 60 to 75 with a high-risk form of acute myeloid leukemia (AML). The goal was to see how well it could put the cancer into remission. Participants received the drug through an IV, and some also had a stem cell …

This completed Phase 4 study compared the safety of baricitinib (a daily pill) to TNF inhibitors (injections) in over 2,600 adults with rheumatoid arthritis. The main goal was to see if baricitinib had a higher risk of blood clots. Participants had to be at least 60, have a histo…

This phase III trial tests whether the drug tipifarnib can prevent acute myeloid leukemia (AML) from coming back in patients who are already in remission. Participants include adults over 60 in first remission, those in second or later remission, or those who achieved remission a…

This study tests whether certolizumab pegol (Cimzia), a drug already used for arthritis, can reduce flares of anterior uveitis—a painful eye inflammation—in people with axial spondyloarthritis who have had uveitis before. About 89 adults with active axial spondyloarthritis and a …

This study tested whether injecting bevacizumab (a drug that blocks blood vessel growth) into the joints of people with hemophilia can prevent repeated bleeding episodes. Eighteen participants with chronic synovitis (joint inflammation) received the injection. Researchers measure…

This study tested a special drilling technique called osseodensification, which compresses bone instead of removing it, to prepare the jaw for dental implants. Twenty-three adults with missing teeth received about 40 implants using this method. The goal was to see if the techniqu…

This study tested three different materials used to treat severe, irreversible tooth inflammation. 72 adults with painful molars received a procedure where the damaged pulp was removed and covered with one of the materials. The goal was to see if newer materials (TheraCal LC and …

This study looks at people who received a total lumbar disc prosthesis (Baguera®L) for lower back pain or sciatica caused by disc degeneration or herniation. The goal is to see how many return to their original job five years after surgery. Unlike spinal fusion, which often limit…

This completed study tested whether a 6-week cardiac rehabilitation program (aerobic and resistance exercises) could improve heart disease risk, blood pressure, and arthritis activity in 40 people with both rheumatoid arthritis and high blood pressure. Participants were randomly …

This study looked at adding the drug pazopanib to standard radiation or chemoradiation before surgery for patients with certain soft tissue sarcomas. The goal was to see if the combination is safe and helps shrink tumors more effectively. About 140 adults and children with newly …

This study tested a procedure that uses a patient's own growth factors to help rebuild lost jawbone. Eleven people with severe bone loss in the upper jaw received a bone graft mixed with plasma rich in growth factors. After 6-9 months, enough bone had grown to place dental implan…

This phase 3 trial is testing whether a combination of three drugs—azacitidine, venetoclax, and ATRA—can safely and effectively treat adults newly diagnosed with acute myeloid leukemia (AML). The drugs work together to stop cancer cell growth by demethylating DNA, promoting cell …

This study tested a daily pill called E7820 in 12 adults with relapsed or treatment-resistant acute myeloid leukemia, myelodysplastic syndromes, or chronic myelomonocytic leukemia. All participants had specific mutations in splicing factor genes. The goal was to see if the drug c…

This study tests whether adding a probiotic (Lactobacillus reuteri) to standard deep-cleaning treatment for gum disease can improve gum health and blood sugar levels in adults with diabetes. Participants receive either the probiotic or a placebo (salt water) applied directly into…

This study tested two different materials used in root canal treatment for teeth with both root and gum infections. 120 adults received either a mineral-based plug (MTA) or a standard resin sealer. Researchers measured healing and inflammation markers after one year to see which …

This trial compares two ways to deliver rehabilitation for women with knee osteoarthritis: in-person clinic visits versus tele-rehabilitation using a smartphone, tablet, or computer. Both groups receive hot packs and strengthening exercises. The study measures knee function, musc…

This phase 3 trial tested whether methotrexate, a drug used for other types of arthritis, can reduce pain and improve quality of life in people with erosive hand osteoarthritis. 64 participants received either methotrexate or a placebo once a week for 12 months. The study measure…

This study tested the drug RAD001 (everolimus) in 29 patients with relapsed or hard-to-treat blood cancers like leukemia, lymphoma, and myelofibrosis. The goal was to find the safest highest dose and see if it helps control the disease. It was a small early-phase trial at a singl…

This study tested different application times (3 seconds to 2 minutes) of 38% silver diamine fluoride solution to see which works best for stopping cavities in preschool children. Over 600 healthy kids aged 3-5 with at least one cavity participated. Researchers checked if the cav…

This study tested whether adding a light-based antibacterial treatment called photodynamic therapy (PDT) to standard deep cleaning improves gum health in people with moderate gum disease. Thirty adults received standard cleaning on one side of the mouth and standard cleaning plus…

This study tests whether a gel made from spirulina (a type of algae) can improve the treatment of stage II gum disease when used alongside standard deep cleaning. Researchers will compare different ways of preparing the spirulina gel and measure gum health and inflammation levels…

This study tested an experimental drug called NVG-291 in people with spinal cord injuries to see if it could help improve movement and strength. The trial was stopped early and included 24 adults with cervical spinal cord injuries. Participants received either the drug or a place…

This study tested the safety and effectiveness of eliglustat, an oral medication, in 57 children aged 2 to 17 with Gaucher disease types 1 and 3. Some children also received the standard enzyme therapy imiglucerase. Researchers measured how the drug moves through the body, side e…

This study looked at 40 adults aged 35–55 with a history of periodontitis (gum disease) who needed a dental implant. Each received one of two implant surface types: sandblasted acid-etched or plasma-sprayed. Researchers measured bone loss around the implant and gum health over on…

This study tested whether adding an immunotherapy drug called APX005M to standard chemotherapy (doxorubicin) could help shrink tumors in people with advanced soft tissue sarcoma. 27 adults with certain sarcoma types took part. The goal was to see if the combination was safe and w…

This study compared a new bone graft material (ABM/P-15) to the standard bone graft in 120 adults having surgery for spinal deformity. The goal was to see if the new graft leads to fewer additional surgeries and better bone healing. Patients were randomly assigned to receive eith…

This early-phase trial tested a personalized cell therapy for people with advanced bone or soft tissue sarcoma that had stopped responding to standard treatment. The therapy uses the patient's own immune cells, modified to better recognize and attack cancer cells carrying a speci…

This Phase 1 study tested a single injection of SHR-3045 in 16 healthy adults to see if it is safe and how the body processes it. The drug is being developed as a potential treatment for rheumatoid arthritis, an autoimmune disease that causes joint pain and swelling. Because this…

This study looked at how safe and effective peficitinib is for people with rheumatoid arthritis (RA) in everyday medical practice. About 3,000 patients who were starting peficitinib for the first time took part. Researchers tracked side effects and measured disease activity using…

This study tested whether a smartphone app could help people with incomplete spinal cord injury manage bladder issues. 88 adults were split into two groups: one received standard nursing, the other used a special app for 4 weeks that provided health education, bladder tracking, a…

This study tested whether a single injection of a patient's own fat-derived stem cells can reduce pain and improve knee function in people with mild to moderate knee osteoarthritis that hasn't responded to other treatments. One hundred participants received either a low dose, a h…

This study tested whether adding a light-activated therapy, called antimicrobial photodynamic therapy (aPDT), to standard deep-cleaning for gum disease could kill more bacteria and improve gum health. Fifty adults with severe periodontitis received standard cleaning alone or with…

This phase 2 trial is testing whether a combination of two drugs, venetoclax and azacitidine, can effectively treat adults aged 18 to 59 who have been newly diagnosed with acute myeloid leukemia (AML) and have not yet received any treatment. Participants take both drugs in cycles…

This study tested whether a two-year course of teriparatide (a bone-building drug) followed by a single infusion of zoledronic acid (a bone-strengthening drug) could reduce fractures in adults with osteogenesis imperfecta, also known as brittle bone disease. 350 participants were…

This study tested whether a stannous fluoride toothpaste can reduce gum inflammation, bleeding, and plaque better than a standard fluoride toothpaste. Over 12 weeks, 133 adults brushed with one of the two toothpastes and had their gums checked at several visits. The goal was to s…

This study tested whether adding natural ingredients like garlic oil and nattokinase to standard hormone replacement therapy (HRT) could reduce the risk of blood clots in menopausal women. The trial involved 60 women divided into premenopausal and postmenopausal groups. Researche…

This study tested whether a hands-on teaching method called Touch-to-Teach helps people with dental crowns clean between their teeth better than standard advice. 36 adults with at least one crown took part and were split into two groups: one got personalized brush training, the o…

This study tested a drug called fedratinib in 25 adults with rare blood cancers (MDS/MPN and CNL). The goal was to see if the drug could shrink the spleen and improve blood counts. While not a cure, the treatment aims to control the disease and reduce symptoms.

This study looked at whether a program of core stabilization exercises could help teenagers who had surgery for scoliosis (a curved spine) have more balanced shoulders and shoulder blades. Twenty teens aged 10 to 18 who had spinal fusion surgery did the exercises and were tested …

This early-phase study tested whether an ozonated sunflower seed oil gel could improve gum disease treatment when used alongside standard deep cleaning. Sixty adults with stage II periodontitis were divided into groups receiving either cleaning alone or cleaning plus a regular or…

This study looked at whether shining a special low-level laser on the gums after getting a dental implant can reduce swelling, pain, and help the implant stay stable. Fifty adults who needed implants took part. The laser was used right after surgery, and the team checked healing,…

This study tested a new way to set the breathing machine during back surgery. Instead of using standard settings, doctors adjusted the machine based on how stiff the patient's lungs were. The goal was to see if this approach could reduce lung problems after surgery. The study inv…

This study followed 152 people who received the Sidus Stem-Free Shoulder implant for severe shoulder pain and disability due to arthritis or other joint diseases. The implant is designed to replace the shoulder joint without a long stem, potentially preserving more bone. Research…

This study looked at the safety and effectiveness of a drug called asciminib in 85 Indian adults with a specific type of leukemia (Ph+ CML-CP). Some participants had a genetic mutation (T315I) that can make treatment harder, while others had already tried two or more other drugs.…

This early-phase trial tested whether adding the drug uproleselan to standard chemotherapy (cladribine and low-dose cytarabine) could help people with treated secondary acute myeloid leukemia (AML). Secondary AML is a type of leukemia that develops after treatment for another bon…

This study tested a new formulation of two chemotherapy drugs (CPX-351) in 56 adults with newly diagnosed acute myeloid leukemia (AML) who were at high risk of not responding to standard treatment. The goal was to find the best dose and see how well it worked to stop cancer cells…

This study tested whether the drug abaloparatide (Tymlos) can reduce bone loss after total knee replacement in people with osteoporosis or osteopenia. 58 participants took the drug for 18 months. The main goal was to see if bone density around the new knee improved compared to be…

This study tested a combination of three drugs (decitabine, venetoclax, and ponatinib) in 20 adults with a rare, aggressive leukemia called Philadelphia chromosome-positive acute myeloid leukemia or chronic myelogenous leukemia in blast phase. The goal was to see if the drugs cou…

This early-stage trial tested the safety of a new drug called SHR-3045 in 40 healthy adults. The study was randomized, double-blind, and placebo-controlled, meaning some participants got the drug and some got a dummy shot. The main goal was to see if the drug causes any side effe…

This study tested a new drug called pelabresib in people with certain blood cancers, including myelofibrosis and leukemia. In the first part, the drug was given alone to find the safest dose. In the second part, it was given with or without another drug (ruxolitinib) to see if it…

This study looked at how different recreational exercises—swimming, Pilates, and walking—affect muscle strength and balance in women at risk for osteoporosis. 60 women who had not exercised regularly took part. The goal was to see which activity might help prevent falls and fract…

This study tested whether adding a drug called oblimersen to standard chemotherapy (daunorubicin and cytarabine) helps older adults (60+) with untreated acute myeloid leukemia live longer or achieve remission. About 500 participants were randomly assigned to receive chemo with or…

This completed study tested a surgical technique called the combined bilaminar tunnel method for treating gum recession in patients with challenging tooth anatomy. Twelve participants received the procedure and were followed for six months. The goal was to see how much of the exp…

This study looked at the long-term safety and effectiveness of bimekizumab in adults with active psoriatic arthritis. Over 1,100 people who completed earlier studies received the drug and were monitored for side effects and disease symptoms. The goal was to see if bimekizumab rem…

This early-phase study tested a new drug called TQ05105 in 79 adults with certain blood cancers (myeloproliferative neoplasms). The main goals were to find the safest dose and understand side effects. The drug works by blocking a protein (JAK2) that can cause abnormal blood cell …

This study tested a new way to treat blood cancers like leukemia in 16 adults who did not have a standard bone marrow donor. Doctors used a single unit of cord blood that was grown in a lab to increase the number of stem cells before transplant. The goal was to see if this method…

This phase 2 trial tested two immunotherapy drugs, nivolumab and ipilimumab, in 10 patients with aggressive pituitary tumors that worsened after surgery and radiation. The goal was to see if the combination could shrink tumors or slow their growth. Researchers also monitored side…

This study tested two types of bone graft materials—alloplastic (man-made) and xenograft (from animals)—to rebuild jaw bone in 20 people who needed dental implants. Each person received both materials in different sides of their jaw so the results could be directly compared. The …

This study looked at the long-term safety and effectiveness of CartiFill, a treatment for knee cartilage damage. Researchers followed 36 people for 6 years after they had microfracture surgery with or without CartiFill. The goal was to see how well the treatment held up over time…

This completed early-phase trial tested whether the drug 4-AP (dalfampridine), combined with special nerve stimulation and leg exercises, could improve muscle strength and control in people with spinal cord injury. 26 adults with injuries at or above the lower back took part. The…

This study compared three approaches for treating dead, infected adult teeth: a regenerative procedure that induces bleeding inside the tooth, standard cleaning and sealing, and a combination. Fifty-four adults with an infected upper premolar were treated and followed for healing…

This study tested a new, less invasive surgery for children aged 4 to 10 with a stubborn clubfoot deformity called 'bean-shaped foot.' Instead of cutting bones, surgeons placed a small metal plate across a joint in the foot to gently guide growth and straighten the foot over time…

This large Phase 3 trial tested a once-weekly injection called retatrutide in over 2,300 adults with obesity or overweight who do not have type 2 diabetes. The study also looked at how the drug affects knee osteoarthritis and obstructive sleep apnea. Participants received either …

This study tested a new drug called TQ05105 in 107 people with moderate to high-risk myelofibrosis, a rare bone marrow disorder that often causes an enlarged spleen. The goal was to see if TQ05105 could shrink the spleen better than the standard drug hydroxyurea. Participants too…

This study tested whether adding a daily fiber supplement (inulin) to standard anti-IL-17 therapy could improve gut bacteria balance and treatment response in 76 adults with axial spondyloarthritis. Participants took either fiber or a placebo powder for three months. The main goa…

This large phase III trial tested whether adding the drugs bortezomib and sorafenib to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) live longer without the cancer returning. Over 1,600 participants took part. The study focused on patients w…

This study tested a new type of dental crown made from a material called PEEK for children's back baby teeth. Fifty healthy children aged 5 to 7 received either a PEEK crown or a standard metal crown. The researchers checked how well the crowns worked and looked over time.

This Phase 3 study tested guselkumab, a drug given by injection, in 741 adults with active psoriatic arthritis. The goal was to see if it reduces joint pain and swelling. Participants received either guselkumab or a placebo. The main measure was a 20% improvement in arthritis sym…

This phase 2 trial tested a combination of intravenous busulfan, etoposide, and low-dose total-body irradiation before a donor stem cell or bone marrow transplant in 30 patients with advanced leukemia or myelodysplastic syndromes. The goal was to see how well this regimen control…

This study tested whether removing a specific type of immune cell (naïve T cells) from donor stem cell grafts could prevent graft-versus-host disease (GVHD) after a stem cell transplant for blood cancers. The trial enrolled 84 patients who received high- or medium-intensity chemo…

This study tested a surgical technique called a dermal roll flap to support the nostril base in 45 people who had a previous cleft lip repair. The flap uses extra skin from the lip to lift and stabilize the nostril on the cleft side. Researchers measured changes in nostril positi…

This pilot study tested whether a butyrate supplement, a type of short-chain fatty acid, could change the gut microbiome and immune responses in people with rheumatoid arthritis who didn't respond well to methotrexate. Twenty participants took the supplement for up to two months.…

This early-stage trial tested a new gene therapy called FLT201 in 10 adults with Gaucher disease type 1. The therapy uses a harmless virus to deliver a working copy of the gene that produces a missing enzyme. The main goal was to check safety and see if the treatment can boost en…

This study tested two types of fillings for deep cavities in back teeth: a new bioactive material and a standard non-bioactive one. Fifty adults aged 18-40 with deep cavities were treated using a technique that removes only the decayed part. The researchers checked tooth sensitiv…

This study looked at whether adding ozone gas to standard deep cleaning helps treat severe gum disease (periodontitis). 39 adults received the usual cleaning plus ozone, and researchers measured bacteria levels and gum pocket depths. The goal was to see if ozone kills more bacter…

This study tested a new treatment for adults with a high-risk form of acute promyelocytic leukemia (APL). The experimental therapy combined arsenic trioxide, ATRA, and a low dose of idarubicin, aiming to improve survival and reduce side effects compared to the standard chemothera…

This study tested a new, less invasive way to treat infected baby molars in children aged 4 to 10. Instead of fully cleaning out the tooth canals (standard pulpectomy), the new method uses an antibiotic paste to kill infection without drilling. The study involved 110 children and…

This phase 2 trial tested whether certain biomarkers in bone marrow can predict how well patients with high-risk acute myeloid leukemia (AML) respond to treatment with sirolimus plus standard chemotherapy (MEC). The study enrolled 39 adults with AML that was hard to treat or had …

This study looked at whether giving tranexamic acid (a medicine that reduces bleeding) both through an IV and directly into the hip joint during hip replacement surgery can safely lower blood loss. 58 adults having elective hip replacement took part. The goal was to see if the co…

This study tested whether adding platelet-rich fibrin (a concentrate from your own blood) plus the antibiotic minocycline works better than the antibiotic Arestin alone for treating gum disease. Fifteen adults with moderate gum disease received both treatments in different parts …

This study tested whether combining a Mediterranean diet with progressive resistance training could improve bone density in adults aged 65 and older. Over 12 months, 22 participants followed the diet and exercise program, while 19 received no structured intervention. Researchers …

This early-phase trial tested a drug called ONC-201 in 20 people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) who had recently received a stem cell transplant. Participants took the drug by mouth once a week for a year to see if it was safe and co…

This study tested a new surgical technique called the NORD flap for treating receding gums, comparing it to the standard method that uses a tissue graft from the roof of the mouth. The goal was to see if the new technique could cover exposed tooth roots just as well, with less pa…

This study tested whether a melatonin gel applied to the gums can improve the results of standard deep-cleaning treatment for gum disease. Thirty adults with periodontitis received either the melatonin gel or a placebo gel alongside their regular dental cleaning. Researchers meas…

This study looked at 51 adults with advanced gum disease and loose front teeth. Researchers compared minimally invasive non-surgical therapy (MINST) alone versus MINST plus splinting (joining teeth together for support). The goal was to see if adding splints improves gum health a…

This study tested a new technique to help women with primary ovarian insufficiency (early ovarian failure) become pregnant. Doctors removed one ovary, treated small pieces of it with drugs to wake up dormant eggs, and then transplanted the tissue back into the patient. After moni…

This study tested whether adding the drug tocilizumab to standard care could reduce the risk of graft-versus-host disease (GVHD) after a cord blood transplant in adults with blood cancers. GVHD is a serious complication where donor cells attack the patient's body. Tocilizumab blo…

This phase 2 trial tests whether a combination of clofarabine and intermediate-dose cytarabine (CLARA) works better than high-dose cytarabine (HDAC) alone as consolidation therapy for younger adults (18-60) with newly diagnosed acute myeloid leukemia (AML). After initial remissio…

This study looked at 31 adults with chronic myeloid leukemia (CML) whose cancer came back after they stopped taking imatinib. They were given nilotinib, a more powerful targeted therapy, to see if it could make their cancer undetectable again and allow them to stop treatment once…

This pilot study tested a sleeve worn on the forearm that uses muscle signals to stimulate hand muscles, helping people with tetraplegia from spinal cord injury grasp and manipulate objects. Twelve adults with chronic cervical SCI completed a 12-week training program using the de…

This study tested whether adding photodynamic therapy (a light-based treatment) and vitamin D to standard deep cleaning helps people with moderate gum disease. Twenty-four adults with stage II grade B periodontitis took part. The goal was to see if the combination improves gum at…

This study looked at how well a special dental material (calcium silicate sealer) works when re-treating root canals that have failed. 136 adults aged 18-65 with infected teeth were included. The main goal was to see if the infection healed on 3D X-rays and if symptoms like pain …

This pilot study tested a surgical technique using donor tissue without metal implants to treat recurrent shoulder dislocation with bone loss. Twenty participants were followed for 24 months to measure arm function and safety. The goal was to see if this approach can stabilize th…

This study tested whether exenatide, a diabetes drug, plus lifestyle changes helps adults with severe weight gain after treatment for a rare brain tumor (craniopharyngioma). 42 adults aged 18-75 took either exenatide or a placebo for 6 months. The main goal was to see if they los…

This study tested whether a special oral gel called PHTALOX® could make standard deep-cleaning treatments for gum disease more effective. Forty-five adults with moderate to severe periodontitis received standard scaling and root planing, plus either the PHTALOX® gel, a chlorhexid…

This study followed 155 French adults with moderate-to-severe rheumatoid arthritis who were prescribed filgotinib (Jyseleca) for the first time. Over two years, researchers measured how many patients stayed on the drug and how well it controlled their disease activity. The goal w…

This study tested whether using a stannous fluoride toothpaste, a cetylpyridinium chloride mouthwash, and a battery-powered toothbrush together can reduce dental plaque and gingivitis (gum inflammation). 134 adults with at least 20 teeth and signs of gum disease used the regimen …

This study tested a new type of dental implant called T3 to see if it helps preserve the jawbone better than a standard implant. Forty adults who needed dental implants took part. Researchers checked how well the implant stayed in place and how much bone was kept over time.

This study tested an experimental oral drug called LY3871801 in 164 adults with moderately-to-severe rheumatoid arthritis. The goal was to see if it reduces joint swelling and pain better than a placebo. The trial is complete, and results will help decide if further testing is wa…

This study looked at whether adding virtual reality games to standard scoliosis exercises helps teenagers with curved spines. Twenty teens aged 10-15 with moderate scoliosis took part. Half did regular exercises, and the other half also played virtual reality games for balance an…

This study tested whether adding ozone gas to a standard deep cleaning (scaling and root planing) helps treat stubborn gum pockets in people with advanced gum disease. Twenty-six adults with stage III or IV periodontitis and pockets 5mm or deeper took part. Researchers measured g…

This study tested whether taking omega-3 or vitamin D supplements daily helps treat gum disease (periodontitis) better than standard deep cleaning alone. 72 adults with moderate gum disease received either omega-3, vitamin D, or no supplement alongside their dental treatment. Res…

This study compared a liquorice nanogel to a diode laser as extra treatments for advanced gum disease (stage III). 27 adults with deep gum pockets received one of the two treatments alongside standard care. The goal was to see which approach better reduced harmful bacteria and im…

This study tested a new 3D bone scan camera (VERITON-CT) that takes only 25 minutes and uses less radiation than standard scans. Researchers compared it to conventional 2D scans in 146 people with suspected or known bone metastases. The goal was to see if the new method could acc…

This study looked at whether certain proteins in saliva can help tell the difference between healthy gums, gingivitis (mild gum inflammation), and periodontitis (serious gum disease). Researchers collected saliva from 60 people and measured three specific biomarkers. The goal is …

This study looks at whether substances in the blood from a tooth's pulp can help dentists tell the difference between reversible pulpitis (a mild inflammation that can heal) and irreversible pulpitis (severe damage needing a root canal). Researchers will collect a small sample of…

This study tested a new structured reporting system called BTI-RADS to help doctors better assess bone tumors from X-rays, CT, and MRI scans. Researchers analyzed images from 1,100 patients to see if the tool could more accurately tell which tumors are likely cancerous. The goal …

This study tested a new DNA-based technique called shotgun metagenomics to see if it can diagnose chronic infections in artificial joints better than standard lab cultures. Researchers took samples from 144 adults undergoing surgery for a suspected joint infection. The goal was t…

This study tests a new radioactive tracer called [F-18]MHF to see if it can detect infections around knee implants using PET scans. Researchers will compare the tracer's uptake in infected versus non-infected implants in 18 adults. The goal is to improve diagnosis and reduce unne…

This study looked at tiny molecules in the blood, called microRNAs, to see if they can help diagnose adolescent idiopathic scoliosis (AIS), a condition that causes a curved spine in teens. Researchers compared blood samples from 20 teens with AIS and 10 healthy teens to find diff…

This study tested two 8-week exercise programs in 45 amateur padel players to see if they could reduce risk factors for lateral epicondylitis (tennis elbow). Both programs involved strength exercises for the forearm and shoulder. The goal was to improve wrist, grip, and rotator c…

This study tested whether a single infusion of zoledronic acid (Reclast) can prevent fractures in men and women aged 60 and older with Parkinson's disease or related conditions. Over 2,700 participants were randomly assigned to receive either the drug or a placebo, and were follo…

This study tests whether a personalized nutrition plan can help people with a recent spinal cord injury avoid gaining unhealthy body fat and becoming obese. About 56 participants will receive tailored dietary advice for one year. The goal is to improve long-term health and preven…

This three-year study tested whether wrestling shoes with built-in arch support can prevent flatfoot in adolescent male wrestlers. 88 boys aged 11 were randomly assigned to wear either arch-support shoes or standard wrestling shoes. Researchers checked foot shape and pressure eac…

This study tested four different dental filling materials in 120 adults at high risk for cavities. The goal was to see if newer 'bioactive' materials could prevent secondary cavities (cavities that form around the edge of a filling) better than a standard composite resin. Partici…

This study tested whether a single infusion of zoledronic acid can prevent bone and muscle loss in adults aged 35 and older who are undergoing bariatric surgery. Fifty-nine participants were randomly assigned to receive either the drug or a placebo. The main goal was to measure c…

This study tested three methods of keeping teeth dry while applying protective sealants to prevent cavities in children's permanent molars. Thirty children at high risk for cavities took part, and each method was compared for how long it took, how well the sealant stayed on after…

This study compares two ultrasound-guided injection treatments for adhesive capsulitis, also known as frozen shoulder. One group receives a steroid and numbing medicine injected directly into the shoulder joint, while the other group gets the same medicine injected near the supra…

This clinical trial tests a gel called ABIO3419, injected into the knee joint, to see if it safely reduces pain and improves function in people with knee osteoarthritis. The study compares ABIO3419 to another treatment and measures pain relief over three months. Participants are …

This study investigates whether adding dance-based exercises to standard scoliosis therapy improves physical fitness, body image, and quality of life in adolescents with mild scoliosis. Twenty-four teens aged 10–18 with a spinal curve between 10 and 30 degrees will be randomly as…

This study tests whether a personalized teaching method called 'Touch-to-Teach' helps people with stage II periodontitis clean between their teeth better than standard instructions. Forty participants will be split into two groups: one gets standard care, the other gets the new m…

This study tests whether a wheelchair-mounted robotic arm called Jaco helps people with tetraplegia perform daily tasks like grasping and reaching at home. Participants use the device for two months after training. Researchers measure changes in performance and satisfaction with …

This study looks at whether people with diabetes experience more pain after a second root canal treatment compared to those without diabetes. About 50 adults with a single-rooted tooth needing retreatment will take part. Pain levels and painkiller use will be tracked for a week a…

This study tests whether a 12-week program of water-based jumping and hopping exercises (hydro-kinetic plyometrics) can reduce pain, strengthen leg muscles, and improve quality of life in adolescents with patellofemoral pain syndrome (PFPS). Fifty-six teens aged 10–18 with persis…

This study looks at whether adding core muscle exercises to a hip and knee workout can lower pain and improve knee alignment in women with patellofemoral pain syndrome (knee pain around the kneecap). Thirty-six women aged 19-35 with a healthy weight will be assigned to different …

This study tested whether a cream made from chili pepper extract (capsaicin) or a common pain-relief gel (diclofenac) works better for long-term jaw joint pain. Fifty women with chronic jaw pain applied one of the creams four times a day for a week. Researchers measured pain leve…

This study tests whether adding hypnosis to standard care helps control pain and anxiety during a knee lavage procedure for people with knee osteoarthritis. About 100 participants will be randomly assigned to receive either usual care alone or usual care plus hypnosis. The main g…

This study tests a new, long-lasting painkiller (liposomal bupivacaine) that works for up to 72 hours after spine surgery, compared to the standard 6-8 hour painkiller. About 204 adults having lower back surgery will be randomly assigned to receive one of the two painkillers. The…

This study looked at four different ways to activate the cleaning solution used during root canals: laser, sonic, ultrasonic, and simple needle irrigation. The goal was to see which method causes the least pain after the procedure and how much debris gets pushed out of the tooth.…

This study looks at whether adding a type of tape called dynamic tape to shoulder exercises helps people with shoulder impingement syndrome. Participants will do motor control exercises either with or without the tape. The goal is to see if the tape improves shoulder movement, mu…

This study tests whether injecting a concentrated sugar-water solution (dextrose) into the knee joint can reduce pain and improve function in people with knee osteoarthritis. Participants receive either the dextrose injection or a placebo (salt-water injection) under ultrasound g…

This study is testing a device called the CORI™ KNEE TENSIONER, which helps surgeons balance the knee during total knee replacement surgery. Fifty adults who need a knee replacement will have the surgery using this device, and their recovery and quality of life will be tracked fo…

This study compares two final rinses inside the tooth after root canal treatment for people with severe tooth pain from irreversible pulpitis. One rinse is a cold saline solution (cryotherapy), the other is a steroid solution (dexamethasone). The goal is to see which better reduc…

This study tests a wearable device that delivers low-intensity ultrasound to the knee for 1-4 hours daily, combined with a diclofenac pain patch, to reduce pain and improve function in people with mild-to-moderate knee osteoarthritis. Participants aged 50-85 with frequent knee pa…

This study tested whether using special lasers during root canal treatment can lower pain afterward compared to standard methods. Forty-five adults with infected front teeth were split into three groups: one got standard cleaning, another got a combination of two lasers, and the …

This study tests whether adding foot massage to standard cold therapy can reduce pain and improve satisfaction in people who have had knee replacement surgery. Sixty participants will be randomly assigned to receive either cold therapy alone or cold therapy plus foot massage for …

This study tested a new type of leg brace designed to help children with cerebral palsy and other movement disorders walk more easily. The brace was custom-made for each child and could be adjusted to provide different kinds of support. Researchers measured how well children walk…

This trial investigates whether jaw exercises (Rocabado programme) work better when guided by a physiotherapist through online video sessions versus doing them at home with written instructions alone. Adults aged 18-60 with jaw-joint pain and teeth grinding are randomly assigned …

This study tests whether a prescription pain cream called Multiprofen-CC™ can help control pain and reduce the need for opioid painkillers after total knee replacement. About 288 adults having knee surgery will use either the cream or a placebo along with standard pain care. The …

This study investigates whether adding focal muscle vibration to shoulder exercises can improve how the brain processes sensory and movement signals in people with chronic subacromial impingement syndrome. Participants will receive 12 sessions of either vibration-assisted exercis…

This study tests whether adding shock wave therapy to a specific trigger point in the forearm muscle can improve grip strength and reduce pain in people with tennis elbow. Fifty-two adults with tennis elbow will receive standard shock wave treatment to the elbow, plus either real…

This study compares two types of Pilates—one done in water and one on a mat—to see which better improves breathing, mobility, and quality of life in older women with a curved upper spine (kyphosis). Forty women aged 55 to 65 with mild to moderate kyphosis will follow a 12-week pr…

This pilot study tested the Atlas Knee System, a device implanted outside the knee joint to reduce pressure on the inner knee, in 50 people with medial knee osteoarthritis. The goal was to see if it safely relieves pain and improves function over 24 months. Participants were foll…

This study looked at whether scoliosis-specific corrective exercises, like the Schroth method, can improve physical fitness in teens with idiopathic scoliosis. Forty-two adolescents aged 10 to 19 with mild to moderate curves took part. They did either supervised exercises twice a…

This study tested two acupuncture methods—thread-embedding and electroacupuncture—in 60 adults with knee osteoarthritis. Participants received 4 weeks of treatment plus standard care. The goal was to see which approach better reduced pain and improved knee function. Results may h…

This study tested a special exercise called blood flow-restricted resistance exercise (BFRE) in 10 people with incomplete spinal cord injury. Participants did arm exercises with a cuff that limits blood flow, plus electrical stimulation if needed, twice a week. The goal was to se…

This study tested two different strengths of ozone gas injections into the jaw joint for people with TMJ disorders. Twenty adults who had clicking, popping, or limited mouth opening that didn't improve with other treatments received the injections. Researchers measured pain and j…

This study tested two ways to whiten teeth: a chemical bleaching gel and a light-activated bleaching gel. Thirty adults with yellowish or brownish stains on their front teeth were randomly assigned to one of the two methods. Researchers measured how white teeth got, how much toot…

This study tested whether adding a special manual therapy that targets the limbic system (the brain's emotion center) to standard physiotherapy can improve pain, jaw movement, balance, and quality of life in people with temporomandibular joint disorder (TMD). Sixty adults with TM…

This study tested whether using ozonated water to flush the jaw joint (arthrocentesis) works better than the standard Ringer's solution for people with a displaced jaw disc that snaps back into place. Thirty adults with TMJ pain and limited mouth opening were treated. The main go…

This study tested whether a supplement made from grape and olive extracts (Oléogrape®SEED) can reduce inflammation in people with knee osteoarthritis. Twelve patients took the supplement or a placebo for 7 days. Researchers then measured anti-inflammatory effects in blood and joi…

This study tested whether injecting botulinum toxin (Botox) into jaw muscles can reduce pain and improve mouth opening in people with temporomandibular joint (TMJ) myofascial pain. 118 adults with at least moderate pain for over a month received injections in their masseter and t…

This study tested whether adding a nerve-stimulating technique (ultrasound-guided percutaneous neuromodulation) to standard treatments (electrolysis and eccentric exercises) helps athletes with jumper's knee. 26 adults aged 18-50 who played sports at least 3 times a week and had …

This study compared two painkillers, oliceridine and morphine, in 252 adults undergoing laparoscopic colorectal surgery. The goal was to see if oliceridine causes less nausea and vomiting after surgery. Patients used a pump to control their pain medicine for up to 3 days after th…

This study tested whether dissolvable mineral-loaded starch strips can quickly relieve dentin hypersensitivity, a common condition causing sharp pain from hot, cold, or touch. 82 adults with sensitive teeth used either the strips or a Novamin toothpaste. The goal was to see if th…

This study tested whether applying low-frequency electromagnetic fields to the lower back could reduce sciatica pain and improve postural control in people with a lumbar disc herniation. Forty-four adults aged 30 to 45 with mild to moderate disc prolapse received either electroma…

This study tested whether a special nerve block given during cleft palate repair can lower pain and reduce the need for opioids in children. Forty children having their first cleft palate surgery received the nerve block. Researchers measured pain scores and opioid use to see if …

This study looked at pain after root canal treatment using two types of sealers: bioceramic and resin. 72 adults with no pain before treatment had a single-root tooth filled. They rated their pain at 6, 24, 48, and 72 hours, and 7 days after. The goal was to see if the sealer typ…

This study looked at how well paracetamol alone or combined with different NSAIDs (ibuprofen, mefenamic acid, or diclofenac) controls pain after root canal treatment. 185 adults with severe tooth pain took part. The goal was to see if combining drugs works better than paracetamol…

This study tested whether taking tramadol or naproxen sodium one hour before a dental procedure helps local anesthesia work better and reduces pain afterward. 139 adults with severe tooth inflammation (irreversible pulpitis) in a lower molar were randomly given one of the two dru…

This study tested whether adding a special breathing therapy (intermittent hypoxia-hyperoxia) to standard physical therapy helps people with knee osteoarthritis. Sixty adults aged 45 and older with knee pain for at least 3 months took part. The breathing therapy involved short cy…

This study tested whether a higher concentration of ozone injected into the knee works better than a lower concentration for treating osteoarthritis. 159 patients received one of two ozone strengths and were followed for 3 months. Researchers measured pain, stiffness, and daily f…

This study tested a dietary supplement called INTOFINE-JOINT SUPPORT in 33 adults aged 40-60 with mild knee osteoarthritis. Participants took the supplement for 60 days, and researchers measured changes in pain, stiffness, and physical function using standard questionnaires and t…

This study tested whether a mobile application could help nurses and caregivers better manage pressure injuries (bedsores) in people receiving home care. Thirty participants were followed for 28 days, with caregivers using the app to track wound healing and receive reminders. The…

This study tested a one-year support program (JASP-1) for children newly diagnosed with juvenile idiopathic arthritis (JIA). The program included seven structured visits with a focus on the child and family. Researchers compared registry data from 56 children who took part in the…

This study compares two treatments for knee osteoarthritis: a nerve block injection guided by ultrasound and standard physical therapy. Researchers want to see which method better reduces pain, improves mobility, and helps balance. The study will include 66 adults aged 40-70 with…

This study tested whether a gentle electrical current, called frequency specific microcurrent, can lower inflammation and pain in obese adults with osteoarthritis. Ten participants received one hour of treatment and had blood drawn to measure inflammatory markers. They also fille…

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether a non-opioid pain regimen (celecoxib plus acetaminophen) works as well as an opioid regimen (oxycodone plus acetaminophen) for pain after ankle arthroscopy. 112 adults were randomly assigned to one of the two groups. The goal is to find a safer way to ma…

This study looked at 120 children aged 1 to 10 with webbed fingers (congenital syndactyly) who had surgery to separate them. After separation, a skin graft was needed to cover the gap. The study compared taking the graft from the foot (plantar area) versus the groin, to see which…

This study looked at whether listening to music while waiting for a dental filling can help people with moderate dental anxiety feel calmer. Researchers measured stress hormones, heart rate, and blood pressure in 90 healthy volunteers. The goal was to see if a simple, non-drug ap…

This study tested a self-guided online program for people with psoriasis. 348 adults were split into two groups: one got the app plus their regular treatment, the other got regular treatment alone. The main goal was to see if the app improved quality of life over 12 months.

This study tested four approaches for treating dentine hypersensitivity (tooth sensitivity): Nd:YAG laser, diode laser, a herbal propolis-based gel, and a sham (fake) treatment. 140 adults with at least two sensitive teeth were followed for 12 months to see which method reduced p…

This study tested two different exercise approaches in 34 people aged 11–24 with idiopathic scoliosis and chronic low back pain. Researchers measured changes in back muscle tissue thickness, pain levels, and daily function. The goal was to see which exercise method works better f…

This trial tests whether a program combining education with high-intensity interval training (HIIT) can improve knee osteoarthritis symptoms and reduce heart disease risk better than a standard neuromuscular exercise program. About 150 adults with knee osteoarthritis and at least…

This study tested whether a technique called apical patency—gently passing a small file just beyond the tooth root during root canal treatment—reduces pain afterward. 150 adults with inflamed but painless teeth (asymptomatic irreversible pulpitis) were randomly assigned to receiv…

This study tested a combination of platelet-rich plasma (PRP) from the patient's own blood and hyaluronic acid injected into the jaw joint. Twenty-two adults with painful clicking and limited mouth opening received the treatment. Researchers used a jaw tracking device to measure …

This study tested two treatments for Golfer's Elbow, a painful elbow condition. Twenty-nine adults received either dry needling (thin needles into trigger points) or neural mobilization (gentle nerve stretches). Researchers measured pain, grip strength, and movement range to see …

This pilot study tested whether village doctors in rural China can effectively deliver an exercise program for people with knee osteoarthritis. Sixteen participants either received supervised exercise three times a week for 12 weeks followed by independent exercise, or usual care…

This completed study compared two minimally invasive surgeries for herniated discs: full endoscopic lumbar discectomy (FELD) and microdiscectomy (MD). Researchers enrolled 200 adults aged 18-85 with single-level disc herniation and sciatica. The goal was to see which technique pr…

This study compared two treatments for plantar fasciitis, a common cause of heel pain: shock wave therapy and whole body vibration. Sixty adults with heel pain for at least 4 weeks were randomly assigned to one of the treatments. The goal was to see which better reduces pain and …

This study tested two physical therapy methods—Mobilization with Movement and Cyriax techniques—in 56 athletes with tennis elbow. Participants received treatment five times a week for four weeks. Researchers measured pain, grip strength, and joint position sense to see which meth…

This trial investigates whether using an electronic apex locator to determine the exact stopping point during root canal treatment can reduce pain afterward. Participants with a single-rooted tooth needing a root canal are randomly assigned to one of three groups: two groups use …

This study compares two ways to manage pain after total knee replacement: a continuous nerve block using a catheter near the femoral triangle versus tissue infiltration with a local anesthetic. The goal is to see which method better prevents long-term chronic pain and improves kn…

This study tested a smart faucet that uses voice, motion, and remote controls to help people with spinal cord injury (SCI) get water for drinking, grooming, and washing without needing help. 40 participants with SCI and control subjects used the faucet in clinics and at home. The…

This study tested two treatments for chronic tailbone pain (coccygodynia) in 100 adults. One group received osteopathic manual therapy—gentle hands-on techniques to mobilize the tailbone and relax muscles—over 6 weeks. The other group got a nerve block injection guided by X-ray. …

This pilot study tested whether a special cushion called Dasuit can reduce low back pain and improve posture in 20 adults with sitting-related discomfort. Participants sat on either the Dasuit cushion or a placebo cushion for 10 minutes while pressure and spinal alignment were me…

This study tested whether using an ultrasonic device to clean root canals causes less pain afterward than a standard needle. 108 adults with tooth pain had root canals and were randomly assigned to one method. Pain was measured using a scale. The goal is to find which cleaning me…

This study tested whether a new prosthetic hand, the SoftHand Pro, helps people with below-elbow limb loss perform daily activities better than a commonly used hand, the i-Limb. Thirty-six adults who already use a myoelectric hand took part over 8 weeks. Researchers measured how …

This study tested two methods to help gums heal after a gingivectomy (removing excess gum tissue). Sixty-four healthy adults received either a hyaluronic acid spray (applied twice daily for 7 days) or low-level laser therapy (applied 4 times over 7 days). Researchers measured wou…

This study tested three treatments—shockwave therapy, high-power laser, and platelet-rich plasma injections—in 96 people with heel spurs. The goal was to see which one best reduces pain and improves daily function. Participants were randomly assigned to one of the treatments, and…

This study tested whether giving multiple doses of gabapentin before and after total knee replacement surgery can reduce the amount of morphine needed for pain. 101 adults having elective knee replacement took part. The goal was to see if gabapentin could lower pain and morphine-…

This study looked at 60 people having total knee replacement surgery to see which of two nerve blocks works better for pain control when added to a standard block. One block targets the space behind the knee (IPACK), the other targets a muscle plane (AMM). The goal was to reduce …

This study compared two types of exercises—clam shell exercises (for hip muscles) and short arc quadriceps exercises (for thigh muscles)—in 34 adults aged 18-40 with patellofemoral pain syndrome, also known as runner's knee. Participants were randomly assigned to one exercise gro…

This study tested whether a device that gently stimulates the vagus nerve through the ear could help control rheumatoid arthritis in one patient who had their spleen removed. The patient used the device at home for 24 months and visited the clinic every two months for checkups. T…

This study tested whether nurse-led consultations can help people with rheumatoid arthritis become more independent in managing their subcutaneous biotherapy. Many patients struggle to recognize warning signs and delay seeking help. The study enrolled 71 adults with rheumatoid ar…

This completed study tested three different rehabilitation approaches—robotic rehabilitation, functional electrical stimulation (FES), and occupational therapy—to see which works best for improving hand and arm function in people with tetraplegia (paralysis of all four limbs) due…

This study tested whether a numbing injection behind the nose (sphenopalatine ganglion block) could reduce confusion and agitation after sinus surgery. 100 adults received either the nerve block or a placebo. The goal was to see if the block helped patients wake up more calmly an…

This study tested whether pain-relieving skin patches work as well as oral tablets for pain after root canal treatment. 80 adults with tooth pain received either a ketoprofen or fentanyl patch, or an oral medication. They rated their pain over 48 hours. The goal was to see if pat…

This study tested a treatment called radial shock wave phonophoresis for people with shoulder impingement syndrome. 70 adults aged 25-40 with shoulder pain were split into two groups: one got shock wave therapy plus standard physical therapy, the other got shock waves alone. The …

This study looked at whether a lumbar epidural steroid injection can reduce restless legs syndrome symptoms in 45 adults with lumbar central spinal stenosis. Participants received a standard injection as part of routine care, and their restless legs severity, pain, disability, an…

This study tested whether a smartphone app designed for patients having gallbladder removal surgery could reduce anxiety, complications, and improve comfort and satisfaction. 64 adults scheduled for laparoscopic cholecystectomy used the app during their hospital stay and recovery…

This study tested whether giving teens extra doses of the steroid dexamethasone after scoliosis surgery could reduce inflammation, pain, nausea, and hospital stay. Forty-two adolescents with scoliosis were randomly assigned to receive either one standard dose or three extra doses…

This study tested whether adding core stability training to standard physical therapy improves trunk control and sitting balance in people with incomplete spinal cord injury. 46 participants aged 25-35 with injuries between T6 and T12 took part. The core training focused on exerc…

This study tested whether adding a resveratrol supplement to a low-calorie diet helps postmenopausal women with obesity and knee osteoarthritis. Ninety-seven women took either the diet alone or the diet plus 150 mg of resveratrol daily for 10 days. Researchers measured pain, func…

This study tested a minimally invasive surgery for people with kneecap pain, dislocation, or instability. Surgeons used their finger to guide a small cut to release tight ligaments, aiming for less tissue damage than open surgery. 23 participants were enrolled. The approach may r…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study looked at 20 people with severe hip arthritis who needed a hip replacement. They were randomly assigned to get either a short or a long stem implant. Researchers used 3D motion capture to measure walking patterns before surgery and at several points after, to see if on…

This study tested whether using a blue laser before a standard red laser can help reduce muscle and joint pain in 44 adults with chronic neck or shoulder pain. Participants received a 13-minute treatment combining both lasers. The goal was to see if at least 65% of people got a 3…

This study tested three treatments for tennis elbow (lateral epicondylitis) in 27 adults over 6 weeks: blood flow restriction exercise with light weights, eccentric exercise with heavier weights, or wearing a wrist brace alone. The goal was to see which approach best reduces pain…

This study tested whether rinsing the sinuses with hot saline (50°C) during surgery for chronic sinusitis reduces bleeding and improves the surgeon's view. 59 adults were split into three groups: hot saline, room-temperature saline, or no rinse. The goal was to see if the hot rin…

This early-stage trial tested a new oral drug called MTR-601 in 89 healthy adults to see if it is safe and how the body processes it. The drug aims to reduce muscle stiffness and spasms, which could help people with conditions like cerebral palsy, multiple sclerosis, or stroke. S…

This completed trial tested a new device called the NEUROCUPLE™ patch, which uses nanotechnology to reduce pain after knee replacement surgery. 156 adults were randomly assigned to receive either the active patch or a placebo patch for 30 days. The goal was to see if the patch co…

This study looked at whether mesotherapy — injecting anti-inflammatory medicine into the skin near the jaw — can help people with chronic jaw muscle pain. Twenty-two adults with myofascial pain syndrome received treatment over 4 weeks. Researchers measured pain levels and how wid…

This study tested whether a non-invasive device that stimulates the vagus nerve, combined with self-care exercises, can reduce jaw and neck pain in people with temporomandibular disorders (TMD). 48 adults with jaw muscle pain participated. They received either real or placebo ner…

This completed study tested a laser device (BTL-043) on 31 adults with temporomandibular joint (TMJ) pain. Participants received four 20-minute laser sessions over a few weeks. Researchers measured pain levels, jaw movement, and daily function at 1 and 3 months after treatment to…

This study compared two treatments for tennis elbow (lateral epicondylitis): shock wave therapy and a single injection of 5% dextrose (sugar water). 96 adults with persistent pain for at least 3 months were split into three groups: standard care alone, standard care plus shock wa…

This study tested a smart faucet that can be controlled by voice, eye gaze, or hand motion to help people with cervical spinal cord injury drink water and groom themselves. Twenty-eight participants tried the faucet to see if they could complete tasks like drinking, rinsing, and …

This study tested whether a personalized, supervised home exercise program helps people recover better after total hip replacement compared to just receiving an exercise brochure. 44 people who had hip replacement surgery were split into two groups: one got a tailored exercise pl…

This study tested whether a non-invasive technique called transcranial direct current stimulation (tDCS) can reduce pain and improve daily function in people with knee osteoarthritis. 102 adults with chronic knee pain received either real or fake tDCS sessions over three weeks. R…

This study compares core stabilization exercises to a daily physical activity program in children aged 10-18 with juvenile spondyloarthropathy, a type of arthritis. The goal is to see if targeted core training can reduce pain, fatigue, and improve quality of life better than gene…

This study tested whether a J-shaped skin incision, instead of the usual straight cut, can reduce numbness and pain after total knee replacement. Sixty-two patients with severe knee arthritis were randomly assigned to get either the standard or the J-shaped incision. The research…

This study looked at whether using a forced-air warming blanket during knee replacement surgery helps prevent hypothermia (low body temperature) and related problems like shivering. Researchers compared 240 patients who either got the warming blanket or standard care. The goal wa…

This study tested whether hip surgery (PAO) followed by exercise is better than exercise alone for reducing pain in adults with hip dysplasia. 69 people aged 18-45 took part. The main goal was to see which approach improved hip pain and function more after 12 months.

This study tested two treatments for tooth sensitivity: a special varnish and an air-polishing system. Thirty adults with sensitive teeth were treated, and researchers measured pain relief and any tooth color changes. The goal was to find which method works better for easing disc…

This study tested whether a mobile app with sensors could help 174 adults with chronic kneecap pain follow their home exercise program. Participants received 1, 3, or 6 face-to-face remote training sessions and then exercised on their own for 6 weeks. The app tracked how much the…

This small study tested whether a device that gently stimulates a nerve in the ear (called auricular vagus nerve stimulation) is safe for people with chronic spinal cord injuries. Sixteen participants received the stimulation over two visits. The main goal was to check for side e…

This study tested whether adding exercise plans created by AI chatbots (ChatGPT-5, Gemini 2.5 Pro, or DeepSeek V3.1) to standard physical therapy helps people with degenerative knee disease feel better and move easier. 84 adults aged 40-65 took part in an 8-week program with supe…

This study tested whether adding a self-massage technique (Self-Mulligan) to online physical therapy helps people with shoulder pain more than online therapy alone. 52 adults with shoulder pain for at least 3 months took part. Both groups improved, but those who also did the self…

This study tested whether a low-cost version of platelet-rich plasma (PRP) injections could safely ease joint pain and swelling in people with bleeding disorders like hemophilia. Fourteen adults with joint damage received the injection and were followed for 6 months. The goal was…

This study tested whether a CBD oral solution (Epidiolex) can help manage pain and reduce the need for opioids in 37 adults undergoing double knee replacement. Participants received either a placebo or one of two CBD doses. The goal was to see if CBD could lower opioid use while …

This study compared two therapies—myofeedback and neuromuscular electrical stimulation—to see which better improves arm and hand function in children aged 6 to 14 who have one-sided weakness (hemiplegia) after brain tumor surgery. Forty-five children participated, and researchers…

This study tested five different non-surgical treatments for jaw joint (TMJ) pain in 160 adults. Treatments included a mouthguard, low-level laser therapy, laser acupuncture, or combinations of these. The goal was to see which approach best reduced pain and improved mouth opening…

This study tested whether a new mouthwash can reduce dental plaque and help prevent gum problems better than a control mouthwash. 80 adults with mild to moderate gum inflammation and plaque used the product for three months. Researchers measured gum health and plaque levels at 2 …

This study tested whether surgeons can give a numbing shot (adductor canal block) during knee replacement surgery as effectively as an anesthesiologist does before surgery. 200 adults with knee osteoarthritis having same-day discharge were randomly assigned to one of the two meth…

This study tested two physical therapy techniques—nerve flossing and deep neck flexor strengthening—in 62 adults with cervical spinal stenosis. The goal was to see which method better reduces pain, improves neck movement, and helps with daily activities. Participants did their as…

This completed Phase 2 trial tested a smart, hands-free faucet called Access-H2O for people with spinal cord injury. The faucet uses voice, motion, and remote controls to let users get water for drinking, grooming, and washing without help. Twenty-three participants with spinal c…

This completed trial looked at whether giving dexamethasone through a nerve block or through a vein works better for pain and inflammation after total knee replacement. 90 older adults were randomly assigned to one of two groups. Researchers measured how long pain relief lasted, …

This study tested three different injections—platelet-rich plasma (PRP), stem cell secretome, and hyaluronic acid—in 45 people with knee osteoarthritis. The goal was to see which one reduces pain and improves function best. Participants received one of the three treatments, and o…

This study compared two physical therapy techniques—Cyriax capsular stretching and Mulligan mobilization—for people with frozen shoulder (adhesive capsulitis). Thirty adults aged 30–65 with symptoms lasting over three months took part. Researchers measured pain, shoulder movement…

This study compared two minimally invasive procedures for knee osteoarthritis pain: genicular nerve radiofrequency ablation and intra-articular pulsed radiofrequency. Both use radiofrequency energy to reduce pain, but in different ways. Researchers enrolled 34 adults with knee os…

This study tested whether ozonized gel or a special laser helps gums heal faster and with less pain after a gingivectomy (gum removal surgery). 48 adults received one of the two treatments or standard care. Researchers checked healing, pain, and tissue regrowth over 28 days. The …

This study tested whether brief periods of breathing low-oxygen air (acute intermittent hypoxia) can improve arm, leg, and walking function in people with incomplete spinal cord injury. Sixty-eight participants received either the low-oxygen treatment or a sham (normal air) over …

This completed pilot study tested an 8-week online mindfulness course in 38 people with rheumatoid arthritis. The goal was to see if patients liked the program, what barriers they faced, and how it might affect symptoms. Half the group took the course while the other half receive…

This study tested whether combining two physical therapy techniques—muscle energy technique and Mulligan mobilization—works better than standard therapy alone for tennis elbow. Forty adults with elbow pain for at least 6 weeks took part. The goal was to reduce pain and improve da…

This study tested two different ways of preparing Platelet-Rich Plasma (PRP) injections for people with knee osteoarthritis. 96 participants received three injections over six weeks and were followed for six months. The goal was to see which method better reduces pain, improves f…

This study looked at whether adding heat therapy or contrast therapy (alternating hot and cold) to a specific exercise program helps people with patellofemoral pain syndrome, a common cause of front knee pain. Forty adults aged 18 to 40 with at least three months of knee pain too…

This study tested whether a special tooth gel can help adults with sensitive teeth. Thirty-one participants used the gel three times a day for two weeks. Researchers measured pain from cold air and touch before and after treatment to see if sensitivity improved.

This study tested two hands-on treatments for frozen shoulder (adhesive capsulitis) in 66 adults aged 40-65. One group received quick thrusts (HVLA), the other a gentler muscle energy technique (MET), both alongside standard physical therapy for four weeks. Both approaches reduce…

This study looked at 324 people with hearing loss and an inner ear problem called enlarged vestibular aqueducts. Researchers collected DNA, hearing tests, and scans to find genes that may cause the condition. The goal was to learn more about why it happens, not to test a treatmen…

This completed study used a 3D camera system called stereophotogrammetry to take pictures of the torso in healthy volunteers and people with scoliosis, chest wall deformities, or obesity. The goal was to refine the imaging technique, not to test a treatment. About 199 participant…

This study looks at families where one sibling has a rheumatic disease (like rheumatoid arthritis or lupus) and the other does not. Researchers compare their blood, genes, and environmental exposures to find clues about why one got sick. Over 1,000 participants are involved, incl…

This study looks at rare genetic disorders where the body can't make cholesterol properly, which can cause birth defects and learning problems. Researchers collect blood, urine, and tissue samples from affected people and their families to learn more about these conditions. The g…

This study looks at how well people with temporomandibular disorder (TMD) can sense the position of their neck, how sensitive their jaw muscles are to pressure, and the angle of their head posture. Researchers will compare 30 adults — half with TMD and half healthy — to see if th…

This study looked at people with suspected bone-related connective tissue disorders (like brittle bone disease) and their healthy family members. The goal was to learn more about these conditions, train doctors, and collect samples for future research. Participants received stand…

This study looked at nearly 1,400 people with rare conditions like PPNAD, Carney Complex, and Peutz-Jeghers syndrome. The goal was to find the genetic causes and link them to specific symptoms. Researchers used clinical exams and genetic testing to better understand how these dis…

This study looked at Smith-Lemli-Opitz syndrome (SLOS), a rare genetic condition that affects cholesterol production and causes birth defects and intellectual disabilities. Researchers enrolled 130 patients and their mothers to learn more about the disease's progression, genetic …

This study looked at how vaping and traditional smoking affect gum healing after a deep dental cleaning in people with stage II gum disease. Researchers measured gum pocket depth, bleeding, and inflammation markers in 117 participants. The goal was to see if vaping is less harmfu…

This study investigates whether a portable, affordable hand dynamometer can reliably measure trunk muscle strength in adolescents with idiopathic scoliosis. Researchers will test the device on 41 teens aged 10-18, comparing results between two evaluators and across two sessions o…

This study looked at 45 people with patellofemoral pain syndrome (pain around the kneecap) to see if different types of the condition have unique movement problems. Participants had X-rays and walking tests to measure how their knees move. The goal was to better understand the co…

This study followed 88 children and young adults with types III and IV osteogenesis imperfecta (brittle bone disease) to track how the condition changes over time. Researchers measured bone density, lung and heart function, hearing, and movement abilities. The goal was to better …

This study examines how different types of bacteria in the mouth are linked to the severity of dental cavities. Researchers will collect saliva and plaque samples from 56 people aged 3 to 45 and grade their cavities using a standard scoring system. The goal is to better understan…

This study is looking at how nutrition affects disease activity in people with rheumatic diseases like rheumatoid arthritis, lupus, and psoriatic arthritis. Researchers will measure the nutritional status of 460 participants using several different tools and compare it to how act…

This study looks at how the muscles around the knee work together to control movement, especially in the kneecap area. Researchers temporarily numbed one muscle with lidocaine in 28 healthy volunteers and used MRI scans to see how the knee moved. The goal is to better understand …

This study follows head and neck cancer patients who received radiation therapy to see how many teeth they lose over two years. It also looks at other mouth problems like dry mouth and bone damage. The goal is to better understand and manage these long-term side effects.

This study follows up with head and neck cancer patients about 7 years after they finished radiation therapy. Researchers will check for cavities, gum disease, tooth loss, bone damage, and saliva flow. The goal is to understand the long-term dental side effects of cancer treatmen…

This study tests whether wearable sensors and digital home tasks can track changes in movement, speech, and falls in people with ALS. About 20 participants will wear neck and wrist sensors and complete speech and handwriting tests over 48 weeks. The goal is to see if these digita…

This study tests whether watching AI-made educational videos can improve how older adults care for their dentures and feel about their oral health. About 50 people over age 50 who use removable dentures will watch the videos and answer questions. The goal is to see if this simple…

This study looks back at medical records from a single hospital in Scotland to see how well the drug bosutinib works and how safe it is for people with chronic myeloid leukemia (CML) in everyday practice. Researchers will track blood cell counts, genetic responses, and side effec…

This study looks at whether computer models can predict if local anesthetic (numbing) will work for people with a painful tooth condition called symptomatic irreversible pulpitis. Researchers analyzed records from 4,390 adult patients to compare three different machine learning a…

This study tested two different robotic exoskeletons—one that balances itself and one that requires the user to balance—in 6 people with spinal cord injury. Researchers measured how fast and far participants could walk with each device, along with muscle activity and user feedbac…

This study followed 55 people with dental implants for 5 years to see if their history of gum disease (aggressive, chronic, or none) affected implant health. Participants received regular dental cleanings. Researchers measured bone loss, gum inflammation, and implant survival. Th…

This completed study examined 22 adolescents with idiopathic scoliosis to see if joint hypermobility (flexibility) and foot posture are linked to the severity of their spinal curve. Researchers measured hypermobility with the Beighton Score, foot posture with the Foot Posture Ind…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study looked at 20 teens with scoliosis (a curved spine) to see if the position of their shoulder blades is linked to how well they can use their arms. Researchers measured shoulder blade movement and arm power using simple tests like throwing a weighted ball. The goal is to…

This study examined 750 emergency patients with joint pain to find out which germs cause septic arthritis. Researchers compared standard lab cultures with a new PCR test to see which works better. The goal is to help doctors diagnose joint infections more quickly and accurately.

This study tested whether using a screening questionnaire called the STarT Back Tool helps doctors tailor low back pain treatment for military members. 290 adults aged 18-50 with low back pain were randomly assigned to either risk-stratified care or usual care. The goal was to se…

This study looked at whether certain amino acids in saliva differ between people with healthy gums, gingivitis, and periodontitis. Researchers also tracked how these amino acids changed after standard non-surgical gum treatment in 32 periodontitis patients. The goal is to see if …

This study looks at how the thigh muscles control the movement of the knee cap in people with long-term knee cap pain. Researchers will use MRI scans to compare knee movement in people with pain and healthy volunteers. In a second session, they will temporarily numb a thigh muscl…

This study looked at 60 children aged 1 to 4 years who had surgery for developmental dysplasia of the hip. Doctors compared two ways of cutting the hip capsule: a U-shaped cut and a T-shaped cut. The goal was to see which method was faster and needed fewer stitches. The results m…

This early-phase trial tested whether adding atovaquone (a drug usually used to prevent pneumonia) to standard chemotherapy is safe and reaches effective levels in the blood. It involved 26 children and young adults (ages 1 month to 21 years) newly diagnosed with acute myeloid le…

This study looked at jaw disorders and teeth grinding in 76 elite basketball referees compared to healthy people. Referees face high stress and often hold a whistle between their teeth, which may strain the jaw. Researchers used ultrasound to measure jaw muscle thickness and foun…

This study looked at 76 children aged 3 to 15 getting dental care with nitrous oxide (laughing gas). Researchers watched for signs that kids wanted to keep the mask on longer, like hand gestures or asking to keep it. The goal was to see if there's a risk of children misusing the …

This study tested three ways to teach oral hygiene to 72 teenagers with braces: verbal instructions, a pamphlet, or a video. Researchers measured plaque and gum health before and after to see which method worked best. The goal is to find the simplest, most effective way to help y…

This study follows people newly diagnosed with psoriatic arthritis (PsA) to see how a 'treat to target' approach works in everyday clinics. Participants receive standard care, often starting with methotrexate, and their disease activity is tracked over time. The goal is to unders…

This study investigates how often people with lateral epicondylitis (tennis elbow) also have posterolateral rotatory instability, a ligament problem that causes similar pain but requires different treatment. Researchers will check the elbow's lateral collateral ligament during sc…

This study tested a new way to measure nose and lip shape in 14 infants with cleft lip and palate using 3D facial scans. Researchers compared these scans to standard photos and manual measurements to see if the digital method is accurate. The goal is to find a better, less invasi…

This study looked at how the COVID-19 lockdown affected people with spondyloarthritis, a type of arthritis. Researchers surveyed 1,000 patients to see if they stopped their usual treatments during confinement and what psychological factors might have played a role. The goal was t…

This study evaluates the SF-6D, a questionnaire that measures health-related quality of life, in people with early inflammatory back pain (symptoms for 3 months to 3 years). Researchers will check if the tool is reliable, sensitive to changes over time, and how factors like age, …

This completed study reviewed data from 31 patients who had knee replacement revision surgery due to aseptic loosening (the implant coming loose without infection). Researchers used a regional registry and X-ray analysis to understand the causes and economic impact. The goal was …

This completed study from France examined joint fluid from 20 people with arthritis to see if acid-sensing ion channels (ASICs) play a role in pain. Researchers wanted to find natural compounds that activate these channels during inflammation. The goal is to validate ASICs as tar…

This study compares two surgical techniques used to rebuild the jawbone so dental implants can be placed. The Split Box Technique and the Split Bone Block Technique both aim to increase bone width. Researchers looked back at records of 31 patients treated at a university dental c…

This completed study from France reviewed the long-term results of a surgery called continent cutaneous urinary diversion in 70 spinal cord injury patients. The surgery creates a new way to drain urine through the belly when patients cannot use a catheter normally. Researchers co…

This study gathered information from 193 adults who had surgery or orthopedic treatment for spine problems. Researchers collected clinical, functional, and social data to create a detailed database. The goal was to better understand patient outcomes and standardize how data is co…

This completed study looked at how oral health problems like cavities and gum issues affect the daily lives of 454 preschool children in Portugal. Researchers asked parents about their child's oral health and its impact on the child and family. The goal was to understand which so…

This completed pilot study aimed to estimate how common osteoporosis is in France, starting with the Alpes-Maritimes region. Researchers enrolled 800 participants who each received a bone densitometry scan. The study was observational and did not test any treatment.

This study looked at a type of immune cell called B regulatory cells in 100 people—some healthy and some with rheumatoid arthritis (RA). The goal was to understand how these cells differ between the two groups and how they might help control the disease. By identifying unique fea…

This study followed 813 people with early rheumatoid arthritis in France to see how often and why doctors prescribe TNF blockers. Researchers tracked symptoms, joint damage, and treatment success over 5 years. The goal was to learn which patients benefit most and how well doctors…

This study checked whether women over 50 who had severe osteoporotic fractures (like hip or spine breaks) were scheduled for osteoporosis treatment at Nîmes University Hospital. Researchers reviewed hospital records of 500 patients to see if treatment was planned. The goal was to…

This completed study from France examined whether a specific type of immune cell (innate CD8+ T cells) is linked to how quickly resistance mutations develop in patients with chronic myeloid leukemia or Philadelphia-positive acute lymphoblastic leukemia. Researchers analyzed blood…

This study followed 813 people with early rheumatoid arthritis in France to see how often doctors prescribe TNF blockers alone (without other arthritis drugs) and how well they work. Researchers tracked symptoms, joint damage, and how long patients stayed on treatment over 5 year…

This study looked for substances in the blood that could signal chronic pain after a spinal cord injury. Researchers compared blood samples from 120 people with and without pain, including those with recent and long-term injuries. The goal was to find early warning signs that cou…

This study looked at whether French doctors follow EULAR recommendations to check heart disease risk every year in patients with rheumatoid arthritis. Over 7000 patients were included. The goal was to see how often tests like blood sugar, cholesterol, and heart scans were prescri…

This study looked at three ways to help people with rheumatoid arthritis take their methotrexate medication as prescribed: usual doctor visits, text message reminders, or a chat with a pharmacist. The goal was to see which method works best to improve adherence. The study include…

This study observed 30 elderly patients (over 65) who had a specific type of neck fracture (odontoid fracture) from a minor fall or low-energy injury. Researchers measured bone density, vitamin D levels, and other bone health markers to understand why these fractures happen. They…

This study compared muscle oxygen levels in the thigh muscle of 34 people with and without knee osteoarthritis. Participants did a simple squat exercise while a device measured oxygen in the muscle. The goal was to understand how knee OA affects muscle function and recovery, whic…

This study looks at whether people with chronic inflammatory rheumatism (like spondyloarthritis) or lupus who still have pain despite treatment have low vitamin C levels. Researchers will measure vitamin C in the blood and ask about pain, fatigue, and quality of life. The goal is…

This completed study looked at 340 people to understand how certain proteins in the lungs, called autoantibodies, might be linked to the start of rheumatoid arthritis (RA). Researchers collected sputum (mucus from the lungs) from people at risk for RA, those already diagnosed, an…

This completed study looked at the natural course of two ultra-rare genetic disorders: GACI and ARHR2. Researchers collected medical records and blood samples from 48 affected individuals and their family members. The goal was to better understand how these diseases progress over…

This completed study surveyed 566 adolescents aged 14 to 16 to understand how jaw pain (temporomandibular disorders) relates to other painful conditions like headaches, neck pain, and back pain. Researchers used anonymous questionnaires to identify common co-occurring health issu…

This study looked at 120 adults with neck or lower back spine issues to compare two types of scans: contrast-enhanced MRI and FDG-PET/CT. Researchers checked how clear the images were and whether the scans caused any short-term changes in kidney function or blood counts. The goal…

This study tested whether a new version of the arthritis drug abatacept (called KSHB002) works similarly to the approved drug Orencia. Three hundred healthy adults received a single injection of either the new drug or Orencia. Researchers measured drug levels in the blood, checke…

This study tested whether wearable motion sensors can accurately measure spinal movement in people with ankylosing spondylitis (AS), a condition that causes back pain and stiffness. Forty participants (20 with AS and 20 healthy volunteers) wore sensors while performing everyday m…

This study looked at whether virtual surgical planning can accurately predict the placement of custom-made jaw joint replacements in 8 patients with severe TMJ disorders, jaw defects, or recurrent joint stiffness. Researchers compared the planned position to the actual position a…

This study looked at 47 people with bullous pemphigoid, a blistering skin condition, who were treated with high-dose topical corticosteroids (clobetasol propionate) for 6 months. Researchers measured bone mineral density at the start, at 3 months, and at 6 months to see if the tr…

This study followed 163 people with chronic inflammatory rheumatism (like rheumatoid arthritis) who had a recent COVID-19 infection. Researchers measured their antibody levels over two years to see how immunosuppressive drugs affect antibody persistence. The goal was to better un…

This study looked at whether healthcare professionals in Saudi Arabia are aware of and follow safety measures for the drug leflunomide, used for rheumatoid and psoriatic arthritis. Researchers surveyed 302 doctors and pharmacists to see if they received and read safety materials,…

This study looked at 49 people with masses in the sellar region of the brain (near the pituitary gland). Researchers compared MRI scans before surgery with the final diagnosis after surgery to see how well imaging predicts the type of tumor. The goal was to improve diagnosis and …

This study involved 20 adults over age 50 to measure how soft tissues (skin, fat, muscle) around the knee react when pressed by a brace. Researchers used an ultrasound probe to push on the leg and record force and displacement. The goal is to gather data that could lead to more c…

This study enrolled 200 adults with lung adenocarcinoma that has spread to the bones. Researchers took bone biopsies, scans, and blood tests to measure bone and metabolic markers. The goal is to see if these markers are linked to how long patients live. This is an observational s…

This study tested two types of magnetic attachments (flat vs. dome-shaped) for lower dentures held by implants. Fourteen adults with no teeth in their lower jaw took part. The goal was to see which design keeps dentures more securely in place.

This study looked at whether teaching mothers about their family health history can help them encourage healthier eating and exercise in their families. About 310 adults with at least one child took part. Researchers gave them a Family Health Package with personalized risk info a…

This study looked at how patients and healthcare professionals experienced a new way of organizing primary care, where different health workers work together as a team. Researchers interviewed 48 patients and staff at one health centre in France. The goal was to understand what w…

This pilot study looked at bacteria in root canal infections, comparing painful and painless cases. Researchers used DNA testing to identify bacteria before and after cleaning with two different strengths of sodium hypochlorite. The goal was to see how well the cleaning removes b…

This pilot study looked at whether measuring arm speed in 3D can help track recovery in people with shoulder pain (subacromial pain syndrome). Thirteen adults had their shoulder movement measured before and after a standard 4-session rehab program. The goal was to see if these sp…

This study looked at medical records of 938 adults with solid tumors who received immunotherapy. Researchers compared how well the treatment worked when cancer had spread to different organs like the liver, brain, lung, or bone. The goal is to understand why some metastatic sites…

This completed study looked at how the COVID-19 pandemic and social distancing impacted the mental health of 259 adults with chronic inflammatory rheumatism (like rheumatoid arthritis or ankylosing spondylitis). Researchers used questionnaires to measure stress, depression, anxie…

This completed trial tested how quickly paramedics can stabilize a patient's spine using a scoop stretcher versus a vacuum mattress. Fifteen emergency medical workers participated in a simulated emergency. The goal was to see which device is faster and whether the quality of stab…

This study looked at whether using a special 3D scan during surgery, combined with a navigation system, helps place screws more accurately in the lower back compared to the usual X-ray method. It involved 126 adults having lumbar spine surgery. The main goal was to see if the new…

This study looked back at records of 200 adults who had heart valve surgery to see if treating gum disease beforehand lowered their risk of infection or death after the operation. Researchers checked dental X-rays and medical charts from 2015 to 2024. The goal is to understand if…

This study examined 180 adults to see if the shape of their gums and their oral habits (like brushing force or teeth grinding) are linked to non-carious cervical lesions — wear on teeth not caused by cavities. Participants filled out a questionnaire and had a dental exam. The goa…

This study examined whether women with autoimmune diseases or inflammatory rheumatism receive proper gynecological follow-up, including cervical cancer screening and contraception advice. Researchers surveyed 318 women with conditions like lupus, rheumatoid arthritis, and Sjögren…

This study examined tissue samples from the shoulder capsule of 40 patients to see if certain changes are linked to shoulder instability. Researchers compared samples from patients with unstable shoulders to those without. The goal was to better understand these tissue changes, w…

This study looked at how the types of bacteria in an infected root canal change during routine dental treatment. Twenty-four adults with a chronic tooth abscess received standard root canal therapy using one of two bleach solutions (5.25% or 3% sodium hypochlorite) followed by a …

This study looked at whether a remote dental exam (teledentistry) can accurately assess treatment needs and behavior guidance for preschool children compared to a standard in-person exam. Researchers included 29 healthy children aged 4 to 6 years. The goal was to see if teledenti…

This study looked at how the interaction between a physical therapist and a patient affects recovery during robot-assisted walking training for people with spinal cord injury. 55 participants were split into two groups: one with high therapist interaction and one with minimal int…

This completed study looked at 160 healthy adults to see if a blood test marker called Pan-Immune-Inflammation Value (PIV) is linked to the severity of gum disease. Researchers measured gum inflammation and compared it to PIV from routine blood work. The goal was to explore if th…

This study tested whether giving general practitioners a simple, evidence-based guideline improves care for people with shoulder pain. 160 adults with shoulder pain took part in Norwegian GP clinics. Researchers measured pain, disability, and quality of life to see if the guideli…

This study looked at the safety of the drug RINVOQ in over 4,200 Japanese adults with rheumatoid arthritis, a condition causing joint pain and swelling. Researchers reviewed medical records for three years to count serious infections and other side effects that happened during no…

This study compared two types of surgical retractors used during hip replacement surgery to see if one caused fewer infections. 144 patients were randomly assigned to receive either a Charnley retractor or an Alexis O-Ring retractor. The researchers took tissue samples during sur…

This study looked at bone density in 448 men with hemophilia and healthy volunteers to see how common bone loss is. Participants had a bone density scan and some gave blood samples. The goal was to understand if hemophilia itself, not just lack of activity, leads to weaker bones.

This study tested a special MRI technique called magnetic resonance elastography (MRE) to see if it can detect scarring in transplanted kidneys. Researchers compared MRE results with traditional biopsy samples from 73 kidney transplant patients. The goal was to find a non-invasiv…

This study tested whether taking common painkillers like paracetamol or ibuprofen before a dental pulp sensitivity test changes the results. 184 healthy adults received either a painkiller or a placebo, and their tooth nerve responses were measured. The goal is to help dentists a…

This study followed 130 adults with advanced gum disease (periodontitis) to see if those who used probiotics on their own during standard non-surgical treatment had better outcomes. Researchers measured plaque, bleeding, pocket depth, and quality of life at 1 and 3 months. The go…

This completed study looked at inherited disorders common in Amish and Mennonite populations. Researchers collected medical histories, blood or cheek swab samples from 157 participants to find the genes behind these conditions. They also built a computer database of family trees …

This study used a special MRI technique to create detailed maps of the Achilles tendon in 121 adults. Researchers compared healthy volunteers to people with a type of arthritis called spondyloarthropathy, both with and without tendon pain. The goal was to better understand tendon…

This completed study looked at over 107,000 patients in Germany to understand the long-term side effects of systemic steroids (corticosteroids) used for conditions like asthma, COPD, and arthritis. Researchers compared patients who took steroids with those who did not, tracking r…

This study looked at whether slow, yogic-style breathing can affect heart rate and blood pressure in people with spinal cord injuries. Seventeen wheelchair users completed breathing exercises while their heart and blood pressure were measured. The goal was to learn more about how…

This study looked at whether alcohol consumption affects the success of local anesthesia for people with a painful tooth condition called irreversible pulpitis. Researchers gave 70 patients (35 who drink alcohol and 35 who don't) a standard numbing injection and measured pain dur…

This study looked at how three types of dental crowns (stainless steel, zirconia, and fiber-glass) affect the gums of 21 children aged 6-9. Researchers measured gum pocket depth, bleeding, plaque, and inflammation markers in the gum fluid. The goal was to see which crown material…

This study looked at how diet affects gum inflammation in healthy people. Researchers compared vegans and omnivores by temporarily stopping their oral hygiene to see how their gums reacted. The goal was to understand if a vegan diet might reduce gum inflammation compared to an om…

This completed study looked at how the skeleton is aligned with gravity in adults with postural problems. Researchers used a low-dose X-ray device called EOS to create 3D images of the spine and pelvis. The goal was to better understand the body's geometry in people with balance …

This study looked at whether a special honey (Trigona sp.) helps heal wounds after cleft palate surgery better than a standard antibiotic dressing. Twenty-four children aged 18 months to 6.5 years participated. Researchers measured a healing marker in saliva before and after surg…

This small study tested two methods for cleaning infected root canals: ultrasonic activation and a 980-nm diode laser. Sixteen adults with dead (necrotic) teeth had their root canals cleaned with one of these methods. Researchers checked for leftover bacterial DNA to see which me…

This study aimed to find blood markers that can predict whether the drug adalimumab will successfully treat ankylosing spondylitis after 6 months. Researchers analyzed blood samples from 50 adults starting adalimumab for the first time. The goal was to create an algorithm to help…

This study followed 220 adults with phenylketonuria (PKU) in France to learn how the disease affects them later in life. Researchers looked for signs of cognitive decline, neurological problems, and how the disease impacts quality of life and social integration. No new treatment …

This study translated a questionnaire that measures how chronic gum disease affects quality of life into Hindi. Researchers tested it on 196 patients with periodontitis to ensure it is accurate and reliable. The goal is to give Hindi-speaking patients a way to report their oral h…

This study looked at the genes of 40 adults with type 2 diabetes to find DNA differences that might explain why some develop Charcot foot, a serious joint problem. Half of the participants had Charcot foot, and half did not. Researchers compared their exomes (the part of DNA that…

This study looked at how teenagers with scoliosis sense and imagine their own bodies compared to healthy teens. Researchers tested touch sensitivity, left-right thinking, and body position awareness. The goal was to better understand how the brain might be involved in scoliosis, …

This completed study tested a smart wearable device called gaitQ that monitors and cues walking in people with long-term movement conditions like Parkinson's, stroke, multiple sclerosis, and arthritis. Researchers collected movement data from 98 participants in a lab to see if th…

This completed study looked at blood vessel cells from 30 people with primary myelofibrosis, a rare bone marrow disorder. Researchers wanted to see if these cells act like stem cells that could be the origin of the disease. By growing the cells in the lab, they aimed to understan…

This study looked at how four different drinks—two prebiotic sodas, regular Coca-Cola, and Diet Coke—affect hunger, blood sugar, insulin, and appetite hormones in healthy men aged 18-40. Ten participants visited the lab four times, each time drinking one of the beverages in a ran…

This completed study investigated whether air pollution affects flare-ups in people with rheumatoid arthritis, ankylosing spondylitis, or psoriatic arthritis. Researchers followed 86 patients for 6 months, asking them to complete weekly questionnaires about their symptoms. They a…

This study investigates whether changes in DNA methylation—a kind of chemical switch—might cause certain rare limb malformations that appear without a family history. Researchers will compare DNA samples from 40 people with Amelia (missing two or four limbs) or Femur Fibula Ulna …

This study looked at 235 people to understand how certain immune cells, called innate T cells, might be involved in systemic sclerosis (a rare disease that causes hardening of the skin and organs). Researchers compared patients with systemic sclerosis to those with other autoimmu…

This study looked at how flatfoot (pes planus) changes the way people walk on flat ground and uphill. Researchers measured walking speed, step length, and hip movement in 30 healthy adults aged 18–35. The goal was to better understand these changes and help design better rehab pr…

This completed study enrolled 33 people with osteogenesis imperfecta (OI), a condition that makes bones fragile. Researchers used special sensors and gait analysis to measure how participants move. The goal was to identify which movement patterns are most useful for understanding…

This study looks at proteins that help parts of cells communicate—specifically mitochondria and the endoplasmic reticulum—in people with healthy gums, gingivitis, or advanced gum disease. Researchers measure these proteins in saliva and gum fluid to see if they relate to inflamma…

This study looked at 343 adults with infections in their artificial hip or knee joints. It compared two common surgeries: one-stage (removing and replacing the joint in one operation) and two-stage (removing the joint, treating the infection, then replacing it later). The main go…

This study looked at how teriparatide (Forsteo), a daily injection, builds new bone in postmenopausal women with osteoporosis. Nineteen women took the drug for two years. The goal was not to test if it works, but to understand exactly how it changes bone density and turnover over…

This study looked at 40 people who had knee replacement surgery to see if the type of implant affects recovery. One group got a cruciate-retaining implant, the other a posterior-stabilized implant. Researchers measured pain, function, fear of movement, quality of life, and how mu…