Skeletal system disorder

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This study looks at how well the drug asciminib works and how safe it is for young adults with chronic myeloid leukemia (CML) in the Gulf region. Researchers will collect information from medical records of about 80 people aged 18 and older who have taken asciminib. The main goal…

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This trial compares two types of rotary files designed for children's primary molars: Fanta AF Baby and EndoArt Pedo Blue. The goal is to see which system prepares root canals faster and with better filling quality during a pulpectomy (removing infected pulp). Thirty children age…

This phase I trial is testing whether combining three drugs—pacritinib, venetoclax, and azacitidine—is safe and tolerable for people with accelerated or blast phase myeloproliferative neoplasms, aggressive blood cancers. The study enrolls about 20 adults whose disease has progres…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This study tests whether adding hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber) to a standard hip procedure (core decompression with bone marrow cells) can reduce pain in people with early-stage avascular necrosis of the hip. The trial will enroll 400 p…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether adding the drug vorinostat to standard care can prevent graft-versus-host disease (GVHD) in children and young adults (ages 1-26) with non-cancerous blood disorders who are getting a bone marrow transplant. GVHD is a serious complication where donor cells…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This early-phase trial is testing an experimental therapy called GT737 for adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatment. GT737 uses specially engineered immune cells (iNKT cells) that are made in large batches and can be given…

This trial investigates whether adding bortezomib and sitagliptin to standard post-transplant cyclophosphamide can prevent graft-versus-host disease (GvHD) in adults with blood cancers receiving a stem cell transplant. Participants receive the drug combination after transplant, w…

This study tests a new combination of three drugs—revumenib, azacitidine, and venetoclax—in people newly diagnosed with a specific, hard-to-treat leukemia called KMT2A-rearranged AML. The goal is to see if this cocktail can help more patients achieve remission with fewer side eff…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-str…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether taking a daily antibiotic (levofloxacin) can safely reduce infections in people with myelodysplastic syndrome (MDS) or acute myeloid leukemia (AML) who are receiving chemotherapy as outpatients. The trial will randomly assign 75 participants to either lev…

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement o…

This study compares two surgical techniques to repair a bone gap in the upper jaw (alveolar cleft) in 20 people who missed earlier treatment. One method uses bone from the patient's jaw, the other from the hip. Researchers will measure bone volume and shape after 6 months to see …

This study tests whether giving personalized maintenance therapy after a stem cell transplant can prevent cancer from coming back in people with certain blood cancers. About 450 adults with myeloid cancers who have signs of disease before transplant will be assigned to treatment …

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years…

This study compares a new drug combination (venetoclax plus azacitidine) against standard chemotherapy for adults with a specific type of acute myeloid leukemia (AML) that has NPM1 or IDH mutations. About 148 people will be randomly assigned to one of the two treatments. The main…

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study tests whether removing some blood during bone cancer surgery and replacing it with fluid (acute normovolemic hemodilution) can reduce the need for donor blood transfusions. The trial will include 420 adults undergoing elective bone cancer surgery. The goal is to see if…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This trial investigates whether adding hip strengthening exercises to a standard quadriceps program better preserves knee cartilage thickness and improves symptoms in people with knee osteoarthritis. Fifty-six adults with mild-to-moderate knee OA will be randomly assigned to one …

This study tests a new oral drug called revumenib in people with acute myeloid leukemia (AML) who have certain genetic changes. After a stem cell transplant, participants will take revumenib or a placebo to see if it helps keep the cancer from coming back. The trial involves 144 …

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This trial tests a highly targeted radiation technique called stereotactic body radiotherapy (SBRT) against standard radiotherapy for people whose cancer has spread to the spine but has not yet compressed the spinal cord. The goal is to see if SBRT can better prevent tumor growth…

This study tests a new combination of drugs (chidamide, venetoclax, azacitidine, and homoharringtonine) as a first treatment for adults aged 18-60 with intermediate- to high-risk acute myeloid leukemia (AML). The goal is to see if this mix can improve remission rates and reduce t…

This study tests two procedures done before ACL surgery: draining excess knee joint fluid (arthrocentesis) or injecting platelet-rich plasma (PRP) from the patient's own blood. The goal is to see if either reduces inflammatory chemicals linked to cartilage damage. About 99 adults…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This early-phase trial tests whether giving healthy stem cells from the mother to a fetus diagnosed with Fanconi anemia can safely improve the baby's blood cell production. The treatment is a one-time injection into the fetus during pregnancy. The study will enroll 12 pregnant wo…

This early-stage trial tests a new drug called JR-446 in 12 children under 6 with MPS IIIB, a rare genetic disorder that damages the brain and body. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in certain substances in the body …

This phase 2 trial tests whether adding olutasidenib to standard treatments helps people with IDH1-mutated acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). For AML, the standard is a chemotherapy pill plus venetoclax; for higher-risk MDS, it's the chemotherapy pill…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This trial tests rusfertide, an injected drug, in Japanese adults with polycythemia vera, a rare blood cancer that causes too many red blood cells. The goal is to see if rusfertide can keep red blood cell levels under control and reduce the need for phlebotomy (blood removal). Al…

This study looks at whether giving the drug venetoclax for a shorter time, along with the combination drug ASTX727, works as well as the usual longer course for adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for strong chemot…

This trial compares two surgical approaches for tennis elbow that has not improved after at least six months of non-surgical treatments like rest or physical therapy. One group receives keyhole (arthroscopic) surgery, while the other receives traditional open surgery. The main go…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This study tests whether combining dasatinib with ropeginterferon can better control chronic myeloid leukemia in its early phase. About 40 adults newly diagnosed with CML will receive the drug pair to see if it improves disease control and reduces side effects. The goal is to man…

This pilot study tests whether the drug ropeginterferon is safe and feasible for 12 people with a JAK2 mutation and high-risk features who do not yet have a blood cancer. Participants receive an injection every 4 weeks and are monitored closely. The goal is to see if this approac…

This trial is testing a combination of three chemotherapy drugs—clofarabine, busulfan, and melphalan—given before a stem cell transplant in 30 adults with acute myeloid leukemia (AML) who are in first remission. The goal is to see if this conditioning regimen improves survival an…

This study tests whether freeze-dried fecal bacteria, given as oral capsules, can improve symptoms in 40 adults with active rheumatoid arthritis that hasn't responded to standard drugs. Participants will receive either the fecal transplant or a placebo for 24 weeks. The main goal…

This study tests whether a two-week course of the VA-CAG chemotherapy works as well as the usual three-week course for adults newly diagnosed with acute myeloid leukemia (AML). About 110 participants will be randomly assigned to one of the two schedules. The goal is to see if the…

This 52-week study will compare three drugs—tocilizumab, telitacicept, and methotrexate—in 204 people with rheumatoid arthritis who also have interstitial lung disease. The main goal is to see which drug best improves lung function. Participants will continue their usual arthriti…

This study looks at whether a higher dose of the blood thinner clopidogrel works better for people with essential thrombocythemia (ET), a rare blood disorder that raises the risk of dangerous blood clots. The standard dose may not work well for many ET patients, so researchers wi…

This study tests a new two-drug combination (pacritinib plus azacitidine) for people with moderate to very high risk myelodysplastic syndrome (MDS), a bone marrow disorder. The first part finds the safest dose of pacritinib, and the second part checks how well the combination wor…

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This study will follow about 98 adults with chronic myeloid leukemia who are taking asciminib after other treatments have stopped working. Researchers want to see how many patients achieve a major molecular response (a key sign of disease control) after two years. The goal is to …

This phase I trial tests a new treatment for adults with acute myeloid leukemia (AML) who have minimal residual disease (MRD) — small amounts of cancer cells that remain after standard therapy. The treatment uses the patient's own T cells, genetically modified to recognize a prot…

This study looks at whether mobile health reminders can help people with gum disease keep their teeth cleaner after standard treatment. The trial will include 76 adults with gum disease affecting the roots of their back teeth. Participants will receive text or app reminders to im…

This phase 2 trial tests whether adding two drugs (SHR2554 and azacitidine) to standard chemotherapy before a stem cell transplant can help people with high-risk or relapsed/refractory acute leukemia or myelodysplastic syndromes. About 180 participants aged 15-60 will be randomly…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study tests a gel made from doxycycline and atorvastatin in tiny chitosan particles, placed directly into gum pockets after standard deep cleaning. The goal is to reduce gum inflammation, pocket depth, and bone loss in 80 adults with moderate to severe chronic periodontitis.…

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This trial tests a new automated radiation method that precisely targets bone marrow and lymph nodes before a stem cell transplant. The goal is to kill cancer cells while reducing damage to healthy tissues. Participants have high-risk myeloid cancers like acute myeloid leukemia o…

This study tests whether adding a new drug called revumenib to the usual treatment (blinatumomab plus chemotherapy) can better clear leftover leukemia cells in people with a specific genetic type of B-cell acute lymphoblastic leukemia (ALL) or mixed-lineage leukemia. About 90 adu…

This study follows 200 adults with severe chronic sinusitis and nasal polyps who are starting tezepelumab as part of their routine care. Researchers will track changes in symptoms and quality of life over up to two years using patient questionnaires. The goal is to see how well t…

This study compares two types of full dentures: 3D printed ones and milled ones. Researchers want to see which lasts longer and causes fewer problems over five years. Sixty-eight adults who need complete dentures will take part, and the main focus is how many dentures are still w…

This study tests whether adding hyaluronic acid gel to standard deep cleaning (scaling and root planing) improves gum healing in people with both diabetes and advanced gum disease. Twenty-three participants will receive the standard cleaning on all teeth, and then two gum pockets…

This trial investigates whether adding selinisole to standard chemotherapy drugs (azacitidine and venetoclax) can improve outcomes for people with newly diagnosed, high-risk myeloid tumors that have a TP53 mutation. These tumors are aggressive and hard to treat. The study will me…

This study compares two ways of making dental crowns for back teeth that have had root canals: 3D-printing from a ceramic-filled resin versus milling from a ceramic block. Sixty adults will receive one of these crowns and be checked for fractures, fit, and color over two years. T…

This study will compare two drugs, tofacitinib and upadacitinib, added to standard methotrexate treatment for rheumatoid arthritis. One hundred adults in Pakistan will take one of the two drugs daily for six months. Researchers will measure disease activity and side effects to se…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This early-stage trial tests a nasal spray for adults with chronic sinusitis (without polyps). The spray contains stem cell exosomes to heal the nose lining, an antibiotic to kill bacteria, and an enzyme to break up thick mucus. 108 participants will use the spray twice daily for…

This study compares two treatments for severely damaged lower molars: a tooth-saving surgery called hemisection (removing the damaged root) versus replacing the whole tooth with a dental implant. Researchers will track 28 participants over 12 months to see which option leads to b…

This study is testing whether a two-drug combination (venetoclax and azacitidine) followed by a stem cell transplant can help people with a rare, hard-to-treat form of acute myeloid leukemia (AML). The trial will enroll 50 adults who have not been treated before. The goal is to s…

This study tests a new drug, INCA033989, against the best current treatments for people with a rare blood cancer called essential thrombocythemia who have a specific gene mutation (CALR). About 426 adults who have already tried at least one prior therapy will be randomly assigned…

This study tests a combination of seven drugs (including asciminib and venetoclax) in 30 adults with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute myeloid leukemia. The first phase checks safety, and the second phase sees if the combo helps control t…

This study tests a surgical procedure to cover exposed tooth roots on the tongue side of lower teeth. Twenty adults with gum recession will receive the surgery and be followed for up to 24 months. The main goal is to see how much root coverage is achieved at 6 months, along with …

This study tests two experimental drugs, goflikicept and olokizumab, in 52 adults with Still's disease, a rare inflammatory condition. The goal is to see if these drugs can quickly bring the disease under control and keep it from flaring up. Participants will receive either the s…

This study tests whether adding a Chinese herbal formula (Si Miao Xiao Bi Tang) to standard rheumatoid arthritis medication can improve symptoms. About 132 adults with active RA will receive either the herbal medicine or a placebo for 12 weeks. The main goal is to see if more peo…

This study tests whether adding hyaluronic acid gel to standard deep-cleaning treatment improves gum healing in smokers with advanced periodontitis. Twenty-three smokers will receive the standard cleaning, then some gum pockets will also get the gel. Researchers will measure gum …

This study tests whether applying a thin, clear surface sealant over tooth-colored fillings helps prevent discoloration and improves how long the filling lasts. Twenty-five adults with cavities in their back teeth will receive either a sealant or standard polishing. Researchers w…

This study tests whether a device that electrically stimulates the abdominal muscles can improve cough strength in 150 adults with a recent spinal cord injury. Participants will use the device during breathing exercises for up to 6 weeks. The goal is to see if it helps clear mucu…

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent mo…

This study looks at whether adding hyaluronic acid to temporary dental crowns (made by 3D printing or milling) can improve gum health and surface smoothness. Sixty adults with moderate gum disease will receive one of the two crown types, and their gum attachment, bleeding, and pl…

This study tests a pill called selinexor in 15 adults with chronic blood cancers (MPN) whose blood cell counts are too high. The goal is to see if selinexor can safely bring those counts down and ease symptoms. Participants take the drug once a week for up to 3 months and are fol…

This early-phase study tests a new drug (ATRN-119) combined with a standard chemotherapy (decitabine) in 27 adults with acute myeloid leukemia or high-risk myelodysplastic syndrome that has a TP53 gene change. The main goals are to find a safe dose and see if the combo can shrink…

This study looks at whether giving radiation and chemotherapy together before surgery can help control high-risk Ewing sarcoma, a type of bone cancer. Researchers will follow 55 patients to see how well the treatment works and how safe it is. The goal is to improve local tumor co…

This study tests whether adding the experimental drug IPN60340 to standard medicines (azacitidine and venetoclax) helps more people with newly diagnosed acute myeloid leukemia (AML) achieve complete remission. About 450 adults who cannot have intensive chemotherapy will take part…

This study tests whether a special collagen matrix can replace tissue taken from the roof of the mouth to fix receding gums. Forty adults with at least two areas of gum recession will receive either the collagen matrix or a standard palate graft. The main goal is to see how much …

This study tests whether combining two drugs, lenvatinib and everolimus, works better than everolimus alone for people with advanced bone sarcoma (osteosarcoma, Ewing sarcoma, or chondrosarcoma) that has progressed after standard treatment. About 94 adults aged 19 to 79 will be r…

This study will test a new cementless hip stem (Mfinity collared stem) in 95 adults needing total hip replacement due to osteoarthritis. The main goal is to see how many implants survive without needing revision after one year, with a follow-up at two years. Researchers will trac…

This study tests whether giving a combination of anlotinib (a targeted therapy) and epirubicin (chemotherapy) before surgery can improve outcomes for people with advanced sinonasal adenoid cystic carcinoma, a rare and aggressive cancer of the nasal cavity and sinuses. About 76 pa…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This study tests whether a special irrigation solution called nanochitosan can help regenerate damaged tissue in infected teeth. Sixty adults with dead teeth and chronic infection will receive one of three irrigation methods during a single dental visit. Researchers will check fo…

This Phase 3 trial tests whether elritercept can improve anemia in people with myelofibrosis who are already taking ruxolitinib. About 324 participants will receive either elritercept or a placebo for at least 9 months. The main goal is to see if the drug reduces the need for red…

This early-stage study tests a new tablet, FXS0683, in 228 adults with blood cancers like lymphoma or leukemia that returned or didn't respond to standard therapy. The main goals are to check safety, find the best dose, and see if the drug shrinks tumors. Participants will be clo…

This study looks at three types of dental cement used to attach zirconia crowns to young children's front teeth. About 120 healthy kids aged 2 to 7 with decayed or injured teeth will get crowns and be checked for up to 3 years. The goal is to see which cement holds the crown best…

This study tests a new gel that slowly releases medicine to treat advanced gum disease (periodontitis). The gel is placed directly into deep gum pockets to fight infection, reduce swelling, and help bone grow back. Researchers will study 80 people with severe gum disease to see i…

This study tests an injectable gel containing a bone-growth protein (BMP-2) to help regrow bone damaged by severe gum disease. The gel is designed to fight bacteria, reduce inflammation, and promote bone repair. Researchers will enroll 80 people with advanced periodontitis and bo…

This trial compares two ways of aligning the knee during a bone-cutting surgery (high tibial osteotomy) for people with knee arthritis and bow legs. One method aims for natural knee motion (kinematic), the other for straight leg alignment (mechanical). The study will track 100 ad…

This early-stage trial tests a new cell-based injection called TG-C for people with long-term lower back pain due to degenerative disc disease. 24 adults aged 22 to 70 will receive either a high, mid, or low dose of TG-C injected into the spinal disc, or a sham (fake) injection. …

This study compares rosemary extract to a standard material (MTA) for treating severe tooth pulp inflammation. Researchers will treat 100 adults with a damaged tooth, placing either rosemary extract or MTA directly on the pulp. They will then measure pain and healing over time to…

This study compares two treatments for severely damaged upper molars: root amputation (removing only the damaged root and keeping the rest of the tooth) versus replacing the whole tooth with a dental implant. Researchers will track pain, bone healing, and implant stability over 1…

This study tests if a new bioactive varnish can fix white spot lesions on teeth better than standard fluoride varnish. About 60 people aged 16-35 with at least four white spots will get one of the two varnishes. Researchers will check how well the spots heal and if tooth color im…

This study tests an experimental injection called TG-C for people with early hip osteoarthritis. The injection contains cells that release a growth factor to help repair damaged cartilage. 255 adults will receive either TG-C or a placebo, and researchers will track pain and hip f…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study tests an experimental drug called LP-005, given as an injection into the gums, for people with moderate-to-severe gum disease (periodontitis). About 100 adults aged 18-70 will receive either the drug or a placebo to see if it reduces gum inflammation, bleeding, and bon…

This study will review medical records and call patients who received AGN1 LOEP, a device injected into the hip bone to treat osteoporosis. Researchers want to see how many patients later had hip fractures and whether any side effects occurred. The goal is to understand how well …

This study tests a new way to treat infected knee replacements. About 100 adults having surgery for an infected knee will be randomly assigned to receive either standard care or standard care plus an extra treatment. The extra treatment involves injecting antibiotics along with s…

This study will test whether a 12-week group exercise program is safe and practical for people with osteoporosis who have recently had a fracture. One hundred participants will attend twice-weekly classes and undergo bone scans and interviews. The goal is to see if this type of p…

This early-stage trial tests whether transplanting a patient's own nose cells into the spinal cord, combined with intensive exercise, is safe and possible for people with chronic spinal cord injury. About 30 participants will receive the cell transplant and a 32-week rehab progra…

This study tests a reduced-intensity chemotherapy combination (fludarabine and treosulfan) before a half-matched stem cell transplant in 77 older or frail adults with AML. The goal is to see if this gentler regimen can control the leukemia long-term while being safe enough for pa…

This early study will test whether using a miswak chewing stick (from the Salvadora persica plant) can reduce gum inflammation better than a regular toothbrush in people with moderate gum disease (periodontitis). Researchers will measure inflammatory markers in gum fluid from 24 …

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This study tests if lisinopril, a common blood pressure drug, can lower red blood cell levels in people with polycythemia (too many red blood cells). Researchers will measure changes in hemoglobin, hematocrit, and a hormone called erythropoietin. The trial enrolls 30 adults with …

This early study tests a new drug called MTM-H-001 in 75 adults with B-cell-related autoimmune diseases, including lupus, multiple sclerosis, and rheumatoid arthritis. The main goal is to check safety and find the right dose. Participants receive the drug by injection, and resear…

This study tests a new gel made from peptides (protein fragments) to see if it can help regrow bone and tissue damaged by gum disease. Forty adults with advanced periodontitis will receive either the new peptide gel or a standard hyaluronic acid gel during surgery. Researchers wi…

This study looks back at medical records of 100 children and teens who had surgery for idiopathic scoliosis (a curved spine) using the REFLECT system. Researchers want to see how often the device's cords break and if more surgeries are needed. The goal is to understand how well t…

This study looks at whether a drug called abaloparatide can improve bone quality in people with osteoporosis who need spine surgery. About 60 participants will take the drug for 3-6 months before and after surgery. The goal is to see if it reduces complications like broken hardwa…

This early-stage trial tests a new treatment called QUAIL-100, made from a live weakened bacteria, in children and young adults with high-risk leukemia or myelodysplastic syndrome who have already had a stem cell transplant. The main goal is to check safety and side effects. Only…

This phase II trial tests whether adding venetoclax to standard chemotherapy and stem cell transplant, followed by venetoclax maintenance, helps adults with acute myeloid leukemia (AML) stay in remission longer. About 244 participants will receive either venetoclax or a placebo a…

This study tests whether a cream made from phenytoin, a seizure drug known to cause gum overgrowth, can help receding gums grow back. Thirty adults who want to avoid surgery will apply either the phenytoin cream or a placebo paste. Researchers will measure changes in gum attachme…

This study compares two treatments for repairing bone damage from advanced gum disease. About 40 adults with deep gum pockets will receive either a combination of hyaluronic acid and polynucleotides (Regenfast) or enamel matrix proteins (Emdogain), both with a bone graft material…

This early-phase trial is testing a new personalized therapy called BSB-2002 for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The therapy uses a patient's own immune cells (T cells) that are genetically modified to …

This early-phase trial tests two oral drugs, olutasidenib and ziftomenib, together in 20 adults with a specific form of acute myeloid leukemia (AML) that has returned or not responded to treatment. The first part finds a safe dose; the second checks if that dose helps control the…

This study tests a surgery called selective dorsal rhizotomy to reduce severe muscle stiffness (spasticity) caused by traumatic brain or spinal cord injury. The surgery involves cutting specific nerve rootlets in the spine to relax overactive muscles. Researchers will enroll 32 p…

This study compares two types of dental fillings for cavities in the back teeth. Researchers will test a bulk-fill flowable resin against a submicron hybrid resin in 25 patients over 18 months. The goal is to see which filling performs better in terms of shape, comfort, and appea…

This early-phase trial tests a radioactive drug called tin-117m-DTPA in 24 people with prostate, breast, or lung cancer that has spread to the bones. The drug is designed to deliver low-level radiation directly to bone tumors while being gentler on the bone marrow. Researchers wi…

This trial looks at whether children with cancer who develop a fever and low white blood cells can safely stop antibiotics earlier than usual. About 136 children will be randomly assigned to either stop antibiotics within 24 hours or continue standard treatment. The goal is to se…

This study looks at how much denture teeth wear down over two years in people who have no natural teeth. It compares three types of teeth made with modern digital methods: 3D-printed, milled from a block, and standard prefabricated ones. The goal is to see which type resists wear…

This study follows 150 people who received a BDyn spine implant for degenerative disc disease to see how many need additional surgery at the level above the implant over at least 4 years. Participants will complete surveys, undergo imaging, and report any side effects. The goal i…

This study compares two ways of giving the drug tocilizumab to people with rheumatoid arthritis that is under control. One method uses a fixed dose for everyone, while the other adjusts the dose based on weight. The goal is to see if the simpler fixed-dose method works just as we…

This study tests a targeted radiation technique (TMLI) combined with two chemotherapy drugs before a stem cell transplant in people aged 50 and older with acute myeloid leukemia or myelodysplastic syndrome that has not responded to treatment or has returned. The goal is to see if…

This study compares a new, simpler treatment called CTZ paste against the standard root canal procedure for infected baby teeth in emergency settings. The CTZ paste is placed directly into the tooth without drilling or cleaning the root canals, aiming to kill bacteria and save th…

This phase 3 trial tests a drug called tralesinidase alfa in 14 children aged 1-5 with Sanfilippo syndrome type B, a rare genetic disease that causes severe brain damage. The drug is given directly into the brain fluid to replace a missing enzyme. The goal is to see if it can slo…

This study looks at whether patients with a rare nasal cancer (sinonasal adenoid cystic carcinoma) can safely avoid radiation after surgery if the tumor was completely removed. About 200 patients will choose either surgery alone or surgery plus radiation, and researchers will tra…

This study tests whether adding pivekimab sunirine to the standard drugs venetoclax and azacitidine helps adults with newly diagnosed acute myeloid leukemia (AML) who are not healthy enough for intensive chemotherapy. About 660 participants will be randomly assigned to receive ei…

This early-phase trial will test two targeted drugs, crizotinib and alectinib, in 10 adults with a rare form of bone cancer that has a specific ALK gene change. Participants must have already tried standard treatments or have no standard options left. The goal is to see if these …

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This pilot study tests whether a gel made from a special form of hyaluronan (HA35) can help people with mild gum recession and chronic gum inflammation. Thirty adults will apply the gel to their gums and teeth twice a day for 42 days. Researchers will measure changes in gum reces…

This study looks at a stem cell transplant from a half-matched donor (haploidentical) combined with drugs to prevent the cancer from coming back. It includes 40 adults aged 18-65 with active AML that has returned or not responded to treatment. The goal is to see if this approach …

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study aims to develop a new blood test that could replace the invasive bone marrow biopsy currently used to diagnose myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will collect blood samples from 500 adults with suspected or confirmed MPN and anal…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study compares artificial intelligence analysis of dental photographs to standard clinical exams for detecting white spot lesions—early signs of tooth decay. Researchers will train AI models (YOLO and Mask-RCNN) on 329 labeled images from adult patients at Cairo University D…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This study tests a special imaging agent (99mTc-NTP 15-5) to see if it can spot arthritis-damaged joints in the hands and tell the difference between osteoarthritis and rheumatoid arthritis. About 80 adults with one of these conditions will get a scan. The goal is to improve diag…

This study tests whether breath samples collected in special bags remain stable for up to 7 days, which could allow people with bad breath (halitosis) to provide samples from home instead of traveling to a clinic. Researchers will compare gas levels measured right away and after …

This study will check if smartphone photos, 3D dental scans, and a special fluorescent light can accurately detect early cavities in people who have finished braces. Thirty participants aged 11 to 46 with early white spots on their teeth will be followed for three months. Researc…

This study explores using millimeter-wave radar and artificial intelligence to detect early signs of scoliosis by analyzing a person's gait. About 200 children and adults with suspected scoliosis will walk in front of a radar sensor, and the AI will compare its findings to standa…

This study explores whether foot pressure patterns, measured while standing and walking, can be used with machine learning to detect adolescent idiopathic scoliosis early. Researchers will collect data from 500 teens aged 10-18, including those with and without scoliosis. The goa…

This study tests whether the drug Lisaftoclax can prevent differentiation syndrome (DS), a severe and sometimes life-threatening side effect, in people with acute promyelocytic leukemia (APL) who are receiving standard treatment. About 60 participants aged 16 and older will take …

This study tests whether light therapy (photobiomodulation) can prevent mouth sores in children receiving chemotherapy. Fifty children aged 0-30 will receive daily light treatments during hospital stays and at home. Researchers will check if the therapy is easy to use and accepta…

This study tests if using a diode laser before applying a tooth-colored sealant helps it stick longer and prevent cavities better. About 111 young adults aged 17-22 will get sealants on their back teeth, with or without laser pre-treatment. Researchers will check sealant retentio…

This study tests whether a program of exercise, lifestyle changes, and a smart chatbot can prevent osteoporosis and sarcopenia in 8,336 adults aged 40-60. Participants are split into two groups: one gets active support with structured workouts and reminders, the other gets basic …

This study tests whether a substance made from a patient's own blood, called platelet-rich fibrin (L-PRF), can prevent a serious condition called jawbone death after tooth extraction. The trial will include 40 people at high risk due to past radiation or certain medications. Half…

This study will test different methods to prevent infections and other problems from central lines (tubes placed in large veins) in 2,500 patients. It compares special antimicrobial caps and a skin anchor device against standard care. The goal is to find the best ways to keep pat…

This study compares two treatments for frozen shoulder (retractile capsulitis): a standard steroid injection into the shoulder joint versus that same injection plus a nerve block near the shoulder blade. The nerve block uses a numbing medicine and a steroid to calm the nerve that…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether doing physiotherapy at home through live video calls works as well as going to a clinic for people with moderate neck pain from cervical spondylosis. Fifty-two adults aged 45-64 will be split into two groups: one gets in-person sessions, the other gets re…

This study tests whether adding a simple numbing injection (SSSI) to standard pain blocks can better control pain after knee replacement surgery. About 90 adults aged 45-90 will be randomly assigned to receive either the extra injection or a sham (fake) one. The main goal is to s…

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approac…

This study compares two ways to break up kidney stones using a laser and a suction device. One method turns stones into dust, the other into small fragments. The goal is to see which leaves fewer stone pieces behind after one month. About 86 adults with small kidney stones will t…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study tests whether adding a manual foot massage (plantar fascia release) to standard foot exercises can immediately improve movement quality in young adults with flat feet. Twenty-nine physically active participants aged 18-35 will try both exercise-only and exercise-plus-m…

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study investigates whether adding High-Intensity Laser Therapy (HILT) to standard physiotherapy helps people with mild-to-moderate knee osteoarthritis. Seventy-two participants will receive either real or sham laser sessions alongside exercise-based physiotherapy. Researcher…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

This study tests whether adding shock wave therapy to a knee strengthening exercise program reduces pain and improves function more than exercise alone in people with knee osteoarthritis. Forty patients with moderate knee pain will be randomly assigned to either exercise only or …

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests whether a personalized exercise program can improve physical function and quality of life in adolescents and young adults who have survived sarcoma. Participants first complete a triage tool to assess their needs, then receive a 12-week exercise plan that may inc…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study looks at whether using a cold saline rinse after ultrasonic cleaning during a root canal can lower pain afterward. Adults with an inflamed tooth nerve will get either ultrasonic cleaning alone or followed by a cold saline flush. Pain levels are tracked for three days a…

This study will compare two treatments—low-level laser therapy and iontophoresis (a method that uses a mild electric current to deliver medication through the skin)—for knee osteoarthritis. Sixty-six adults aged 45 to 65 with mild to moderate knee arthritis will be randomly assig…

This study tests whether artificial intelligence can help teens with idiopathic scoliosis improve their posture. Thirty participants aged 10–18 will receive either standard physical therapy or additional AI-based feedback on their body alignment. The goal is to see if the AI guid…

This study tests whether pelvic floor down training—gentle breathing and relaxation exercises—can reduce tailbone pain in new mothers. Fifty-two women, 6 months to 1 year after childbirth, will practice these exercises daily. Researchers will measure pain and daily function befor…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study tests whether giving magnesium during back surgery can reduce the confusion and agitation some patients feel when waking up. 70 adults having a single-level lumbar microdiscectomy will receive either magnesium or a placebo. Researchers will monitor agitation, pain, and…

This Phase 3 trial compares three different toothpaste technologies for relieving tooth sensitivity (dentin hypersensitivity). About 132 adults with sensitive teeth will brush with one of three toothpastes: one with 8% arginine, one with 8% arginine plus zinc, or one with 5% calc…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This study compares core stability exercises versus proprioceptive (balance) training in 63 adults aged 18-40 with patellofemoral pain syndrome (runner's knee). Participants will be assigned to one of two exercise programs to see which better reduces pain and improves knee functi…

This study will test whether an 8-week yoga program done live over Zoom can improve balance, endurance, and well-being in 32 children aged 8-12 with juvenile idiopathic arthritis (JIA). The yoga sessions are led by certified physiotherapists and include breathing, poses, and medi…

This study investigates whether high-intensity laser acupuncture, combined with exercise, can reduce pain and improve knee function in people aged 18 to 25 with patellofemoral pain syndrome (front knee pain). Participants receive either real laser acupuncture or a sham laser, plu…

This study tests whether a 12-week program of core and breathing exercises can improve spine curvature, breathing, and appearance in teens aged 10-17 with mild scoliosis (Cobb angle 10-25°). 32 participants will be split into two groups: one doing the special exercises, the other…

This study tests whether an 8-week virtual program of yogic breathing and meditation can improve breathing, fatigue, emotional well-being, and quality of life in adults with spinal cord disorders. Participants attend two coach-guided sessions per week via Zoom and complete questi…

This study tests whether adding a pain-relieving gel (diclofenac) to shock wave therapy can better reduce pain and improve shoulder function in people with shoulder impingement syndrome. Seventy adults aged 25–40 with moderate shoulder pain will be randomly assigned to receive ei…

This study compares two non-surgical treatments—shockwave therapy and high-power laser—for chronic tennis elbow (lateral epicondylitis) that has lasted over 3 months. Seventy-two adults aged 40-50 will receive one of the treatments plus standard physical therapy. Researchers will…

This study tests if a new pain medicine called tegileridine works as well as morphine for teenagers recovering from scoliosis surgery. About 171 teens will receive either tegileridine or morphine through a pump they control. Researchers will compare pain levels and side effects o…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study tests whether adding neck-strengthening exercises to standard physical therapy can reduce pain and improve shoulder function in people with shoulder impingement syndrome. Forty-two adults with shoulder pain will be split into two groups: one gets standard therapy alone…

This study will follow 300 adults aged 50 and older with knee osteoarthritis who are scheduled for a 3-week thermal spa treatment. Researchers will use wearable sensors to measure knee movement fluidity before and after the spa program, and at 3 and 12 months later. They will als…

This study tests a new drug, JMKX000197, against a standard chemotherapy drug (cisplatin) to see which works better at controlling fluid buildup around the lungs in people with advanced cancer. About 120 participants with moderate to large fluid collections will receive the drug …

This study looks at two ways to help people recover after surgery for a slipped disc in the lower back. One group will start moving early, and the other will do the same plus get mild electrical stimulation on their muscles. The goal is to see which approach reduces pain and impr…

This study compares two ways to manage knee osteoarthritis: doing your own exercise at a local fitness center versus supervised sessions with a physiotherapist. Researchers want to see if the cheaper, more flexible gym option is just as good at reducing pain and improving quality…

This study tests two simple treatments for tooth sensitivity caused by worn enamel: a blue diode laser and a bioactive glass powder. Thirty adults with two similarly sensitive teeth will each receive both treatments (one per tooth) to see which works better. The goal is to find a…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and …

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether an AI-based digital rehabilitation system can help people with shoulder impingement syndrome. 93 adults will either do traditional in-clinic therapy plus home exercises, or use the 'ShuKangShi' AI system at home for daily training. The goal is to see if t…

This study tests whether a specialized acupuncture technique called 'Three-Needle Dazhui' combined with electroacupuncture can reduce pain and improve daily function better than standard electroacupuncture alone. The trial will involve 74 adults with cervical spondylotic radiculo…

This study tests if deltoid strengthening exercises can reduce pain and improve movement in people with frozen shoulder (adhesive capsulitis). 48 adults aged 40-60 with stage II or III frozen shoulder will do specific isometric exercises targeting the deltoid muscle. Researchers …

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests whether Mat-Pilates exercises can improve balance and walking ability in adolescents aged 12 to 15 with mild scoliosis (curves between 10 and 25 degrees). Forty participants will be randomly assigned to either Mat-Pilates or standard physical therapy. The goal is…

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study tests whether a special exercise method called Sahrmann's approach can reduce pain and improve knee function better than standard physical therapy in people with knee osteoarthritis. Forty adults aged 40 to 60 with moderate knee arthritis will be assigned to one of two…

This study compares two physical therapy techniques for athletes with tightness in the back of the shoulder, a common issue in overhead sports like cricket. 34 athletes will receive either Kaltenborn joint mobilization or a specific stretch for 4 weeks. Researchers will measure p…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study will test Mobithron Xtra, an oral supplement containing hyaluronic acid, collagen, and Boswellia extract, in 100 adults with knee osteoarthritis. Participants will take it once daily for 3 months while researchers track changes in pain, stiffness, and daily function us…

This study compares two pain relief methods after total knee replacement: a long-acting pain shot (Zynrelef) given directly into the knee during surgery versus a standard nerve block. The goal is to see which method better reduces the need for opioid painkillers in the first 72 h…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests whether taking essential amino acid supplements before and after spinal surgery helps adults with spinal deformity recover better. Twenty participants will take either the supplement or a placebo for two weeks before surgery and three months after. Researchers wi…

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This study compares two surgical methods for treating unstable pelvic fractures in people aged 60 and older with osteoporosis. Half of the 88 participants will receive robot-assisted minimally invasive screw placement, while the other half will have conventional open surgery. The…

This study tests whether three different desensitizing toothpastes can reduce tooth sensitivity in people with braces. About 200 adults aged 18-40 with mild to moderate sensitivity will use one of the toothpastes or a placebo for 8 weeks. The goal is to see if the special toothpa…

This study tests whether a device that delivers high-intensity electromagnetic pulses to the thigh muscles can reduce pain and improve quality of life in people with patellofemoral pain syndrome (front knee pain). Sixty adults with persistent knee pain will be randomly assigned t…

This study tests whether adding Osteopathic Manipulative Treatment (OMT) — a non-invasive, hands-on therapy — to standard care helps people with frozen shoulder recover faster and feel more satisfied. About 300 adults who have not yet been treated for frozen shoulder will be assi…

This study tests whether TECAR therapy—a device that delivers gentle heat deep into the knee—can reduce pain, improve balance, and boost quality of life in elderly men with knee osteoarthritis. Eighty men will receive either real TECAR plus standard physiotherapy or a sham versio…

This study compares 3D-printed hand orthoses (braces) to traditional custom-made ones in 100 adults with chronic hand conditions from nerve, muscle, or bone issues. The goal is to see if the 3D-printed versions work just as well for daily activities, are more satisfying, and cost…

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This study compares two ways to perform total hip replacement: the standard direct lateral approach and a newer, less invasive method called SuperPATH. Researchers want to see if SuperPATH reduces pain, blood loss, and recovery time while improving joint stability. 100 adults nee…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study looks at whether starting physical therapy two weeks after cervical spine surgery helps adults with degenerative myelopathy recover walking, balance, and strength better than waiting six weeks. Twenty participants will be randomly assigned to start rehab at either two …

This study looks at whether adding a special relaxation training (EMG-biofeedback) to a standard exercise program can help people with jaw joint pain (TMJ disorder). The training helps people become more aware of their muscle tension so they can relax better. Forty adults with TM…

This study tests whether a special adhesive filled with strontium-doped bioactive glass-ceramic can reduce tooth sensitivity. 142 adults with sensitive teeth will receive a single application of either the new adhesive or a standard one. Pain levels will be checked right after an…

This study will test whether taking prednisone for 5 days after knee or hip replacement surgery helps reduce pain, swelling, and the need for opioids compared to the standard steroid given only during surgery. About 104 adults will participate, and their blood sugar will be track…

This study tests whether adding dry needling to exercise improves shoulder function, strength, and pain in athletes with subacromial pain syndrome. Forty amateur athletes will be randomly assigned to receive either dry needling plus exercise or exercise alone. The goal is to see …

This study compares two spinal anesthetics, ropivacaine and bupivacaine, in 176 people having hip replacement surgery. The goal is to see which one allows faster return of feeling and movement while still controlling pain well enough for same-day discharge.

This study compares two exercise programs—the Tyler Twist and traditional eccentric exercises—for people with tennis elbow (lateral epicondylalgia). Researchers will measure pain, grip strength, and daily function in 38 adults aged 20 to 40. The goal is to find which approach pro…

This study tests whether shining specific light wavelengths (635, 940, or 1064 nm) on the jaw muscles can reduce pain and improve jaw function in people with chronic jaw muscle disorder (TMD). About 45 adults with moderate-to-severe jaw pain lasting over 3 months will receive sev…

This study tests whether a short, digitally guided exercise program before total knee replacement is practical and helpful. Sixty adults with knee osteoarthritis will either do the 10-14 day program or receive usual care. The main goal is to see if people stick with it and find i…

This study tests whether an AI-powered app can guide people with knee osteoarthritis through exercises at home, reducing pain and improving function as well as in-person physiotherapy. About 176 adults aged 50 and older with knee pain will be split into two groups: one receiving …

This study tests whether motivational interviewing, a patient-centered counseling approach, can improve outcomes of standard gum disease treatment (subgingival instrumentation) in 66 adults aged 30-50 with periodontitis. Participants will receive either motivational interviewing …

This study compares two strengths of sodium hypochlorite (a disinfectant used during root canals) to see which causes less pain afterward. 116 adults needing a root canal will be randomly assigned to receive either a 2.5% or 5.25% solution. Pain levels will be measured at 6, 12, …

This study tests a home-based exercise program called CAREFit-BMT for people with high-risk acute myeloid leukemia who are about to have a stem cell transplant. The program includes aerobic and strength training to improve heart function before the procedure. Researchers will enr…

This study tests whether adding suzetrigine (Journavx) to standard pain management can lower pain and reduce the need for opioid painkillers after total knee replacement. About 75 adults with knee arthritis will take the drug as part of their post-surgery care. The goal is to imp…

This study compares two dental varnishes—one with fluoride and one without—to see which better reduces tooth sensitivity. Sixty-six adults with sensitive teeth will have each varnish applied to different teeth and rate their pain over time. The goal is to find a simple, effective…

This study looks at how well RHINOSEDAL works for people aged 8 and older with a stuffy nose caused by colds, allergies, or sinus issues. About 126 participants will use the treatment as prescribed and report their symptoms over 6 days. The goal is to see if it provides meaningfu…

This study will test a 16% carbamide peroxide gel used at home in custom trays for 90 minutes daily over six weeks. Ten adults with healthy gums and no prior whitening will have their tooth color measured by a special device and report how their quality of life changes. The goal …

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This study tests whether a roller device that delivers essential oils during self-massage can reduce pain and improve function in people with chronic tennis elbow (lasting over 3 months). Eighty adults will use the roller twice daily for 3 months. Researchers will measure pain an…

This early study tests the safety of a single injection of a new polymer called ABR1 for knee osteoarthritis. About 25 adults with moderate to severe knee pain will receive the injection and be followed for 12 weeks. The main goal is to see if the treatment causes any side effect…

This study tests whether a special behavioral program can help people with gum disease who lack confidence in their oral hygiene. 78 adults with stage I-III periodontitis will get standard gum treatment plus either the behavioral program or regular instructions. Researchers will …

This study tests whether using a virtual reality (VR) system during cycling exercise makes rehabilitation more motivating for adults with conditions like stroke, Parkinson's, multiple sclerosis, or frailty. About 70 participants will try cycling with and without VR over 4 weeks. …

This study compares three different root canal sealers—AH Plus, ProRoot Bio Sealer, and BC Sealer ion+—to see which one leads to the least pain after treatment. About 135 adults with irreversible pulpitis in a lower molar will be randomly assigned to one of the three sealers. Pat…

This study looks at two treatments for a jaw joint condition called disc displacement without reduction, which causes pain and trouble opening the mouth. Fifty-two adults who haven't gotten better with standard care will be randomly assigned to get either arthroscopic surgery alo…

This study tests two ways to guide a steroid injection for people with lumbar spinal stenosis, a condition that causes back and leg pain when walking or standing. One method uses X-ray (fluoroscopy) alone, the other adds ultrasound before the X-ray (hybrid). The goal is to see wh…

This study tests whether applying local heat to the jaw can reduce pain and fatigue caused by teeth clenching in people with chronic temporomandibular disorder (TMD). Ten adults with TMD will receive heat therapy and report their pain levels daily for 8 days. Researchers will com…

This study looks at whether using a gentle pulling force (mechanical traction) on the knee before or after exercise works better for easing pain and improving movement in people with knee osteoarthritis. Researchers will compare three groups: traction before exercise, traction af…

This study tests whether colchicine, a drug used for gout, can lower inflammation and pain in people with CPPD disease. About 150 adults will take either colchicine or a placebo daily for 6 months. Researchers will measure blood markers and joint symptoms to see if the drug helps…

This study tests whether a special knee and heel brace, combined with strength exercises done while sitting or lying down, can reduce pain and improve walking in people with knee osteoarthritis. Twenty participants will be randomly assigned to get either this new brace or a stand…

This study tests a new type of nerve block (PENG block) for people with chronic shoulder pain that hasn't improved with other treatments. 45 adults will get an ultrasound-guided injection of numbing medicine and steroid. Researchers will measure pain, shoulder function, and satis…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study tests whether a special light treatment, called photobiomodulation, can reduce pain and swelling in people with long-term knee osteoarthritis. Researchers will measure pain levels before and after treatment in 30 adults aged 50 and older. The goal is to find a drug-fre…

This study will compare two types of nerve blocks—lumbar paravertebral block and lumbar erector spinae plane block—for pain control after lumbar spine surgery in people aged 65 and older. The goal is to see which block reduces the need for opioid painkillers in the first 48 hours…

This study compares two ways to remove cavities in children's baby molars: a special gel that softens decay, versus scraping by hand. The goal is to see which method causes less pain and is more acceptable to kids. Twenty-eight healthy children aged 5 to 9 will take part, and the…

This study looks at whether adding a special nerve block (PENG block) to standard spinal anesthesia can lower inflammation and pain in children aged 3 to 8 having hip surgery. One hundred children will be randomly assigned to receive either spinal anesthesia alone or spinal anest…

This study compares two types of nerve blocks (thoracolumbar interfascial plane block and retrolaminar block) to see which one helps patients recover better after lumbar spine fusion surgery. 70 adults scheduled for surgery will receive one of the two blocks before the procedure.…

This study tests whether a gel made from the Libidibia ferrea plant can reduce tooth sensitivity after professional whitening. Seventy-five adults will receive either the experimental gel, a standard desensitizing gel, or a placebo before bleaching with hydrogen peroxide. Partici…

This study tests which injection mixture works better for people with a displaced jaw joint (TMJ) that still clicks and moves. Twenty adults will receive either a mix of hyaluronic acid and steroids or hyaluronic acid and platelet-rich plasma after a joint washout. The goal is to…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This study tests whether adding brain stimulation to spinal cord stimulation can improve leg strength and walking in adults with chronic incomplete spinal cord injury. 24 participants will receive either combined therapy or spinal stimulation alone over 16 weeks. The goal is to s…

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This study looks at whether using a home-based electrical stimulation device, along with standard physical therapy, can help reduce pain and improve shoulder function in people with frozen shoulder. Ten adults diagnosed with the condition will use the device at home while continu…

This study tests whether a new type of root canal filling material (bioceramic nano-coated gutta-percha with a bioceramic sealer) causes less pain and swelling after treatment compared to the standard material (gutta-percha with a resin sealer). About 30 adults aged 20-55 with a …

This study tests whether adding Functional Electrical Stimulation (FES) to standard rehab can reduce leg stiffness, build muscle strength, and improve walking in people with paraplegia. Forty adults with spinal cord injury will be split into two groups: one gets rehab alone, the …

This study tests a 12-week individualized rehabilitation program for youth athletes aged 10–17 with Osgood-Schlatter disease (knee pain) or Sever disease (heel pain). The program includes education, pain monitoring, and tailored exercises. Researchers want to see if it's feasible…

This study tests whether adding a mind-body therapy called Basic Body Awareness Therapy (BBAT) to standard corrective exercises can improve body image, self-esteem, and posture in 60 adolescents with postural hyperkyphosis (a rounded upper back). Participants will do exercises tw…

This study tests whether combining blood-flow-restricted exercise (light exercise with a cuff on the leg) and pain education can reduce pain and improve movement in people with knee osteoarthritis. About 90 adults aged 40 and older with knee osteoarthritis will take part. The goa…

This study tests a smoking cessation program delivered via telemedicine and wearable devices. About 102 adult smokers will either get the program with remote monitoring or standard in-person support. The goal is to see if the tech-based approach helps more people quit and stay sm…

This study tests a special gel (HA35) applied to the jaw at night to relieve pain and muscle tightness from temporomandibular joint disorder (TMD). About 30 adults with TMD will use the gel nightly for 8-12 hours. Researchers will check how well it reduces pain and tension after …

This study will test whether a hard dental splint or a simpler approach (ibuprofen gel plus counseling) works better for jaw joint pain. About 60 adults with TMJ disorders will be randomly assigned to one of the two treatments. Pain levels will be measured after 1 week and 4 week…

This study will compare two types of tooth separators—elastomeric and nickel-titanium—used before placing orthodontic bands for braces. Thirty patients with crowded teeth will have one separator type on each side of their mouth. Researchers will measure how well they create space…

This study compares two common shoulder replacement surgeries—anatomic and reverse—for people with shoulder arthritis and an intact rotator cuff. Researchers want to see which surgery leads to better pain relief and function one year after the procedure. About 108 participants wi…

This study tests whether a newer bioceramic filling material reduces pain after root canal treatment better than the standard calcium hydroxide filling. Twenty-eight adults with painful lower molar infections will receive one of the two fillings during their root canal. Pain leve…

This study tests whether adding high-intensity pulsed electromagnetic field (HI-PEMF) therapy to standard exercise can reduce pain and improve daily function in people who have had a total hip replacement. Forty adults who had hip replacement due to osteoarthritis will receive ei…

This study tests whether adding Mulligan mobilization with movement (MWM) to exercise reduces pain and improves grip strength in people with tennis elbow. 45 adults with elbow pain for at least 3 months will be split into three groups: MWM plus exercise, sham MWM plus exercise, o…

This study will compare two exercises—prone row and lateral pull down—in 54 adults aged 40-65 with shoulder impingement and scapular dyskinesia. The goal is to see which exercise better reduces pain, improves strength in key shoulder muscles, and enhances function. Participants w…

This study tests whether the drug vilamakitug can reduce symptoms of axial spondyloarthritis, a type of arthritis that causes back pain and stiffness. About 150 adults with active disease will receive either the drug or a placebo. The main goal is to see if more people get at lea…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This trial tests whether a genicular nerve block given before knee replacement surgery can reduce pain and the need for opioids. About 70 adults with knee osteoarthritis will receive either the nerve block or a placebo injection. Researchers will track pain levels, opioid use, an…

This pilot study tests whether combining two types of non-invasive stimulation—one on the brain and one on the spine—can improve arm and hand function in people with chronic incomplete cervical spinal cord injury. 24 adults will receive either both stimulations plus rehabilitatio…

This study tests whether a gel made from hyaluronan (HA35) can safely reduce gum pain and swelling after dental procedures. About 30 adults will chew on gel-soaked cotton balls for 30 minutes. Researchers will measure pain and swelling changes at 1, 30, and 60 minutes after appli…

This study looks at three different ways to manage pain during and after hip replacement surgery in people aged 60 and older. All participants will get spinal anesthesia, but some will also get a nerve block around the hip joint, with or without an extra anti-inflammatory drug. T…

This pilot study tests whether a small device that gently stimulates a nerve in the ear can safely reduce nerve pain in people with spinal cord injury. 32 adults will use the device at home for 30 days. The main goal is to see if the treatment is practical and well-tolerated, whi…

This study looks at whether a drug called acemetacin can reduce pain and control disease activity in adults with active axial spondyloarthritis, a type of inflammatory arthritis that mainly affects the spine. About 150 people aged 18 to 65 will take a daily pill for 4 weeks. Rese…

This study compares two methods of pain control after total knee replacement: a single injection of numbing medicine versus a continuous drip through a small tube for 48 hours. About 78 adults aged 40-80 will be randomly assigned to one of the two groups. The goal is to see which…

This study tests two different methods of radiofrequency ablation (a procedure that uses heat to calm pain nerves) for people with long-term low back pain. The standard method uses a slight angle, while the new method places the needle more straight in from the back. Researchers …

This study tests whether applying bee venom to the face using ultrasound can ease chronic sinusitis symptoms. Thirty adults with sinusitis will either get bee venom phonophoresis or standard care (decongestants and saline rinses). Researchers will measure changes in symptom sever…

This study compares three types of knee-strengthening exercises (isometric, isotonic, and eccentric) in 90 adults aged 18-40 with patellofemoral pain syndrome. Participants will do their assigned exercises three times a week for 8 weeks, alongside standard physiotherapy. Research…

This study tests two ways to numb the knee after total knee replacement. One method uses a low-dose anesthetic on three main nerves, while the other uses a higher dose on two smaller nerves. The goal is to see which provides better pain relief with less muscle weakness, so patien…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This study tests whether a substance made from stem cells (called secretome) can reduce pain and improve knee function in people with moderate knee osteoarthritis. Fifty adults aged 40-70 will receive either the secretome or a standard treatment (sodium hyaluronate) via injection…

This study tests whether electroacupuncture can improve sleep in people with long-term sciatica caused by a slipped disc. About 114 adults with chronic insomnia and leg pain will receive either real electroacupuncture or a sham version three times a week for four weeks. Researche…

This study will enroll 100 children with solid tumors or Hodgkin lymphoma who are receiving proton therapy. Researchers will take weekly or bi-weekly CT or MRI scans during treatment to check if the original radiation plan is still accurate. If tumor coverage drops by 5% or radia…

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study looks at patients who had a cartilage cell transplant (using their own cells on a special material) for knee injuries between 1999 and 2006. Researchers will check their knee function, pain, and quality of life up to 25 years after surgery. The goal is to see how well …

This study tests whether correcting a flat foot position with shoe inserts (orthoses) changes how the kneecap sits during standing. Ten adults with flexible flatfoot will have weight-bearing CT scans with and without orthoses, with knees straight and slightly bent. The goal is to…

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study looks at whether checking gum health 4 weeks after non-surgical treatment is better than waiting 8-10 weeks. Researchers will compare healing and pocket depth in 24 adults with advanced gum disease. The goal is to find the best time for follow-up to improve care.

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study translates and tests a Turkish version of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQAIS), a tool designed to measure body image and perceived deformity in teens with scoliosis. Researchers will enroll 100 adolescents aged 10–19 with idiopat…

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study will collect information from 400 people having surgery for bone cancer. The goal is to track complications like infections or blood clots and understand how to improve care. By analyzing this data, researchers hope to find ways to make surgery safer and recovery faste…

This study looks at whether screening adults with leukemia for social needs (like housing or food) and offering early social work help is practical and helpful. About 80 newly diagnosed patients will either get the screening and consultation or usual care. The goal is to see if t…

This study looks at how a standard laryngoscope blade (Macintosh) works during breathing tube placement in 100 adults with normal mouth opening. The goal is to gather measurements that may later help doctors manage patients with restricted mouth opening from submucous fibrosis. R…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study will test whether artificial intelligence programs like ChatGPT can interpret brain monitoring data (BIS) as accurately as experienced clinicians during spine surgery. Researchers will compare AI responses to those of two doctors in 63 patients. The goal is to see if A…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study will collect blood and bone marrow samples from 55 adults with acute leukemia or myelodysplastic syndrome. Researchers want to understand how natural killer (NK) cells interact with cancer cells over time. The goal is to identify genetic markers and immune patterns tha…

This study will collect and analyze nasal tissue from 230 Greek patients with chronic sinusitis (with or without nasal polyps) to identify different inflammation patterns, called endotypes. By understanding these patterns, researchers hope to better match patients with the most e…

This study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…

This study looks at how two thumb muscles work in people with and without thumb base osteoarthritis while they do six daily tasks like turning a key or writing. Researchers will use sticky sensors to record muscle activity. The goal is to find differences that could lead to bette…

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at whether using a cousin as a stem cell donor works as well as using a sibling for people with blood cancers. Researchers will compare survival, relapse, and side effects like graft-versus-host disease in patients who received a transplant from either a cousin o…

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study will observe 10 adults with acute myeloid leukemia who are receiving the drug gilteritinib after a stem cell transplant. Researchers want to understand how gilteritinib affects the behavior, metabolism, and function of immune cells like T-cells and monocytes. The goal …

This study aims to create a patient decision aid for young people aged 11-18 who are missing one or both upper front teeth, a condition affecting 1 in 50 people. Researchers will interview patients and their parents, and hold focus groups with clinicians, to understand what matte…

This study aims to create a score that uses a special blood test to predict bleeding risk in people with blood cancers and very low platelet counts. Researchers will take an extra blood sample from 410 participants and analyze it with viscoelastometric tests. The goal is to ident…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This study tests whether artificial intelligence (AI) can improve how dental students and experienced dentists detect cavities on X-rays. About 60 participants will view dental X-rays, some enhanced by AI and some not, and answer questions about what they see. The goal is to see …

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study will follow about 950 people who receive hip or knee replacements using Stryker implants, some with the Mako robotic-arm system and some without. Researchers will track how long the implants last and how well patients feel and function over five years. The goal is to g…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study looks at 80 people having hip or knee replacement surgery to compare two ways of giving a drug called tranexamic acid, which helps reduce bleeding. Half will get the drug through a standard IV, and the other half will get it injected into the bone. Researchers will mea…

This study looks at how aerobic exercise influences pain processing in people with chronic jaw pain (TMD). Researchers will compare pain responses among three groups: patients with jaw pain, inactive healthy people, and healthy endurance athletes. The goal is to understand if exe…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study looks at whether a simple hip weakness test (the Trendelenburg sign) is linked to spine problems seen on MRI in people with low back pain. Researchers will check MRI scans and measure hip strength in 120 adults aged 18 to 65. The goal is to better understand how hip fu…

This study looks at how knee pain intensity relates to the knee's ability to sense its own position (proprioception) in people with patellofemoral pain syndrome. Researchers will measure pain and joint position error during a single-leg squat in 82 adults aged 18–35. The goal is …

This study will compare two FDA-approved machines that make platelet-rich plasma (PRP) for people with knee osteoarthritis. PRP is made from a person's own blood and is injected into the knee to help with pain and stiffness. The researchers will check if the two machines produce …

This study looks at how mental health, especially stress, affects gum disease in people who grind their teeth. About 110 adults aged 30-50 with both teeth grinding and gum disease will answer mental health questions and get a dental check-up. The goal is to see if poor mental hea…

This study looks at 700 adults who had jaw joint (TMJ) surgery and received either platelet-rich plasma (PRP) or platelet-rich fibrin (PRF) injections during the operation. Researchers will review medical records to see which group had less pain and better jaw function six months…

This study will collect data from 2,000 patients in the Netherlands and France who are receiving standard, minimally invasive cancer treatments like tumor ablation or catheter-based therapies for liver, lung, kidney, or bone cancers. During these procedures, a special CT scanner …

This study looks at how often muscle weakness and loss (sarcopenia) happens in people aged 15 to 40 with juvenile idiopathic arthritis. Researchers will measure grip strength, do body scans, and use questionnaires to check muscle health. The goal is to find out how common this pr…

This study tests how well three different toothpastes repair early tooth damage (enamel lesions) in 30 healthy adults aged 18-70. Participants wear a removable mouth device with human enamel pieces for 14 days per toothpaste, with breaks in between. Researchers measure mineral ga…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study follows 70 adults aged 20-60 who need root canal treatment on a premolar or molar. Researchers measure how hard they can bite and how force spreads across teeth before treatment, after root canal, after a crown, and up to 4 years later. They also ask about chewing comf…

This study looks at how stress levels, sleep quality, and teeth grinding (bruxism) together affect gum disease in adults aged 30-45. Researchers will compare two groups of people with gum disease: those who grind their teeth and those who do not. The goal is to understand how the…

This pilot study will test whether temporarily stimulating nerves in the lower spine can improve movement and bladder function in one person with a spinal cord injury. The participant will have small electrodes placed near the spinal nerves and undergo 10 days of rehabilitation s…

This study looks at whether psychological resilience — the ability to bounce back from stress — can reduce the harmful effects of stress on gums in people who grind their teeth (bruxers). Researchers will measure stress and resilience using questionnaires and check gum health in …

This study checks whether two short questionnaires can accurately measure physical fitness in children aged 10–18 with juvenile idiopathic arthritis or familial Mediterranean fever. Researchers will compare the questionnaire results with standard fitness tests. If the questionnai…

This study looks at whether Guanxinning tablets can help repair tiny blood vessels in the heart after a heart attack. About 70 people who have had a severe heart attack will take the tablets or a placebo for 6 months. The main goal is to see if the tablets reduce bleeding in the …

This study looks at whether giving patients clear, standardized instructions before and after pituitary surgery can improve their recovery. Researchers will compare hospital stay length, complication rates, and unplanned readmissions in 102 adults having elective surgery. The goa…

This study looks at how people with gum disease (periodontitis) value their dental health and how their oral health beliefs relate to the severity of their condition. Researchers will ask 112 adults aged 30-50 to complete questionnaires and a clinical exam in one visit. The goal …

This study looks at how thumb arthritis changes joint pressure and how two types of surgery (with or without a metal implant) affect that pressure. Researchers will use CT scans and computer models to simulate loads in the thumb joint. 40 adults aged 50 to 88 with moderate to sev…

This study looks at how obesity changes the way genes work in people with gum disease. Researchers will compare obese and non-obese adults before and after a deep cleaning treatment. They aim to understand why obese individuals may have worse gum inflammation and how it might be …

This study looks at how gum inflammation and the bacteria in your mouth interact with your body's immune system. Twenty healthy adults will use a special toothpaste and then stop brushing for a period to see how inflammation and bacteria change. The goal is to better understand t…

This early-stage study in 16 healthy adults checks if taking a common stomach acid drug (rabeprazole) changes how the body absorbs a new experimental drug (TQ05105) being developed for myelofibrosis. Participants take TQ05105 alone and later with rabeprazole to compare drug level…

This study is testing a new blood test called AlloHeme that looks for tiny traces of a patient's own cells after a stem cell transplant. The goal is to see if the test can predict whether leukemia or MDS will come back before it happens. About 400 adults who have had or will have…

This study is a registry that will collect health information from up to 5,000 women experiencing perimenopause, menopause, or premature ovarian insufficiency. Researchers will gather data from medical records and ongoing visits to a specialized clinic, tracking symptoms, treatme…

This study looks at how the Achilles tendon behaves during walking in people with spastic paresis, a condition causing muscle stiffness after stroke or spinal cord injury. Researchers will measure tendon stiffness, length, and volume using ultrasound and motion analysis. The goal…

This study will follow 100 adults with X-linked hypophosphatemia (XLH) who are already taking burosumab. Researchers want to see how phosphate levels change over time and how they relate to bone health and overall disease burden. The goal is to better understand the condition and…

This study follows 150 people aged 18-60 who had big toe fusion surgery for hallux rigidus or hallux valgus. Researchers want to see how well patients return to physical activities, especially cross-country skiing, by comparing current sports function to before surgery. Participa…

This study looks at how the width of healthy gum tissue affects the success of covering exposed tooth roots in 30 adults with gum recession. Participants will receive a minimally invasive gum graft surgery. The goal is to see if wider gum tissue leads to better root coverage and …

This study will explore if menopause and blood sugar levels are linked to frozen shoulder in women. Researchers will survey women who have had frozen shoulder and closely monitor a smaller group of perimenopausal women with and without the condition. The goal is to understand why…

This study will follow 500 people with knee injuries or knee osteoarthritis who receive standard care at a hospital in China. Researchers will collect medical history, imaging, and function tests at the start and then again at 6, 12, and 24 months. The goal is to better understan…

This study follows 75 adults with Crohn's disease or ulcerative colitis who are starting guselkumab, a drug used for inflammatory bowel disease. Researchers want to see if the drug also helps with joint pain and stiffness linked to spondyloarthritis. Participants will report symp…

This study looks at whether people with oral lichen planus (a chronic mouth condition) have more gum disease than those without it. Researchers will compare 88 patients with oral lichen planus to 88 healthy people, all getting standard dental exams. The goal is to understand shar…

This study tests whether smartphone data and optional smartwatches can detect early signs of psoriatic arthritis in people with psoriasis. About 3,458 adults with psoriasis but no arthritis will use an app that passively collects phone data. The goal is to develop algorithms that…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study will check if people with Lynch syndrome, a genetic condition that raises cancer risk, have more gum disease than the general population. Researchers will look at dental records from 25 adults with Lynch syndrome. The goal is to see if gum disease is a hidden health is…

This early-phase study at St. Jude Children's Research Hospital will test whether it is safe and possible to collect blood stem cells from 12 young adults with inherited bone marrow failure syndromes. Participants will receive two drugs (filgrastim and plerixafor) to move stem ce…

This study will test a new care pathway for rehabilitation after total knee replacement. The pathway includes a patient education booklet and optimized scheduling of physical therapy. Researchers want to see if this approach improves recovery and reduces differences based on race…

This study will measure certain proteins and antioxidants in the fluid from gum pockets in 21 adults with gum disease. Researchers will take samples before and after a deep cleaning procedure (scaling and root planing) to see how these markers change during healing over 3 months.…

This study looks at whether getting complete dentures for the first time changes how anxious patients feel about dental visits. Researchers will measure anxiety in 70 adults who have lost all their teeth at two points: when they first get impressions made and when they receive th…

This study looks at adults aged 25-40 who had surgery for scoliosis as teenagers, comparing them to people with scoliosis who didn't have surgery and to healthy individuals. Researchers want to understand how the surgery affects daily life, pain, breathing, and quality of life ma…

This study will review medical records of 400 adults in Kuwait with chronic myeloid leukemia (CML) who have received at least one type of targeted therapy (TKI). Researchers want to understand patient backgrounds, other health conditions, and how treatments are used in everyday p…

This study looks at whether a deep dental cleaning (called non-surgical periodontal therapy) can change levels of a substance called asprosin in the blood of people who have both stable angina and gum disease. Asprosin is a protein that may play a role in heart health and inflamm…

This study looks at how a disrupted body clock (like in night-shift workers) affects gum inflammation. Researchers will measure clock proteins and immune markers in the gum fluid of 116 people with and without gum disease. The goal is to understand the link between sleep-wake cyc…

This study will test a new positioning aid called Tru-Vu that helps radiographers take clearer wrist x-rays. About 1,800 adults with wrist injuries or arthritis will be included across three different healthcare centers in Newfoundland and Labrador. Researchers want to see if the…

This study will follow 100 people getting a total knee replacement to see if those with chronic venous insufficiency (poor blood flow in leg veins) have more wound healing problems. Participants will have an ultrasound before surgery to check their veins and then be monitored for…

This study translates the Foot Posture Index (FPI-6), a tool that checks foot shape while standing, into Spanish and tests if it works well. About 100 people aged 6 to 89 will take part. The goal is to give Spanish-speaking doctors and researchers a reliable way to assess foot po…

This study compares two ways to prepare the jawbone for dental implants in people with low bone density. One method uses Densah burs to compact bone, while the other removes bone with standard drilling. The goal is to see which gives better implant stability right after placement…

This observational study follows 400 adults with psoriatic arthritis who are starting a new biologic or targeted synthetic drug as part of their routine care. Researchers want to see if treatment response differs based on how many prior advanced therapies a person has tried, and …

This study will look at how jaw bone quality changes over time in patients with medication-related osteonecrosis of the jaw (MRONJ), a side effect of drugs like bisphosphonates. Researchers will analyze existing CBCT scans from 25 adults to measure bone density and structure at d…

This study looks at how the severity of cervical spinal stenosis (narrowing of the spine in the neck) affects hand function, including grip strength and fine motor skills. Researchers will measure hand strength and dexterity in 180 adults with neck pain who have had an MRI. The g…

This study aims to understand why some teeth fail to erupt (come in) properly. Researchers will look at dental records and test for changes in the PTH1R gene in 50 patients with eruption problems. The goal is to improve diagnosis and distinguish between different causes, such as …

This study looks at how well the mouth heals after gum surgery in people with diabetes compared to those without. Researchers will track healing, measure gum recession, and check factors like bacteria and inflammation. The goal is to understand what affects recovery in diabetic p…

This study compares what happens when surgeons place a small drain in the neck after ACDF surgery versus not using one. The drain is meant to remove fluid and lower the risk of complications like bleeding or infection. About 360 adults having elective ACDF will be randomly assign…

This study will track sleep patterns in 20 people before and after reverse shoulder replacement surgery. Participants will wear a MotionWatch 8 sleep tracker for a week before surgery and again 6 months after. The goal is to see if better sleep is linked to better recovery and sh…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study asks 200 practicing midwives in Germany about their role in oral health for pregnant women and young children. Through an anonymous online survey, researchers will learn how confident midwives feel giving dental advice, what barriers they face, and what training they n…