Skeletal system disorder

This trial is testing a new type of knee replacement for younger patients with severe knee osteoarthritis. Instead of the standard metal and plastic implant, surgeons will use a graft made of donor bone, cartilage, and meniscus to replace the damaged parts of the knee. The goal i…

This trial is testing whether a new conditioning regimen, called VABu, can improve outcomes for adults with acute myeloid leukemia (AML) who are in first remission but are too frail for standard transplant prep. The regimen combines venetoclax, azacitidine (or decitabine), and bu…

This trial tests whether a combination of sonrotoclax, cladribine, and cytarabine, followed by a stem cell transplant, can improve survival in adults with relapsed or refractory acute myeloid leukemia (AML). Participants receive the chemotherapy regimen, then undergo an allogenei…

This trial tests a combination of two drugs, azacitidine and venetoclax, as the first treatment for young, fit adults (ages 18-50) with newly diagnosed acute myeloid leukemia (AML). The goal is to see how many patients achieve complete remission after one or two cycles of this th…

This early-phase trial tests whether adding arsenic trioxide to a standard stem cell transplant can prevent the cancer from coming back in people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The study enrolls about 20 patients whose cancers have …

This phase 3 trial compares two drug combinations for adults with a high-risk form of myelodysplastic syndrome (MDS-IB2) or newly diagnosed acute myeloid leukemia (AML) that is either secondary to prior treatment or occurs in older age. One group receives a standard regimen of az…

This trial is testing whether adding venetoclax to standard intensive chemotherapy plus midostaurin can improve outcomes for adults with a type of acute myeloid leukemia that has a FLT3 mutation. The study enrolls people aged 18 to 70 with newly diagnosed disease who are healthy …

This phase 3 trial tests whether an experimental drug called KP-100IT, injected into the spinal fluid, can help people with severe acute spinal cord injuries regain function. Participants, aged 18 to 89 with a complete loss of motor and sensory function (AIS grade A), receive fiv…

This study tests whether bone marrow from deceased donors can be used to treat people with blood cancers like leukemia and lymphoma. Participants receive a transplant of cryopreserved marrow from a deceased donor or standard cells from a living donor. The goal is to see if the de…

This study tests a new drug called SX-682 (a tablet) combined with the chemotherapy docetaxel in people whose head/neck, salivary gland, or prostate cancer has spread or returned after treatment. The goal is to find the right dose and see if the combination shrinks tumors. About …

This trial tests two different types of drugs—an IL-17 inhibitor (secukinumab) and a JAK inhibitor (upadacitinib)—in people with axial spondyloarthritis who have not improved with a TNF inhibitor. The goal is to see which approach is more effective at reducing disease activity ov…

This trial tests whether adding a gel made of hyaluronic acid and polynucleotides to standard gum graft surgery helps cover receding gums better. Twelve people with receding gums will receive the surgery with the gel applied to the graft. Over six months, the study measures how m…

This early-phase study tests a new drug called PLM-102 in 12 adults whose acute myeloid leukemia (AML) has come back or not responded to standard treatments. The main goals are to find the highest safe dose and to monitor side effects. Participants must have relapsed or refractor…

This pilot study tests whether a virtual-reality system controlled by muscle activity can help improve arm and hand movement in people recovering from stroke or spinal cord injury. Participants use a wearable device that detects muscle signals through sensors on the skin and prov…

This trial asks whether GLP-1 receptor agonists, a class of drugs used for weight management, can improve gum health and boost the response to standard deep-cleaning treatment in people with obesity and periodontitis. Adults with both conditions will be split into two groups: tho…

This trial is investigating whether a new drug called sonrotoclax, when combined with other anti-cancer medicines, is safe and effective for children and adolescents with acute myeloid leukemia (AML) or B-cell acute lymphoblastic leukemia (ALL) that has returned or not responded …

This trial tests whether combining AI with clinical exams and imaging can create a more targeted treatment plan for people with temporomandibular disorders (TMD), which cause jaw pain and limited movement. Participants receive either low-level laser acupuncture, proprioceptive tr…

This trial asks whether daily caffeine intake can improve recovery after standard gum disease treatment. About 90 adults with periodontitis will receive non-surgical treatment and then be randomly assigned to avoid caffeine or consume low or moderate amounts for 6 months. Researc…

This study tests whether a procedure called full pulpotomy can successfully treat permanent teeth with irreversible pulpitis and apical periodontitis. Instead of removing the entire nerve like a root canal, full pulpotomy removes only the inflamed pulp from the crown, preserving …

This trial tests whether combining traditional Ayurvedic treatments with standard medical care can better ease knee osteoarthritis symptoms than either approach alone. It enrolls 300 adults aged 30-65 with mild to moderate knee osteoarthritis, randomly assigning them to receive s…

This study tests an oral chemotherapy drug, cladribine, combined with two other drugs (low-dose cytarabine and venetoclax) in people with acute myeloid leukemia (AML). The first part finds the safest dose; the second part checks if that dose helps control the disease. About 58 ad…

This trial is testing whether adding hydroxyurea to a standard chemotherapy combination can improve outcomes for adults with acute myeloid leukemia (AML) that has returned or not responded to treatment. The study is conducted in two parts: first to find the safest dose of hydroxy…

This trial is testing whether a minimally invasive technique for robotic knee replacement, which uses a smaller incision and less tissue disruption, can improve scar appearance and recovery compared to the standard approach. The study will involve 100 adults with knee osteoarthri…

This trial tests whether rusfertide, a synthetic version of the hormone hepcidin, can help people with polycythemia vera—a condition where the bone marrow makes too many red blood cells—by lowering iron availability and keeping red blood cell counts in check. The study enrolls Ch…

This phase 2 trial is testing whether combining two immunotherapy drugs—vilastobart and retifanlimab—can shrink tumors in people with metastatic pancreatic cancer that has a BRCA1, BRCA2, or PALB2 gene mutation. Participants receive both drugs by IV infusion over several months. …

This study follows about 1,020 people who receive the oneKNEE total knee prosthesis during knee replacement surgery. Researchers track safety and how well the implant works by measuring changes in knee pain and function using the Oxford Knee Score two years after surgery. The goa…

This study tests whether taking ibuprofen after a platelet-rich plasma (PRP) injection changes pain relief and knee function in adults with knee osteoarthritis. Participants receive one ultrasound-guided PRP injection and then take either ibuprofen or acetaminophen for five days.…

This trial asks whether it is safe to skip the routine removal of impacted teeth before radiation therapy for nasopharyngeal carcinoma. Half of the participants will have the extraction as usual, while the other half will not. The study will compare the risk of jaw bone damage (o…

This trial compares two types of clear retainers worn after braces to see if the way they are made affects gum health. One retainer is created from a digital scan of the teeth, while the other uses a traditional plaster mold. About 52 people who recently finished braces will wear…

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This trial asks whether a minimally invasive root canal procedure can match the success of the traditional approach in treating lower molars with dead nerves and an infected root tip. Sixty adults aged 20 to 50 with such molars will be randomly assigned to receive either a conser…

This trial tests whether adding silver nanoparticles to a standard antibiotic paste used inside root canals can better reduce pain and inflammation in people with symptomatic apical periodontitis, a painful infection at the tooth root. Half of the 50 adult participants receive th…

This study tests a combination of an experimental drug (ficerafusp alfa), an immunotherapy (pembrolizumab), and targeted radiation before surgery for people with advanced head and neck cancer that is HPV-negative. About 45 participants will receive these treatments over several w…

This trial tests whether a calcium-rich food chew, made from milk-derived minerals, is easier for women to take daily than a standard calcium carbonate pill. Women aged 40 to 90 at increased risk for osteoporosis will be randomly assigned to one of the two forms for four weeks. T…

This phase 3 trial is testing whether adding an umbilical cord blood infusion to standard consolidation chemotherapy can help older adults with intermediate- or high-risk acute myeloid leukemia (AML) stay free of relapse. About 132 patients aged 60 to 80 who achieved remission af…

This Phase 2 trial tests a combination of two drugs—blinatumomab (given as a shot under the skin) and olverembatinib (a pill)—in 60 adults with Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL). The goal is to see if this combo can control the disease safely. Pa…

This study tests whether adding core stabilization exercises to standard scoliosis-specific physical therapy (BSPTS) can improve trunk rotation and core endurance in adolescents with idiopathic scoliosis. Participants will be randomly assigned to receive either BSPTS alone or BSP…

This study follows people with bone loss caused by long-term steroid use to compare two treatment approaches. One group received romosozumab for the first year and then switched to denosumab, while the other group took denosumab throughout. After six years, researchers will measu…

This pilot study explores whether a gentle manual therapy applied to the hip bone, in addition to standard treatment with a Pavlik harness, can improve hip joint coverage in infants with developmental dysplasia of the hip (DDH). Thirty infants aged 1 to 5 months with moderate to …

Steroid injections for knee arthritis can temporarily raise blood sugar in people with type 2 diabetes. This trial tests whether giving a short course of NPH insulin right after the injection can prevent those high blood sugar episodes. Adults with type 2 diabetes and knee osteoa…

This trial tests whether a daily routine of tummy time and careful positioning can help correct cranial asymmetry—a flattened head shape—in premature newborns. About 300 babies born before 37 weeks who are in the neonatal ICU or intermediate care unit will be split into two group…

This trial tests whether applying a gel containing either metformin or zoledronate under the gums can improve healing of bone defects caused by periodontitis in people with well-controlled type 2 diabetes. Participants receive standard deep-cleaning treatment, and some also get o…

This trial tests whether an experimental cell therapy called agenT-797 is safe for people receiving a stem cell transplant for blood cancers like leukemia or myelodysplastic syndrome. Participants get an infusion of agenT-797 about a week after their transplant. The main goal is …

This trial tests whether a minimally invasive deep-cleaning technique (MINST) works better than the usual scaling and root planing for severe periodontitis in back teeth. Adults aged 18–35 with stage III/IV gum disease will have one molar treated with standard cleaning and anothe…

This trial tests whether a powered leg exoskeleton called ZEPU AI9 can safely and effectively help people with walking difficulties caused by stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will be randomly assigned to receive either exoskeleton-assiste…

This study looks at how well the drug asciminib works and how safe it is for young adults with chronic myeloid leukemia (CML) in the Gulf region. Researchers will collect information from medical records of about 80 people aged 18 and older who have taken asciminib. The main goal…

This trial tests whether a toothpaste containing arginine can alter the bacteria living below the gumline in people with gum disease who are already receiving ongoing dental care. Participants will brush twice daily for six months with either an arginine toothpaste or a standard …

This trial tests whether adding gilteritinib to the standard drugs azacitidine and venetoclax can help adults with a type of acute myeloid leukemia (AML) that has returned or stopped responding to prior treatment. Participants receive the three-drug combination in repeated 28-day…

This trial tests whether taking a GLP-1 medication (semaglutide) for at least six months before hip or knee replacement surgery can improve recovery and reduce complications in patients with obesity. Participants will be randomly assigned to receive either the medication plus beh…

This trial is testing whether adding the drug venetoclax to different chemotherapy regimens can improve outcomes for people newly diagnosed with acute myeloid leukemia (AML). It compares three experimental combinations against the standard treatment in 320 patients aged 14 and ol…

This phase 2 trial is testing whether an oral drug called flonoltinib maleate can help adults with myelofibrosis, a rare bone marrow disorder that often causes an enlarged spleen and severe symptoms. The study compares three different daily doses (50 mg, 75 mg, and 100 mg) to see…

This trial tests whether extra follow-up—via phone calls, digital messages, or both—helps people recover better after a tooth extraction. Adults having a tooth pulled will get standard instructions, and some will also receive structured phone or digital check-ins during the first…

This trial tests whether adding inspiratory muscle training (IMT) — breathing exercises using a resistance device — to usual care can improve cardiopulmonary endurance and functional mobility in people with knee osteoarthritis. Adults aged 40-65 with bilateral knee osteoarthritis…

This early-phase trial is testing an experimental drug called VTRU200 in people with certain blood cancers that have returned or not responded to standard treatments, including acute myeloid leukemia, high-risk myelodysplastic syndromes, and diffuse large B-cell lymphoma after CA…

This Phase 2 trial tests whether a topical drug called KH001 can preserve the pulp (nerve) inside teeth with deep cavities. Adults with deep dentinal caries will receive either KH001 or a placebo applied to the cavity. The study tracks how many people develop irreversible pulpiti…

This trial tests whether a single injection of a new gel, called 2107, can relieve pain and improve function in people with mild-to-moderate knee osteoarthritis. About 286 adults aged 40–80 will receive either 2107 or an existing hyaluronic acid injection (DUROLANE) directly into…

This trial is testing an experimental drug called TLL-018 in adults with moderate-to-severe rheumatoid arthritis who haven't responded well to or couldn't tolerate standard treatments. Participants will receive either TLL-018 or a placebo for a period, and the study will measure …

This trial tests whether robotic devices that guide arm and leg movements can safely improve strength, coordination, and daily function in adults with movement problems from stroke, spinal cord injury, brain injury, or orthopedic conditions. Participants will use the devices thre…

This trial tests two methods for sealing the socket left after a tooth is removed, with the goal of preserving the gum and bone for a future replacement. One method uses a fixed, 3D-printed temporary tooth that supports the gum tissue, while the other uses a removable plastic gua…

This trial tests whether adding robotic rehabilitation devices to standard physiotherapy can improve arm and leg function in adults with movement problems from stroke, spinal cord injury, traumatic brain injury, or orthopedic surgery. Participants will receive robotic-assisted se…

This trial tests whether a one-time injection of a person's own concentrated fat can reduce pain and improve function in adults with chronic tendinopathy—tendon pain lasting more than three months that hasn't improved with usual treatments. Participants undergo a same-day procedu…

This phase 2 trial is testing whether an investigational drug called arumakimig can improve symptoms of VEXAS syndrome, a rare genetic autoinflammatory condition. The study will compare arumakimig against a placebo in about 120 adults with VEXAS, with the goal of seeing if the dr…

This trial tests whether cold atmospheric plasma can match standard sodium hypochlorite irrigation for disinfecting root canals in teeth with dead nerves. Sixty adults with a single necrotic tooth will receive one of the two treatments. Researchers will compare post-treatment pai…

This trial tests whether antiplatelet medications, specifically clopidogrel and aspirin, can reduce inflammation in the blood vessels of people with psoriasis or psoriatic arthritis. Participants take each drug or a placebo for four weeks, and researchers measure changes in infla…

This study compares two FDA-approved drugs, momelotinib and ruxolitinib, in people with myelofibrosis who also have low blood cell counts. The main goal is to see which drug does a better job at shrinking the spleen and reducing the need for blood transfusions. About 268 particip…

This trial is testing a robotic exoskeleton called ABLE Kids to see if it is safe and practical for children who have trouble walking due to conditions like cerebral palsy, spinal cord injury, or muscle weakness. Fifteen children will use the device in up to ten one-hour training…

This trial tests whether testosterone therapy can help men with spinal cord injury who have low testosterone and difficulty walking. The goal is to see if it increases muscle and bone in the legs, reduces body fat, and improves strength. Some participants also receive finasteride…

This trial tests a new surgical technique that avoids cutting the gum tissue between teeth to repair deep bone defects caused by gum disease. The procedure uses a synthetic bone graft and a special gel to help the bone regenerate. The study includes 60 adults aged 35 to 65 with a…

This early-stage trial is testing whether combining a robotic exoskeleton with spinal cord stimulation can help people with chronic spinal cord injury walk more easily. The study will include a small group of adults who already have a spinal stimulator implanted and have complete…

This study tests whether adding a mild electrical stimulation to the spinal cord (tSCS) during walking therapy can improve leg movement in people with recent spinal cord injury (within 6 months). Forty participants will receive either real or sham stimulation during 20 training s…

This trial tests whether adding electrical stimulation to the lower back muscles, alongside standard rehabilitation, can improve spine and pelvis alignment after total knee replacement surgery. People aged 40-80 with knee osteoarthritis and measurable spinal misalignment will be …

This trial compares two surgical techniques for total knee replacement—the subvastus approach and the medial parapatellar approach—to see which one leads to better recovery and function. The study will enroll 84 people with severe knee osteoarthritis who need a knee replacement. …

This trial investigates how the drug zoledronic acid is processed in the body of people with chronic kidney disease who are on dialysis and also have osteoporosis. It aims to find the best dose—either 2.5 mg or 5 mg—given as a single intravenous injection during a dialysis sessio…

This phase 2 trial is testing whether lifileucel, a therapy made from a patient's own tumor-infiltrating lymphocytes (immune cells), can shrink tumors in adults with advanced soft tissue sarcoma. Participants will have their tumor removed to create the personalized therapy, then …

This trial tests whether adding a robotic leg-training device (ZEPU-AI5) to standard rehab can safely improve walking, strength, and balance in adults aged 18–60 with lower-limb problems from stroke, incomplete spinal cord injury, or orthopedic surgery. Participants will receive …

This phase I trial is testing whether combining three drugs—pacritinib, venetoclax, and azacitidine—is safe and tolerable for people with accelerated or blast phase myeloproliferative neoplasms, aggressive blood cancers. The study enrolls about 20 adults whose disease has progres…

This study tests a robotic device called ZEPU-AI1 that helps people with leg weakness practice standing and walking. The trial includes adults aged 19 to 60 who have walking problems from stroke, spinal cord injury, or orthopedic surgery. Half of the participants will use the rob…

This trial is testing whether a single injection of stem cells from umbilical cord tissue, given into the spinal fluid, is safe and tolerable for people who have had a traumatic spinal cord injury within the past ten years. The study will monitor participants for side effects and…

This trial compares two types of zirconia crowns—custom-made versus prefabricated—for restoring severely decayed baby molars after a pulpotomy (a procedure to save the tooth). Children aged 5-8 with deep cavities in their primary molars will receive one of the two crowns, and res…

This pilot trial asks whether adding a robotic hand-training device to standard rehabilitation is safe, practical, and helpful for people with arm and hand motor problems caused by stroke, incomplete spinal cord injury, traumatic brain injury, or orthopedic conditions. Participan…

This trial tests whether adding a small piece of connective tissue from the roof of the mouth to a standard gum-saving surgery helps repair deep bone defects caused by gum disease. Thirty adults with two or more deep gum pockets will receive the surgery on both defects, but only …

This trial tests whether a one-bottle or a two-bottle HEMA-free dental adhesive works better for filling cavities on the front surfaces of teeth. About 50 adults with early to moderate cavities will receive a filling using one of the two adhesives. Researchers will check how well…

This study tracks the safety of secukinumab, a biologic injection, in Indian adults with axial spondyloarthritis — a group of inflammatory conditions that cause back pain and stiffness. Over 16 weeks, researchers will monitor side effects and disease activity in about 60 particip…

This phase 2 trial tests whether using a comprehensive geriatric assessment to guide treatment selection can reduce side effects and improve outcomes in adults aged 60 and older with newly diagnosed acute myeloid leukemia. Participants are classified as fit, vulnerable, or frail,…

This trial tests whether common antibiotics—amoxicillin or amoxicillin-clavulanate—actually reduce symptoms in children aged 2 to 12 with acute sinusitis. About 1,100 children are randomly assigned to one of the two antibiotics or a placebo, and parents track daily symptoms. The …

This trial tests whether screening older adults for sarcopenia (loss of muscle strength and mass) before hip replacement surgery, followed by a structured exercise program after surgery, can improve recovery. Participants aged 65 and older with advanced hip osteoarthritis will be…

This phase 3 trial tests whether giving radiation therapy early — before symptoms appear — can reduce the risk of bone complications (like fractures or spinal cord pressure) in people with solid tumors that have spread to the bone. Participants have bone lesions that are consider…

This trial tests whether adding high-intensity laser therapy (HILT) to a physiotherapy programme can improve bone health in postmenopausal women with osteopenia or osteoporosis. Forty women will receive either real or sham laser sessions on their lower back, three times a week fo…

This trial tests whether adding a procedure called expansile duraplasty — opening and expanding the tough membrane around the spinal cord — to standard spinal surgery can improve neurological recovery in adults with acute severe spinal cord injury. Participants are randomly assig…

This trial investigates whether revumenib, a menin inhibitor, can safely and effectively treat myelofibrosis, a type of bone marrow cancer. The study first tests revumenib alone in patients who have already tried a JAK inhibitor, then tests it in combination with a JAK inhibitor.…

This trial tests whether finasteride, a drug that blocks testosterone production, can reduce levels of Cutibacterium acnes bacteria on the skin. High testosterone is linked to more of this bacteria, which can cause serious infections during shoulder replacement surgery. Healthy m…

This trial tests whether nicorandil, a drug currently used for heart conditions, can reduce disease activity and symptoms in people with rheumatoid arthritis. About 70 adults with moderate-to-severe RA will take either nicorandil or a placebo twice daily for three months, while c…

This phase 1 trial tests an experimental cell therapy called LMY-922 (BAFF CAR-T cells) in people aged 16 to 75 with refractory autoimmune diseases, including rheumatoid arthritis, lupus, dermatomyositis, and systemic sclerosis. The therapy uses donor immune cells engineered to t…

This study tests whether a robotic device called ZEPU-AI3 can safely help people with lower limb weakness from stroke, spinal cord injury, or orthopedic surgery improve their walking. Participants receive either standard rehabilitation alone or standard rehab plus robot-assisted …

This trial compares two methods for removing black tooth stains in children aged 4 to 13. After an initial ultrasonic cleaning, one group receives a standard polish with paste and brush, while the other gets an air-polishing treatment using erythritol powder. Researchers will tra…

This study tests a device called the ReWire system, which is implanted to stimulate the vagus nerve during leg rehabilitation. The goal is to see if this paired stimulation can safely improve walking in people with chronic, incomplete spinal cord injury. The trial involves 20 par…

This trial tests whether an 8-week upper-limb resistance training program can improve cardiovascular autonomic function in adults with chronic spinal cord injury. Participants are randomly assigned to either supervised arm exercises three times per week or a control group. Resear…

This study tests an experimental drug called dibotatug (DR-01) in adults with bone marrow failure syndromes, including severe aplastic anemia. The goal is to see if the drug is safe and can improve blood cell counts. Participants receive dibotatug by IV infusion, and researchers …

This trial tests whether an experimental drug called bomedemstat can help people with polycythemia vera (a condition where the body makes too many red blood cells) who did not get better with or could not tolerate the common treatment hydroxyurea. Participants will receive either…

This trial tests whether a machine learning tool, called the Drum Tower Rule, can help surgeons select the lowest vertebra to fuse during corrective surgery for adolescent idiopathic scoliosis. About 300 teens with specific curve types will be randomly assigned to have surgery gu…

This early-stage trial is testing an experimental drug called AMX-883, taken by mouth, for people with acute myeloid leukaemia (AML) or high-risk myelodysplastic syndrome (MDS) that has come back or not responded to standard treatments. The study will first test AMX-883 alone, th…

This trial tests whether adding an experimental drug called CLN 049 to two standard AML drugs (azacitidine and venetoclax) is safe and tolerable for adults newly diagnosed with acute myeloid leukemia who are not candidates for intensive chemotherapy. The study will first find the…

This trial tests whether adding a posterior cervical fusion (using the CORUS PCSS 3D device) to the standard anterior cervical discectomy and fusion (ACDF) improves bone fusion success for people with two-level degenerative disc disease in the neck. About 225 adults with neck or …

This trial is testing an experimental drug called S243249, which blocks a protein called menin, in people whose acute leukemia has come back or not responded to standard treatment. The study focuses on patients with specific genetic changes (KMT2A or NUP98 translocations, or NPM1…

This study compares two ways to handle severely decayed front baby teeth in children aged 3 to 5: restoring them with zirconia crowns or simply extracting them. Researchers want to see which approach leads to better quality of life, parental satisfaction, child self-image, and sp…

This early-phase trial is testing an experimental drug called S241656, taken as a tablet, in people with relapsed or refractory acute myeloid leukemia (AML) and related blood cancers. The study aims to find a safe dose and see how the drug behaves in the body, both alone and when…

This trial tests whether adding the drug revumenib to standard chemotherapy (fludarabine and cytarabine) can help children and young adults with a rare form of acute myeloid leukemia (AML) that has come back or not responded to treatment. The study enrolls up to 27 participants a…

This trial compares two types of platelet-rich plasma (PRP) injections for people with tennis elbow that hasn't improved with standard treatments. One injection uses PRP made from the patient's own bone marrow, while the other uses PRP from their blood. The study aims to see if t…

This study investigates whether a daily probiotic lozenge containing Limosilactobacillus reuteri can reduce inflammation and improve gum health in adults with severe periodontal disease. Researchers will also analyze participants' oral and gut bacteria to identify who is most lik…

This trial compares robotic-assisted total knee replacement to the conventional manual approach in adults with knee osteoarthritis. All participants follow the same structured home-based rehabilitation program before and after surgery. The study measures knee pain, function, and …

This clinical trial tests whether injecting a person's own purified blood cells into the knee can reduce pain and improve movement in people with knee osteoarthritis. The study compares two doses of these cells against a standard steroid injection. Participants are adults aged 40…

People who have spine surgery for cancer that has spread are at high risk for dangerous blood clots in the legs or lungs. Currently, blood-thinning medicine is stopped when patients leave the hospital. This trial tests whether taking apixaban (Eliquis) by mouth for 30 days after …

This study compares two materials used in gum graft surgery for people with thin or missing gum tissue around teeth or dental implants. One group receives a graft made from their own palate tissue, while the other group receives a graft made from a collagen matrix derived from pi…

This study tests whether a new, chlorhexidine-free mouthwash can reduce plaque buildup, gum inflammation, and bad breath in children aged 12 to 17 who wear fixed metal braces. Participants rinse twice daily for 21 days alongside their usual brushing and flossing. The trial compar…

This study tests a combination of four drugs—sotoclax, carfilzomib, lenalidomide, and dexamethasone (called SonKRd)—in people newly diagnosed with multiple myeloma that has a specific genetic change called t(11;14). Participants must be healthy enough for a stem cell transplant. …

This phase 2 trial tests whether a once-weekly oral combination of decitabine-cedazuridine and venetoclax is safer and as effective as standard therapy for people with relapsed or refractory acute myeloid leukemia, high-risk myelodysplastic syndrome, or high-risk myeloproliferati…

This phase 3 trial tests an injectable drug called ribupatide in people who have both obesity and knee osteoarthritis. The study measures whether ribupatide can reduce knee pain and stiffness, improve joint function, and help with weight loss over 68 weeks. Participants are rando…

This trial investigates whether taking pimicotinib—a drug that blocks a protein driving tumor growth—for 12 weeks before surgery can improve outcomes for people with diffuse tenosynovial giant cell tumor (D-TGCT), a rare but aggressive joint tumor with a high recurrence rate. Par…

This phase 2 trial tests an experimental oral drug called CBP-0276 in adults with active psoriatic arthritis, a condition causing joint pain, swelling, and skin plaques. Participants receive either a low dose (200 mg), a high dose (800 mg), or a placebo daily for 24 weeks. The ma…

This study investigates whether ginkgo biloba extract can improve outcomes for people with moderate to severe rheumatoid arthritis who are already on standard disease-modifying drugs. Participants take ginkgo biloba for 12 weeks, and researchers measure changes in inflammation ma…

This trial compares a standardized siwak (chewing stick) oral hygiene program to conventional toothbrushing for improving gum health in young adults with gingivitis. Participants are dental students aged 18–24 who will follow either the siwak module or toothbrushing for 21 days. …

This trial investigates whether combining high-frequency magnetic stimulation of the sacral nerve roots with ultrasound therapy to the bladder can reduce involuntary bladder contractions in people with spinal cord injury. Participants receive daily treatments for three weeks, and…

This phase 1 trial tests an experimental therapy called 20-19 Tan BB06z CAR-T for people with certain blood cancers (like lymphoma or leukemia) that have come back or not responded to treatment. The therapy involves taking a patient's own immune T cells, genetically modifying the…

This study compares virgin coconut oil mouthwash to the standard chlorhexidine mouthwash as an add-on to deep cleaning for people with stage II periodontitis (gum disease). Over 30 days, researchers measure gum health indicators like pocket depth, bleeding, and inflammation. They…

This trial tests whether a device that uses alternating magnetic fields to heat metal knee implants can help treat infections without removing the implant. Adults with a knee implant infection receive surgery, antibiotics, and either active or sham magnetic treatment. The study m…

This study tests whether a new synthetic membrane, called Inox Nanoksa G-Plus, can help rebuild bone in the upper or lower jaw for adults who need dental implants but lack sufficient bone width or height. All participants receive the same surgery: the membrane is placed under the…

This trial investigates whether adding bacteriophages—viruses that specifically target and kill bacteria—to standard surgery and antibiotics can improve outcomes for people with infected hip or knee replacements. The study enrolls adults with an infection caused by Staphylococcus…

This study looks at how well the chemotherapy drug temozolomide works for people with aggressive pituitary tumors or pituitary cancer that hasn't responded to standard treatments like surgery or radiation. Researchers are collecting data from medical records across multiple hospi…

This study tests a 3-month virtual program called Choose to Move Replacement Ready for people on waitlists for hip or knee replacement due to osteoarthritis. The program offers choice-based physical activity and group support to help participants stay active, reduce pain, and imp…

This study tests a stepwise injection plan for adults with joint hypermobility and instability who haven't improved enough with physical therapy. The first step uses dextrose prolotherapy to stimulate healing in ligaments. If that doesn't reduce pain by at least 40%, participants…

This early-phase trial tests a single injection of PID23, a gene therapy that instructs a patient's own immune cells to attack leukemia cells. It targets three markers (CD19, BCMA, and CD70) on cancer cells. The study enrolls up to 18 people aged 3 to 75 with relapsed or refracto…

This study aims to develop an artificial intelligence tool that helps doctors choose the right dose of cyclosporine for patients who have received a bone marrow transplant. Cyclosporine is used to prevent graft-versus-host disease, a serious complication where donor cells attack …

This study tests a 6-month nutritional program for adults aged 60–80 who wear complete dentures. Participants receive personalized dietary advice, meal plans, cooking workshops, and a mobile app. The goal is to see if the program improves diet quality, chewing ability, muscle str…

This study tracks the safety and effectiveness of a stent graft device used to treat aneurysms, dissections, or trauma in the aortic arch (the curved part of the main artery from the heart). Researchers will follow 75 patients in Japan who receive the device, monitoring for compl…

This trial tests a new toothpaste containing a Bio-Descaling Powder (BDP) to see if it can reduce hardened dental plaque (calculus) and gum inflammation. It includes 100 adults with gum disease or who are in a gum maintenance program. Participants brush with either the BDP toothp…

This early study tests whether washing the bladder with an antibiotic (gentamicin) followed by a probiotic (Lactobacillus) can help restore healthy bacteria and prevent urinary tract infections in people with neurogenic bladder due to spinal cord injury, multiple sclerosis, or sp…

This study follows 100 adults who received short dental implants (7 or 8 mm) in the back part of the upper or lower jaw. Researchers want to see how well these implants hold up over 5 years by measuring bone loss, stability, and overall success. The goal is to determine if shorte…

This study looks at whether using a miswak stick—a natural teeth-cleaning twig—along with regular brushing can improve gum health in people with gingivitis. Researchers will measure markers of inflammation and oxidative stress in saliva and plaque. The goal is to see if this trad…

This trial tests whether taking the anti-bleeding medication tranexamic acid (TXA) for three days after hip or knee replacement surgery helps people recover faster and with less pain. Adults with osteoarthritis who are having a first-time joint replacement receive either TXA or a…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This study tests a smartphone app called DinSkoliose, designed to help adolescents with idiopathic scoliosis stick to their treatment plan. The app includes features like reminders for brace wear and exercises, symptom tracking, and educational content. Thirty teens will use the …

This study tests whether amla (Emblica officinalis), a medicinal plant, can replace standard sodium hypochlorite as a disinfectant during root canal treatment. The trial includes 66 people aged 18–50 with infected single-rooted front teeth. Researchers measure how well each solut…

This early-stage trial tests a new drug called JR-446 in 12 children under 6 with MPS IIIB, a rare genetic disorder that damages the brain and body. The main goal is to see if the drug is safe and tolerable. Researchers will also measure changes in certain substances in the body …

This trial tests whether a combination of two drugs, lisaftoclax and azacitidine, can help prevent acute myeloid leukemia (AML) from coming back in patients who have already received a stem cell transplant and are at high risk of relapse. Participants are randomly assigned to rec…

This trial investigates whether surgically removing the primary breast tumor, followed by standard systemic therapy, improves survival compared to systemic therapy alone in women with stage IV breast cancer that has spread only to a single bone site. The study enrolls women aged …

This study tests an experimental oral drug called JAB-8263 in adults with active rheumatoid arthritis. The goal is to see if it is safe and can reduce joint inflammation and pain. Participants take the drug or a placebo every other day for 28 days. The trial is small and early-st…

This study investigates whether adding diaphragm manual techniques to standard three-dimensional scoliosis exercises (Schroth method) improves outcomes for adolescents with idiopathic scoliosis. Twenty-four participants aged 10–18 with mild curves (Cobb angle under 30°) will be s…

This study tests whether two common heart medications—atorvastatin (a statin) and lisinopril (an ACE inhibitor)—can prevent or reduce heart damage caused by radiation therapy for chest cancers like breast, lung, and esophageal cancer. About 60 adults receiving chest radiation wil…

This study tests whether a newer type of dialysis filter (medium cut-off membrane) can better manage bone and mineral problems common in people with end-stage kidney disease. Thirty adults on maintenance dialysis will try both the new and standard filters for three months each. R…

This trial tests whether a gentle electrical earpiece, worn twice daily for two weeks, can reduce brain swelling caused by radiation necrosis. The device stimulates a nerve in the ear to calm inflammation. Forty people with brain tumors who need a laser procedure will be randomly…

This trial compares two types of rotary files designed for children's primary molars: Fanta AF Baby and EndoArt Pedo Blue. The goal is to see which system prepares root canals faster and with better filling quality during a pulpectomy (removing infected pulp). Thirty children age…

This study tests whether wearing a knee sleeve daily for five years can slow the progression of knee arthritis and reduce pain in adults aged 50 to 64 who have had knee pain for at least three months. Participants are randomly assigned to either wear a knee sleeve every day or no…

This study tests whether adding a Chinese herbal formula (Xuanyin Ning) to a standard cancer drug (bevacizumab) can better control malignant pleural effusion—fluid buildup in the chest caused by advanced lung cancer. About 308 participants will receive either the herbal formula o…

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether oxymetazoline, a common nasal decongestant, can replace sodium hypochlorite as a bleeding control agent during pulp treatment in children's baby teeth. About 50 Egyptian children aged 4-8 with decayed molars will receive either treatment. The goal is to s…

This early-phase trial is testing an experimental therapy called GT737 for adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatment. GT737 uses specially engineered immune cells (iNKT cells) that are made in large batches and can be given…

This trial investigates whether adding bortezomib and sitagliptin to standard post-transplant cyclophosphamide can prevent graft-versus-host disease (GvHD) in adults with blood cancers receiving a stem cell transplant. Participants receive the drug combination after transplant, w…

This study explores whether applying mild electrical stimulation to the spinal cord through the skin can improve blood pressure control in people with spinal cord injury. Participants will undergo tilt-table tests to measure immediate effects, plus 20 stimulation sessions to see …

This study investigates whether a patient's own platelet concentrate, called A-PRF, can improve early wound healing after tooth extraction in people at high risk for medication-related osteonecrosis of the jaw (MRONJ). Participants are adults who have taken or are taking bone-str…

This study looks at whether a special gel, called Sterify Gel, can improve the results of standard non-surgical gum disease treatment. Researchers will review records from 20 adults with moderate to severe periodontitis who received deep cleaning plus the gel. The main goal is to…

This study tests whether adding a daily synbiotic supplement (probiotics plus prebiotic) to standard non-surgical gum treatment improves gum health in smokers with advanced periodontitis. 92 smokers and non-smokers will be split into four groups, receiving either the supplement o…

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years…

This study compares a new drug combination (venetoclax plus azacitidine) against standard chemotherapy for adults with a specific type of acute myeloid leukemia (AML) that has NPM1 or IDH mutations. About 148 people will be randomly assigned to one of the two treatments. The main…

This study tests whether a hyaluronic acid mouthwash is more acceptable to children than a standard chlorhexidine mouthwash, while still controlling plaque-induced gingivitis. Thirty-two children aged 8 to 12 with signs of gingivitis will use one of the two mouthwashes. Researche…

This study will compare two materials used for the caps that attach dentures to dental implants: acetal resin and nylon. The goal is to see which one causes less bone loss around the implants and keeps gums healthier. Twenty-two people with no teeth in their lower jaw will be enr…

This study tests whether removing some blood during bone cancer surgery and replacing it with fluid (acute normovolemic hemodilution) can reduce the need for donor blood transfusions. The trial will include 420 adults undergoing elective bone cancer surgery. The goal is to see if…

This study tests whether a low dose of colchicine, a common anti-inflammatory drug, can slow down blood vessel hardening and bone problems in people with stage 3 chronic kidney disease. About 60 adults will take colchicine or receive usual care for 12 months. The goal is to see i…

This trial compares two surgical approaches for people who develop spinal stenosis near a previous lumbar fusion. One group receives a smaller surgery (microdecompression alone), while the other gets the standard larger surgery (decompression plus extending the fusion). The study…

This trial investigates whether adding hip strengthening exercises to a standard quadriceps program better preserves knee cartilage thickness and improves symptoms in people with knee osteoarthritis. Fifty-six adults with mild-to-moderate knee OA will be randomly assigned to one …

This study tests whether removing a specific type of immune cell (naive T cells) from a donor's stem cell graft can prevent graft-versus-host disease (GVHD), a serious complication where donor cells attack the recipient's body. The trial enrolls people with non-malignant blood di…

This trial tests a highly targeted radiation technique called stereotactic body radiotherapy (SBRT) against standard radiotherapy for people whose cancer has spread to the spine but has not yet compressed the spinal cord. The goal is to see if SBRT can better prevent tumor growth…

This study tests a new combination of drugs (chidamide, venetoclax, azacitidine, and homoharringtonine) as a first treatment for adults aged 18-60 with intermediate- to high-risk acute myeloid leukemia (AML). The goal is to see if this mix can improve remission rates and reduce t…

This early study tests a new surgical device called the Microtable® Stereotactic System for cochlear implants. The device uses a custom-made frame to guide a drill precisely to the inner ear, potentially making surgery faster, less painful, and better at preserving taste. The stu…

This study tests whether a deep dental cleaning (subgingival instrumentation) can slow the progression of chronic kidney disease in 40 adults with diabetes and stage IV-V kidney disease. The cleaning aims to reduce inflammation that may worsen kidney function. Researchers will me…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This trial compares two surgical approaches for tennis elbow that has not improved after at least six months of non-surgical treatments like rest or physical therapy. One group receives keyhole (arthroscopic) surgery, while the other receives traditional open surgery. The main go…

This first-in-human study tests the safety of a new drug called HBM7020. It will first be given to healthy volunteers at low doses, then to people with moderate to severe autoimmune diseases like lupus, rheumatoid arthritis, scleroderma, and Sjögren's disease. The goal is to see …

This trial is testing a combination of three chemotherapy drugs—clofarabine, busulfan, and melphalan—given before a stem cell transplant in 30 adults with acute myeloid leukemia (AML) who are in first remission. The goal is to see if this conditioning regimen improves survival an…

This study tests whether a two-week course of the VA-CAG chemotherapy works as well as the usual three-week course for adults newly diagnosed with acute myeloid leukemia (AML). About 110 participants will be randomly assigned to one of the two schedules. The goal is to see if the…

This study looks at whether a higher dose of the blood thinner clopidogrel works better for people with essential thrombocythemia (ET), a rare blood disorder that raises the risk of dangerous blood clots. The standard dose may not work well for many ET patients, so researchers wi…

This study tests whether a supervised resistance exercise program, done for 2 weeks before and 12 weeks after total hip replacement, improves muscle mass and strength in adults aged 60 and older with severe hip osteoarthritis. Participants are randomly assigned to either the exer…

This study looks at whether mobile health reminders can help people with gum disease keep their teeth cleaner after standard treatment. The trial will include 76 adults with gum disease affecting the roots of their back teeth. Participants will receive text or app reminders to im…

This study tests a gel made from doxycycline and atorvastatin in tiny chitosan particles, placed directly into gum pockets after standard deep cleaning. The goal is to reduce gum inflammation, pocket depth, and bone loss in 80 adults with moderate to severe chronic periodontitis.…

This early-phase trial is testing whether stem cells from donated bone marrow (CG-BM1) are safe for people with ankylosing spondylitis, a chronic inflammatory arthritis. Forty adults aged 18 to 40 will receive either the stem cells or a placebo by IV once a week for four weeks. T…

This trial tests a new automated radiation method that precisely targets bone marrow and lymph nodes before a stem cell transplant. The goal is to kill cancer cells while reducing damage to healthy tissues. Participants have high-risk myeloid cancers like acute myeloid leukemia o…

This trial investigates whether adding selinisole to standard chemotherapy drugs (azacitidine and venetoclax) can improve outcomes for people with newly diagnosed, high-risk myeloid tumors that have a TP53 mutation. These tumors are aggressive and hard to treat. The study will me…

This study tests whether adding a light-activated dye (photodynamic therapy) to standard deep cleaning improves gum disease more than cleaning alone. Thirty adults with periodontitis will have one side of their mouth treated with cleaning plus the dye/laser, and the other side wi…

This study tests a new nasal spray for adults with chronic sinusitis. The spray turns into a gel inside the nose and releases three active ingredients: stem cell exosomes to help repair the nasal lining, an antihistamine to reduce inflammation, and an antiviral agent. The goal is…

This study tests a combination of seven drugs (including asciminib and venetoclax) in 30 adults with advanced chronic myeloid leukemia or Philadelphia chromosome-positive acute myeloid leukemia. The first phase checks safety, and the second phase sees if the combo helps control t…

This study tests whether a paste made from Salvadora persica (a plant used in traditional toothbrushes) mixed with zinc oxide can work as well as the standard material (MTA) for treating severe tooth inflammation. The trial involves 78 adults aged 18-40 with infected permanent mo…

This study investigates whether measuring two proteins, CD38 and CD56, on white blood cells called neutrophils can help diagnose chronic myeloid leukemia (CML). Researchers will compare the levels of these markers in 200 people with CML to see if a high percentage is a reliable s…

This trial is testing a new wireless, non-invasive device that measures muscle activity on the back to monitor scoliosis in adolescents. The device uses skin electrodes to detect imbalances in muscle activation on each side of the spine during sitting and movement. The goal is to…

This study tests whether combining two screening questionnaires with a musculoskeletal ultrasound can detect spondyloarthritis—a type of inflammatory arthritis—in people who already have inflammatory bowel disease (IBD) but have not been diagnosed with arthritis. Two hundred adul…

This study tests whether a new eye-tracking device called SONDA can accurately measure visual field loss in people with pituitary tumors. Standard visual field tests require patients to press a button when they see lights, which can be tiring and unreliable. The SONDA test instea…

This study is developing an artificial intelligence (AI) system that can analyze standard MRI brain scans to determine the specific molecular subtype of a child's brain tumor before surgery. The research includes 1,400 children under 18 with suspected brain tumors, using both pas…

Rheumatoid arthritis and gout can look alike, making them hard to tell apart early. This study will use ultrasound to see if it can reliably distinguish between the two conditions. Researchers will examine 100 adults with suspected or confirmed arthritis, scoring joint inflammati…

This study aims to develop a new blood test that could replace the invasive bone marrow biopsy currently used to diagnose myeloproliferative neoplasms (MPNs), a group of blood cancers. Researchers will collect blood samples from 500 adults with suspected or confirmed MPN and anal…

This study tests a wearable microwave sensor that monitors bladder fullness without needles or catheters. About 40 adults with spinal cord injury who use self-catheterization will wear the sensor while their bladder fills and empties. The goal is to see if the device can accurate…

This study looks at whether CT scans taken during lumbar spine surgery can detect spinal instability more reliably than standard X-rays taken before surgery. Researchers will review imaging and medical records from 100 adults undergoing surgery for degenerative spine conditions. …

This study explores whether a single MRI fat-fraction (MRI-FF) scan can accurately diagnose osteoporosis and sarcopenia (muscle loss) in people with chronic kidney disease (CKD). Researchers will compare MRI-FF results with standard DXA scans in 868 participants—half with CKD and…

This trial tests whether sending oral health tips via WhatsApp to mothers, in addition to standard face-to-face advice, improves their knowledge and their children's toothbrushing habits. Mothers of children aged 3 to 6 will receive either usual education alone or with 16 additio…

This trial tests whether swabbing toddlers' teeth with povidone iodine can prevent tooth decay and reduce cavity-causing mouth germs. Children aged 1 to 3 will have their teeth swabbed weekly for the first month and then monthly, with some also receiving a daily probiotic. The st…

This trial tests whether a silver nanoparticle mouthwash can reduce cavity-causing bacteria in children as effectively as chlorhexidine, but without the staining and taste issues. About 96 children aged 6–12 at high risk for cavities will rinse twice daily for 14 days. The study …

This trial tests whether cleaning the chewing surfaces of children's teeth with a fine erythritol powder spray (Guided Biofilm Therapy) before applying a protective sealant helps the sealant stay in place longer than the standard rotary-brush polishing. Each child aged 6–10 will …

This trial tests whether a fluoride-releasing adhesive used to attach braces can prevent white spot lesions—early signs of decay—on teeth. About 40 adolescents getting braces will have standard adhesive on one side of their upper jaw and the fluoride sealant on the other. After 3…

This trial tests whether applying a 5% lidocaine plaster daily for two months can prevent chronic nerve pain after an osteoporotic vertebral fracture. Participants aged 50 and older with a recent fracture and moderate pain are randomly assigned to receive the plaster plus standar…

This study tests whether applying povidone iodine (a disinfectant) to toddlers' teeth before fluoride varnish prevents cavities better than fluoride varnish alone. About 393 children aged 6-24 months with healthy teeth or early white spots will be followed to see which approach r…

This study tests whether injecting platelet-rich plasma (PRP) into the epidural space during endoscopic disc herniation surgery can reduce nerve pain in the leg. PRP is made from the patient's own blood and may help healing and reduce inflammation. The trial will enroll 50 adults…

This study tests whether a special omega-3 supplement can reduce pain in adults with chronic temporomandibular disorder (TMD), a condition causing jaw pain. One hundred participants will take either the supplement or a placebo daily for 8 weeks. Researchers will measure changes i…

This trial tests an online platform called Ready Set Recover, designed to help people prepare for and recover from spine surgery. The platform offers education, mindfulness, gratitude exercises, and gentle movement to support mental well-being and patient engagement. Researchers …

This study compares two types of virtual reality (VR) during common ear, nose, and throat (ENT) procedures. One group will watch calming scenery, while the other plays an interactive puzzle game. Researchers want to see which better reduces pain and anxiety. The study will includ…

This trial asks whether a newer 'bulk-fill' composite filling causes less tooth sensitivity after cavity repair than the traditional layer-by-layer method. Dentists often apply standard fillings in thin layers to avoid shrinkage gaps, but bulk-fill materials can be placed in thic…

This trial tests whether a new hand rehabilitation program, called SMART-HAND, can improve hand function, joint position sense, pain, and dexterity in people with rheumatoid arthritis. The program combines sensory training, massage, joint approximation, range-of-motion exercises,…

This trial tests whether adding pain neuroscience education and graded motor imagery to standard physiotherapy can improve pain, movement, and fear of movement in people with type 2 diabetes and frozen shoulder. Fifty adults aged 40-65 with diabetic adhesive capsulitis will recei…

This study looks at whether using AI-made videos to show patients what happens during knee replacement surgery can lower their anxiety and fear of moving after the operation. About 150 adults aged 55 and older who are scheduled for knee replacement will take part. Half will get s…

This trial tests whether a structured 12-week physiotherapy exercise program can improve balance, posture, and reduce fall risk in people with osteoporosis. Participants, aged 50 and older, will be randomly assigned to either the exercise program or a control group. The program f…

This trial tests whether a structured self-care education program can reduce joint stiffness and improve functional ability in people with rheumatoid arthritis. Participants are split into two groups: one receives the education program alongside usual care, while the other gets u…

This study compares two ways of numbing a child's tooth for a root canal on a baby molar: a computer-controlled system that delivers anesthetic slowly and steadily, versus a traditional injection. The goal is to see which method causes less anxiety and pain in children aged 6 to …

This study tests whether a single injection of concentrated bone marrow cells can reduce pain and improve function in people with hip osteoarthritis better than a standard steroid injection. One hundred adults with moderate to severe hip arthritis will be randomly assigned to rec…

This trial tests whether a new type of dental splint—made with both hard and soft 3D-printed materials—can improve comfort and outcomes for people with temporomandibular joint (TMJ) disorders. It compares the hybrid splint to conventional chairside splints and standard 3D-printed…

This trial tests whether duloxetine, an FDA-approved osteoarthritis drug, can improve walking ability and physical activity in people with chronic knee osteoarthritis pain. Participants take duloxetine or a placebo for six weeks, then complete surveys, physical tasks, brain imagi…

This study tests whether wearing an insole or a medial arch support during a short walk can ease pain and change muscle stiffness in young adults with flatfoot. Ninety participants will be randomly assigned to one of two support devices or to a control group. Researchers will mea…

This trial tests whether adding custom-made, prefabricated, or sham (fake) foot orthoses to a standard exercise and education program can reduce foot pain and improve function in adults with progressive collapsing foot deformity, a condition that causes a painful, flattening foot…

This pilot study tests whether photobiomodulation therapy—using a special laser device—can reduce pain in people who go home the same day as their total knee replacement surgery. Participants receive the light therapy as part of their post-operative pain plan, and their pain leve…

This study looks at two ultrasound-guided nerve blocks used to manage pain after lumbar spine surgery: the classic TLIP block and the QIP block. Adults aged 18-65 having elective lumbar discectomy will receive one of these blocks as part of their routine care. Researchers will tr…

This trial asks whether keeping the knee slightly bent for a few hours after knee replacement surgery improves recovery compared to the usual straight position. About 150 adults scheduled for a knee replacement will be randomly assigned to either have their knee positioned at a 6…

This study tests a small ear device that gently stimulates a nerve (taVNS) in people who recently had a spinal cord injury. The goal is to see if it is safe and comfortable, and whether adding it to walking therapy might help improve mobility. About 50 adults will take part in tw…

This trial tests whether giving the sedative dexmedetomidine during hip replacement surgery can dampen the body's stress and inflammatory response to the operation. Researchers will compare two doses of the drug against a placebo in 90 adults aged 50-90 undergoing total hip arthr…

This trial tests whether a procedure called genicular artery embolization can reduce pain and improve function in people with knee osteoarthritis who have not responded to standard treatments. Doctors insert a thin tube into an artery in the groin, guide it to blood vessels aroun…

This study tests whether applying bee venom to the face using ultrasound can ease chronic sinusitis symptoms. Thirty adults with sinusitis will either get bee venom phonophoresis or standard care (decongestants and saline rinses). Researchers will measure changes in symptom sever…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This trial compares two ultrasound-guided nerve blocks for pain control after total knee replacement. The goal is to see if one block preserves leg muscle strength better, allowing earlier movement, while providing similar pain relief. Sixty adults scheduled for knee replacement …

This trial tests whether taking a single dose of diclofenac potassium before dental treatment can improve the numbing effect of local anesthesia and reduce pain after the procedure. Adults with severe tooth pain from irreversible pulpitis in lower molars will receive either 50mg,…

This pilot study tests whether playing a collaborative virtual reality game during the first walk after scoliosis surgery can reduce pain and anxiety in teens aged 10 to 17. Half of the participants will use a VR headset to explore a magical jungle with a physiotherapist, while t…

This phase 3 trial tests whether a single injection of hyaluronic acid into the knee can reduce pain and improve function in people with moderate knee osteoarthritis over 12 months. The study includes adults aged 40 to 75 who have persistent knee pain despite standard treatments …

This pilot study will test whether a 'Comfort Tote' filled with items like aromatherapy oils, stress balls, acupressure guides, and a journal can help teens aged 10-21 feel less pain, anxiety, and stress after scoliosis surgery. Half the participants will get a tote with therapeu…

This trial tests whether washing out the jaw joint (arthrocentesis) works as well as Botox injections for treating painful temporomandibular joint (TMJ) disorders. Adults with TMJ pain that hasn't improved with standard care will be randomly assigned to one of the two procedures.…

This trial tests whether taking a placebo pill that patients know is inactive — called an open-label placebo — can help reduce chronic pain from temporomandibular disorders (TMD). Some participants also receive a brief behavioral session to boost their expectations. The study foc…

This trial tests whether adding hormone replacement therapy (HRT) to a standard physiotherapy program improves pain, movement, and function in postmenopausal women with frozen shoulder. Fifty-six women aged 40 to 60 with stage I or II frozen shoulder will receive 12 weeks of supe…

This trial tests whether an ultra-high molecular weight hyaluronic acid injection works better than a standard high molecular weight version for subdeltoid bursitis, a painful shoulder condition. About 50 adults with recent shoulder pain will receive an ultrasound-guided injectio…

This trial tests whether mirror therapy — a low-cost technique where a child watches the reflection of their good arm moving, creating the illusion that their affected arm is moving — can improve arm and hand function in children with hemiparetic cerebral palsy. Twenty-six childr…

This trial tests whether flushing the inside of a tooth with cold saline (about 2.5°C) after root canal retreatment can lower pain and inflammation. One hundred adults needing retreatment on a lower premolar will be randomly assigned to receive either cold or room-temperature sal…

This trial tests whether injecting hyaluronic acid into the shoulder, combined with physical therapy, can reduce pain and disability from subdeltoid bursitis. Fifty participants receive either cross-linked or non-cross-linked hyaluronic acid, guided by ultrasound. Researchers tra…

This phase 3 trial tests whether ecnoglutide, a GLP-1 drug similar to semaglutide, can reduce knee pain and body weight in obese adults with knee osteoarthritis. Participants receive either ecnoglutide injections or a placebo for several months. The study measures changes in pain…

This trial tests whether two simple distractions — watching a betta fish or playing with a hand puppet — can lower pain, fear, and anxiety in children aged 5 to 7 during a blood draw. One group will use the fish, another the puppet, and a third will receive standard care. Researc…

This trial tests an experimental drug called VC004 for people with moderate-to-severe pain caused by cancer that has spread to the bones. About 26 adults will receive either a low or high dose of VC004 or a placebo capsule, and researchers will track changes in daily pain scores …

This pilot trial tests whether a web-based conversational assistant can help people recovering from total knee replacement. About 60 adults who have had knee replacement surgery will either receive standard care alone or standard care plus access to the online assistant for 6 wee…

Pseudo-angina is chest pain that feels like a heart attack but comes from muscle knots, not the heart. This trial tests whether two hands-on treatments—Graston Technique (using a stainless-steel tool to massage muscles) and local ischemic compression (sustained finger pressure on…

This trial tests whether a hands-on spinal manipulation technique, called lever positioning manipulation, can ease the leg and back pain caused by a herniated disc. About 84 adults with a herniated disc will receive either the real manipulation or a sham version three times a wee…

This trial tests whether a personalized, smartwatch-supported home exercise program can increase physical activity and improve heart health, mobility, and quality of life in adolescents and young adults who have survived bone or soft tissue sarcoma. Participants wear a fitness tr…

This trial compares two adaptive indoor rowing seats designed for Veterans who have limited trunk stability due to spinal cord injury, stroke, or neurodegenerative conditions. Participants will try both seats during short rowing sessions, and researchers will measure trunk moveme…

This trial compares two hands-on therapy techniques—Gong's mobilization and Maitland mobilization—for treating adhesive capsulitis, commonly known as frozen shoulder. The study includes adults aged 40 to 65 with moderate pain and limited shoulder movement. Researchers are measuri…

This trial tests whether adding a hands-on technique called manual traction to standard physical therapy can reduce pain and improve function in women recovering from total knee replacement. Forty-eight women aged 50 to 75 with knee osteoarthritis will be randomly assigned to rec…

This trial compares two different file systems used during root canal treatment for infected lower molars. The goal is to see whether a newer, minimally invasive single-file system leads to less pain after the procedure than the standard Wave One Gold system. Adults with a specif…

This study compares two physical therapy approaches for patellofemoral pain syndrome, a common cause of front knee pain. One group performs the Mikhled Knee Exercise Program alone, while the other adds Stecco fascial manipulation, a manual therapy technique. Researchers will meas…

This trial looks at whether changing how the dentist's tool moves during a root canal can reduce pain afterward. Adults with an infected lower premolar will get standard root canal treatment, but the file system will use either a continuous spin or a back-and-forth motion, with d…

This Phase 2 trial tests an experimental oral drug, LY4065967, for knee pain caused by osteoarthritis. About 150 adults with chronic knee pain and confirmed osteoarthritis will receive either the drug or a placebo. The main goal is to see if the drug safely reduces pain intensity…

This study tests whether applying myofascial release—a manual therapy that relaxes tight muscles—to the arms can improve sprint speed in wheelchair rugby players with spinal cord injury. Twelve athletes will complete a 20-meter sprint test with and without the therapy on separate…

This study tests whether adding femoral nerve gliding or lumbopelvic manipulation to standard hip-knee exercises improves pain, knee function, and nerve health in people with patellofemoral pain syndrome (front knee pain). Sixty adults aged 18–35 with unilateral knee pain will be…

This study tests whether a simple breathing exercise—inhaling against resistance using a handheld device—can reduce knee pain in people aged 55 and older with knee osteoarthritis. Participants will do the exercises at home for 8 weeks, with gradually increasing resistance. The tr…

This study tests whether using a virtual reality (VR) headset during hip replacement surgery can lower anxiety and prevent post-surgery confusion in older adults. Half of the participants will watch calming nature scenes through VR while under regional anesthesia, while the other…

This trial tests whether an injection of tergase (berahyaluronidase alfa) can reduce swelling after total knee replacement surgery. The study involves 30 older adults with severe knee osteoarthritis who are having both knees replaced at the same time. One knee receives the inject…

This study tests whether adding Kinesio Taping to a standard bowel program can improve bowel function in adults with spinal cord injury. Thirty participants will be randomly assigned to receive either the bowel program alone or the bowel program plus Kinesio Taping applied to the…

This study tests whether a 3% hypertonic saline (saltwater) rinse, used at the end of a root canal procedure, can reduce pain and inflammation better than the standard 0.9% saline rinse. Forty adults with painful tooth inflammation will receive one of the two rinses, and their pa…

This study tests whether adding a gentle muscle-release technique called Strain Counter-Strain to standard Rocabado exercises provides better relief for people with temporomandibular joint (TMJ) dysfunction. The trial includes 44 adults aged 20 to 50 with mild to moderate TMJ pai…

This study tests whether adding short foot exercises—which train the small muscles in the foot—to standard hip and knee strengthening can better relieve pain and improve function in women with patellofemoral pain syndrome (PFPS). Thirty-eight women aged 18 to 45 with PFPS will be…

This trial tests whether using a laser to ablate (destroy) specific nerves around the knee provides better pain relief than the standard radiofrequency method for people with chronic knee osteoarthritis. Fifty adults with persistent knee pain will receive one of the two procedure…

This study compares two hands-on physical therapy techniques—popliteus muscle release and patellofemoral mobilization—for treating patellofemoral pain syndrome, a common cause of knee pain. Researchers will measure changes in pain intensity, knee function, and quadriceps strength…

This trial investigates whether a single injection of dexamethasone, a steroid, given before a root canal can lower pain during the procedure. It includes adults with severe tooth pain from symptomatic irreversible pulpitis. Participants receive either dexamethasone or a placebo,…

This study tests whether adding a simple leg exercise to standard recovery care can reduce swelling and inflammation after total knee replacement. The exercise involves lying or sitting while lifting the leg and moving the ankle. Researchers will measure leg swelling and pain in …

This trial compares two types of nerve blocks given before hip replacement surgery to control pain afterward. One is the standard supra-inguinal fascia iliaca compartment block (SI-FICB), and the other is a newer quadro-iliac plane block (QIPB). The study includes adults aged 18-…

This study tests whether adding shockwave therapy to a tailored exercise program reduces pain and improves function in people with Achilles tendon pain. Two hundred adults with pain in the mid-portion or insertion of the tendon will be randomly assigned to exercise alone or exerc…

This pilot study compares two standard-of-care radiofrequency ablation (RFA) techniques for chronic knee pain caused by osteoarthritis. Adults already scheduled for knee RFA are randomly assigned to receive either a standard 3-target or a novel 6-target nerve ablation protocol. T…

This study compares two treatments for frozen shoulder (retractile capsulitis): a standard steroid injection into the shoulder joint versus that same injection plus a nerve block near the shoulder blade. The nerve block uses a numbing medicine and a steroid to calm the nerve that…

This study tests whether adding an oral supplement (PEA) to a series of knee injections (adelmidrol and hyaluronic acid) can better reduce pain and improve function in people with knee arthritis. The injections aim to protect the joint from damage, while the supplement may help c…

This study tests whether doing physiotherapy at home through live video calls works as well as going to a clinic for people with moderate neck pain from cervical spondylosis. Fifty-two adults aged 45-64 will be split into two groups: one gets in-person sessions, the other gets re…

This trial compares three ways to manage pain after total knee replacement. All patients receive standard nerve blocks, but some also get an anti-inflammatory drug (dexamethasone) or a combination of dexamethasone and a sedative (dexmedetomidine). The goal is to see which approac…

This study compares two ways to break up kidney stones using a laser and a suction device. One method turns stones into dust, the other into small fragments. The goal is to see which leaves fewer stone pieces behind after one month. About 86 adults with small kidney stones will t…

This study tests whether using very cold water (around 2-3°C) to rinse the inside of a tooth during a root canal can lower pain afterward. The trial includes adults aged 20-40 with painful, infected lower molars. Participants are randomly assigned to receive either cold rinses th…

This study tests whether adding a manual foot massage (plantar fascia release) to standard foot exercises can immediately improve movement quality in young adults with flat feet. Twenty-nine physically active participants aged 18-35 will try both exercise-only and exercise-plus-m…

This study investigates whether adding High-Intensity Laser Therapy (HILT) to standard physiotherapy helps people with mild-to-moderate knee osteoarthritis. Seventy-two participants will receive either real or sham laser sessions alongside exercise-based physiotherapy. Researcher…

This study compares two surgical options for people who develop spinal stenosis (narrowing of the spine) above a previous fusion site. One group gets decompression alone (removing tissue pressing on nerves), while the other gets decompression plus extended fusion (adding screws a…

This study tests whether a personalized exercise program can improve physical function and quality of life in adolescents and young adults who have survived sarcoma. Participants first complete a triage tool to assess their needs, then receive a 12-week exercise plan that may inc…

This study tests whether an 8-week program of yoga and meditation delivered through a mobile app can reduce anxiety in adults with stable rheumatoid arthritis. About 100 participants will either use the app daily or continue with standard care. Researchers will measure changes in…

This study tests whether the drug zoledronate can reduce pain in children aged 4 to 17 with chronic recurrent multifocal osteomyelitis (CRMO), a rare auto-inflammatory bone disease. The 30 participants have not responded to standard anti-inflammatory drugs. They will receive eith…

This study looks at whether using a cold saline rinse after ultrasonic cleaning during a root canal can lower pain afterward. Adults with an inflamed tooth nerve will get either ultrasonic cleaning alone or followed by a cold saline flush. Pain levels are tracked for three days a…

This study will compare two treatments—low-level laser therapy and iontophoresis (a method that uses a mild electric current to deliver medication through the skin)—for knee osteoarthritis. Sixty-six adults aged 45 to 65 with mild to moderate knee arthritis will be randomly assig…

This study tests whether artificial intelligence can help teens with idiopathic scoliosis improve their posture. Thirty participants aged 10–18 will receive either standard physical therapy or additional AI-based feedback on their body alignment. The goal is to see if the AI guid…

This study tests whether pelvic floor down training—gentle breathing and relaxation exercises—can reduce tailbone pain in new mothers. Fifty-two women, 6 months to 1 year after childbirth, will practice these exercises daily. Researchers will measure pain and daily function befor…

This early-phase trial tests a wearable device that delivers mild electrical stimulation to a nerve near the genitals, aiming to improve bladder control in men with spinal cord injury. The study will enroll 12 participants and measure changes in bladder capacity and device usabil…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This study compares core stability exercises versus proprioceptive (balance) training in 63 adults aged 18-40 with patellofemoral pain syndrome (runner's knee). Participants will be assigned to one of two exercise programs to see which better reduces pain and improves knee functi…

This study will test whether an 8-week yoga program done live over Zoom can improve balance, endurance, and well-being in 32 children aged 8-12 with juvenile idiopathic arthritis (JIA). The yoga sessions are led by certified physiotherapists and include breathing, poses, and medi…

This study investigates whether high-intensity laser acupuncture, combined with exercise, can reduce pain and improve knee function in people aged 18 to 25 with patellofemoral pain syndrome (front knee pain). Participants receive either real laser acupuncture or a sham laser, plu…

This study tests whether adding a pain-relieving gel (diclofenac) to shock wave therapy can better reduce pain and improve shoulder function in people with shoulder impingement syndrome. Seventy adults aged 25–40 with moderate shoulder pain will be randomly assigned to receive ei…

This study compares two non-surgical treatments—shockwave therapy and high-power laser—for chronic tennis elbow (lateral epicondylitis) that has lasted over 3 months. Seventy-two adults aged 40-50 will receive one of the treatments plus standard physical therapy. Researchers will…

This study will test whether walking on an antigravity treadmill can boost heart and lung fitness and improve leg function in 60 people with incomplete spinal cord injury. Participants will do gait training on the treadmill or between parallel bars. The goal is to see if this spe…

This study tests whether a gentle neck mobilization technique can improve jaw movement and reduce pain in people with chronic jaw muscle pain (TMD myalgia). 48 adults with jaw pain will receive either the neck treatment or a placebo. Researchers will measure jaw motion, muscle ac…

This study tests whether adding neck-strengthening exercises to standard physical therapy can reduce pain and improve shoulder function in people with shoulder impingement syndrome. Forty-two adults with shoulder pain will be split into two groups: one gets standard therapy alone…

This study tests a new drug, JMKX000197, against a standard chemotherapy drug (cisplatin) to see which works better at controlling fluid buildup around the lungs in people with advanced cancer. About 120 participants with moderate to large fluid collections will receive the drug …

This study tests two simple treatments for tooth sensitivity caused by worn enamel: a blue diode laser and a bioactive glass powder. Thirty adults with two similarly sensitive teeth will each receive both treatments (one per tooth) to see which works better. The goal is to find a…

This study tests whether combining the medication duloxetine with a structured walking program can improve physical function, reduce pain, and ease depressive symptoms in veterans with knee osteoarthritis. Participants will be assigned to either the drug-plus-exercise group or a …

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This study will follow 80 people with chronic pain (like back, hip, or nerve pain) who are getting a procedure called cryoneurolysis, which uses cold to temporarily block pain signals. Researchers want to see if it leads to meaningful pain relief and better daily function over 12…

This study tests whether an AI-based digital rehabilitation system can help people with shoulder impingement syndrome. 93 adults will either do traditional in-clinic therapy plus home exercises, or use the 'ShuKangShi' AI system at home for daily training. The goal is to see if t…

This study tests if deltoid strengthening exercises can reduce pain and improve movement in people with frozen shoulder (adhesive capsulitis). 48 adults aged 40-60 with stage II or III frozen shoulder will do specific isometric exercises targeting the deltoid muscle. Researchers …

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study tests whether Mat-Pilates exercises can improve balance and walking ability in adolescents aged 12 to 15 with mild scoliosis (curves between 10 and 25 degrees). Forty participants will be randomly assigned to either Mat-Pilates or standard physical therapy. The goal is…

This study tests a physical therapy program designed for older adults with knee osteoarthritis. The program focuses on mobility, balance, and fall prevention, and also considers each person's mental abilities. Forty participants aged 60 and older will take part in 16 sessions ove…

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study compares two physical therapy techniques for athletes with tightness in the back of the shoulder, a common issue in overhead sports like cricket. 34 athletes will receive either Kaltenborn joint mobilization or a specific stretch for 4 weeks. Researchers will measure p…

This study tests whether a special exercise method called Sahrmann's approach can reduce pain and improve knee function better than standard physical therapy in people with knee osteoarthritis. Forty adults aged 40 to 60 with moderate knee arthritis will be assigned to one of two…

This pilot study will test whether a dental gel called theranovis can improve gum health in people with gingivitis (mild gum disease). Twenty adults with gingivitis will use either the gel or a placebo twice daily for a period. Researchers will measure changes in gum bleeding and…

This study tests whether eating at least 6 servings of fermented foods daily for 10 weeks can improve bowel function and gut health in adults with chronic spinal cord injury. Participants will be randomly assigned to either a high-fermented-food diet or a control diet. The resear…

This study tests whether three different desensitizing toothpastes can reduce tooth sensitivity in people with braces. About 200 adults aged 18-40 with mild to moderate sensitivity will use one of the toothpastes or a placebo for 8 weeks. The goal is to see if the special toothpa…

This study tests whether TECAR therapy—a device that delivers gentle heat deep into the knee—can reduce pain, improve balance, and boost quality of life in elderly men with knee osteoarthritis. Eighty men will receive either real TECAR plus standard physiotherapy or a sham versio…

This study will develop and test a new digital pain rehabilitation program for people with spinal cord injury (SCI) who have chronic pain. The program is based on a biopsychosocial model, which looks at physical, emotional, and social factors. The study will enroll 32 adults who …

This study will test a 16% carbamide peroxide gel used at home in custom trays for 90 minutes daily over six weeks. Ten adults with healthy gums and no prior whitening will have their tooth color measured by a special device and report how their quality of life changes. The goal …

This study screens up to 1,000 people with personal or family histories of certain cancers to see if they qualify for ongoing genetics research at the National Cancer Institute. Participants fill out a 15-20 minute online survey about their health and family history. No treatment…

This study aims to translate and culturally adapt the Hip Disability and Osteoarthritis Outcome Score-12 (HOOS-12) into Turkish and test its reliability and validity in patients with hip osteoarthritis. Participants will complete the Turkish HOOS-12 and a general health survey at…

This study uses ultrasound to examine the joints of adults with mild hemophilia, a group that often goes understudied. Researchers will scan six joints (ankles, knees, elbows) to look for early signs of damage that may not cause symptoms yet. The goal is to see how common joint p…

This study compares sleep quality between adolescents with idiopathic scoliosis and healthy peers of similar age and sex. Researchers will use questionnaires to assess sleep, and in the scoliosis group, they will also look at curve severity, pain, body image, and brace use. The g…

This observational study looks at whether the size of two lower-back muscles, the psoas and multifidus, measured on MRI scans taken before surgery, is related to how well patients recover after surgery for a herniated disc. The study will include 100 adults aged 18 to 75 schedule…

This study looks at whether a newer, minimally invasive endoscopic technique for removing a herniated disc leads to less back pain in the first few days after surgery compared with traditional open surgery. Researchers will follow 140 adults scheduled for lumbar discectomy and me…

This study investigates whether the thickness of fat over the shin bone, measured on a standard knee X-ray, is a better predictor of infection after total knee replacement than Body Mass Index (BMI). Researchers will review data from 400 adults who had knee replacement surgery, c…

This study will follow 200 children with acute lymphoblastic leukemia or lymphoma to learn more about the short- and long-term side effects of asparaginase drugs. Researchers will track how often serious toxicities occur during standard treatment and a newer therapy called SJALL2…

This study explores whether a digital tool can help monitor adults with chronic myeloid leukemia who have stopped treatment for up to two years. Over 12 months, researchers will track how often patients use the tool, aiming for a usage rate of at least 60%. The goal is to see if …

This study tracks blood sugar changes after an epidural steroid injection for back or leg pain. Researchers will compare 36 adults with and without type 2 diabetes using a continuous glucose monitor worn for 15 days. The goal is to see if the injection causes higher or longer-las…

This study will test two different levels of positive pressure (PEEP) on a breathing machine during lumbar spine surgery performed face-down. The goal is to see which setting helps patients breathe better and maintain good oxygen levels. Sixty adults aged 18-65 having elective ba…

This study is building a biobank of blood samples and imaging data from 300 people with suspected inflammatory heart or autoimmune rheumatic diseases. Researchers aim to identify immune biomarkers that could predict major heart events like heart failure, stroke, or atrial fibrill…

This study is translating and testing an Italian version of a questionnaire that measures kinesiophobia—the fear of movement—in people with temporomandibular disorders (TMDs), which affect the jaw joint and muscles. Researchers will ask 250 adults diagnosed with TMD to complete t…

This study looks at whether a blood test that detects tumor DNA (ctDNA) can give the same information as bone marrow tests in children with acute leukemia. Researchers will compare ctDNA results with standard bone marrow checks for minimal residual disease. The goal is to see if …

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study explores whether a non-invasive, painless skin measurement called electrical bioimpedance can help monitor acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS). About 25 adults who are already scheduled for a bone marrow biopsy will also receive this skin te…

This study investigates how to engineer T cells to more effectively target acute myeloid leukemia (AML). Researchers will analyze samples from healthy donors and AML patients to identify T-cell receptors that recognize leukemia cells. The goal is to create next-generation enginee…

This study will examine 108 adults aged 30-65 to see if a gene called Klotho, certain mouth bacteria, and viruses are linked to gum disease and acute coronary syndrome (a type of heart attack). Researchers will measure gum health and collect samples to look for these markers. The…

This study investigates whether children and adults with neuromuscular scoliosis have a stronger immune response after spinal fusion surgery compared to those with idiopathic scoliosis. Researchers will analyze blood samples taken before and after surgery to measure immune marker…

This pilot study tests whether adults aged 65 and older with acute leukemia can use a digital platform to complete health questionnaires from home. Twenty participants will fill out surveys about their quality of life and symptoms on a tablet or phone, with results sent directly …

This study aims to find biological markers in saliva, mouth rinse, blood, or tissue that could help identify and predict the course of oral cancer, gum disease, and tooth decay. Researchers will collect health information and samples from 4,000 adults with these conditions and he…

This study looks at how a procedure called temporomandibular joint arthrocentesis—a washout of the jaw joint—affects the masseter muscle, a key chewing muscle. Researchers will use ultrasound and strain elastography to measure the muscle's thickness and elasticity before and afte…

This study compares two ways of giving the same experimental biosimilar drug, DRL_AB, which is designed to work like abatacept for autoimmune conditions. Healthy male volunteers receive a single dose either through an autoinjector or a prefilled syringe. Researchers measure how m…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study will measure how much of the drug TREMFYA (guselkumab) passes into breast milk of 10 nursing women who are already taking it for conditions like psoriasis, psoriatic arthritis, ulcerative colitis, or Crohn's disease. Researchers will collect milk samples to estimate th…

This trial tests whether adding midazolam, dexmedetomidine, or esketamine to standard propofol anesthesia helps maintain the right depth of unconsciousness during knee replacement. One hundred adults scheduled for surgery will have their brain waves and vital signs monitored as t…

This quality improvement initiative tests whether a standardized electronic medical record template for progress notes, combined with a pharmacist-led medication titration service, can improve the management of polycythemia vera (PV). The study enrolls hematologists and oncologis…

This study looks at whether inflammation from gum disease during pregnancy can affect the womb environment and lead to early delivery. Researchers will measure markers of inflammation and oxidative stress in saliva and amniotic fluid from 80 healthy pregnant women. The goal is to…

This study compares survival and other outcomes in patients with acute leukemia or myelodysplastic syndrome who received a stem cell transplant with a personalized dose of an immune-suppressing drug (r-ATG) to similar patients from a large registry who received standard treatment…

This study tests whether correcting a flat foot position with shoe inserts (orthoses) changes how the kneecap sits during standing. Ten adults with flexible flatfoot will have weight-bearing CT scans with and without orthoses, with knees straight and slightly bent. The goal is to…

This pilot trial tests whether a single-use flexible bronchoscope can safely and effectively replace the semi-rigid pleuroscope for diagnosing pleural effusion—a buildup of fluid around the lungs. Hospitalized patients needing a tissue sample will be randomly assigned to one of t…

This study looks at how common cavities are in the first permanent molars of 6- to 7-year-old Egyptian children and whether diet and tooth-brushing habits play a role. Researchers will examine 272 children's teeth and ask parents about their child's eating and oral hygiene routin…

This study investigates what factors — such as pain intensity, fear of movement, and confidence in managing pain — influence how adults with chronic tennis elbow perceive their illness and what they expect from treatment. Researchers will survey 137 participants and analyze the d…

This study compares two approaches for runners with flat feet (pes planus): custom foot orthoses versus an eight-week foot-core strengthening program. Researchers will measure how each intervention affects hip, knee, and ankle motion during a prolonged run. The goal is to underst…

This study looks at whether GLP-1 receptor agonists like semaglutide and tirzepatide, used for weight loss, change saliva composition and increase tooth wear. Researchers will measure saliva calcium, pH, flow rate, and dental erosion in 40 adults before and 3 months after startin…

This study will measure a protein called IL-41 in the blood of 90 people with ankylosing spondylitis or psoriatic arthritis, plus healthy volunteers. Researchers want to see if higher levels of this protein are linked to more active disease. The goal is to find a simple blood tes…

This study tracks how Sanfilippo syndrome type C, a rare genetic disorder that affects the brain, progresses over time. Caregivers of children and young adults aged 1 to 25 will record videos of daily activities and answer questionnaires using a smartphone app every six months fo…

This observational study looks at whether children aged 3 months to 16 years are more likely to complete their full course of antibiotics when prescribed at a primary care clinic versus a hospital emergency department. Researchers surveyed parents by phone after treatment ended t…

This study looks at whether having insomnia before dental surgery leads to more pain afterward. Adults getting teeth pulled will be grouped by their sleep quality and will report pain levels using questionnaires. The goal is to see if poor sleep makes recovery harder.

This study looks at saliva from people with osteoporosis to measure certain immune markers and an enzyme called MMP-8. Researchers also check participants' dental cavities. The goal is to better understand how osteoporosis might affect oral health. No treatments are given—only sa…

This trial tests whether monitoring sacral reflexes during surgery can predict nerve function afterward. Patients undergoing sacrectomy for pelvic bone cancer or spinal procedures will have their reflexes tracked in real time. The goal is to help surgeons make decisions and prepa…

This study looks at whether a gel made from polynucleotides and hyaluronic acid can help gum tissue heal better after a graft is taken from the roof of the mouth. Fifteen adults with gum recession will have grafts taken from both sides of their palate in two separate surgeries, n…

This study checks how consistently six doctors can grade degeneration of the small joints in the spine (facet joints) using CT scans. It includes 12 patients and uses the Pathria scale. The goal is to see if the grading method is reliable, not to test a treatment.

This study looks at whether children with molar-incisor hypomineralization (MIH) — a condition that weakens tooth enamel — have different levels of gum inflammation markers compared to children without MIH. Researchers will measure inflammatory substances in gum fluid from 76 chi…

This study tracks 30 people receiving a CATALYSTEM cementless hip implant to measure how much the stem moves (subsides) in the thigh bone over two years. Using specialized CT scans, researchers aim to see if the implant stays firmly in place, which is key for long-term success. P…

This study investigates whether increased muscle tone in the legs can predict neurogenic detrusor overactivity (NDO)—a condition where the bladder contracts involuntarily—in adults with upper sacral spinal cord injury. Researchers will compare medical records of 300 patients with…

This study aims to create a tool that predicts which patients are likely to have persistent pain after lumbar spine surgery, a condition known as failed back surgery syndrome. Researchers will combine routine blood tests, MRI scans, and psychological questionnaires from 150 adult…

This study is developing a way to predict who might develop a serious jaw bone condition called medication-related osteonecrosis of the jaw (MRONJ) after dental procedures. Researchers are following adults who have taken bone-strengthening drugs like bisphosphonates or denosumab …

This study looks at how different types of obesity—central (belly fat) versus peripheral (fat elsewhere)—affect blood loss and complications during major lower back surgery. Researchers will measure pressure inside the abdomen and blood loss in 90 adults having lumbar spine surge…

This study looks at different presurgical treatments for infants born with cleft lip and palate. These treatments help shape the mouth and nose before surgery. Researchers will compare how well each approach works, how many clinic visits are needed, and how much burden it places …

This study looks at how different types of dialysis affect heart health, bone metabolism, inflammation, and quality of life in people with end-stage kidney disease. Researchers will compare patients on hemodialysis, continuous ambulatory peritoneal dialysis, and automated periton…

This study looks at people who had treatment for peri-implantitis—an infection around dental implants—between 5 and 23 years ago. Researchers will check gum health, bone levels, and other signs to see which surgical or non-surgical approaches worked best over the long term. The g…

This study will measure how well people with gum disease can chew. One hundred adults with periodontitis will chew a special gum for 20 cycles to test their chewing performance. Researchers will also check the severity of their gum disease to see if there is a link. This is an ob…

This study looks at whether treating gum disease (periodontitis) can improve how well people chew and their overall oral quality of life. Researchers will ask 44 adults with gum disease to fill out questionnaires, do a chewing test with colored gum, and provide saliva samples. Th…

This study is testing whether a blood test can locate where colorectal cancer has returned or spread after surgery. Researchers are analyzing genetic markers in the blood to build a model that predicts whether a recurrence is local or distant. The goal is to improve early detecti…

This observational study will follow 150 people with thoracolumbar spine fractures to see how the injury and its treatment (surgery or non-surgical care) affect joint and disc degeneration over time. Researchers will compare CT scans and pain scores between treated patients and a…

This study looks at whether checking gum health 4 weeks after non-surgical treatment is better than waiting 8-10 weeks. Researchers will compare healing and pocket depth in 24 adults with advanced gum disease. The goal is to find the best time for follow-up to improve care.

This study translates and tests a Turkish version of the Staffordshire Questionnaire for Adolescent Idiopathic Scoliosis (SQAIS), a tool designed to measure body image and perceived deformity in teens with scoliosis. Researchers will enroll 100 adolescents aged 10–19 with idiopat…

This study tests whether two different capsule forms of the experimental drug SKI-O-703 are absorbed similarly in the body. About 48 healthy adults (Korean and Caucasian) will take a single dose of each form on separate days, with blood samples taken to compare drug levels. The r…

This study will collect information from 400 people having surgery for bone cancer. The goal is to track complications like infections or blood clots and understand how to improve care. By analyzing this data, researchers hope to find ways to make surgery safer and recovery faste…

This study will test whether artificial intelligence programs like ChatGPT can interpret brain monitoring data (BIS) as accurately as experienced clinicians during spine surgery. Researchers will compare AI responses to those of two doctors in 63 patients. The goal is to see if A…

This study will test whether a short health aid—a tool that corrects common misunderstandings about knee osteoarthritis—can help patients feel less worried and make clearer treatment choices. About 159 adults with knee osteoarthritis will be randomly assigned to review the health…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study looks at whether the way your jaw and teeth fit together (called malocclusion) is related to your body posture. Researchers will use a 3D scanner to measure the spine's curves and alignment in people with different types of jaw misalignment. The goal is to better under…

This study looks at how two thumb muscles work in people with and without thumb base osteoarthritis while they do six daily tasks like turning a key or writing. Researchers will use sticky sensors to record muscle activity. The goal is to find differences that could lead to bette…

This study will take 3D scans of the inside of the mouth from 240 people with rare bone or cartilage diseases and from healthy volunteers. Researchers will use shape analysis and artificial intelligence to see if these scans can help tell different diseases apart. The goal is to …

This study uses brain MRI to compare brain activity in women over 40 with knee osteoarthritis who have two different types of pain: joint-related pain and nerve-related pain. Researchers will look at a brain region called the anterior insula to see if activity differs between the…

This study looks at whether using a cousin as a stem cell donor works as well as using a sibling for people with blood cancers. Researchers will compare survival, relapse, and side effects like graft-versus-host disease in patients who received a transplant from either a cousin o…

This study looks at how to safely place a breathing tube in people with acromegaly, a condition that can cause changes in the face and airway. It compares two methods: direct laryngoscopy and video laryngoscopy. The goal is to find which method gives a better view of the airway a…

This observational study will check vitamin C levels in 40 people with osteoporosis, comparing those who have had a spine fracture to those who haven't. The goal is to see if lower vitamin C is more common in the fracture group. No treatment is given; the study simply measures an…

This study will observe 10 adults with acute myeloid leukemia who are receiving the drug gilteritinib after a stem cell transplant. Researchers want to understand how gilteritinib affects the behavior, metabolism, and function of immune cells like T-cells and monocytes. The goal …

This study aims to create a patient decision aid for young people aged 11-18 who are missing one or both upper front teeth, a condition affecting 1 in 50 people. Researchers will interview patients and their parents, and hold focus groups with clinicians, to understand what matte…

This study aims to create a score that uses a special blood test to predict bleeding risk in people with blood cancers and very low platelet counts. Researchers will take an extra blood sample from 410 participants and analyze it with viscoelastometric tests. The goal is to ident…

This study observes 150 infants and toddlers having cleft lip or palate repair to understand how often breathing complications occur and what factors increase risk. Researchers will use standard airway scoring tools to see if they can predict problems like laryngospasm or low oxy…

This study looks at skull bone samples from 80 infants aged 3 to 12 months who have craniosynostosis, a condition where skull bones fuse too early. Researchers will measure the bone's strength, structure, and tissue makeup both near and far from the fused area. The goal is to bet…

This study reviews medical records of 120 adults with low back pain who completed 15 sessions of physical therapy. Researchers will group patients based on their MRI results (disc herniation, disc degeneration, or normal findings) to see if certain types of back pain respond bett…

This study investigates whether alexithymia—a condition where people struggle to identify and describe their emotions—affects how well patients with knee osteoarthritis respond to physical therapy. Sixty participants aged 40 to 75 with moderate knee osteoarthritis will receive a …

This study will look at whether SPECT scans taken after Lu-PSMA therapy can help predict how well patients with metastatic castration-resistant prostate cancer (mCRPC) are doing. Researchers will measure tumor activity and volume on the scans and compare them to standard PET-base…

This study will check 45 adults with ankylosing spondylitis for peripheral neuropathy (nerve damage in the arms and legs) using nerve conduction tests. Researchers want to see if nerve problems are linked to higher disease activity, increased pain sensitivity, and worse quality o…

This study looks at how knee pain intensity relates to the knee's ability to sense its own position (proprioception) in people with patellofemoral pain syndrome. Researchers will measure pain and joint position error during a single-leg squat in 82 adults aged 18–35. The goal is …