Skeletal system disorder

This study tests whether adding a targeted drug called ganitumab to standard chemotherapy helps people with newly diagnosed Ewing sarcoma that has spread. The trial includes 312 participants and aims to see if the combination improves survival without the cancer growing back. The…

This study tests whether adding the targeted therapy cabozantinib to standard immunotherapy (nivolumab and ipilimumab) helps people with advanced kidney cancer live longer. About 1,175 adults with kidney cancer that has spread will receive either the usual treatment or the usual …

This study was designed to test whether a combination of an educational booklet, team-based care from a rheumatologist, physical therapist, and psychologist, plus nurse-led phone calls and home symptom tracking, could help more Hispanic adults with rheumatoid arthritis achieve re…

This expanded access program provides tazemetostat, a drug that blocks a protein called EZH2, to adults with serious or life-threatening solid tumors that have lost the INI1 or SMARCA4 protein. Eligible patients must have tried other treatments without success and cannot join a f…

This study tests whether 3D-printed composite resin fillings work as well as semi-direct composite resin fillings for cavities or damaged back teeth. About 60 adults aged 25 to 40 who need two similar fillings will get one of each type. Researchers will check for cracks, wear, an…

This study follows patients who have already been taking ruxolitinib alone or with panobinostat in earlier trials and are still benefiting. Researchers will track side effects over time to see how safe these drugs are for long-term use. About 296 participants with conditions like…

This study tests an inhaled form of pirfenidone (AP01) in 375 adults with progressive pulmonary fibrosis (PPF), a condition where lung scarring worsens over time. Participants receive either a high dose, low dose, or placebo twice daily for 52 weeks, alongside their usual care. T…

This phase 2 trial tests whether a daily pill called miransertib can slow or stop the abnormal tissue overgrowth seen in Proteus syndrome, a rare genetic condition. About 38 people aged 3 and older will take the drug for up to 4 years. Researchers will measure changes in foot ove…

This phase 2 study tests the drug selinexor against standard treatments in 112 people with myelofibrosis who have already tried JAK inhibitors. The main goal is to see if selinexor can shrink the spleen and improve symptoms. Participants are randomly assigned to receive either se…

This study tests a surgical technique to restore the natural curve (lordosis) of the lower spine in people who have had a previous spinal fusion that failed or caused ongoing pain. The procedure is done through the same incision used in the prior surgery. Researchers will measure…

This phase 2 trial compares two standard CML drugs—imatinib (Gleevec) at two different doses and dasatinib (Sprycel)—in 406 newly diagnosed patients with chronic phase CML. The main goal is to see which treatment leads to the best molecular response after 12 months, meaning a ver…

This Phase 3 trial is testing whether adding the drug quizartinib to standard chemotherapy helps adults with newly diagnosed acute myeloid leukemia (AML) that lacks a specific genetic mutation (FLT3-ITD). About 700 participants will receive either quizartinib or a placebo alongsi…

This study is testing a new hip implant called the OR3O Dual Mobility System in 177 people who need hip replacement surgery. The goal is to see if the implant is safe and lasts longer without needing another surgery. Researchers will follow participants for up to 10 years to chec…

This study compares the standard drug azacitidine alone versus azacitidine combined with either lenalidomide or vorinostat in 282 patients with higher-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML). The goal is to see if any combination improves re…

This study tests an experimental oral drug called LY3410738 in people with advanced blood cancers such as acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) that have specific IDH1 or IDH2 gene mutations. The drug is designed to block the mutated IDH proteins that he…

This study tests a new approach for people receiving a stem cell transplant from a partially matched family donor. The donor's immune cells (T cells) are modified in the lab to include a 'suicide gene' that can be activated by a drug if the cells attack the patient's body, causin…

This phase 2 trial is testing two immunotherapy drugs, nivolumab and ipilimumab, in children and young adults with rare INI1-negative cancers that have come back or not responded to treatment. The study aims to see if the combination can shrink tumors or slow disease progression.…

This study tested a combination of two drugs, azacitidine and gemtuzumab ozogamicin, in 133 older adults (age 60+) with untreated acute myeloid leukemia. The goal was to see how well the treatment could put the cancer into remission and improve survival. The approach uses chemoth…

This study compares two types of implants used in spinal fusion surgery: 3D-printed cages and titanium-coated cages. The goal is to see which leads to better bone fusion and less disability for patients with herniated discs or degenerative spine disease. About 78 adults undergoin…

This study looks at whether doing blood flow-restricted exercise two or three times per week makes a difference in muscle strength recovery for people with incomplete cervical spinal cord injury. Participants perform low-load muscle contractions while a cuff partially restricts b…

This study compares two ways of managing rheumatoid arthritis in people taking adalimumab. One group gets standard care, while the other has their dose adjusted based on regular blood tests that measure drug levels and antibodies. The goal is to see if personalized dosing helps m…

This study tests the drug ruxolitinib (Jakafi) in 29 people with chronic myelomonocytic leukemia (CMML), a rare blood cancer. The goal is to see if the drug can improve blood counts, shrink the cancer, or delay its turning into a more aggressive leukemia. Researchers are also che…

This trial tests whether specially modified T cells from a partially matched donor can help patients recover their immune system faster after a stem cell transplant. The T cells are engineered with a 'suicide gene' that allows doctors to destroy them if they cause graft-versus-ho…

This early-stage trial is testing a new drug called AOH1996 in 12 adults with acute myeloid leukemia (AML) that has come back or not responded to standard treatments. The drug works by blocking a protein that helps cancer cells grow and repair themselves. The main goals are to fi…

This phase 1 trial is testing a combination of total marrow and lymphoid irradiation (TMLI) plus two chemotherapy drugs, fludarabine and melphalan, given before a donor stem cell transplant. The goal is to find the safest dose of radiation that can kill cancer cells while prepari…

This study tests a precise radiation method called total marrow and lymphoid irradiation (TMLI) given with two chemotherapy drugs (etoposide and cyclophosphamide) before a donor stem cell transplant. The goal is to safely deliver higher radiation doses to the bone marrow to wipe …

This phase 2 trial tests whether adding the drug pomalidomide to standard chemotherapy (daunorubicin and cytarabine liposome) helps people with a newly diagnosed, aggressive form of acute myeloid leukemia (AML) linked to prior bone marrow disorders. About 50 participants will rec…

This early-stage trial is testing a new oral drug called SNDX-5613 alongside standard intensive chemotherapy in people newly diagnosed with acute myeloid leukemia (AML) that has specific genetic changes (KMT2A, NPM1, or NUP98). The study aims to see if the combination is safe and…

This early-phase trial is testing a new drug, PIT565, in 57 adults with rheumatoid arthritis. The main goal is to check if the drug is safe and how the body processes it. Researchers will monitor side effects and measure drug levels in the blood.

This study follows 176 adults aged 21-80 who are already scheduled for a single-level lower back fusion surgery using screws and cages. The goal is to collect real-world data on pain, mobility, and safety over 24 months. It does not test a new treatment but observes standard care…

This study tests a single dose of PBGM01, a gene therapy delivered directly into the fluid around the brain and spinal cord, in children with GM1 gangliosidosis. The therapy uses a harmless virus to carry a working copy of the GLB1 gene, which is missing or faulty in these patien…

This study tests whether adding hyaluronic acid gel and bone graft during dental implant surgery improves the quality of the surrounding gum and bone. Thirty-six adults needing implants are split into three groups: one gets hyaluronic acid, one gets both hyaluronic acid and bone …

This early-stage trial tests whether injections of tiny particles from umbilical cord stem cells are safe for people with syringomyelia, a condition where fluid-filled cavities form in the spinal cord. The study will enroll 18 adults whose symptoms haven't improved after surgery …

This study aimed to test a finger prosthetic system called Point Mini in 5 children aged 5-15 with partial hand loss. The device uses ratcheting mechanical digits to help with gripping and lifting tasks. However, the trial was withdrawn before any participants were enrolled, so n…

This study tests a new device called MOTUS, which replaces a worn-out joint in the lower back with an artificial one. The goal is to see if it works as well as the standard surgery (spinal fusion) for reducing pain and improving function. About 158 adults aged 21-80 with single-l…

This study follows 383 people who received a cementless hip replacement part called the Trident II Tritanium Acetabular Shell. Researchers want to see how many need a revision surgery within 5 years, compared to similar devices. The goal is to confirm the part works well and stay…

This Phase 3 trial tests whether adding ivosidenib (a targeted pill) to standard azacitidine helps adults with a specific IDH1-mutated acute myeloid leukemia (AML) who cannot have intensive chemotherapy. About 146 participants receive either the combo or a placebo plus azacitidin…

This study tests two methods of placing a bulk-fill composite filling material in cavities on the chewing surfaces of back teeth. One method places the material all at once, while the other builds it up in thin layers. Researchers will check how well each method holds up over tim…

This phase 3 trial compares two types of stem cell transplants for children, adolescents, and young adults with acute leukemia or myelodysplastic syndrome (MDS). One uses a half-matched family donor (haploidentical), the other a fully matched unrelated donor. The goal is to see w…

This trial investigates the best way to treat children with acute myeloid leukaemia (AML) by comparing different chemotherapy drugs and doses. It tests whether adding up to three doses of the targeted drug gemtuzumab ozogamicin to standard chemo is safe and effective. The study a…

This phase 3 trial tests the drug pexidartinib in 40 adults with tenosynovial giant cell tumor (TGCT), a rare, non-cancerous growth in joints that causes pain and limits movement. The study focuses on people whose tumors are severe and cannot be helped by surgery. Researchers are…

This study tests whether adding three drugs (vincristine, irinotecan, and regorafenib) to standard chemotherapy can help people with Ewing sarcoma that has spread. About 437 participants will receive either the new combo or standard treatment. The goal is to see if the new approa…

This study tests whether a robotic exoskeleton called ReWalk can help people with complete spinal cord injury below T4 walk and improve their health. Fifty participants will either use the exoskeleton or receive standard physical therapy. The goal is to see if the device improves…

This Phase 2 trial tests whether the oral drug gilteritinib works better than midostaurin for adults with a specific genetic subtype of acute myeloid leukemia (FLT3-mutated AML). All 181 participants also receive standard chemotherapy. The goal is to see which drug leads to more …

This phase 3 trial compares a two-drug combination (pevonedistat plus azacitidine) against azacitidine alone in 302 older or unfit adults newly diagnosed with acute myeloid leukemia (AML) who cannot have standard intensive chemotherapy. The main goal is to see if the combination …

This phase 2 trial tests whether giving patients with hard-to-treat acute myeloid leukemia (AML) a special type of immune cell—called a cytokine-induced memory-like natural killer (NK) cell—after a stem cell transplant can improve their chances of staying cancer-free. About 60 ad…

This study compares a new biodegradable nasal dressing that slowly releases a steroid (mometasone furoate) to a standard steroid-releasing stent, both used after sinus surgery. About 110 adults with chronic sinusitis (with or without nasal polyps) will receive the new dressing in…

This early-phase trial is testing whether adding the targeted drug venetoclax to standard chemotherapy can safely treat adults newly diagnosed with acute myeloid leukemia (AML). About 50 participants will receive the combination to find the best dose and see how many achieve remi…

This study tests whether adding a radioactive drug (radium-223) to standard treatment (cabozantinib) helps people with advanced kidney cancer that has spread to the bones. About 134 participants will receive either the combination or cabozantinib alone. The goal is to see if the …

This study tests an experimental drug called LY2784544 in people with three types of blood cancers known as myeloproliferative neoplasms: polycythemia vera, essential thrombocythemia, and myelofibrosis. The trial enrolls patients who have not responded to, cannot tolerate, or hav…

This study tests a combination of three drugs—radium-223, M3814, and avelumab—in men with advanced prostate cancer that no longer responds to hormone therapy and has spread to the bone. The goal is to see if the combination can slow cancer growth better than radium-223 alone. The…

This study tests whether adding hyaluronic acid to a platelet-rich fibrin membrane improves the treatment of receding gums. Thirty adults with a specific type of gum recession will receive either the PRF membrane alone or with hyaluronic acid, alongside a surgical flap procedure.…

This study tests a drug called vimseltinib in people with a rare joint tumor (tenosynovial giant cell tumor, or TGCT) and advanced solid tumors. The drug blocks a protein that helps these tumors grow. The trial has two phases: first, finding the safest dose, then expanding to see…

This study tests a chemotherapy drug called CPX-351 (Vyxeos) in 25 patients under 22 years old who have secondary myeloid neoplasms, a type of blood cancer that develops after previous cancer treatment. Participants receive one or two rounds of CPX-351, followed by a stem cell tr…

This phase II trial tested whether adding veliparib (a targeted drug) to standard chemotherapy (topotecan and carboplatin) helps people with advanced myeloproliferative disorders, acute myeloid leukemia, or chronic myelomonocytic leukemia. The study enrolled 25 adults whose cance…

This phase 3 trial is testing whether adding radiation therapy to standard care can prevent bone complications like fractures or spinal cord compression in cancer patients with high-risk bone metastases that aren't causing symptoms yet. About 280 patients with multiple metastatic…

This study tests whether adding two adult cancer drugs, bortezomib and vorinostat, to standard chemotherapy is safe and effective for infants with acute lymphoblastic leukemia (ALL). About 50 newly diagnosed infants will receive the combination. The goal is to see if it reduces l…

This study follows 299 people who received the Smith+Nephew Porous Total Knee System, a titanium knee replacement for severe arthritis. The goal is to see if the implant reduces pain, improves movement, and lasts at least two years without needing revision surgery. Participants a…

This study tests whether acetyl L-carnitine, a dietary supplement, can help reduce pain, inflammation, and improve blood sugar control in obese, diabetic, postmenopausal women with osteoarthritis. One hundred women will take either the supplement or a placebo for 12 weeks, alongs…

This study tests dalbavancin, a long-acting antibiotic given as a few shots over two months, for infections that occur after hip or knee replacement surgery. The standard treatment requires 12 weeks of daily antibiotics, which can be hard to tolerate and complete. The trial inclu…

This phase II trial tests two immunotherapy drugs, oleclumab and durvalumab, in 75 people with advanced sarcoma (angiosarcoma, dedifferentiated liposarcoma, or osteosarcoma) that has returned, spread, or stopped responding to treatment. The goal is to see if the combination can s…

This study tests a new drug called bomedemstat against the best available treatments for people with essential thrombocythemia (a blood disorder causing too many platelets) who did not respond well to or couldn't tolerate the standard drug hydroxyurea. About 340 adults will be ra…

This study follows 94 people who received the FDA-approved H3 total ankle replacement for arthritis. Researchers will track serious device-related problems and how well the ankle works over 2 to 5 years. The goal is to confirm the device's safety and effectiveness in real-world u…

This phase 2 trial tests the drug atezolizumab in 27 people with chondrosarcoma or clear cell sarcoma that cannot be removed by surgery or has spread. Atezolizumab is an immunotherapy that helps the body's immune system attack cancer cells. The main goal is to see if the drug can…

This study tests whether a special wipe containing xylitol, a natural sweetener, can reduce dangerous bloodstream infections in children and young adults undergoing stem cell transplants. These infections often start from bacteria in the mouth and can be life-threatening. Partici…

This trial tests a fracture liaison service (FLS) — a coordinated care program for people aged 50 and older who have had a hip or spine fracture. The program follows best-practice standards to ensure patients receive bone density tests and appropriate osteoporosis management. Res…

This study tests a new device called VCFix for treating a broken bone in the spine (vertebral compression fracture). Ten adults with a single recent fracture will receive the implant to see if the procedure is safe and works as intended. The goal is to gather early data to plan a…

This study tests a stem cell transplant method for people with acquired or inherited bone marrow failure. Donor stem cells are specially processed to remove certain immune cells, which may lower the risk of graft rejection and graft-versus-host disease. The goal is to see if this…

This study tests whether using each child's unique genetic information to guide treatment can improve outcomes for acute lymphoblastic leukemia and lymphoma. About 790 children aged 1-18 will receive a combination of chemotherapy and newer targeted therapies, such as CAR T cells …

This early-phase trial tests a reduced-intensity stem cell transplant using a half-matched donor and a drug called cyclophosphamide after the transplant to prevent rejection. The goal is to see if this approach is safe enough for patients with advanced myelofibrosis, a serious bo…

This study provides extended access to the drug momelotinib for 237 people with a type of bone marrow cancer called myelofibrosis. Participants had already been taking momelotinib in earlier studies and had not seen their disease get worse. The goal is to see how safe the drug is…

This early-stage study tests whether a mix of immune-boosting drugs and targeted radiation can help the body fight advanced solid tumors that cannot be removed by surgery. About 14 adults with certain types of skin cancer, sarcoma, or breast cancer will receive the treatment dire…

This study tests whether a cancer-killing virus (T-VEC) combined with radiation can shrink soft tissue sarcomas before surgery. About 40 adults with newly diagnosed, removable sarcomas will receive the virus injected into the tumor plus radiation. The main goals are to see how ma…

This study tests whether nerve transfer surgery can improve arm and hand function in people with complete spinal cord injuries who have no hand movement. Seventy participants will undergo surgery followed by 48 months of occupational therapy. The goal is to help them regain indep…

This study tests a precise type of proton radiation (IMPT) for people with chordoma or chondrosarcoma in the spine, sacrum, or skull base. The goal is to control the tumor while reducing damage to healthy tissue. Some participants may also have surgery. The study includes 64 adul…

This study tests whether using limited surgery followed by proton therapy can control craniopharyngioma, a rare brain tumor, in children and young adults. The goal is to reduce radiation side effects by using a tighter radiation margin. Some patients who have complete tumor remov…

This phase 3 trial tests a drug called imetelstat against the best available treatments for people with advanced myelofibrosis whose disease has stopped responding to JAK inhibitors. The study includes 327 participants and aims to see if imetelstat can help them live longer and f…

This phase 2 trial is testing a combination of two immunotherapy drugs, nivolumab and ipilimumab, in 798 people with over 50 types of rare cancers. The goal is to see if these drugs can shrink tumors by helping the immune system attack cancer cells. Participants receive the drugs…

This study tests a newer form of radiation called intensity-modulated proton therapy in children and young adults with craniopharyngioma, a rare brain tumor. The goal is to see if this precise radiation can better control the tumor while causing fewer side effects than older radi…

This study tests whether adding the drug selinexor to standard chemotherapy can help older adults with untreated acute myeloid leukemia (AML) live longer and achieve remission. About 57 participants will receive either standard chemo alone or chemo plus selinexor, followed by mai…

This study tests a service designed to help people with osteoporosis take their medications as prescribed. Participants receive education, reminders, and regular follow-up calls. The goal is to see if this support improves medication adherence and reduces fracture risk over 18 mo…

This study tests whether adding the immunotherapy drug pembrolizumab to standard tyrosine kinase inhibitors (TKIs) can eliminate tiny amounts of leftover leukemia cells in people with chronic myeloid leukemia (CML). About 40 adults with CML who still have detectable cancer marker…

This clinical trial compares three different chemotherapy regimens for young adults (ages 18-65) newly diagnosed with low-risk acute myeloid leukemia (AML). One regimen includes a new drug called lisaftoclax combined with standard chemotherapy drugs. The study aims to see which c…

This study tests three different chemotherapy regimens in 450 young adults (ages 15-65) with intermediate- or high-risk acute myeloid leukemia (AML). All regimens include the experimental drug lisaftoclax plus standard chemotherapies. The main goal is to see which combination lea…

When a tooth is removed, the bone and gum often shrink, making it harder to place a dental implant later. This study tests a new magnesium membrane that is placed over a bone graft in the socket. Unlike standard membranes, it is rigid enough to protect the graft but dissolves on …

This study looks at whether placing a calcium hydroxide paste inside a tooth between root canal appointments helps infected teeth heal better. About 110 adults with painful tooth infections will receive standard root canal treatment over multiple visits. One group gets the extra …

This study tests a single injection of VIA Disc NP, a processed human disc tissue, for people with long-term lower back pain from degenerated discs. About 121 participants will receive either the injection or a sham procedure. The goal is to see if the injection safely reduces pa…

This study tests whether injections of platelet-rich plasma (PRP) or stem cells from belly fat can help people with knee osteoarthritis. 160 adults aged 40-70 with mild to moderate knee arthritis will be randomly assigned to get PRP, stem cells, both, or a placebo. Researchers wi…

This phase 3 study tests setrusumab, a monthly IV infusion, in 6 Japanese children with osteogenesis imperfecta (types I, III, or IV), a condition that causes fragile bones and frequent fractures. The main goal is to see if the drug lowers the number of fractures, including spine…

This study was designed to test whether adding olutasidenib to standard chemotherapy drugs could help control certain blood cancers in people with an IDH1 gene mutation. The trial was withdrawn before enrolling any participants, so no results are available.

This study tests a minimally-invasive non-surgical therapy (MINST) for treating gum disease-related bone defects. The approach uses small instruments and magnification to clean deep gum pockets with less tissue damage than traditional surgery. Researchers will measure bone healin…

This phase 2 trial tests a combination of six drugs, called the Beach regimen, in 32 adults with relapsed or refractory acute myeloid leukemia (AML). The goal is to see if this mix can bring about remission and improve survival. Participants receive the drugs in a specific schedu…

This study tests a drug called sonelokimab in 960 adults with active psoriatic arthritis who have not used biologic treatments before. The goal is to see if it reduces joint pain and swelling better than a placebo. Participants receive injections over several months, and research…

This study looks at the long-term safety and effects of an experimental drug called DNL310 for people with Hunter syndrome (MPS II), a rare genetic disorder. About 99 participants who completed earlier studies will receive the drug for up to 5 years. Researchers will monitor side…

This study tests a new dental filling made with coconut nanoparticles for children's baby teeth. Sixty children aged 5 to 9 with cavities will receive either the new coconut filling or a standard glass ionomer filling. Researchers will check the fillings' surface, shape, and how …

This phase 2 trial tests an oral drug called venglustat, given alongside the standard enzyme therapy Cerezyme, in adults with Gaucher disease type 3 (a rare genetic disorder affecting the body and brain). The study has four parts: first, it checks spinal fluid biomarkers to disti…

This study was designed to test the safety and effectiveness of a new treatment called GC012F for people with difficult-to-treat rheumatoid arthritis. It planned to enroll adults aged 18 to 75 whose arthritis did not respond well to standard therapies. However, the study was with…

This early-phase trial tests whether adding special immune cells called veto cells to a stem cell transplant can help donor cells grow in the patient without causing severe graft-versus-host disease (GVHD). The study includes 16 people with various blood cancers or bone marrow fa…

This early-phase trial tests a new drug called navtemadlin (KRT-232) combined with two standard drugs (decitabine and venetoclax) for people with acute myeloid leukemia (AML) that has come back, not responded to treatment, or is newly diagnosed. The main goal is to find the safes…

This study looks at the long-term safety and effectiveness of a drug called sonelokimab for people with psoriatic arthritis. About 1560 adults who finished an earlier study will receive the drug as a shot under the skin. Researchers will track side effects and how well the drug c…

This study tests whether a wearable suit that delivers small electrical pulses to leg muscles can improve walking speed in people with incomplete spinal cord injury. Participants first do standard treadmill training, then add the electrical stimulation suit for 20 sessions. The m…

This phase II trial tests two targeted drugs, vemurafenib and cobimetinib, in 24 people with a rare type of brain tumor called papillary craniopharyngioma that has a specific genetic mutation (BRAF V600E). The drugs work by blocking enzymes that help tumor cells grow. The main go…

This Phase II trial is studying whether proton beam therapy, with or without standard photon radiation, can effectively treat skull base chordoma, a rare tumor at the base of the skull. Nineteen participants who had surgery to remove as much tumor as possible are receiving daily …

This study tests a device that reads brain signals and sends them to the spinal cord to help people with chronic spinal cord injury move their legs. Three participants will use the system during rehabilitation to see if it is safe and can improve walking. The goal is to create a …

This study looks at whether lower doses of the chemotherapy drug CPX-351 can help older patients with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) that have come back or not responded to other treatments. The goal is to control the disease while being gentler o…

This phase 2 trial tests whether adding the immunotherapy drug pembrolizumab to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) achieve a deeper remission. About 49 participants will receive either chemo alone or chemo plus pembrolizumab. The …

This phase 3 study tested whether adding venetoclax to azacitidine helps people with untreated acute myeloid leukemia (AML) who cannot receive standard chemotherapy. About 443 adults took part, with two-thirds receiving the drug combo and one-third getting a placebo plus azacitid…

This early study tests whether elotuzumab can help people with a specific type of myelofibrosis, a serious bone marrow disorder. The drug targets a protein on cancer cells to try to improve blood counts, shrink an enlarged spleen, and ease symptoms. The trial includes 15 adults w…

This study looks at how well a new knee replacement system, the JOURNEY™ II CR, works for people with knee osteoarthritis. About 170 adults aged 22 to 75 who need a total knee replacement will receive the implant. Researchers will measure knee movement, survival of the implant, a…

This study tests a combination of two drugs, venetoclax and ASTX727, in people with high-risk myelodysplastic syndrome (MDS) or chronic myelomonocytic leukemia (CMML) who haven't had treatment before. The goal is to find the safest dose and see if the combo can shrink or control …

This study tests a new drug called tulisokibart for people with active rheumatoid arthritis who are already taking methotrexate. About 182 participants will receive either tulisokibart or a placebo to see if the drug reduces joint pain and swelling better than a dummy treatment. …

This early-phase trial tests a new drug called M3814 alongside three chemotherapy drugs (mitoxantrone, etoposide, and cytarabine) in 48 adults with acute myeloid leukemia that has returned or not responded to treatment. The main goal is to find the safest dose and understand side…

This phase 2 trial tests an injectable form of methotrexate called FBL-MTX for people with moderate-to-severe rheumatoid arthritis. The drug is designed to deliver methotrexate directly into the body using tiny fat bubbles, which may improve how well it works and reduce side effe…

This early-stage trial tests a combination of two drugs, gilteritinib and momelotinib, for adults with a specific type of acute myeloid leukemia (AML) that has come back or not responded to treatment. The main goal is to find a safe dose of momelotinib when given with gilteritini…

This early-phase study tests a new drug called navtemadlin (KRT-232) combined with standard chemotherapy (cytarabine and idarubicin) in adults with newly diagnosed acute myeloid leukemia (AML). The goal is to find the safest dose and see how well the combination works. About 24 p…

This phase 2 trial tests the drug cabozantinib in 90 patients with osteosarcoma or Ewing sarcoma that has come back or spread. The drug works by blocking enzymes that help cancer cells grow and by cutting off the blood supply tumors need. Researchers are checking whether the canc…

This study tests whether combining venetoclax with ASTX727 can help control acute myeloid leukemia (AML) in two groups: patients whose cancer returned or didn't respond to prior treatment, and older adults newly diagnosed who cannot handle strong chemotherapy. The drugs work toge…

This study tests whether adding a radioactive drug (radium-223) to standard chemotherapy (paclitaxel) helps people with advanced breast cancer that has spread to the bones. The radioactive drug targets bone tumors directly, while chemo works throughout the body. About 70 particip…

This study tests adding the targeted drug sorafenib to standard chemotherapy (busulfan and fludarabine) before a donor stem cell transplant in adults with acute myeloid leukemia that has returned or not responded to treatment. The goal is to find the safest dose of sorafenib and …

This early-phase trial is testing a drug called flotetuzumab in children and young adults with acute myeloid leukemia (AML) that has returned or not responded to standard treatment. Flotetuzumab is an immunotherapy designed to help the body's immune cells find and attack cancer c…

This study looks at whether a special dental sealer (bioceramic) helps heal infections and reduces pain after a repeat root canal done in one visit. About 70 adults with failed root canals and silent infections in their back teeth will take part. They will get the new sealer or a…

This phase II trial tests whether a combination of two drugs, azacitidine and venetoclax, can help keep acute myeloid leukemia (AML) in remission after initial treatment. The study enrolls 50 adults whose AML is in first remission but who are not ready for a stem cell transplant.…

This study looks at whether adding the drug abaloparatide (Tymlos) to the standard treatment denosumab (Prolia) can improve bone density more than denosumab alone in postmenopausal women with osteoporosis. Seventy women who have already been on denosumab will either continue with…

This study is testing a new modular shoulder replacement system in 105 people who need complex revision surgery due to joint disease, trauma, or cancer. The device can replace part or all of the upper arm bone. Researchers are tracking how long the implant lasts and how well pati…

This study tests whether a surgically implanted device that sends electrical pulses to the spinal cord can help people with spinal cord injury regain voluntary leg movement. Only 2 participants with specific injury levels and MRI evidence of spared nerve fibers will be enrolled. …

This phase 2 trial tests whether combining venetoclax and azacitidine after a stem cell transplant can prevent leukemia from returning in high-risk patients. About 100 adults aged 18-75 with certain types of acute leukemia who are in remission after transplant will receive the dr…

This study compares two ways to remove infection at the tip of a tooth root: using a rotary bur (a small drill) or a piezoelectric unit (a vibrating tool). 124 adults with root infections will have surgery and then be followed for 12 months to see which method leads to better bon…

This early-stage trial tests a new drug called MP0533 in adults with acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS) that has come back or not responded to treatment. The drug is designed to help the body's immune cells find and attack cancer cells. The study will …

This study looks at a natural protein called Natural Matrix Protein (NMP) used as a bone graft substitute during lumbar spinal fusion surgery. Researchers will review the medical records of about 100 adults who had this surgery to see how well their bones fused and if there were …

This study tests a new daily pill, asciminib, against several standard drugs for people newly diagnosed with a type of leukemia called CML. About 405 adults will be randomly assigned to receive either asciminib or a standard tyrosine kinase inhibitor (TKI). The main goal is to se…

This study is testing a new type of knee replacement implant that does not use cement to hold it in place. The implant, called ATTUNE Cementless Rotating Platform, is designed for people with osteoarthritis. Researchers will follow 540 patients for two years to see if their abili…

This Phase 2 study tests an experimental drug called SPY002-072 in 285 adults with moderately to severely active rheumatoid arthritis, psoriatic arthritis, or axial spondyloarthritis. Participants receive either the drug or a placebo, and researchers measure changes in disease ac…

This Phase 3 study tests a new drug called JR-141 against the current standard treatment (idursulfase) in 86 people with Hunter syndrome (MPS II). The goal is to see if JR-141 can better reduce harmful substances in the brain and improve thinking skills. Participants can switch t…

This phase 3 study tests guselkumab (Tremfya) in 453 adults with active psoriatic arthritis who did not respond to or could not tolerate a prior anti-TNF drug. Participants receive either guselkumab or a placebo injection. The main goal is to see if guselkumab reduces joint swell…

This phase 3 trial tested guselkumab, a biologic drug given as a shot, in over 1,000 people with active psoriatic arthritis who had not responded well to other treatments. The goal was to see if it reduces symptoms like joint pain and swelling and slows joint damage seen on X-ray…

This early-phase trial tests a new cell therapy called BEN301 for several autoimmune diseases, including scleroderma and rheumatoid arthritis. The therapy uses specially engineered immune cells (CAR-Treg cells) to calm the overactive immune system. The study involves 24 adults an…

This phase 2 trial tests whether eltrombopag, a drug already approved for other blood disorders, can improve blood cell counts in people with low-risk myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (CMML) who have a mutation in the TET2 gene. Participants take…

This study tests a combination of a patient's own stem cells and platelet-rich plasma to help heal broken bones that won't mend on their own and to treat knee arthritis. For people needing a knee replacement, doctors use custom 3D-printed guides made from the patient's scans to i…

This study tests whether bimekizumab works better than risankizumab for adults with active psoriatic arthritis (PsA), a condition causing joint pain and skin lesions. About 684 participants will receive one of the two drugs for 16 weeks. The main goal is to see who gets at least …

This phase 4 trial tests whether guselkumab (TREMFYA) can reduce spine-related symptoms in people with active psoriatic arthritis who have not used biologic drugs before. About 411 participants will receive either guselkumab or a placebo as a shot under the skin. The main goal is…

This study aimed to find a safe dose of revumenib when given with standard chemotherapy drugs for children and young adults with acute leukemia. It was designed for patients with certain genetic markers. However, the trial was withdrawn before any participants were enrolled, so n…

This early-stage trial tests a new drug called JNJ-89853413 in 64 people whose acute myeloid leukemia (AML) or myelodysplastic neoplasms (MDS) have come back or stopped responding to treatment. The main goal is to check safety and find the right dose, with a second part looking a…

This study tests an experimental drug called JNJ-77242113 (icotrokinra) against a placebo in 552 adults with active psoriatic arthritis who have not tried biologic treatments before. The main goal is to see if the drug reduces joint swelling and tenderness after 16 weeks. Partici…

This study aimed to see if romosozumab (Evenity) could improve bone density and muscle mass in postmenopausal women with osteoporosis undergoing lumbar spine surgery. Participants would have received monthly injections of romosozumab or weekly alendronate pills for 12 months. How…

This study follows 159 children aged 2 to 17 who have already completed a prior ustekinumab study for Crohn's disease, ulcerative colitis, or psoriatic arthritis. The goal is to collect long-term safety data by monitoring side effects, lab results, and injection-site reactions. P…

This study monitors long-term safety in 120 cancer patients who are already benefiting from treatments like JNJ-75348780, safimaltib, or ibrutinib in earlier trials. Participants have blood cancers, solid tumors, or prostate cancer. The goal is to track serious side effects over …

This study tests if a new 2mL auto-injector or pre-filled syringe delivers the same amount of the drug ianalumab into the body as the current 1mL syringe. About 155 adults with rheumatoid arthritis, Sjögren's disease, or lupus will receive the drug both ways to compare how much g…

This early-stage study tests a new treatment called TAR-210 in 5 Japanese patients with a type of bladder cancer that has specific genetic changes (FGFR mutations). The treatment is placed directly into the bladder to deliver the drug erdafitinib. The main goal is to see if it is…

This study tests whether stimulating the vagus nerve while doing rehabilitation exercises can help people with chronic spinal cord injury regain movement and sensation. Twenty participants who completed an earlier trial will receive active VNS paired with exercises targeting the …

This study tests a gene therapy called RGX-121 in children aged 4 months to 5 years with Hunter syndrome, a rare genetic disease that affects the brain and body. The therapy delivers a working copy of the missing gene to the central nervous system. Researchers will measure improv…

This study is testing two injectable drugs, ustekinumab and guselkumab, in 50 children with active juvenile psoriatic arthritis. The goal is to see how well the drugs work, how they move through the body, and if they are safe. Participants will receive one of the drugs and be mon…

This early-stage study tests a new drug called bleximenib combined with other leukemia treatments for people with acute myeloid leukemia (AML) that has specific genetic changes (KMT2A or NPM1). The main goals are to find the best dose and check for side effects. About 196 partici…

This study compares two types of dental crowns for baby molars in 100 children aged 3-7. Each child gets a zirconia crown on one molar and a stainless steel crown on the opposite molar. Researchers will check gum health, plaque buildup, and parent satisfaction over 3 years to see…

This trial tests whether adding a healing material made from the patient's own blood (Advanced Platelet-Rich Fibrin, or A-PRF) to standard gum surgery helps cover exposed tooth roots better than surgery alone. Eleven adults with gum recession will receive either the combined trea…

This study tests a new way to treat children and young adults with high-risk blood cancers like leukemia and lymphoma. Doctors take blood cells from a family donor, remove certain T cells that can cause a harmful immune reaction, and then transplant the modified cells. The goal i…

This study tests whether adding pevonedistat to standard chemotherapy (cytarabine and idarubicin) can improve remission rates in people newly diagnosed with high-risk acute myeloid leukemia (AML). About 53 participants will receive the combination to find the best dose and check …

This study compares two treatments for end-stage hip osteoarthritis: total hip replacement surgery and progressive resistance training (strength exercises). About 109 adults aged 50 and older with severe hip arthritis will be randomly assigned to one of the two treatments. The ma…

This study tests whether adding an immunotherapy drug (pembrolizumab) to standard chemotherapy (azacitidine and venetoclax) can improve outcomes for older adults with newly diagnosed acute myeloid leukemia (AML) who cannot have intensive chemo. About 60 participants will be rando…

This program provides ongoing access to certolizumab pegol (Cimzia) for adults with rheumatoid arthritis who took part in earlier open-label studies. Participants receive the standard maintenance dose of 200 mg every two weeks. The goal is to allow continued disease management or…

This study tests whether new plastic-like PEEK crowns work as well as standard metal crowns for children's back teeth after a common nerve treatment (pulpotomy). Sixty kids aged 5-9 got one PEEK crown and one metal crown on opposite sides of their mouth. Researchers checked gum h…

This study looks at whether choosing stem cell donors based on certain genes (KIR) in addition to standard matching can reduce the chance of leukemia returning after a bone marrow transplant. About 511 people with acute myeloid leukemia (AML) are taking part. Doctors will test do…

This study tests whether simple text messages and online activities can encourage people with Type 2 Diabetes to get more preventive dental care, like cleanings, instead of waiting for expensive treatments. Researchers will track dental insurance claims from 10,000 adults over 18…

This study looks at whether giving people with PTSD a personalized mix of gut bacteria (called pharmabiotics) can help their mental health. The researchers will track changes in PTSD symptoms, anxiety, depression, and thinking skills over 14 days. The goal is to see if fixing the…

This study tests a pill called ruxolitinib for people whose immune system attacks their bone marrow, causing conditions like severe anemia. The drug aims to stop this attack and help the bone marrow recover. Participants take the pill twice daily for up to 6 months and are follow…

This early-phase study tests a new drug called uproleselan combined with two standard chemotherapy drugs for children and teens with acute myeloid leukemia or related blood cancers that have returned or not responded to treatment. The drug works by blocking a protein that helps c…

This study tests whether adding the drug itacitinib to the usual two-drug regimen (cyclophosphamide and tacrolimus) can better prevent graft-versus-host disease (GVHD) in people receiving stem cell transplants for blood cancers. GVHD is a serious complication where donor cells at…

This study tests a stem cell transplant from a matched unrelated donor for people with advanced blood cancers or blood disorders. Patients get chemotherapy and radiation before the transplant to prepare their body, then take drugs to prevent the donor cells from attacking their o…

This study tests a new treatment called Orca-T for people with advanced blood cancers like leukemia. It uses a special mix of stem cells and immune cells from a donor to help the body accept the transplant while reducing serious side effects like graft-versus-host disease. The go…

This study tests a drug called sapablursen in 50 adults with polycythemia vera, a rare blood cancer that causes too many red blood cells. Participants currently need regular blood removal (phlebotomy) to manage their condition. The goal is to see if the drug can reduce how often …

This study looks at whether people with a type of spinal arthritis (non-radiographic axial spondyloarthritis) who are in remission need to keep taking secukinumab to avoid flare-ups. About 240 adults with confirmed inflammation will either continue the drug or switch to a placebo…

This study tests a combination of two chemotherapy drugs (CPX-351) plus a targeted drug (quizartinib) in people with acute myeloid leukemia (AML) or high-risk myelodysplastic syndrome (MDS). The goal is to find the best dose and see if the combo helps control the cancer. About 52…

This phase 2 trial tests the drug olaparib in 14 adults with acute myeloid leukemia or myelodysplastic syndrome that has returned or not responded to treatment, and whose cancer has a specific change in the IDH gene. Olaparib is a pill that may block enzymes cancer cells need to …

This phase 2 trial compares a drug combo (ASTX727 plus iadademstat) against ASTX727 alone for people with advanced myeloproliferative neoplasms (MPNs), a group of rare blood cancers. The study aims to see if adding iadademstat improves complete response rates. However, the trial …

This study tested a simplified care plan for people with acute promyelocytic leukemia (APL), a rare blood cancer. The goal was to see if following easy-to-use guidelines and getting support from APL experts could lower the number of deaths soon after starting treatment. About 200…

This early-phase trial is testing the drug selinexor (KPT-330) in 16 children and young adults with leukemia that has come back or not responded to standard treatments. The main goal is to find the safest dose and understand side effects. The drug works by blocking a protein that…

This study tests whether a graft made from a person's own extracted tooth, with or without low-level laser therapy, helps regrow jawbone after a tooth is pulled. About 21 healthy adults who need at least two back teeth removed and later replaced with implants will take part. The …

This early-stage study tested a combination of three immunotherapy drugs (blinatumomab, nivolumab, and ipilimumab) in 28 adults with a severe form of B-cell leukemia that had returned or not responded to prior treatments. The main goal was to find safe doses and identify side eff…

This study tests whether adding a special nano-gel (nano-hydroxyapatite) to a deep-cleaning gum treatment helps heal deep gum pockets better than cleaning alone. About 28 adults with advanced gum disease will be randomly assigned to get either the cleaning plus gel or just the cl…

This early-phase trial is testing whether adding an experimental drug called Q702 to two standard leukemia drugs (azacitidine and venetoclax) is safe for people with relapsed or refractory acute myeloid leukemia (AML). About 17 adults whose leukemia has not responded to or has re…

This phase 3 trial compares two treatments for people with a bone marrow disorder called myelodysplastic syndrome (MDS) who have low red blood cell counts (anemia). One group gets lenalidomide alone, the other gets lenalidomide plus epoetin alfa, a drug that stimulates red blood …

This study tests a new totally implantable cochlear implant system (TICI G2) that has a microphone under the skin, so you can hear without any external devices. Researchers will enroll 18 adults with sensorineural hearing loss to see how well the internal microphone works over ti…

This pilot study tests a fludarabine-based drug regimen to prepare children with bone marrow failure syndromes for a bone marrow transplant from a matched sibling donor. The goal is to help the donor cells successfully take root while reducing serious side effects. The study incl…

This study planned to test a new cell therapy (CD19-BCMA CAR-T) for people with connective tissue diseases like lupus and rheumatoid arthritis. The goal was to see if it is safe and can control the disease. However, the study was withdrawn before enrolling any participants, so no…

This study tests whether the immunotherapy drug nivolumab can wipe out any leftover leukemia cells and prevent the cancer from returning in people with acute myeloid leukemia (AML) who are already in remission after chemotherapy. The trial enrolled 82 adults whose AML had respond…

This study aimed to see if giving special immune cells (γδ T cells) after a stem cell transplant could help prevent leukemia from coming back in high-risk patients. It was planned for adults aged 18-65 with acute myeloid leukemia. However, the study was withdrawn before any parti…

This study tests a drug called trametinib in children with a rare blood cancer (juvenile myelomonocytic leukemia) that has returned or not responded to treatment. The drug works by blocking certain enzymes that help cancer cells grow. The goal is to see if it can shrink or contro…

This study looks at how well upadacitinib (RINVOQ) works for people with axial spondyloarthritis, a type of inflammatory arthritis that causes chronic back pain. About 338 adults in Germany will take the drug as prescribed by their doctor and be followed for 52 weeks. Researchers…

This study tests whether a special clot made from a patient's own bone marrow can help spine bones heal together faster and more reliably after spinal fusion surgery. The trial involves 96 adults with degenerative spine disease. Half will receive the standard bone graft, and the …

This study tests whether asciminib is easier to tolerate than nilotinib in adults newly diagnosed with a type of leukemia called Philadelphia chromosome-positive CML. About 568 participants take either asciminib once daily or nilotinib twice daily. The main goal is to see how lon…

This study tests if Prolia can improve bone density in people whose bones have weakened from taking steroids (glucocorticoids). About 102 adults in China will receive the drug and be monitored for 12 months. The main goal is to see if bone mass in the lower spine increases.

This study tests a drug called romosozumab against standard bone-strengthening medicines (bisphosphonates) in children and teens with osteogenesis imperfecta, a condition that causes fragile bones and frequent fractures. The goal is to see if romosozumab can reduce the number of …

This study looks at whether 10 weeks of regular exercise (on land or in water) can lower blood sugar and blood pressure in people aged 60 and older who have several health conditions like diabetes, high blood pressure, and arthritis. 63 volunteers will be split into two exercise …

This study tests whether a toothpaste with stannous fluoride works better than regular fluoride toothpaste at reducing dental plaque and gum inflammation (gingivitis). About 85 adults with mild to moderate gum disease will brush twice daily for 6 months. Dentists will measure pla…

This study is for children with hypochondroplasia, a condition that causes short stature and bone differences. Researchers are testing a drug called infigratinib to see if it is safe and helps improve growth over the long term. Participants must have already completed a previous …

This Phase 2 trial tests JK07, a lab-made protein designed to help heart cells repair and pump better. About 282 adults with chronic heart failure will receive either JK07 or a placebo. The study looks at safety and whether JK07 can improve heart function in two groups: those wit…

This phase 3 trial tests whether a new oral drug called TLL-018 works better than tofacitinib for active rheumatoid arthritis. The study includes 459 adults aged 18-65 who have not responded well to or cannot tolerate biologic treatments. Participants take either TLL-018 or tofac…

This study tests whether adding cabergoline to osilodrostat works better than osilodrostat alone for controlling Cushing's disease. About 50 adults with active Cushing's disease will receive either the combination or the single drug. The goal is to see if the combo can lower cort…

This phase 2 trial tests a treatment called LN-145, made from a patient's own immune cells taken from their tumor. These cells are grown in a lab and then given back to the patient to attack the cancer. The study includes people with ovarian cancer, triple-negative breast cancer,…

This study is testing a special implant (Tapestry) that helps repair a key shoulder tendon (subscapularis) during shoulder replacement surgery. About 100 adults with shoulder arthritis or injury will be followed for 2 years to see if the tendon heals better with the implant. The …

This trial tests a 12-month lifestyle medicine program for 1000 adults with obesity and related conditions like diabetes or high blood pressure. Participants get regular visits with a dietitian and a doctor, plus optional behavioral health support. The goal is to see if the progr…

This program gives eligible people with acute spinal cord injury early access to the investigational drug elezanumab before it is officially approved. A doctor must decide if the potential benefit outweighs the risks for each patient. The program is only available in certain terr…

This study tests a non-invasive device that uses low-frequency electromagnetic fields to improve communication between immune cells. 120 adults with lupus, rheumatoid arthritis, or multiple sclerosis will receive either active or sham sessions three times a week for 12 weeks. The…

This early-phase trial tests whether adding high-dose vitamin C (ascorbate) to the chemotherapy drug gemcitabine can help adults with advanced soft tissue or bone sarcoma that cannot be surgically removed or has spread. About 30 participants will receive the combination intraveno…

This early-stage trial tests two new targeted drugs (AG-120 and AG-221) given alongside standard chemotherapy for people with a specific genetic form of acute myeloid leukemia (AML). The study includes about 153 adults with newly diagnosed AML that has an IDH1 or IDH2 mutation. T…

This study is testing the long-term safety and effectiveness of bimekizumab, a drug that reduces inflammation, in 508 adults with active axial spondyloarthritis (including ankylosing spondylitis). Participants who completed earlier trials will receive the drug for an extended per…

This study tests whether adding nano-hyaluronic acid gel to a non-surgical deep cleaning procedure helps heal gum pockets better than cleaning alone. About 28 adults with moderate to severe gum disease will be randomly assigned to receive either the gel plus cleaning or just clea…

This study compares a new, less invasive surgery to the standard open surgery for children with paralytic scoliosis (a curved spine) after a spinal cord injury. The minimally invasive approach uses smaller cuts and aims to correct the spine while causing less blood loss, fewer co…

This study tests a combination of two chemotherapy drugs (CPX-351 and gemtuzumab ozogamicin) in about 50 adults with acute myeloid leukemia (AML) that has returned or not responded to treatment, or with high-risk myelodysplastic syndrome (MDS). The goal is to see if the combo is …

This study tests the drug bimekizumab in 89 adults with moderate to severe plaque psoriasis, some of whom also have psoriatic arthritis. Researchers will measure changes in gene activity in skin samples after 48 weeks of treatment. The goal is to understand how the drug affects t…

This study tests a surgical approach for medication-related osteonecrosis of the jaw (MRONJ), a condition where jaw bone dies after certain drugs. Surgeons use a special ultrasonic device (piezosurgery) to remove dead bone, then close the area with a double-layer flap. Twenty pat…

This early-phase trial is testing whether adding the drug venetoclax to standard chemotherapy before and after a bone marrow transplant can help prevent cancer from coming back in people with high-risk acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), or related blood…

This study looks at whether children with chronic myeloid leukemia (CML) who have very low levels of disease can stop taking their daily tyrosine kinase inhibitor (TKI) medication and still stay in remission. About 110 children will stop their TKIs and be closely monitored. If th…

This study looks at how well the Insignia Hip Stem works and how safe it is for people needing a total hip replacement. It includes 313 adults with conditions like hip arthritis or fractures. Researchers will check implant survival and hip function for up to 10 years after surger…

This early-stage trial tests a combination of two drugs, venetoclax and azacitidine, in people with a serious type of myelodysplastic syndromes (MDS) who have not had treatment before. The goal is to find the safest dose and see how well the drugs work together to control the dis…

This early-phase study is testing a drug called TAK-243 in people whose acute myeloid leukemia or myelodysplastic syndrome has come back or is not responding to treatment. The goal is to find the best dose and check for side effects. The trial is currently on hold.

This study tests whether a Fracture Liaison Service (FLS) helps people aged 50 and older who have had a hip or spine fracture. Half of the 400 participants get the FLS, which includes bone health checks, medication guidance, diet and exercise advice, and regular phone follow-ups …

This study planned to test a hip implant called the Restoration Anatomic Acetabular Shell in people needing revision surgery after a previous hip replacement failed. The goal was to see how well the implant holds up over time. However, the study was withdrawn before enrolling any…

This study tests four different ways to apply a new universal dental adhesive when fixing cavities on the side of teeth. Fifty patients will receive a total of 200 fillings, each using a different application method. The fillings will be checked every six months for four years to…

This study aims to find the safest and most effective initial chemotherapy for older adults (60-75) newly diagnosed with acute myeloid leukemia who can handle strong treatment. About 90 participants will be randomly assigned to one of two drug combinations or a standard treatment…

This phase II trial is testing whether combining venetoclax and azacitidine can help people with therapy-related myelodysplastic syndrome (t-MDS), a blood cancer that develops after prior cancer treatment. The study will enroll 33 adults and measure how many achieve complete remi…

This study compares two surgical approaches for severe ossification of the posterior longitudinal ligament (OPLL), a condition where a ligament in the spine hardens and presses on the spinal cord. One surgery (ACAF) goes through the front of the neck to remove the hardened ligame…

This study tests a personalized treatment for age-related osteoporosis using the drug teriparatide. Researchers aim to match treatment to each patient's bone turnover rate using simple blood tests, avoiding the need for painful bone biopsies. The trial involves 60 adults aged 45 …

This study tests a combination of two drugs, venetoclax and decitabine, in 20 adults with acute myeloid leukemia that has returned or not responded to prior treatment. The goal is to see if the combination can shrink or control the cancer. Participants will take the drugs by mout…

This early-phase trial tests whether a combination of two drugs, MBG-453 and azacitidine, can eliminate leftover cancer cells in people with acute myeloid leukemia (AML). The goal is to prevent relapse by treating the disease when it is still at a very low level. Only 3 participa…

This phase 2 trial tests two different chemotherapy combinations in adults aged 60-75 with acute myeloid leukemia (AML). One group gets a standard drug combo plus venetoclax (DAV/IAV), while the other gets a newer combo with homoharringtonine (HAV). The goal is to see which regim…

This early-phase trial is testing whether adding a drug called iadademstat to the standard combination of venetoclax and azacitidine is safe and tolerable for adults with untreated acute myeloid leukemia (AML). About 45 people with intermediate- or high-risk AML will take part. T…

This trial aimed to test the drug ASTX727 (Inqovi) alone or with donor immune cells in people with blood cancers who had a stem cell transplant. The goal was to see if it could control cancer that remained or came back. However, the study was withdrawn before enrolling any patien…

This early-phase study tests a new three-drug combination for adults with newly diagnosed acute myeloid leukemia (AML) who cannot receive standard chemotherapy. The treatment includes a targeted radiation antibody (lintuzumab-Ac-225) plus two oral drugs (venetoclax and ASTX-727).…

This early-stage trial tests an experimental drug called INCB000928, given alone or with the standard drug ruxolitinib, for people with myelofibrosis who have severe anemia or need regular blood transfusions. The main goals are to check the drug's safety, find the right dose, and…

This study gives venetoclax to people with certain blood cancers who already benefited from it in earlier studies. The main goal is to track side effects and safety over a longer period. About 165 participants will continue taking the drug to see how well it works and how safe it…

This study tests whether adding venetoclax to ASTX727 (a two-in-one pill) works better than ASTX727 alone for people with chronic myelomonocytic leukemia or related bone marrow cancers with too many immature cells. About 132 adults will be randomly assigned to one of the two trea…

This trial tests four methods of activating the cleaning liquid during root canal treatment in adults aged 20 to 40 with an infected lower first molar. The goal is to see which method helps the infection at the root tip heal best after 12 months. Participants receive one-visit ro…

This study tests a new drug called ziftomenib (KO-539) in people with acute myeloid leukemia (AML) that has come back or not responded to treatment. The drug targets a specific genetic change (MLL rearrangement or NPM1 mutation) found in some patients. The goal is to find the saf…

This was a very early (Phase 1) study to test the safety of a new drug called MT-0169 in people with certain types of acute leukemia (AML or T-ALL) that had come back or not responded to treatment. The drug was given through a vein. However, the study was withdrawn before any pat…

This study tests whether taking teriparatide (a bone-building drug) for one month before lumbar fusion surgery helps surgeons place screws more securely in patients with osteoporosis. About 192 participants will be randomly assigned to receive either the drug or no pretreatment. …

This study tests two immunotherapy drugs, tiragolumab and atezolizumab, in children and adults with rare cancers that have come back or not responded to treatment. These cancers lack certain genes (SMARCB1 or SMARCA4), making them hard to treat. The goal is to see if the drug com…

This study was designed to test the safety and tolerability of a new drug called JK07 in people with heart failure and a specific type of high blood pressure in the lungs. It planned to enroll about 20 to 30 adults aged 18 to 85. However, the study was withdrawn before any partic…

This study is for people with FSHD, a genetic disease that causes muscle weakness. It tests the long-term safety and how well the body tolerates a drug called AOC 1020, given through a vein. About 84 adults who completed a previous study will take part. The main goal is to check …

This study offers voluntary screening for newborns in North Carolina to detect a wide range of rare health conditions early. Using a small blood sample already collected at birth, the program tests for dozens of disorders, including spinal muscular atrophy, cystic fibrosis, and m…

This study tests whether a special PET scan using a radioactive form of methionine (a natural amino acid) can help doctors see tumors in children and young adults with various cancers, including brain tumors and sarcomas. About 503 participants will be scanned to see if the metho…

This study tests a 3D body scanner called NSite to see if it can reliably monitor scoliosis in teenagers. Thirteen teens with scoliosis will be scanned by three different users to check if the results are consistent. If it works, this device could offer a radiation-free way to tr…

This study was designed to see if a special bone scanner (bone mineral analyser) could predict how well osteoporotic women would respond to a zoledronic acid infusion. The plan was to measure bone texture and density before and one year after treatment. However, the study was wit…

This study tests a new ultrasound device that measures bone properties in the lower leg to predict fracture risk in adults over 55. It aims to see if it works as well as or better than standard DXA scans, without using radiation. Researchers will follow 1,600 participants for thr…

This study is testing whether artificial intelligence (AI) can accurately diagnose periodontitis (severe gum disease) and monitor gum inflammation using dental records and X-rays. Researchers will develop and validate AI models using data from 900 patients across multiple hospita…

This study compares a new ultra-high resolution PET/CT scanner, the NeuroEXPLORER, with standard clinical PET/CT scanners for imaging the head and neck. Researchers aim to see if the new device provides more detailed images to improve diagnosis of conditions like dementia, Parkin…

This trial investigates whether a daily effervescent supplement containing calcium, magnesium, and citrate can prevent bone loss, magnesium deficiency, and kidney damage in adults who take proton pump inhibitors (PPIs) long-term for conditions like heartburn or GERD. Participants…

This pilot study tests a culturally adapted fall prevention program for adults aged 60 and older living in urban Karachi, Pakistan. Participants take part in a 7-week group program covering strength and balance exercises, home safety, and medication awareness. The study aims to s…

This study tests whether a dedicated care coordinator can help people with psoriasis or psoriatic arthritis reduce their risk of heart disease. About 520 adults aged 40-75 who do not already take cholesterol medication will receive support to manage risk factors like high cholest…

This study tests whether a new toothpaste can prevent enamel erosion better than a standard cavity-protection toothpaste. Eighty healthy adults will brush twice daily for 18 days with either the test or control toothpaste. Researchers will measure enamel loss on a small block wor…

This study tests whether specially designed videos can help parents of young children prevent early childhood cavities. The program uses motivational messages to encourage good oral health habits. Researchers are following over 1,200 families enrolled in the WIC program in Iowa, …

This study tests whether a non-invasive electrical stimulation device placed on the skin over the spine can help veterans with spinal cord injury improve blood pressure, exercise capacity, and body temperature regulation. Twenty veterans with injuries between the neck and upper b…

This study tests whether a non-invasive electrical stimulation applied to the back can boost the benefits of walking therapy for people with incomplete spinal cord injury. 18 adults with chronic spinal cord injury will receive either real or fake stimulation during their walking …

This study compares two 12-week exercise programs—eccentric training and heavy-slow resistance training—in 30 adults aged 18–50 with patellar tendinopathy (knee pain lasting over 3 months). Researchers measure changes in tendon thickness, stiffness, strength, and pain to see whic…

This study tests whether a specific ultrasound-guided nerve block can reduce pain after elective lower back surgery better than the usual method of injecting pain medicine into the wound. Adults aged 18-65 undergoing surgery for conditions like a herniated disc or spinal stenosis…

This study compares two types of nerve blocks for pain after hip replacement surgery. Sixty adults will receive either a sacral erector spinae plane block or a fascia iliaca compartment block, both using a numbing medicine through a small tube. The goal is to see which method red…

This study compares lifestyle counseling alone versus lifestyle counseling combined with clinical Pilates in 62 women with temporomandibular disorders (TMD). Participants will be randomly assigned to one of two groups for 8 weeks. Researchers will measure pain, jaw function, post…

This study looks at whether adding special balance training to standard scoliosis exercises can improve balance in teenagers with mild scoliosis. About 72 teens aged 10-17 will either use a high-tech platform that gives real-time feedback or do simple balance exercises at home. T…

This study tests two ways to activate a bleaching gel on teeth: using a laser or an LED light. Researchers want to see which method whitens better, causes less tooth sensitivity, and leaves teeth smoother. 45 adults aged 20-35 who want whiter teeth will take part in this single-s…

This pilot study tests a WeChat-based program that provides daily mental health check-ins and tailored coping strategies for people with ankylosing spondylitis who also have mild-to-moderate depression or anxiety. Thirty-six adults will be split into two groups: one receives the …

This study looks at whether a structured physiotherapy and exercise program can improve pain, strength, balance, and quality of life in one person with melorheostosis, a rare bone condition. The patient will do exercises three times a week for eight weeks, along with education ab…

This study tests whether using a portable light device (photobiomodulation) at home for 8 minutes daily can reduce pain, root damage, and improve gum health in adults getting braces. Fifty patients aged 18–35 who need premolar extractions will use the device alongside standard br…

This study looks at whether writing about their experiences can improve the health of Asian American breast cancer survivors. About 192 people who finished cancer treatment in the last 5 years will take part. They will write and report how they feel, and researchers will track an…

This study compares two robotic-assisted systems (Velys J&J and Cori S&N) for total knee replacement in 200 people with severe knee arthritis. Researchers will measure knee alignment, movement, and patient-reported outcomes like pain and function. The goal is to see if one robot …

Many people with spinal cord injury struggle with slow bowel emptying and constipation. This study tests whether a small device that delivers gentle electrical pulses to the belly can speed up bowel movements and improve stool consistency. Twelve participants will use the stimula…

This study tests whether two devices, used one after the other, can reduce pain and disability from temporomandibular joint (TMJ) disorders. Adults aged 22 and older with TMJ pain will receive four treatment sessions and be followed for three months. Researchers will measure chan…

This study tests whether a single high dose of psilocybin (the active ingredient in magic mushrooms) combined with specialized talk therapy can help people with advanced cancer feel less anxious and more at peace. Fifteen adults with stage IV cancer will receive the treatment and…

This small early-phase trial tests whether a single oral dose of a hemp-derived CBD/CBD-A extract can reduce neuropathic pain and change brain activity in people with spinal cord injury. Six participants with moderate to severe nerve pain for at least three months will receive ei…

This early-stage trial tests an experimental drug called RAB001, given as an injection into the knee joint, for people with knee osteoarthritis. The study includes 60 participants aged 40 to 75 who have persistent knee pain despite conservative treatments. Researchers are primari…

This study tests whether a single injection of rexlemestrocel-L (a type of stem cell) combined with hyaluronic acid can reduce chronic low back pain for at least 12 months. It involves 300 adults with moderate to severe pain from a worn spinal disc who haven't improved with stand…

This study combines artificial intelligence with ultrasound imaging to better understand and treat frozen shoulder (adhesive capsulitis). Researchers will compare three different ultrasound-guided injection techniques in 192 participants to see which one best reduces pain and imp…

This study tests whether injecting tiny beads into an elbow artery can safely reduce chronic tennis elbow pain. The beads block blood flow to the painful area, which may ease pain. The trial includes 25 adults with moderate-to-severe pain who have not improved with standard treat…

This study tests a new toothpaste designed to reduce tooth sensitivity. About 850 people with sensitive teeth will brush twice daily for 8 weeks. Researchers will measure pain from air puffs and gentle touch to see if the new formula works better than other toothpastes.

This study tests a wearable device called TracPatch that sticks to the shin after total knee replacement surgery. The patch tracks knee motion, temperature, and steps for six weeks, sending data to doctors. Researchers want to see if this real-time monitoring helps patients regai…

This study aimed to see if adding a mild electrical current to the brain (transcranial stimulation) during shoulder strengthening exercises helps people with subacromial pain syndrome more than exercise alone. Participants would have done 8 weeks of shoulder exercises while weari…

This study planned to test whether a nerve block in the cheek area could reduce the need for morphine after cleft palate repair in children aged 5 months to 12 years. The experimental group would have received the nerve block, while the control group would not. However, the study…

This study compares two manual therapy techniques—Reciprocal Inhibition and Passive PNF Stretching—for people with chronic neck pain from cervical spondylitis. Sixty participants will receive 12 sessions over 4 weeks. Researchers will measure pain, disability, and neck movement t…

This study tests whether a supervised exercise program before hip or knee replacement surgery can improve recovery, function, and quality of life. 44 adults with advanced osteoarthritis will do 3 weekly physiotherapy sessions plus daily home exercises for several weeks before the…

This study tests whether giving people with rotator cuff shoulder pain regular updates on their progress (like pain scores and strength) helps them recover better. 56 adults aged 18–35 will either get standard rehab or standard rehab plus these progress updates. The goal is to se…

This pilot study explores whether a 7-day fast followed by 11 weeks of a plant-based diet can reduce skin and joint symptoms in people with psoriasis and psoriatic arthritis. Researchers will also look at changes in gut bacteria and overall quality of life. The study involves 30 …

This study looks at whether using a blood flow restriction cuff during physical therapy can help people with tennis elbow feel less pain and recover faster. The trial plans to enroll 250 adults aged 18 to 65 with confirmed tennis elbow. Participants will either receive standard p…

This Phase 2 trial tests whether a paste made with ejiao (a traditional Chinese ingredient) can reduce knee pain in people with osteoarthritis. Sixty adults with knee pain will use either the ejiao paste, a similar paste without ejiao, or a synthetic control. The study aims to se…

This study was designed to compare two types of nerve-blocking procedures for people with long-term knee pain from osteoarthritis. The goal was to see if targeting six nerves works better than the usual three nerves for reducing pain and improving daily function. The trial was wi…

This study tests whether an implanted spinal cord stimulator can reduce chronic pain and improve rehabilitation outcomes in people with thoracic spinal cord injury. Twenty-five participants will either have the device turned on or off for three months, while both groups continue …

This study looks at whether time-restricted eating (a form of intermittent fasting) is a practical way for veterans with spinal cord injury and obesity to lose weight. Fifteen veterans with paraplegia will try eating all their daily calories within a set window of time for 6 week…

This study tests whether doing physical therapy from home (via video calls or a mix of home and clinic visits) works as well as going to a clinic in person for young adults with patellofemoral pain syndrome, a common cause of front knee pain. About 42 people aged 18 to 35 will be…

This study tests whether using cold or laser-activated fluids during a root canal can reduce pain and kill more bacteria than standard treatment. Sixty adults with an infected lower molar will receive one of four rinses: room-temperature, cold, heated, or laser-activated sodium h…

This study tests whether a dietary supplement called Native CT-II® (a type of collagen from chicken sternum) can reduce pain and improve knee function in people with knee osteoarthritis. About 114 adults aged 40-65 with moderate-to-severe knee pain will take either the supplement…

This study compares four different rinsing tools used after root canal treatment to see which one reduces pain the most. Fifty-two adults with an infected lower back tooth will be randomly assigned to one of four groups. They will rate their pain at several times over two days an…

This study tests whether robotic-assisted walking training (using a device called Lokomat) can improve balance and walking smoothness in people with incomplete spinal cord injury. Thirty participants will be randomly assigned to either robotic training or standard physiotherapy. …

This study tests whether adding levocarnitine, a natural nutrient, to standard chemotherapy can prevent severe liver damage in teens and young adults (ages 15-39) with leukemia or lymphoma. About 440 participants will receive either chemotherapy alone or chemotherapy plus levocar…

This study follows 166 people aged 45 and older who received the Superion IDS implant for lumbar spinal stenosis, a condition that narrows the spine and causes leg pain. The implant is designed to limit certain movements that worsen symptoms. Researchers are checking if patients …

This study tests whether an injection called ZILRETTA can reduce pain in people with shoulder osteoarthritis. About 150 adults aged 50 to 80 will receive either ZILRETTA, a standard steroid, or a placebo. The main goal is to see if ZILRETTA provides better pain relief over 12 wee…

This pilot study tests a procedure called geniculate artery embolization for people with mild to moderate knee osteoarthritis. The treatment blocks abnormal blood vessels in the knee to reduce pain and swelling. Twenty participants will be randomly assigned to either receive the …

This study tested whether a personalized exercise program done 2-4 weeks before knee or hip replacement surgery could improve thinking and reduce delirium in adults aged 55 and older. Participants wore activity trackers and used a smartphone app. The study was suspended, so resul…

This small pilot study at Mayo Clinic is testing whether Electromagnetic Transduction Therapy (EMTT) can help people with osteoarthritis of the foot or ankle. Twenty participants will receive the treatment, and researchers will measure changes in pain and daily function. The goal…

This study looks at two different ways to manage pain after lower back surgery without relying on drugs. About 267 adults will be randomly assigned to either standard care or an enriched pain management plan. The goal is to see which approach better reduces pain and helps people …

This study tests whether dronabinol, a drug made from cannabis, can help control pain after knee arthroscopy. About 30 adults will take part to see if it reduces the need for opioid painkillers and causes fewer side effects. The results will help decide if larger studies are need…

This study tests whether injecting tiny beads into arteries around the knee can reduce pain in people with moderate to severe knee osteoarthritis. The beads block blood flow to the painful area. Nine adults aged 40 to 80 who have not gotten relief from standard treatments are tak…

This study tests whether releasing a tight pectoralis minor muscle (a chest muscle) can improve shoulder function and reduce pain in people with shoulder impingement syndrome. Sixty adults aged 40–60 with chronic shoulder pain will receive either standard physical therapy alone o…

This study tests two types of exercise for people with a common knee condition called patellofemoral pain. One group does neuromuscular control exercises (like balance and coordination), the other does muscle strengthening. Researchers will measure pain, function, and movement in…

This small pilot study tests two different stitching techniques during gum surgery to cover exposed tooth roots caused by gum recession. Seven healthy adults with multiple areas of gum recession will receive both techniques in different parts of their mouth. The goal is to see wh…

This study aimed to compare different treatments—like mouthguards, jaw exercises, and anti-inflammatory drugs—for jaw muscle or joint pain in children aged 7 to 14. The goal was to see which works best and if any affect jaw growth. However, the study was withdrawn before enrollin…

This study tests whether adding yellow or green light therapy to standard care (ice and exercises) can reduce pain and improve knee function in 60 athletes with jumper's knee. Participants will receive either yellow light, green light, or standard care alone. The goal is to see i…

This study looks at whether adding desensitization exercises to the usual hand rehab program can help rheumatoid arthritis patients who have central sensitization—a condition where the nervous system is extra sensitive to pain. About 81 adults with mild-to-moderate RA will be spl…

This study compares two exercise programs—closed kinetic chain exercises and isometric exercises—to see which better reduces pain and improves function in women aged 35-60 with patellofemoral pain syndrome and knee osteoarthritis. Seventy participants will be randomly assigned to…

This study tested two different ways of applying a whitening gel to see which causes less tooth sensitivity. Forty adults with darker teeth received two bleaching sessions one week apart. One group had the gel applied for 40 minutes straight, the other for two 20-minute sessions.…

This study looks at whether cognitive behavioral therapy (CBT) can help adults with acute myeloid leukemia or lymphoma who feel very tired from their cancer or treatment. Participants will attend up to 7 counseling sessions to learn skills to cope with fatigue, anxiety, and depre…

This study tests a new physical therapy approach for people with frozen shoulder (stage 2 or 3). The technique combines specific stretches with shoulder mobilization. Researchers will measure improvements in shoulder movement and daily function. The trial is currently on hold.

This study looks at whether a non-surgical treatment called spinal decompression can help people with chronic low back pain. About 42 adults with back pain from disc problems or sciatica will receive the treatment over 12 weeks. Researchers will use MRI scans and movement tests t…

This study looks at whether playing active video games can help teenagers regain balance and posture better than standard exercises after scoliosis surgery. About 51 teens who had spinal fusion will be split into three groups: video game training, standard stabilization exercises…

This study compares two types of nerve blocks—genicular nerve block and adductor canal block—for pain relief after total knee replacement. It involves 42 adults over 65 undergoing elective knee surgery. The goal is to see which block provides better pain control and helps patient…

This study compares two methods of giving the pain medicine EXPAREL during knee replacement surgery. About 40 adults will receive the medicine either as a targeted block or as local infiltration. Participants will report their pain levels and any extra pain medicines they need. T…

This study compares a single large injection of hyaluronic acid to three smaller weekly injections for knee osteoarthritis. Researchers want to see if the one-shot approach is as safe and effective at reducing pain and improving knee function. The trial involves 46 adults aged 40…

This study tests different ways of applying a dental adhesive and filling material to see which method keeps fillings intact and stain-free for up to 5 years. Fifty adults with cavities or old fillings needing replacement will receive four different filling types. The goal is to …

This study tests a new treatment called BRC-OA, made from donated human fat tissue, for people with mild to severe knee osteoarthritis. The goal is to see if it safely reduces pain and improves knee function. About 42 adults aged 18-80 will receive one of two doses or a control, …

This study looks at whether starting to walk earlier after a type of knee surgery (open wedge high tibial osteotomy) helps reduce pain and improve function in people with knee osteoarthritis. About 72 participants will either start partial weight bearing at 2 weeks or wait until …

This study tests whether taking vitamin D3 before a root canal can reduce pain afterward. Fifty-four adults with low vitamin D and painful tooth inflammation will receive either a single high dose, a three-day course, or a placebo. Pain levels and painkiller use will be tracked f…

This study observes 80 children with Marfan syndrome to understand how the condition impacts their quality of life, self-image, and ability to manage their health. Participants fill out questionnaires about their well-being and medication habits. The goal is to identify who might…

This study looks for biological markers in the blood and tissue of adults with Marfan syndrome that could signal when an aortic aneurysm is dangerous enough to require surgery. Researchers will compare three groups of Marfan patients: those without aortic aneurysms, those with st…

This study tracks 80 adults with different smell disorders (like total loss, partial loss, or distorted smell) plus healthy volunteers over one year. Researchers use brain scans, smell tests, and questionnaires to see how the brain changes and how smell loss impacts mood and dail…

This study aims to validate a new questionnaire that measures emotional wellbeing and patient perceptions after total knee replacement surgery for knee arthritis. Researchers will enroll 167 adults who had knee replacement within the last 3 months. The goal is to ensure the quest…

This study explores whether a new type of resistance exercise is practical and safe for people with low bone mass, including those with osteopenia, osteoporosis, or sarcopenia. Over two months, one group performs progressive muscle-strengthening exercises while a control group co…

This study looks at whether a genetic test can predict who will develop Paget's disease of the bone, a condition that can cause pain, deformity, and hearing loss. Researchers are studying 135 people aged 45 and older who have a parent or sibling with Paget's but do not have the d…

This study tests whether a simple isometric (static) hand exercise can change how people with rheumatoid arthritis feel pain. Researchers will measure pain tolerance, pressure thresholds, and muscle oxygen levels in 66 adults. The goal is to see if this type of exercise can help …

This study tests whether a simple mathematical formula, applied to routine CT scans, can accurately predict the size of a bone defect that will be created during surgery to remove a bone tumor. Accurate prediction could help surgeons select the right-sized donor bone graft before…

This study tests whether offering online educational videos and mailed saliva genetic testing kits helps more first-degree relatives of people with BRCA mutations get tested, compared to standard care with a family letter. About 820 participants will be enrolled across several me…

This study looks at whether people with flat feet (pes planus) are more likely to have piriformis syndrome, a condition that causes pain in the hip and lower back. Researchers will compare foot posture and pain in adults aged 18-65 who have piriformis syndrome with those who do n…

This study examines health data from about 800,000 Korean adults to see how often conditions like obesity, type 2 diabetes, heart disease, chronic kidney disease, and fatty liver occur together. Researchers will analyze national survey and insurance records from 2013 to 2023. No …

This study is a national registry in China that will track 500 women who experience an aortic dissection (a tear in the main artery) during pregnancy or within 12 weeks after giving birth. Researchers will collect information on treatments and outcomes for both mothers and babies…

This study was designed to look back at the health of people with Cushing's disease in Western France between 1990 and 2015. The goal was to find out how many patients went into remission and how many had their disease come back after their first surgery. However, the study was w…

This study aims to find genetic changes that may cause sporadic chordoma, a rare bone cancer. Researchers will collect saliva and medical records from 188 patients across the U.S. and Canada who are the only ones in their family with chordoma. No treatment is given; the goal is t…

This study follows 30 adults aged 45-80 who are having spinal fusion surgery for spondylolisthesis. Researchers will use CT scans to measure changes in the bone graft placed between vertebrae over time. The goal is to develop an objective way to assess whether the bones have fuse…

This study collects blood and bone marrow samples from up to 550 people with blood cancers like leukemia, lymphoma, and myelodysplastic syndrome. Researchers will study the cells, genes, and proteins in these samples to better understand how these cancers develop and to find new …

This study looks at how patients with advanced blood cancers (like acute myeloid leukemia) who are not eligible for a cure, along with their nurses and doctors, feel about the benefits of blood transfusions. Researchers will give questionnaires before each transfusion to compare …

This study follows 50 adults who had surgery for a broken shinbone to see if changes in the kneecap tendon's stiffness relate to knee pain. Researchers use a special ultrasound before and up to 6 months after surgery. The goal is to better understand why some people develop front…

This phase 2 trial is testing whether a special type of PET/CT scan (FDG-PET/CT) can better measure how breast cancer that has spread to the bones responds to treatment. The study involves 138 participants with hormone receptor-positive metastatic breast cancer that is mostly in …

This study was designed to see how accurately patients report their own medication and healthcare use in diaries compared to official health insurance records. It planned to include people with diabetes, arthritis, kidney disease, or prostate cancer. However, the study was withdr…

This study examines how often healthcare workers in a hospital's intensive care unit (ICU) experience physical, verbal, or sexual assaults from patients or their relatives. Researchers will review medical records of 865 adults who were in the ICU and had a reported incident of vi…

This study uses MRI scans to track changes in the jaw joint over 18 months in people with degenerative joint disease. Researchers will compare these scans to those from healthy volunteers to learn more about how the disease progresses. No drugs or contrast agents are used. The go…

This study looks at records from over 500,000 Medicare beneficiaries with rheumatoid arthritis or ankylosing spondylitis who had major orthopedic procedures like joint replacements or spine surgery between 1999 and 2015. Researchers want to understand how often complications happ…

This study tests whether the way a clear aligner's edge meets the gumline changes the types of bacteria living in the gum pocket. 36 people in the finishing phase of orthodontic treatment wore aligners with two different edge designs at the same time—one covering a bit of gum, th…

This was a planned French study to collect information on chronic myeloid leukemia (CML) in young adults aged 18 to 30 who were treated with tyrosine kinase inhibitors. The goal was to describe their diagnosis, treatment choices, side effects, and quality of life. However, the st…

This large observational study aims to collect medical data and biological samples from up to 5,000 people with chronic spinal cord injury or traumatic brain injury, as well as their family members and healthy volunteers. Researchers hope this information will help them better un…

This study looks at people and families who have a high risk of cancer to learn what genes and environmental factors might increase that risk. Over 5,000 participants are followed over time with questionnaires, medical records, and optional genetic testing. No treatment is given,…

This study looks at whether a 3-month non-surgical program—including patient education, supervised exercise, and diet counseling—can help people with knee osteoarthritis avoid knee replacement surgery while maintaining their quality of life. Researchers will follow 2,500 patients…

This study at Duke University tests whether a special MRI scan using inhaled xenon gas can detect changes in lung function over time in people with progressive pulmonary fibrosis. Sixty adults with various types of lung scarring will have MRI scans before starting anti-fibrotic m…

This study was designed to see if X-rays taken before knee replacement surgery could reliably show ligament damage in people with knee arthritis. It was an observational study, meaning no treatment was given. However, the study was withdrawn before enrolling any participants, so …

This study looks at two different ways clear aligners are trimmed—one that sits on the gums and one that stops at the gum line—to see which leads to less plaque and healthier gums. Twenty adults with mild to moderate crowding will wear both designs at the same time (one on top, o…

This study compares three types of dental onlays (a type of filling that covers part of a tooth) for treating cavities. It involves 36 adults who each need at least three onlays. The onlays are made using 3D printing, milling, or indirect resin composite. Researchers will check h…

This study looked at how well 3D-printed custom insoles work for healthy adults and those with flat feet. About 100 people wore the insoles for 3 weeks, at least 3 hours each day. Researchers measured foot pressure, walking patterns, and how satisfied people were with the insoles…

This study aimed to compare how well people could walk after two different hip replacement surgeries: one through the front (direct anterior) and one through the back (posterior). It planned to include adults over 50 with hip arthritis. However, the study was withdrawn before enr…

This study looked at whether having more frequent contact with a clinician (at least once a week) improves satisfaction for people with long-lasting musculoskeletal conditions. Participants were split into two groups: one with standard contact and one with extra check-ins via tex…

This study watches 242 adults with high-risk polycythemia vera (a rare blood cancer that thickens the blood) who have already had a blood clot. Researchers track health data like blood pressure, weight, and lab tests to see which factors best predict future clots. The goal is to …

This study looks at how well different types of dentures and implant-supported dental devices help people chew and how they affect quality of life. Researchers will compare conventional dentures, mini-implant overdentures, and implant-assisted partial dentures in 240 adults. The …

This study looks at whether a short, reassuring message given to adults before a clinic visit for common muscle or joint issues can affect their interest in extra care like tests, injections, or surgery. About 144 participants will either read the message or receive usual care, t…

This study looks at whether taking CT scans of the lower back while standing up gives doctors more useful information than the usual lying-down scans. About 20 adults who are already scheduled for a standard CT scan will also get a standing scan. The goal is to see if the standin…

This study looks at how radiation and chemotherapy change the bone marrow in people with acute leukemia. Researchers will use special scans and collect blood and bone marrow samples to track these changes over time. The goal is to learn more about the effects of treatment, not to…

This study aimed to test different regional anesthesia techniques to help people recover faster and go home sooner after total knee replacement. It planned to compare a standard pain injection with an added nerve block or continuous nerve block infusion. However, the study was wi…

This study tests a quick, non-invasive brain scan called Magnetic Resonance Fingerprinting (MRF) in children and young adults with acute leukemia. The goal is to see if the scan can detect early brain changes caused by chemotherapy. Participants also take a fun, game-like memory …

This study follows over 1,300 people with psoriatic arthritis who are starting either guselkumab (Tremfya) or an IL-17 inhibitor as part of their routine care. Researchers will track how long patients continue each treatment and monitor joint swelling and tenderness. The goal is …

This study follows over 1,500 people who received an Attune total knee replacement to see how long the implant lasts—up to 15 years. Participants had non-inflammatory degenerative joint disease (like osteoarthritis). The goal is to gather real-world data on the durability of four…

This study follows 200 people who received a smart knee implant (Persona IQ) that tracks movement after total knee replacement. The goal is to see if data from the implant and a phone app can help doctors understand recovery and spot problems early. Participants use a smartphone …

This study is a large registry that follows nearly 16,000 people with psoriasis to monitor the long-term safety of several treatments, including biologic drugs like infliximab and ustekinumab. Participants receive their usual care while researchers track side effects, disease act…

This study tests whether a special website and video coaching for parents can help children aged 6-12 who had leukemia or lymphoma improve their learning and school performance. Many children survive these cancers but may struggle with memory, attention, and thinking due to treat…

This study uses an iPhone app to track symptoms of psoriasis and psoriatic arthritis in 1,000 adults. Participants complete surveys, take photos of their skin, and use phone sensors to measure joint function. The goal is to see if smartphones can reliably monitor these conditions…

This study follows 600 people with Albright hereditary osteodystrophy, a rare genetic condition affecting bones and hormones. Researchers are looking at how growth hormone treatment affects height and weight in those with a related hormone problem, and also studying thinking and …

This study looks at how bone contributes to citrate levels in urine, which may help explain why some people have low urine citrate. Researchers will study 25 adults with untreated osteoporosis, giving them potassium citrate and measuring changes in urine citrate and bone markers.…

This study looks at a protein called progranulin in the blood of people with ankylosing spondylitis (a type of arthritis that affects the spine) and compares it to healthy volunteers. Researchers want to see if progranulin levels are linked to disease activity and whether they ch…

This study looks at patients in intensive care who have an infection in a joint replacement (like a hip or knee). Researchers want to understand their care path, recovery, and survival over two years. The study will collect data from medical records and phone calls with patients …

This study follows 23 people with tumor-induced osteomalacia (TIO), a rare condition where tumors cause weak bones. The goal is to see how well the drug burosumab works over time and to monitor any tumor changes. Participants continue their usual care, and no new treatments are g…

This observational study looks at 103 adults with knee osteoarthritis to see if repetitive negative thinking (rumination and worry) is linked to worse pain and disability, even when X-ray damage is similar. Participants fill out questionnaires about their thoughts, pain, and dail…

This study follows 201 adults with chronic myeloid leukemia who are taking asciminib (Scemblix) as a third or later treatment option. Researchers want to see how long patients stay on the drug and how well it controls their cancer in real-world settings. The goal is to gather pra…

This study tests a web-based tool called gp-multitool.de that helps general practitioners follow guidelines for older patients with multiple chronic conditions. About 659 patients from GP practices in Germany are taking part. The tool lets patients fill out questionnaires online …

This study looks at 54 obese women getting knee replacements to see if a stemmed or non-stemmed tibial implant works better. The goal is to find out which type reduces the risk of the implant collapsing or loosening over time. Researchers will track these outcomes to guide future…

This study looks at skin cells (fibroblasts) from people with Marfan syndrome and other genetic conditions that cause thoracic aortic aneurysms (a bulging of the main artery in the chest). Researchers want to find out how these cells behave differently and what genes or proteins …

This study tests whether a special PET/CT scan using a radioactive tracer called FLT can measure how well chemotherapy is working in people with newly diagnosed acute myeloid leukemia (AML). The scan lights up fast-growing cancer cells, and researchers want to see if it can predi…

This study looks at why some people with early rheumatoid arthritis develop long-lasting chronic pain while others do not. Researchers will use pain sensitivity tests and brain scans to find clues. The goal is to better understand the transition from acute to chronic pain, which …

This observational study follows 782 people with X-linked hypophosphatemia (XLH), a rare genetic bone disease, to understand how the condition changes over time. It also monitors the long-term safety and effectiveness of the drug burosumab. No new treatment is given; participants…

This study aimed to find out how often chronic sinusitis occurs in children treated for head and neck cancer, and how it affects their quality of life. Researchers planned to compare these children to those treated for cancer elsewhere in the body using a questionnaire called SNO…

This study looks back at medical records of 725 older adults (over 65) with acute myeloid leukemia (AML). Researchers want to see if using a special 'fitness' score to choose treatment leads to longer survival. No new treatments are given; the goal is to learn which treatment app…

This pilot study tests whether adults aged 65 and older with acute leukemia can use a digital platform to complete health questionnaires from home. Twenty participants will fill out surveys about their quality of life and symptoms on a tablet or phone, with results sent directly …

This study follows 113 people who recently had a spinal cord injury to understand how feelings of injustice (like blaming others or feeling cheated) change over time and affect their mental health, pain, and quality of life. Researchers will interview some participants and use su…

This study follows 400 patients for two years after they have endoscopic endonasal skull base surgery (surgery through the nose to reach the base of the skull). The goal is to measure their quality of life and nose function using standard questionnaires. It does not test a new tr…

This study looks at whether artificial intelligence can help dentists plan where to place dental implants in people who have lost all their lower teeth. Researchers will use old CT scans to compare AI-generated implant plans with plans made by expert dentists. The goal is to see …

This study looks at how quality of life differs among older adults (60+) newly diagnosed with acute myeloid leukemia (AML) who receive either intensive or non-intensive chemotherapy. Researchers aim to build a decision-making model that helps patients and doctors choose treatment…

This study follows 200 adults with high blood pressure and gum disease to see how gum health affects blood pressure and cholesterol levels over 6 to 12 months. Researchers will measure triglycerides and LDL cholesterol to understand the link. The goal is to learn whether treating…

This study follows 75 adults with benign or slow-growing brain tumors who are receiving partial brain radiation. Researchers will use memory tests and MRI scans before treatment and at 6 and 12 months after to see how radiation affects thinking and memory. The goal is to identify…

This Stanford study is testing whether non-intrusive sensors placed in the home can automatically track neuropsychiatric symptoms like mood changes and agitation in older adults. Researchers will enroll 25 participants with or at risk of mild cognitive impairment or dementia, alo…

This study collects medical information from patients whose cancer has spread to the bone. The goal is to learn more about how cancer affects bones and how to prevent complications like fractures and pain. No extra tests or visits are needed—just data from regular care. The study…

This study looks at whether offering doctors educational meetings about biosimilar medications leads them to prescribe more of these lower-cost alternatives instead of the original brand-name drugs. About 1,325 clinicians who prescribe adalimumab for conditions like rheumatoid ar…

This study follows 510 people who had ACL knee reconstruction surgery, with or without an extra procedure called LET, about 10 years ago. Researchers want to see if adding LET increases the chance of developing knee osteoarthritis. Participants will get X-rays and answer question…

This study aimed to see if tracking a specific gene mutation (c-Kit) could help predict relapse in acute myeloid leukemia patients. It planned to compare this method with current monitoring techniques. However, the study was withdrawn before enrolling any participants, so no resu…

This study investigates how common spinal nerve pain is in people with ankylosing spondylitis (AS) and whether it affects their sleep. Researchers will use questionnaires to assess pain, sleep quality, quality of life, and fatigue in 292 AS patients. The goal is to better underst…

This study follows 26 people who had hip surgery (periacetabular osteotomy) for hip dysplasia. Researchers want to see how many return to their favorite sports and how well they recover. The study collects data from medical records and patient reports, focusing on pain levels and…

This study looks at nerve-related pain in people with ankylosing spondylitis, a type of arthritis that mainly affects the spine. Researchers will use a questionnaire to describe the pain and see how it relates to daily activities. About 130 adults with the condition will take par…

This study tests whether sending a short screening questionnaire directly to people with psoriasis can help detect psoriatic arthritis earlier. 18,000 participants will be randomly assigned to receive the questionnaire or not. Those with high scores will be advised to see a rheum…

This study looks at tissue samples taken from deep gum pockets in people with periodontitis who have already completed initial treatment. Researchers want to describe the tissue features and see if they relate to how well the gums heal. The goal is to better understand healing pa…

This study looks at over 110,000 people who had hip replacement surgery to see if a longer or shorter hip stem works better. It compares death rates, how often the hip implant needs to be replaced, and patient-reported pain and function. The goal is to find out which stem length …

This study collects tissue and blood samples from 1,600 people with various advanced cancers, along with their medical information, over the course of their treatment. Researchers will store these samples and data in a biobank for current and future studies. The goal is to better…

This study looks at how the size of root canal preparation and the amount of remaining tooth structure affect the survival of treated lower molars. Sixty patients with infected pulp will receive either a conventional or conservative root canal preparation. Researchers will track …