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New study tests gentler tooth whitening to reduce sensitivity

NCT ID NCT07597044

Symptom relief Sponsor: Universidade Federal Fluminense Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested two different ways of applying a whitening gel to see which causes less tooth sensitivity. Forty adults with darker teeth received two bleaching sessions one week apart. One group had the gel applied for 40 minutes straight, the other for two 20-minute sessions. Researchers measured pain and color change up to 30 days later.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
40% hydrogen peroxide gel (Opalescence Boost)
What this could lead to
If one protocol causes less pain, dentists may adopt it to make whitening more comfortable.
What could go wrong
This is a small, early study with only 40 people, so results may not apply to everyone. Tooth sensitivity is still possible with either method.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

40 people

The number who actually took part.

Started

Oct 2025

Expected to finish

Sep 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * The selected volunteers should: * Present Good general state of health * Be at least 18 years of age * Have an acceptable oral hygiene * Present the upper and lower arches without absence of teeth of first premolar right to the left first premolar. * Have anterior teeth with any kind of restoration. * Be No smoker * Have the upper right canine with color 2M2 or darker Exclusion Criteria: * The selected volunteers should not: * Have medical history of diseases that can affect the results of the study * Have made use of cigarettes in the last 30 days * Have some important pathology in the oral cavity * Be pregnant * Be breastfeeding * Have moderate advanced periodontal disease; * Have consumed drugs, alcool or any medication that can cover the results, as other types of anti-inflammatories or painkillers; * Have used products indicated for dental sensitivity, as desensitizing toothpaste or similar product * Present gingival recession * Present exacerbated hypersensitivity history

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Tooth sensitivity

Contacts and locations

Locations

  • Universidade Federal Fluminense - School of Dentistry

    Nova Friburgo, Rio de Janeiro, 28625-650, Brazil

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