New toothpaste may stop whitening pain

NCT ID NCT07506850

Completed Symptom relief Sponsor: Universidade Federal do Para Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether special pastes containing CPP-ACP and fluoride could reduce tooth sensitivity after in-office bleaching. 64 adults received either a paste with CPP-ACP and sodium fluoride, CPP-ACP and stannous fluoride, or a placebo before and after whitening. Pain was measured over 72 hours. The goal is to find a way to make whitening more comfortable without reducing its effectiveness.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: CPP-ACP combined with sodium fluoride or stannous fluoride paste
What this could lead to: If it works, dentists may have a proven way to reduce pain after teeth whitening, making the procedure more comfortable.
What could go wrong: This is a small, completed trial with 64 people, so results may not apply to everyone. The pastes might not reduce sensitivity better than a placebo.

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Conditions

The condition(s) this trial relates to.

dentin sensitivity

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

TOOTH SENSITIVITY

Contacts and locations

Locations

Universidade Federal do Pará

Belém, Pará, 66075-110, Brazil

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