Tiny particles in bleaching gel could mean whiter teeth and fewer zings
NCT ID NCT06904118
First seen Aug 31, 2026 · Last updated Sep 01, 2026 · Updated 1 time
Summary
This trial tests whether a bleaching gel fortified with tiny titanium oxide particles can whiten teeth better and cause less sensitivity than a standard gel. Sixty adults with tooth discoloration will receive either the nano-enriched gel or the conventional gel during a single session. Researchers will measure color change with a spectrophotometer and track pain scores over several days.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- A bleaching gel enriched with titanium oxide nanoparticles derived from corn hair fibers, compared with a conventional hydrogen peroxide gel without nanoparticles.
- What this could lead to
- If it works, this could offer a way to whiten teeth more effectively while causing less post-treatment sensitivity.
- What could go wrong
- This is a small, early-stage trial, so results may not apply broadly. The nano-enriched gel might not outperform the standard gel, and some tooth sensitivity is still possible.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
60 people
The number who actually took part.
- Started
-
Jun 2024
- Finished
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Dec 2024
- Lead sponsor
-
A government agency
The lead sponsor is a government body.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
20 to 40 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria:Patients enrolled in the current trial ranged between 20- 40 years old with good general and oral health. Participants selected without any caries, restorations or periodontal disease in anterior teeth. The selected participants possessed maxillary incisors having shade A3 or darker after checking with Vita Classical Shade Guide Exclusion Criteria:The patients having poor oral hygiene; caries, restorations, periodontal disease, root canal treatment, fractures, gingival recessions, cervical lesions, bruxism, severe internal discoloration, dental prosthesis, cracks and spontaneous TS, in anterior teeth shall be excluded from this study. Moreover, pregnant, lactating women, smokers, patients taking medications, those having fixed orthodontic appliances and undergone tooth whitening will be also excluded
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
School of Dentistry, Pakistan Institute of Medical Sciences
Islamabad, Punjab Province, 44080, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can a daily chewing gum soothe sensitive teeth and banish bad breath?
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- New study tests gentler tooth whitening to reduce sensitivity
- New study reveals best way to erase ugly tooth spots in kids
- New foam toothpaste promises whiter teeth and less pain