Nerve gliding or back manipulation: which eases knee pain better?
NCT ID NCT07712146
First seen Jul 17, 2026 · Last updated Jul 17, 2026
Summary
This study tests whether adding femoral nerve gliding or lumbopelvic manipulation to standard hip-knee exercises improves pain, knee function, and nerve health in people with patellofemoral pain syndrome (front knee pain). Sixty adults aged 18–35 with unilateral knee pain will be randomly assigned to one of three groups: exercises alone, exercises plus nerve gliding, or exercises plus back manipulation. All treatments last 6 weeks, and outcomes are measured before and after.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- femoral nerve gliding technique and lumbopelvic manipulation
- What this could lead to
- If effective, these techniques could offer better pain relief and knee function for people with patellofemoral pain syndrome, potentially reducing the need for more invasive treatments.
- What could go wrong
- This is a small, early-stage study with only 60 participants, so results may not apply to everyone. The techniques are manual therapies, and their effectiveness may vary between individuals.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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About 60 people
The number the study aims to enrol. It can still change while the study runs.
- Expected to start
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Jul 2026
An estimate. Start dates often move.
- Expected to finish
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Apr 2027
An estimate. End dates often move.
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 35 years
- Sex
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Anyone
- Healthy volunteers
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Not accepted
This study is not open to healthy volunteers. The entry requirements below say who it is open to.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Age of the subjects is between 18-35 years. * BMI will be from 18.5 to ≤ 29.5 Kg/m2 * Anterior or retro patellar knee pain either on the dominant or non- dominant leg for at least 6 weeks duration . * Worst pain level in the previous month of up to 3cm on a 10cm numerical rating scale (NRS) * Per or retropatellar pain during at least 2 of the following activities: squatting, prolonged sitting, kneeling, running, jumping and climbing stairs * Showing 2 or more positive signs on the following clinical tests: Clarke's sign, Waldron test, active patellar grind test, patellar compression test, and palpation of the medial/lateral articular border of the patella . * Patients had positive femoral slump test with limited active lumber ROM. Exclusion Criteria: * History of previous knee surgery and any knee pathology (meniscus tear, patellar tendinopathy, ligament sprain and osteoarthritis) . * Any systemic diseases and/or connective tissue disorders . * Bursitis and ligament tears . * Lower back dysfunction such as disc lesion, sciatica or spondylolisthesis. * participants that had undergone physiotherapy during the preceding 3 month. * Pregnant women. * Osteoporosis or recent fracture of the hip or spinal joints.• . Radiographic evidence or medical diagnosis of spinal instability (Grade II spondylolithesis or greater), spondyloarthritides, or severe spinal misalignment * Nervous system disease or disorder * .Lumbosacral nerve root compression (any of the following signs present) a. Positive straight leg raise (SLR) test less than 45°, marked paresis (\<3/5 on manual muscle testing) involving a major muscle group of the lower extremity, diminished, and asymmetric (lower than uninvolved side), lower extremity muscle stretch reflex and diminished or absent sensation to pinprick in any lower extremity dermatome (D'Agati M 2022).
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
How to take part
Only the study team decides who joins. These are the ways to reach them.
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The places running it
1 site. The list below names each one and where it is.
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The official record
ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.
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A doctor treating you
A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.
Contacts and locations
Locations
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Faculty of physical therapy-Cairo University
Cairo, Egypt
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