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Can gentle exercise with a cuff beat knee pain in athletes?

NCT ID NCT07585305

Symptom relief Sponsor: Ibadat International University, Islamabad Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares two exercise methods that use a cuff to partly restrict blood flow to the leg: resistance training with light weights versus stationary cycling. Both aim to reduce pain and improve strength in athletes with patellofemoral pain syndrome. Forty-eight athletes aged 18-40 will train three times a week for eight weeks. The goal is to find a safer, effective way to rehab knee pain without heavy loading.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Blood flow restriction (BFR) training using a pneumatic cuff
What this could lead to
If successful, this could offer athletes a low-load exercise option to reduce knee pain and build strength without heavy weights.
What could go wrong
This is a small, early-stage trial with only 48 participants. Results may not apply to all athletes, and the benefits over standard rehab are uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 48 people

The number the study aims to enrol. It can still change while the study runs.

Started

May 2026

Expected to finish

Jul 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Male and female athletes aged 18-40 years 2. Clinically diagnosed with patellofemoral pain syndrome 3. Anterior or retropatellar knee pain of at least 3 months duration 4. Pain provoked by at least two functional activities (e.g., squatting, stair climbing, running, prolonged sitting) 5. Willingness to participate and provide written informed consent Exclusion Criteria: 1. History of knee surgery or significant knee trauma in the past 6 months 2. Presence of ligament, meniscal, or cartilage injuries 3. Neurological, vascular, or systemic inflammatory conditions 4. Contraindications to BFR training (e.g., deep vein thrombosis, uncontrolled hypertension) 5. Pregnancy

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Conditions

The condition(s) this trial relates to.

patellofemoral pain syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Patello femoral pain syndrome

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

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Contacts and locations

Locations

  • Ibadat International University, Islamabad (Iiui)

    RECRUITING

    Islamabad, 46000, Pakistan

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