Healing protein injection could ease back pain without surgery

NCT ID NCT07668466

Not yet recruiting Disease control Sponsor: Cartago Biotech Pty Ltd Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a new medicine called CBT005, a healing protein injected directly into damaged spinal discs. The goal is to see if it is safe and can reduce long-term back pain in 60 adults with disc degeneration. Participants get one injection and are followed for up to 3 years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Growth differentiation factor 6 (CBT005)
What this could lead to: If it works, this could offer a new injection-based treatment for chronic back pain caused by damaged discs, potentially reducing the need for surgery.
What could go wrong: This is an early phase 1/2 trial with only 60 people, so it is too soon to know if it is truly effective or safe. The injection itself carries risks like infection or nerve damage.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Back Pain intervertebral disk degenerative disorder lumbar disk degenerative disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

BACK PAIN DISC DEGENERATIVE DISEASE

Contacts and locations

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Locations

Spine & Scoliosis Service

Kogarah, New South Wales, 2217, Australia

Contact Email: •••••@•••••

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